DrLLPS - Data resource of LLPS

LLPS-Xim-2455
EIF3G

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Eukaryotic translation initiation factor 3 subunit G
Gene Name:	EIF3G, EIF3S4
Ensembl Gene:	ENSXMAG00000018061.2
Ensembl Protein:	ENSXMAP00000018091.2
Organism:	Xiphophorus maculatus
Taxa ID:	8083
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule, Others	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1869	O75821	Regulator	Stress granule	79.06	2e-175	495
Saccharomyces cerevisiae	LLPS-Sac-0178	Q04067	Client	Stress granule, Others	30.69	2e-31	124

▼ FUNCTION

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSXMAT00000018118.2	ENSXMAP00000018091.2
UniProt		M4AUE6, M4AUE6_XIPMA

▼ SEQUENCE

Protein Sequence (FASTA)
1 MPSIEYDDSK PSWADQVEEE GDEGTLPSPK ETIKGNIKTV TDYKIDDDGK KSKIVRTFKI 60 61 ETRKASKAVA RRKNWKKFGN SERDAPGPNV ATTTVSDDVF MTFISSKDDL NAQDQEEDPM 120 121 NKLKGQKIVS CRICKGDHWT TRCPYKDTLG PMQKELAEQL GLSTGDKEKS PGSAEPEPVQ 180 181 PAQTKTGKYV PPSLRDGGTR RGESMQPNRR ADDNATIRVT NLSEDTRETD LQELFRPFGS 240 241 ISRIYLAKDK NTGQSKGFAF ISFHRREDAA RAIAGVSGFG YDHLILNVEW AK 292
Nucleotide CDS Sequence (FASTA)
1 ATGCCGTCGA TTGAATACGA CGACTCCAAG CCCAGCTGGG CCGACCAGGT CGAGGAGGAA 60 61 GGAGATGAAG GCACTCTACC ATCTCCTAAG GAAACCATTA AAGGAAACAT AAAAACTGTC 120 121 ACTGACTATA AAATAGATGA TGACGGAAAA AAATCCAAGA TTGTGCGGAC CTTCAAGATC 180 181 GAGACACGGA AAGCATCCAA AGCTGTTGCC AGAAGGAAGA ACTGGAAGAA ATTTGGCAAC 240 241 TCTGAGCGTG ATGCACCAGG TCCCAACGTT GCTACCACTA CAGTTAGCGA CGACGTCTTT 300 301 ATGACCTTTA TATCCAGCAA AGATGACTTA AATGCTCAAG ATCAGGAAGA AGATCCCATG 360 361 AACAAACTTA AGGGACAGAA GATTGTGTCC TGTCGTATTT GTAAAGGCGA CCACTGGACA 420 421 ACTCGCTGTC CGTACAAGGA CACCCTGGGT CCCATGCAGA AGGAGCTGGC TGAACAGCTG 480 481 GGTCTTTCTA CTGGGGACAA AGAGAAGTCT CCTGGCTCTG CTGAACCAGA ACCTGTGCAG 540 541 CCTGCGCAAA CCAAGACTGG AAAATACGTT CCCCCGAGTC TGAGGGATGG AGGAACGCGA 600 601 AGAGGAGAGT CTATGCAGCC TAACCGCAGG GCTGATGATA ATGCCACAAT CCGTGTGACC 660 661 AACCTGTCTG AGGACACCCG TGAGACCGAC CTGCAGGAGC TTTTCAGACC ATTTGGCTCC 720 721 ATCTCAAGAA TTTATCTGGC GAAAGACAAG AATACCGGAC AGTCCAAGGG ATTTGCTTTC 780 781 ATCAGTTTCC ACCGGCGGGA GGATGCAGCC AGAGCCATCG CAGGCGTGTC AGGATTCGGA 840 841 TATGATCATC TTATTCTCAA TGTTGAATGG GCCAAGTGA 879

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0396	Initiation factor
KW-0648	Protein biosynthesis
KW-1185	Reference proteome
KW-0694	RNA-binding

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0016282	Cellular Component	Eukaryotic 43S preinitiation complex
GO:0033290	Cellular Component	Eukaryotic 48S preinitiation complex
GO:0005852	Cellular Component	Eukaryotic translation initiation factor 3 complex
GO:0003743	Molecular Function	Translation initiation factor activity
GO:0001732	Biological Process	Formation of cytoplasmic translation initiation complex

▼ KEGG

xma:102238350

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Pof-0828	Poecilia formosa	98.97	0.0	598
LLPS-Orn-3307	Oreochromis niloticus	96.92	0.0	588
LLPS-Tar-0567	Takifugu rubripes	94.86	0.0	577
LLPS-Scm-3079	Scophthalmus maximus	94.39	0.0	550
LLPS-Icp-2563	Ictalurus punctatus	93.86	0.0	568
LLPS-Dar-3972	Danio rerio	93.84	0.0	570
LLPS-Orl-1765	Oryzias latipes	93.52	0.0	565
LLPS-Scf-0020	Scleropages formosus	93.15	0.0	566
LLPS-Asm-3703	Astyanax mexicanus	92.12	0.0	558
LLPS-Urm-2966	Ursus maritimus	90.87	2e-172	488
LLPS-Myl-2213	Myotis lucifugus	90.64	2e-175	494
LLPS-Lac-0998	Latimeria chalumnae	90.41	3e-176	495
LLPS-Cas-1362	Carlito syrichta	89.73	4e-168	476
LLPS-Sah-0346	Sarcophilus harrisii	89.14	8e-174	491
LLPS-Anc-1822	Anolis carolinensis	88.85	9e-174	492
LLPS-Leo-1814	Lepisosteus oculatus	88.67	0.0	529
LLPS-Ten-1748	Tetraodon nigroviridis	85.85	0.0	554
LLPS-Gaa-3150	Gasterosteus aculeatus	85.49	0.0	552
LLPS-Ora-1749	Ornithorhynchus anatinus	84.25	3e-83	254
LLPS-Eqc-2256	Equus caballus	81.41	2e-175	495
LLPS-Otg-0759	Otolemur garnettii	81.25	3e-178	502
LLPS-Tut-1981	Tursiops truncatus	80.89	5e-179	504
LLPS-Fec-0245	Felis catus	80.62	3e-180	507
LLPS-Caf-4330	Canis familiaris	80.62	3e-180	507
LLPS-Ict-3714	Ictidomys tridecemlineatus	80.62	3e-177	499
LLPS-Aon-4799	Aotus nancymaae	80.62	3e-176	498
LLPS-Aim-3146	Ailuropoda melanoleuca	80.62	3e-177	499
LLPS-Mup-2536	Mustela putorius furo	80.62	3e-177	499
LLPS-Pap-2056	Pan paniscus	80.31	1e-176	498
LLPS-Hos-1869	Homo sapiens	80.31	1e-176	498
LLPS-Mod-0503	Monodelphis domestica	80.31	3e-180	508
LLPS-Poa-1688	Pongo abelii	80.31	1e-176	498
LLPS-Cap-3956	Cavia porcellus	80.31	2e-177	500
LLPS-Mam-1127	Macaca mulatta	80.31	1e-176	498
LLPS-Nol-1819	Nomascus leucogenys	80.31	1e-176	498
LLPS-Mea-2644	Mesocricetus auratus	80.31	2e-178	502
LLPS-Chs-0510	Chlorocebus sabaeus	80.31	1e-176	498
LLPS-Sus-0896	Sus scrofa	80.31	1e-176	498
LLPS-Gog-0691	Gorilla gorilla	80.31	1e-176	498
LLPS-Caj-2089	Callithrix jacchus	80.31	1e-176	498
LLPS-Bot-2293	Bos taurus	80.31	1e-176	498
LLPS-Ova-0982	Ovis aries	80.31	1e-176	498
LLPS-Pat-2349	Pan troglodytes	80.25	8e-177	498
LLPS-Mum-3554	Mus musculus	80.0	1e-177	500
LLPS-Gaga-0355	Gallus gallus	79.94	5e-180	512
LLPS-Ran-2482	Rattus norvegicus	79.69	4e-177	499
LLPS-Fud-0745	Fukomys damarensis	79.38	5e-176	496
LLPS-Xet-0825	Xenopus tropicalis	79.25	8e-177	498
LLPS-Man-2591	Macaca nemestrina	79.08	9e-177	498
LLPS-Maf-3067	Macaca fascicularis	79.08	9e-177	498
LLPS-Rhb-1732	Rhinopithecus bieti	79.01	7e-177	499
LLPS-Paa-0442	Papio anubis	79.01	7e-177	499
LLPS-Mal-2108	Mandrillus leucophaeus	79.01	7e-177	499
LLPS-Cea-4111	Cercocebus atys	78.95	2e-176	498
LLPS-Pes-1425	Pelodiscus sinensis	77.9	9e-148	425
LLPS-Loa-2880	Loxodonta africana	77.24	6e-136	392
LLPS-Fia-0583	Ficedula albicollis	73.15	6e-163	463
LLPS-Dio-3946	Dipodomys ordii	72.15	2e-138	400
LLPS-Cii-0445	Ciona intestinalis	49.12	1e-78	247
LLPS-Drm-1251	Drosophila melanogaster	46.1	3e-79	248
LLPS-Put-0827	Puccinia triticina	44.64	4e-64	211
LLPS-Sem-0918	Selaginella moellendorffii	44.59	9e-61	201
LLPS-Sot-0545	Solanum tuberosum	44.59	3e-09	61.6
LLPS-Pug-1355	Puccinia graminis	43.24	1e-65	214
LLPS-Sol-0565	Solanum lycopersicum	43.24	4e-09	61.2
LLPS-Mel-0013	Melampsora laricipopulina	43.14	3e-55	187
LLPS-Amt-1362	Amborella trichopoda	42.64	3e-56	189
LLPS-Php-0266	Physcomitrella patens	42.41	5e-59	196
LLPS-Fus-1284	Fusarium solani	42.38	5e-56	189
LLPS-Asni-0724	Aspergillus niger	42.32	2e-59	197
LLPS-Spr-0965	Sporisorium reilianum	42.27	1e-61	204
LLPS-Usm-0297	Ustilago maydis	42.07	1e-60	201
LLPS-Met-0522	Medicago truncatula	41.86	9e-59	196
LLPS-Ast-0740	Aspergillus terreus	41.78	2e-61	203
LLPS-Miv-1020	Microbotryum violaceum	41.75	3e-61	202
LLPS-Aso-0733	Aspergillus oryzae	41.24	1e-60	201
LLPS-Asf-0051	Aspergillus flavus	41.24	1e-60	201
LLPS-Fuo-0584	Fusarium oxysporum	41.2	7e-57	191
LLPS-Fuv-0398	Fusarium verticillioides	41.2	8e-59	196
LLPS-Hea-2564	Helianthus annuus	41.16	2e-54	185
LLPS-Gor-0204	Gossypium raimondii	41.11	6e-58	194
LLPS-Scj-1274	Schizosaccharomyces japonicus	40.97	5e-55	186
LLPS-Beb-0564	Beauveria bassiana	40.92	4e-57	192
LLPS-Abg-1202	Absidia glauca	40.88	9e-64	209
LLPS-Dac-1504	Daucus carota	40.73	1e-53	183
LLPS-Viv-1958	Vitis vinifera	40.71	2e-52	180
LLPS-Coc-2291	Corchorus capsularis	40.68	8e-59	196
LLPS-Brr-2504	Brassica rapa	40.61	3e-57	192
LLPS-Bro-0120	Brassica oleracea	40.61	2e-57	192
LLPS-Brn-2442	Brassica napus	40.61	2e-57	192
LLPS-Pot-2261	Populus trichocarpa	40.43	3e-53	182
LLPS-Zyt-0868	Zymoseptoria tritici	40.28	4e-50	174
LLPS-Glm-1979	Glycine max	40.27	4e-54	184
LLPS-Cog-0260	Colletotrichum gloeosporioides	40.26	7e-50	182
LLPS-Osl-1259	Ostreococcus lucimarinus	40.15	1e-57	192
LLPS-Trr-0947	Trichoderma reesei	40.14	4e-52	179
LLPS-Prp-2042	Prunus persica	40.14	4e-56	189
LLPS-Nef-0813	Neosartorya fischeri	40.0	2e-57	192
LLPS-Mae-1049	Manihot esculenta	40.0	1e-09	60.5
LLPS-Dos-0545	Dothistroma septosporum	40.0	1e-10	62.8
LLPS-Tum-0960	Tuber melanosporum	39.87	9e-52	178
LLPS-Asn-0957	Aspergillus nidulans	39.86	2e-54	184
LLPS-Thc-0020	Theobroma cacao	39.6	1e-56	191
LLPS-Asfu-0456	Aspergillus fumigatus	39.58	3e-58	194
LLPS-Ors-1554	Oryza sativa	39.53	4e-59	197
LLPS-Orr-1041	Oryza rufipogon	39.53	4e-59	197
LLPS-Orb-0144	Oryza barthii	39.53	4e-59	197
LLPS-Ori-1924	Oryza indica	39.53	4e-59	197
LLPS-Orni-2064	Oryza nivara	39.53	4e-59	197
LLPS-Orgl-1278	Oryza glumaepatula	39.53	1e-56	197
LLPS-Asc-0149	Aspergillus clavatus	39.46	1e-59	198
LLPS-Blg-1178	Blumeria graminis	39.46	5e-60	199
LLPS-Pytr-0136	Pyrenophora triticirepentis	39.38	4e-52	179
LLPS-Pyt-1114	Pyrenophora teres	39.38	6e-52	178
LLPS-Brd-0746	Brachypodium distachyon	39.38	3e-56	189
LLPS-Arl-1277	Arabidopsis lyrata	39.38	1e-60	201
LLPS-Scc-0623	Schizosaccharomyces cryophilus	39.26	2e-55	187
LLPS-Cus-1156	Cucumis sativus	39.25	2e-55	187
LLPS-Orp-0250	Oryza punctata	39.2	1e-58	196
LLPS-Trv-0510	Trichoderma virens	39.2	5e-54	184
LLPS-Org-1079	Oryza glaberrima	39.2	7e-58	194
LLPS-Nec-1329	Neurospora crassa	39.06	3e-50	176
LLPS-Cogr-0917	Colletotrichum graminicola	39.02	5e-53	181
LLPS-Mua-0901	Musa acuminata	39.02	1e-49	172
LLPS-Lem-1004	Leptosphaeria maculans	38.95	6e-52	178
LLPS-Tru-1850	Triticum urartu	38.87	1e-47	167
LLPS-Scp-1443	Schizosaccharomyces pombe	38.78	4e-54	184
LLPS-Mao-0209	Magnaporthe oryzae	38.71	1e-48	171
LLPS-Sei-1425	Setaria italica	38.7	3e-55	187
LLPS-Phv-1431	Phaseolus vulgaris	38.59	3e-53	181
LLPS-Zem-1321	Zea mays	38.49	2e-55	187
LLPS-Lep-0479	Leersia perrieri	38.36	9e-55	186
LLPS-Ved-0715	Verticillium dahliae	38.23	1e-50	175
LLPS-Phn-0462	Phaeosphaeria nodorum	38.14	1e-52	180
LLPS-Nia-2153	Nicotiana attenuata	37.88	3e-51	176
LLPS-Meg-2847	Meleagris gallopavo	37.84	4e-09	60.8
LLPS-Anp-1528	Anas platyrhynchos	37.84	4e-09	60.8
LLPS-Orc-1912	Oryctolagus cuniculus	37.84	5e-09	60.8
LLPS-Tag-0591	Taeniopygia guttata	37.84	4e-09	60.8
LLPS-Ere-0202	Erinaceus europaeus	37.84	5e-09	60.8
LLPS-Coo-0769	Colletotrichum orbiculare	37.75	2e-50	174
LLPS-Art-2448	Arabidopsis thaliana	37.72	2e-58	196
LLPS-Gas-0839	Galdieria sulphuraria	37.72	2e-49	172
LLPS-Via-1891	Vigna angularis	37.7	8e-55	186
LLPS-Chr-0896	Chlamydomonas reinhardtii	37.54	1e-44	159
LLPS-Sob-1178	Sorghum bicolor	37.46	2e-54	184
LLPS-Tra-1185	Triticum aestivum	37.37	2e-52	179
LLPS-Orbr-1672	Oryza brachyantha	36.91	4e-55	186
LLPS-Chc-0680	Chondrus crispus	36.82	3e-37	140
LLPS-Hov-0107	Hordeum vulgare	36.15	3e-51	177
LLPS-Cae-1909	Caenorhabditis elegans	35.11	2e-39	144
LLPS-Yal-0641	Yarrowia lipolytica	34.95	1e-42	154
LLPS-Crn-0077	Cryptococcus neoformans	34.8	9e-41	149
LLPS-Asg-0979	Ashbya gossypii	34.73	2e-38	142
LLPS-Cym-0809	Cyanidioschyzon merolae	34.29	9e-43	156
LLPS-Gag-0282	Gaeumannomyces graminis	33.47	2e-19	89.0
LLPS-Kop-0781	Komagataella pastoris	32.99	7e-34	130
LLPS-Sac-0178	Saccharomyces cerevisiae	32.01	8e-35	132

LLPS-Xim-2455EIF3G

Protein Sequence

Nucleotide Sequence

LLPS-Xim-2455
EIF3G