LLPS-Mum-a065
Psd
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6; Exchange factor for ARF6 A; Pleckstrin homology and SEC7 domain-containing protein 1 |
| Gene Name: | Psd, Efa6a, Kiaa2011, Psd1 |
| Ensembl Gene: | ENSMUSG00000037126.16 |
| Ensembl Protein: | ENSMUSP00000039728.4 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Neuronal granule | "...We performed a 2D-PAGE study followed by a MS/MS analysis to systematically identify the proteins in the granule and determined a total of 42 proteins including those for RNA transport, protein synthesis, translational silencing, and so on." | Mouse brain | 15312650 |
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Mouse cortex | 23071613 |
▼ FUNCTION
| Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers (PubMed:19494129). |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLIRRV VGPGPRGRDL 60 61 GRVTAPCTPL RAPPSPHIAP SPWGPSSPTG QPPPGAQSSV VIFRFVEKAS VRPLNGLPAS 120 121 GGLSRSWDLG GISAPRPTPA LGPGCNRKLR LEASTSDPLP AGGGSVLPGS RDPSRGPLVP 180 181 PQIGADGLYS SLPNGLGGTP EHLAMHFRGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW 240 241 EFFYGSLDAP SSGAKPPEQV LPSRGVGSKQ GSGVAVGRAA KYSETDLDKV PLRCYRETDI 300 301 DEVLAEREEA DSAIESQPSS EGPHGTAQPP ASRPSPCPGP SSSLGSGNED DEAGGEEDVD 360 361 DEVFEASEGA RPGDHMPHSG LLKSPVPFLL GTSPSADGPD SFSCVFEAIL ESHRAKGTSY 420 421 SSLASLEALA SPGPTQSPFF TFEMPPQPPA PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ 480 481 RREVEESDAG ATLAPRKELP SPSHSEDSFG LGAAPLGSSE PPLSQLVSDS DSELDSTERL 540 541 ALGSTDTLSN GQKADLEAAQ RLAKRLYRLD GFRKADVARH LGKNNDFSKL VAGEYLKFFV 600 601 FTGMTLDQAL RVFLKELALM GETQERERVL AHFSQRYFQC NPEALSSEDG AHTLTCALML 660 661 LNTDLHGHNI GKRMTCGDFI GNLEGLNDGG DFPRELLKAL YSSIKNEKLQ WAIDEEELRR 720 721 SLSELADPNP KVIKRVSGGS GSSSSPFLDL TPEPGAAVYK HGALVRKVHA DPDCRKTPRG 780 781 KRGWKSFHGI LKGMILYLQK EEYQPGKALS EAELKNAISI HHALATRASD YSKRPHVFYL 840 841 RTADWRVFLF QAPSLEQMQS WITRINVVAA MFSAPPFPAA VSSQKKFSRP LLPSAATRLS 900 901 QEEQVRTHEA KLKAMASELR EHRAAHLGKK ARGKEADEQR QKEAYLEFEK SRYGTYAALL 960 961 RVKMKAASEE LDTIEAALAQ AGSTEDGCPP PHSSPSLRPK PTSQPRAQRP GSETRAGAGS 1020 1021 TRPKP 1025 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCCAGG GTGCCATGCG CTTCTGCTCA GAAGGCGACT GTGCCATCTC CCCACCACGA 60 61 TGTCCTCGTC GCTGGCTCCC CGAAGGCCCA GTGCCCCAAA GTCCCCCAGC CAGCATGTAT 120 121 GGCAGCACAG GATCCCTTAT ACGACGAGTG GTGGGCCCAG GTCCTCGAGG CCGGGATCTG 180 181 GGACGTGTGA CAGCACCTTG TACCCCTCTG CGAGCCCCTC CCTCACCCCA TATAGCTCCC 240 241 TCACCCTGGG GACCCTCTTC ACCCACTGGG CAGCCTCCAC CAGGGGCACA GAGTTCTGTG 300 301 GTCATCTTCC GTTTTGTGGA GAAGGCCAGT GTGAGGCCAC TGAATGGCCT ACCTGCTTCT 360 361 GGAGGCCTGA GTCGGAGCTG GGACCTGGGC GGGATTTCTG CCCCCAGGCC CACCCCAGCC 420 421 CTTGGACCTG GCTGCAACCG GAAGTTGCGG CTAGAGGCAT CCACATCAGA CCCACTCCCA 480 481 GCTGGAGGAG GCTCTGTTCT TCCTGGCAGC AGGGACCCCT CACGTGGACC ATTGGTCCCA 540 541 CCCCAGATCG GGGCAGATGG GCTTTACTCC TCCCTCCCCA ATGGGCTGGG GGGGACCCCT 600 601 GAGCACCTGG CCATGCACTT CCGAGGACCT GCAGACACCG GATTCCTAAA CCAGGGGGAC 660 661 ACCTGGTCCT CCCCCCGGGA AGTCTCCTCT CATGCCCAGA GAATCGCTCG AGCCAAGTGG 720 721 GAATTCTTCT ATGGCTCCTT GGACGCCCCC AGCTCAGGTG CTAAGCCCCC AGAGCAGGTC 780 781 CTCCCATCAC GTGGGGTGGG CTCCAAGCAA GGCTCTGGGG TGGCTGTGGG GCGAGCAGCC 840 841 AAGTACTCCG AGACAGACCT GGACAAGGTG CCCCTGAGGT GCTACCGAGA GACTGACATC 900 901 GATGAGGTGC TGGCTGAGCG GGAGGAGGCC GACTCTGCCA TTGAGAGTCA GCCCAGCTCT 960 961 GAGGGCCCCC ATGGCACTGC CCAACCACCT GCCTCACGAC CTAGCCCATG CCCTGGCCCT 1020 1021 TCTTCCAGTC TGGGCAGTGG CAACGAAGAT GATGAGGCAG GAGGTGAAGA GGATGTGGAT 1080 1081 GATGAGGTGT TCGAGGCCTC GGAGGGGGCC CGGCCAGGGG ACCACATGCC TCACTCTGGG 1140 1141 CTTCTCAAGT CACCAGTACC CTTCCTGCTT GGGACCAGCC CCTCAGCGGA TGGGCCTGAC 1200 1201 TCCTTCAGTT GTGTGTTTGA AGCTATCTTG GAGTCACACC GGGCCAAGGG CACCTCCTAT 1260 1261 AGTAGCCTTG CCTCCCTGGA GGCACTGGCC TCACCTGGCC CAACCCAGAG CCCCTTCTTC 1320 1321 ACCTTTGAGA TGCCTCCCCA GCCCCCAGCT CCCAGGCCTG ACCCACCTGC ACCTGCCCCA 1380 1381 CTTGCCCCTC TTGAACCTGA TTCTGGCACC AGCTCTGCTG CTGATGGTCC TTGGACCCAG 1440 1441 AGAAGGGAGG TGGAAGAGTC AGATGCTGGG GCCACGCTGG CCCCAAGGAA GGAGCTTCCT 1500 1501 AGTCCCTCCC ACTCTGAGGA TAGCTTTGGG CTGGGGGCAG CACCCCTAGG CAGTGAACCA 1560 1561 CCCCTAAGTC AGCTGGTATC CGACTCAGAC TCAGAGCTGG ACAGCACAGA GCGGCTGGCC 1620 1621 CTGGGAAGCA CAGACACCTT GTCCAATGGA CAGAAAGCAG ATTTGGAGGC TGCACAGCGC 1680 1681 CTAGCCAAGA GGCTATACCG ACTCGATGGC TTCAGGAAGG CCGATGTGGC ACGGCATCTG 1740 1741 GGCAAGAACA ATGACTTCAG CAAATTGGTG GCTGGCGAGT ATCTGAAGTT TTTTGTCTTC 1800 1801 ACGGGCATGA CTCTGGACCA AGCTCTCAGG GTATTTCTAA AGGAGCTGGC CTTAATGGGT 1860 1861 GAGACCCAGG AGCGGGAGCG TGTACTGGCC CACTTCTCCC AGCGATATTT CCAGTGTAAT 1920 1921 CCTGAAGCCC TGTCCTCAGA GGACGGTGCT CACACGCTGA CCTGTGCCCT CATGCTCCTC 1980 1981 AACACAGATC TCCATGGCCA TAACATTGGG AAGCGCATGA CCTGTGGGGA CTTCATCGGA 2040 2041 AACCTGGAGG GCCTCAATGA TGGTGGCGAC TTCCCCAGGG AGCTGCTCAA GGCCTTGTAC 2100 2101 AGCTCCATCA AGAATGAAAA ATTGCAATGG GCCATAGACG AGGAGGAGCT GCGACGGTCT 2160 2161 CTGTCCGAGT TGGCCGATCC TAACCCCAAG GTCATCAAGC GGGTCAGCGG AGGCAGTGGC 2220 2221 AGCAGTTCCA GCCCCTTCCT GGACCTGACT CCTGAGCCCG GGGCAGCTGT CTACAAGCAC 2280 2281 GGGGCCCTGG TGCGAAAGGT GCACGCAGAC CCTGACTGCA GGAAGACACC TCGTGGCAAG 2340 2341 CGGGGCTGGA AGAGCTTCCA CGGGATCCTC AAGGGCATGA TCCTCTACCT GCAGAAGGAG 2400 2401 GAGTATCAGC CTGGGAAGGC TCTTTCCGAG GCAGAGCTGA AGAATGCTAT CAGCATCCAC 2460 2461 CACGCCCTGG CTACCCGCGC CAGCGATTAT AGCAAGAGAC CACACGTCTT CTACCTGCGC 2520 2521 ACAGCTGACT GGCGGGTCTT CCTCTTCCAG GCTCCGAGCC TGGAGCAAAT GCAGTCCTGG 2580 2581 ATCACTCGCA TCAATGTGGT GGCTGCCATG TTTTCTGCAC CCCCCTTCCC AGCTGCTGTT 2640 2641 AGCTCCCAGA AGAAATTCAG CCGCCCTCTG CTGCCCAGTG CTGCCACCCG CCTCTCCCAG 2700 2701 GAGGAGCAGG TGAGGACCCA TGAGGCCAAG CTGAAGGCCA TGGCCAGCGA GCTGAGAGAG 2760 2761 CACCGGGCTG CACATCTGGG AAAGAAGGCC CGAGGCAAGG AGGCGGATGA GCAGCGGCAG 2820 2821 AAGGAGGCCT ACCTGGAGTT TGAGAAATCC CGCTACGGCA CCTATGCAGC ACTGCTTCGA 2880 2881 GTCAAGATGA AGGCAGCCAG CGAGGAGCTG GACACCATAG AGGCAGCCCT GGCCCAGGCT 2940 2941 GGGAGCACGG AGGATGGATG CCCTCCGCCT CACTCCAGTC CTTCCCTGCG GCCCAAGCCC 3000 3001 ACCAGCCAGC CCCGGGCTCA GCGTCCTGGC TCAGAAACCC GGGCTGGAGC AGGCAGTACA 3060 3061 AGGCCAAAGC CCTGA 3075 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cleavage furrow | |
Cellular Component | Dendritic spine | |
Cellular Component | Extrinsic component of postsynaptic endosome membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Postsynaptic density | |
Cellular Component | Postsynaptic density, intracellular component | |
Cellular Component | Ruffle membrane | |
Molecular Function | ARF guanyl-nucleotide exchange factor activity | |
Molecular Function | Phospholipid binding | |
Biological Process | Neuron projection development | |
Biological Process | Regulation of ARF protein signal transduction |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CORUM | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-a066 | Rattus norvegicus | 97.56 | 0.0 | 2006 |
| LLPS-Orc-a062 | Oryctolagus cuniculus | 97.2 | 0.0 | 896 |
| LLPS-Mea-a061 | Mesocricetus auratus | 94.64 | 0.0 | 1839 |
| LLPS-Nol-a065 | Nomascus leucogenys | 94.25 | 0.0 | 1137 |
| LLPS-Pat-a062 | Pan troglodytes | 91.74 | 0.0 | 1745 |
| LLPS-Hos-a063 | Homo sapiens | 91.74 | 0.0 | 1747 |
| LLPS-Gog-a063 | Gorilla gorilla | 91.55 | 0.0 | 1740 |
| LLPS-Fud-a064 | Fukomys damarensis | 91.5 | 0.0 | 1680 |
| LLPS-Dio-a062 | Dipodomys ordii | 91.22 | 0.0 | 1747 |
| LLPS-Aon-a065 | Aotus nancymaae | 90.96 | 0.0 | 1732 |
| LLPS-Sus-a065 | Sus scrofa | 90.92 | 0.0 | 1661 |
| LLPS-Maf-a063 | Macaca fascicularis | 90.77 | 0.0 | 1749 |
| LLPS-Fec-a066 | Felis catus | 90.74 | 0.0 | 1674 |
| LLPS-Mal-a063 | Mandrillus leucophaeus | 90.57 | 0.0 | 1734 |
| LLPS-Man-a064 | Macaca nemestrina | 90.57 | 0.0 | 1734 |
| LLPS-Cea-a065 | Cercocebus atys | 90.48 | 0.0 | 1734 |
| LLPS-Chs-a064 | Chlorocebus sabaeus | 90.48 | 0.0 | 1732 |
| LLPS-Paa-a063 | Papio anubis | 90.48 | 0.0 | 1741 |
| LLPS-Mam-a063 | Macaca mulatta | 90.48 | 0.0 | 1731 |
| LLPS-Rhb-a063 | Rhinopithecus bieti | 90.48 | 0.0 | 1735 |
| LLPS-Ict-a064 | Ictidomys tridecemlineatus | 90.36 | 0.0 | 1716 |
| LLPS-Eqc-a067 | Equus caballus | 90.36 | 0.0 | 1700 |
| LLPS-Caj-a062 | Callithrix jacchus | 89.8 | 0.0 | 1717 |
| LLPS-Caf-a062 | Canis familiaris | 89.79 | 0.0 | 1705 |
| LLPS-Myl-a063 | Myotis lucifugus | 89.57 | 0.0 | 1721 |
| LLPS-Mup-a064 | Mustela putorius furo | 89.48 | 0.0 | 1679 |
| LLPS-Tut-a034 | Tursiops truncatus | 89.38 | 0.0 | 1707 |
| LLPS-Loa-a063 | Loxodonta africana | 89.38 | 0.0 | 1690 |
| LLPS-Bot-a067 | Bos taurus | 89.19 | 0.0 | 1661 |
| LLPS-Otg-a063 | Otolemur garnettii | 88.82 | 0.0 | 1468 |
| LLPS-Aim-a062 | Ailuropoda melanoleuca | 88.81 | 0.0 | 1643 |
| LLPS-Cap-a064 | Cavia porcellus | 88.61 | 0.0 | 1658 |
| LLPS-Pap-a061 | Pan paniscus | 88.58 | 0.0 | 1659 |
| LLPS-Urm-a060 | Ursus maritimus | 87.62 | 0.0 | 1641 |
| LLPS-Ova-a067 | Ovis aries | 87.18 | 0.0 | 1664 |
| LLPS-Poa-a062 | Pongo abelii | 86.21 | 0.0 | 1602 |
| LLPS-Mod-a060 | Monodelphis domestica | 76.08 | 0.0 | 1203 |
| LLPS-Sah-a062 | Sarcophilus harrisii | 74.69 | 0.0 | 1399 |
| LLPS-Meg-a053 | Meleagris gallopavo | 67.58 | 0.0 | 1031 |
| LLPS-Lac-a057 | Latimeria chalumnae | 67.41 | 0.0 | 697 |
| LLPS-Tag-a058 | Taeniopygia guttata | 67.13 | 0.0 | 1003 |
| LLPS-Dar-a1057 | Danio rerio | 64.98 | 0.0 | 652 |
| LLPS-Xet-a056 | Xenopus tropicalis | 63.14 | 9e-120 | 378 |
| LLPS-Anp-a055 | Anas platyrhynchos | 62.0 | 0.0 | 952 |
| LLPS-Fia-a059 | Ficedula albicollis | 61.77 | 0.0 | 1082 |
| LLPS-Ora-a055 | Ornithorhynchus anatinus | 61.57 | 0.0 | 607 |
| LLPS-Anc-a059 | Anolis carolinensis | 61.2 | 0.0 | 1084 |
| LLPS-Scf-a052 | Scleropages formosus | 58.24 | 0.0 | 706 |
| LLPS-Leo-a050 | Lepisosteus oculatus | 57.93 | 0.0 | 842 |
| LLPS-Pof-a059 | Poecilia formosa | 57.26 | 0.0 | 709 |
| LLPS-Tar-a055 | Takifugu rubripes | 56.38 | 0.0 | 639 |
| LLPS-Pes-a057 | Pelodiscus sinensis | 55.56 | 0.0 | 640 |
| LLPS-Gaga-a059 | Gallus gallus | 55.2 | 0.0 | 657 |
| LLPS-Ten-a053 | Tetraodon nigroviridis | 54.52 | 0.0 | 759 |
| LLPS-Cas-a061 | Carlito syrichta | 54.03 | 0.0 | 624 |
| LLPS-Gaa-a053 | Gasterosteus aculeatus | 53.17 | 0.0 | 713 |
| LLPS-Orn-a055 | Oreochromis niloticus | 52.71 | 0.0 | 783 |
| LLPS-Asm-a053 | Astyanax mexicanus | 51.03 | 0.0 | 751 |