LLPS-Hos-1947
STAU2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Double-stranded RNA-binding protein Staufen homolog 2 |
| Gene Name: | STAU2 |
| Ensembl Gene: | ENSG00000040341.17 |
| Ensembl Protein: | ENSP00000428284.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Several RBPs were confirmed as PB components by immunostaining and/or GFP tagging as well as the molecular motor MYO6, which may be involved in PB trafficking." | HeLa cells | 29908710 |
| P-body | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
| P-body | "...Comparing protein relative abundances between the sorted and pre-sorted fractions, we identified 125 proteins as significantly enriched in P-bodies." | HEK293 cells | 28965817 |
| Stress granule | "...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs." | HEK293T cells, Neural progenitor cells | 29373831 |
| Stress granule | "...Mass spectrometry analysis identified 317 proteins from cross-linked and 139 proteins from non cross-linked cells as having ≥ 2 fold spectral counts over IP from unstressed cells." | U-2OS cells | 26777405 |
| Stress granule | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
| Stress granule | "...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell." | U-2OS cells | 26777405 |
| Stress granule | "...283 proteins identified as APEX hits in HEK293T cells or previously shown to associate with SGs." | N/A | 29373831 |
| Stress granule | "...A list of candidate SG proteins identified by mass spectrometry in NPCs, including statistical analysis." | Neural progenitor cells | 29373831 |
| Nucleolus, Neuronal granule | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MANPKEKTAM CLVNELARFN RVQPQYKLLN ERGPAHSKMF SVQLSLGEQT WESEGSSIKK 60 61 AQQAVANKAL TESTLPKPVQ KPPKSNVNNN PGSITPTVEL NGLAMKRGEP AIYRPLDPKP 120 121 FPNYRANYNF RGMYNQRYHC PVPKIFYVQL TVGNNEFFGE GKTRQAARHN AAMKALQALQ 180 181 NEPIPERSPQ NGESGKDVDD DKDANKSEIS LVFEIALKRN MPVSFEVIKE SGPPHMKSFV 240 241 TRVSVGEFSA EGEGNSKKLS KKRAATTVLQ ELKKLPPLPV VEKPKLFFKK RPKTIVKAGP 300 301 EYGQGMNPIS RLAQIQQAKK EKEPDYVLLS ERGMPRRREF VMQVKVGNEV ATGTGPNKKI 360 361 AKKNAAEAML LQLGYKASTN LQDQLEKTGE NKGWSGPKPG FPEPTNNTPK GILHLSPDVY 420 421 QEMEASRHKV ISGTTLGYLS PKDMNQPSSS FFSISPTSNS SATIARELLM NGTSSTAEAI 480 481 GLKGSSPTPP CSPVQPSKQL EYLARIQGFQ AALSALKQFS EQGLDPIDGA MNIEKGSLEK 540 541 QAKHLREKAD NNQAPPGSIA QDCKKSNSAV 570 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTTCAAA TAAATCAGAT GTTCTCAGTG CAGCTGAGTC TTGGTGAGCA GACATGGGAA 60 61 TCCGAAGGCA GCAGTATAAA GAAGGCTCAG CAGGCTGTTG CCAATAAAGC TTTGACTGAA 120 121 TCTACGCTTC CCAAACCAGT TCAGAAGCCA CCCAAAAGTA ATGTTAACAA TAACCCAGGC 180 181 AGTATAACTC CAACTGTGGA ACTGAATGGG CTTGCTATGA AAAGGGGAGA GCCTGCCATC 240 241 TACAGGCCAT TAGATCCAAA GCCATTCCCA AATTATAGAG CTAATTACAA CTTTCGGGGC 300 301 ATGTACAATC AGAGGTATCA TTGCCCAGTG CCTAAGATCT TTTATGTTCA GCTCACTGTA 360 361 GGAAATAATG AATTTTTTGG GGAAGGAAAG ACTCGACAAG CTGCTAGACA CAATGCTGCA 420 421 ATGAAAGCCC TCCAAGCACT GCAGAATGAA CCTATTCCAG AAAGATCTCC TCAGAATGGT 480 481 GAATCAGGAA AGGATGTGGA TGATGACAAA GATGCAAATA AGTCTGAGAT CAGCTTAGTG 540 541 TTTGAAATTG CTCTGAAGCG AAATATGCCT GTCAGTTTTG AGGTTATTAA AGAAAGTGGA 600 601 CCACCACATA TGAAAAGCTT TGTTACTCGA GTGTCAGTAG GAGAGTTCTC TGCAGAAGGA 660 661 GAAGGAAATA GCAAAAAACT CTCCAAGAAG CGCGCTGCGA CCACCGTCTT ACAGGAGCTT 720 721 AAAAAACTTC CACCTCTTCC TGTGGTGGAA AAGCCAAAAC TATTTTTTAA AAAACGCCCT 780 781 AAAACAATAG TAAAGGCCGG ACCAGAATAT GGCCAAGGGA TGAACCCTAT TAGCCGCCTG 840 841 GCGCAAATTC AACAGGCCAA AAAGGAAAAG GAGCCGGATT ATGTTTTGCT TTCAGAAAGA 900 901 GGAATGCCTC GACGTCGAGA ATTTGTGATG CAGGTGAAGG TAGGCAATGA AGTTGCTACA 960 961 GGAACAGGAC CTAATAAAAA GATAGCCAAA AAAAATGCTG CAGAAGCAAT GCTGTTACAA 1020 1021 CTTGGTTATA AAGCATCCAC TAATCTTCAG GATCAACTTG AGAAGACAGG GGAAAACAAA 1080 1081 GGATGGAGTG GTCCAAAGCC TGGGTTTCCT GAACCAACAA ATAATACTCC AAAAGGAATT 1140 1141 CTTCATTTGT CTCCTGATGT TTATCAAGAG ATGGAAGCCA GCCGCCACAA AGTAATCTCT 1200 1201 GGCACTACTC TAGGCTATTT GTCACCCAAA GATATGAACC AACCTTCAAG CTCTTTCTTC 1260 1261 AGTATATCTC CCACATCGAA TAGTTCAGCT ACAATTGCCA GGGAACTCCT TATGAATGGA 1320 1321 ACATCTTCTA CAGCTGAAGC CATAGGTTTA AAAGGAAGTT CTCCTACTCC CCCTTGTTCT 1380 1381 CCAGTACAAC CTTCAAAACA ACTGGAATAT TTAGCAAGGA TTCAAGGCTT TCAGGTATGA 1440 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Membrane | |
Cellular Component | Microtubule | |
Cellular Component | Nucleolus | |
Molecular Function | Double-stranded RNA binding | |
Molecular Function | RNA binding |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| ENPD | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-0154 | Gorilla gorilla | 99.65 | 0.0 | 1055 |
| LLPS-Mal-1942 | Mandrillus leucophaeus | 99.65 | 0.0 | 1057 |
| LLPS-Chs-0099 | Chlorocebus sabaeus | 99.61 | 0.0 | 938 |
| LLPS-Man-0947 | Macaca nemestrina | 99.44 | 0.0 | 980 |
| LLPS-Rhb-0950 | Rhinopithecus bieti | 99.41 | 0.0 | 936 |
| LLPS-Mam-2744 | Macaca mulatta | 99.41 | 0.0 | 937 |
| LLPS-Nol-0118 | Nomascus leucogenys | 99.3 | 0.0 | 1028 |
| LLPS-Caj-1621 | Callithrix jacchus | 98.6 | 0.0 | 1046 |
| LLPS-Otg-0262 | Otolemur garnettii | 97.59 | 0.0 | 637 |
| LLPS-Loa-3280 | Loxodonta africana | 97.02 | 0.0 | 1025 |
| LLPS-Fud-2415 | Fukomys damarensis | 96.87 | 0.0 | 910 |
| LLPS-Myl-1497 | Myotis lucifugus | 96.67 | 0.0 | 904 |
| LLPS-Aim-0394 | Ailuropoda melanoleuca | 96.67 | 0.0 | 1024 |
| LLPS-Cap-2430 | Cavia porcellus | 96.32 | 0.0 | 1021 |
| LLPS-Dio-0290 | Dipodomys ordii | 95.51 | 0.0 | 931 |
| LLPS-Mum-1794 | Mus musculus | 93.86 | 0.0 | 1003 |
| LLPS-Paa-0223 | Papio anubis | 93.59 | 0.0 | 1041 |
| LLPS-Pap-0768 | Pan paniscus | 93.59 | 0.0 | 1041 |
| LLPS-Maf-3506 | Macaca fascicularis | 93.42 | 0.0 | 1040 |
| LLPS-Cea-2017 | Cercocebus atys | 93.17 | 0.0 | 962 |
| LLPS-Aon-0161 | Aotus nancymaae | 92.6 | 0.0 | 1029 |
| LLPS-Pat-0732 | Pan troglodytes | 92.48 | 0.0 | 959 |
| LLPS-Orc-2485 | Oryctolagus cuniculus | 91.28 | 0.0 | 1013 |
| LLPS-Mup-2477 | Mustela putorius furo | 90.62 | 0.0 | 1006 |
| LLPS-Fec-2760 | Felis catus | 90.62 | 0.0 | 1007 |
| LLPS-Urm-2234 | Ursus maritimus | 90.62 | 0.0 | 1007 |
| LLPS-Ict-1480 | Ictidomys tridecemlineatus | 90.62 | 0.0 | 1003 |
| LLPS-Caf-0478 | Canis familiaris | 90.46 | 0.0 | 1003 |
| LLPS-Sus-0195 | Sus scrofa | 90.13 | 0.0 | 1003 |
| LLPS-Ova-0820 | Ovis aries | 90.13 | 0.0 | 999 |
| LLPS-Bot-0751 | Bos taurus | 90.13 | 0.0 | 998 |
| LLPS-Eqc-1466 | Equus caballus | 89.37 | 0.0 | 919 |
| LLPS-Poa-2303 | Pongo abelii | 87.66 | 0.0 | 972 |
| LLPS-Meg-1351 | Meleagris gallopavo | 87.28 | 0.0 | 808 |
| LLPS-Anp-0907 | Anas platyrhynchos | 86.77 | 0.0 | 805 |
| LLPS-Pes-0100 | Pelodiscus sinensis | 86.19 | 0.0 | 799 |
| LLPS-Gaga-3626 | Gallus gallus | 85.61 | 0.0 | 898 |
| LLPS-Tag-0996 | Taeniopygia guttata | 85.26 | 0.0 | 890 |
| LLPS-Cas-0372 | Carlito syrichta | 83.14 | 0.0 | 764 |
| LLPS-Ran-0011 | Rattus norvegicus | 81.21 | 0.0 | 750 |
| LLPS-Mea-1251 | Mesocricetus auratus | 80.18 | 0.0 | 808 |
| LLPS-Fia-0130 | Ficedula albicollis | 79.77 | 0.0 | 871 |
| LLPS-Mod-1709 | Monodelphis domestica | 78.78 | 5e-133 | 397 |
| LLPS-Sah-3704 | Sarcophilus harrisii | 78.55 | 6e-113 | 346 |
| LLPS-Anc-0028 | Anolis carolinensis | 77.45 | 0.0 | 714 |
| LLPS-Lac-0971 | Latimeria chalumnae | 73.23 | 0.0 | 824 |
| LLPS-Orn-3218 | Oreochromis niloticus | 71.0 | 0.0 | 686 |
| LLPS-Scf-1048 | Scleropages formosus | 69.23 | 0.0 | 734 |
| LLPS-Asm-0151 | Astyanax mexicanus | 68.97 | 0.0 | 747 |
| LLPS-Dar-0957 | Danio rerio | 68.91 | 0.0 | 753 |
| LLPS-Xet-1722 | Xenopus tropicalis | 68.59 | 0.0 | 733 |
| LLPS-Scm-0581 | Scophthalmus maximus | 67.01 | 0.0 | 701 |
| LLPS-Orl-2182 | Oryzias latipes | 66.38 | 0.0 | 684 |
| LLPS-Icp-0981 | Ictalurus punctatus | 66.1 | 0.0 | 701 |
| LLPS-Xim-0460 | Xiphophorus maculatus | 66.04 | 0.0 | 679 |
| LLPS-Tar-0866 | Takifugu rubripes | 65.59 | 0.0 | 685 |
| LLPS-Pof-0606 | Poecilia formosa | 65.2 | 0.0 | 675 |
| LLPS-Gaa-0926 | Gasterosteus aculeatus | 64.31 | 0.0 | 706 |
| LLPS-Ora-2474 | Ornithorhynchus anatinus | 63.92 | 2e-60 | 204 |
| LLPS-Leo-0484 | Lepisosteus oculatus | 62.24 | 0.0 | 573 |
| LLPS-Ten-3314 | Tetraodon nigroviridis | 61.47 | 0.0 | 597 |
| LLPS-Drm-0171 | Drosophila melanogaster | 50.0 | 3e-24 | 112 |
| LLPS-Cae-0792 | Caenorhabditis elegans | 35.18 | 2e-43 | 168 |