Homo sapiens      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 45 genes.  Reviewed (43 or Unreviewed (2

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-2292
ENSG00000183684.7
Q86V81
ALYREF
2
LLPS-Hos-0521
ENSG00000135387.20
Q14444
CAPRIN1
3
LLPS-Hos-0652
ENSG00000099622.13
Q14011
CIRBP
4
LLPS-Hos-1891
ENSG00000113742.12
Q17RY0
CPEB4
5
LLPS-Hos-2503
ENSG00000079785.14
Q92499
DDX1
6
LLPS-Hos-1500
ENSG00000215301.10
O00571
DDX3X
7
LLPS-Hos-0055
ENSG00000108654.14
P17844
DDX5
8
LLPS-Hos-2726
ENSG00000156508.17
P68104
EEF1A1
9
LLPS-Hos-1098
ENSG00000144895.11
Q9BY44
EIF2A
10
LLPS-Hos-1729
ENSG00000134001.12
P05198
EIF2S1
11
LLPS-Hos-0510
ENSG00000125977.6
P20042
EIF2S2
12
LLPS-Hos-0768
ENSG00000151247.12
P06730
EIF4E
13
LLPS-Hos-0052
ENSG00000162374.16
P26378
ELAVL4
14
LLPS-Hos-0808
ENSG00000182944.17
Q01844
EWSR1
15
LLPS-Hos-2426
ENSG00000102081.14
Q06787
FMR1
16
LLPS-Hos-1714
ENSG00000114416.17
P51114
FXR1
17
LLPS-Hos-2553
ENSG00000129245.11
P51116
FXR2
18
LLPS-Hos-0862
ENSG00000145907.14
Q13283
G3BP1
19
LLPS-Hos-2535
ENSG00000177733.6
Q13151
HNRNPA0
20
LLPS-Hos-2438
ENSG00000135486.17
P09651
HNRNPA1
21
LLPS-Hos-2608
ENSG00000122566.21
P22626
HNRNPA2B1
22
LLPS-Hos-1343
ENSG00000197451.11
Q99729
HNRNPAB
23
LLPS-Hos-2022
ENSG00000138668.18
Q14103
HNRNPD
24
LLPS-Hos-0747
ENSG00000153187.19
Q00839
HNRNPU
25
LLPS-Hos-2491
ENSG00000121774.17
Q07666
KHDRBS1
26
LLPS-Hos-1461
ENSG00000107643.16
P45983
MAPK8
27
LLPS-Hos-1736
ENSG00000115053.15
P19338
NCL
28
LLPS-Hos-0189
ENSG00000147140.15
Q15233
NONO
29
LLPS-Hos-a063
ENSG00000059915.16
A5PKW4
PSD
30
LLPS-Hos-2824
ENSG00000121390.18
Q8WXF1
PSPC1
31
LLPS-Hos-2699
ENSG00000185129.5
Q00577
PURA
32
LLPS-Hos-1690
ENSG00000102317.17
P98179
RBM3
33
LLPS-Hos-0792
ENSG00000157110.15
Q93062
RBPMS
34
LLPS-Hos-0936
ENSG00000100316.15
P39023
RPL3
35
LLPS-Hos-0123
ENSG00000100220.11
Q9Y3I0
RTCB
36
LLPS-Hos-0276
ENSG00000087302.8
Q9Y224
RTRAF
37
LLPS-Hos-0948
ENSG00000116560.10
P23246
SFPQ
38
LLPS-Hos-1688
ENSG00000188529.14
O75494
SRSF10
39
LLPS-Hos-2653
ENSG00000124214.19
O95793
STAU1
40
LLPS-Hos-1947
ENSG00000040341.17
Q9NUL3
STAU2
41
LLPS-Hos-2095
ENSG00000135316.17
O60506
SYNCRIP
42
LLPS-Hos-0620
ENSG00000109654.14
Q9C040
TRIM2
43
LLPS-Hos-1960
ENSG00000110171.19
O75382
TRIM3
44
LLPS-Hos-3386
ENSG00000183421.11
P57078
RIPK4
45
LLPS-Hos-4493
ENSG00000161642.17
Q96PM9
ZNF385A