• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fia-0583
EIF3G

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit G
Gene Name: EIF3G, EIF3S4
Ensembl Gene: ENSFALG00000007791.1
Ensembl Protein: ENSFALP00000008128.1
Organism: Ficedula albicollis
Taxa ID: 59894
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSFALT00000008161.1ENSFALP00000008128.1
UniProtU3JZC4, U3JZC4_FICAL
GeneBankAGTO01012518

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPTGDYDSKP  SWADQVEEEG  GEDDKVITSE  LLKDLPLPGV  LGGPSSAEAE  LLKGGPLPSP  60
61    KEVVNGNIKT  ITEYREEEDG  RKVKVGTGHR  WAQGAPEPQF  FSPQNWKKFG  NSEFDAPGPN  120
121   VATTTVSDDV  FMTFITSKED  LNCQEEEDPM  NKLKGQKIVS  CRICKGDHWT  TRCPYKDTLG  180
181   PMQKELAEQL  GLSTGEKEKL  PGEPEPVAAQ  VSKTGKYVPP  SLRDGASRRG  ESMQPNRRAD  240
241   DNATIRVTNL  SEDTRETDLQ  ELFRPFGSIS  RIYLAKDKTT  GQSKGFAFIS  FHRREDAARA  300
301   IAGVSGFGYD  HLILNVEWAK  PSTN  324
Nucleotide CDS Sequence (FASTA)
1     ATGCCGACCG  GGGATTACGA  CTCCAAGCCC  AGCTGGGCTG  ACCAGGTGGA  GGAGGAGGGA  60
61    GGAGAGGATG  ACAAGGTCAT  CACCAGCGAG  CTGCTGAAGG  ACCTGCCCCT  GCCCGGGGTC  120
121   CTGGGAGGCC  CCTCCAGCGC  TGAGGCCGAG  CTGCTCAAGG  GAGGGCCCCT  CCCCTCCCCC  180
181   AAGGAGGTCG  TCAATGGCAA  CATCAAAACC  ATCACCGAGT  ACCGCGAGGA  GGAGGACGGG  240
241   CGCAAGGTCA  AGGTGGGCAC  GGGGCACAGG  TGGGCACAGG  GGGCACCTGA  ACCCCAGTTT  300
301   TTTTCCCCCC  AGAACTGGAA  GAAATTTGGG  AATTCCGAGT  TCGACGCCCC  CGGGCCCAAC  360
361   GTGGCCACGA  CGACCGTGAG  CGACGACGTC  TTCATGACCT  TCATCACCAG  CAAGGAGGAC  420
421   CTGAACTGCC  AGGAGGAGGA  GGACCCCATG  AACAAGCTCA  AGGGCCAGAA  GATCGTCTCG  480
481   TGCCGCATCT  GCAAGGGCGA  CCACTGGACC  ACGCGCTGCC  CCTACAAGGA  CACGCTGGGG  540
541   CCAATGCAGA  AGGAGCTGGC  CGAGCAGCTG  GGGCTGTCCA  CGGGGGAGAA  GGAGAAACTC  600
601   CCGGGGGAGC  CGGAGCCGGT  GGCCGCCCAG  GTGAGCAAGA  CGGGCAAGTA  CGTCCCGCCC  660
661   AGCCTGAGGG  ACGGCGCCAG  CCGGCGCGGG  GAGTCCATGC  AGCCCAACCG  GCGGGCCGAC  720
721   GACAACGCCA  CCATCCGCGT  CACCAACCTG  TCGGAGGACA  CGCGCGAGAC  CGACCTGCAG  780
781   GAGCTGTTCC  GCCCCTTCGG  CTCCATCTCC  CGCATCTACC  TGGCCAAGGA  CAAGACCACG  840
841   GGCCAGTCCA  AGGGTTTCGC  CTTCATCAGC  TTCCACCGGC  GCGAGGACGC  GGCGCGAGCG  900
901   ATCGCGGGCG  TGTCGGGCTT  CGGCTACGAC  CACCTGATCC  TCAACGTGGA  GTGGGCCAAG  960
961   CCCTCCACCA  ACTGA  975

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Viral translational termination-reinitiation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-0355Gallus gallus91.250.0 563
LLPS-Mum-3554Mus musculus85.196e-180 508
LLPS-Ran-2482Rattus norvegicus84.881e-179 507
LLPS-Tut-1981Tursiops truncatus84.570.0 517
LLPS-Ova-0982Ovis aries84.265e-178 503
LLPS-Mup-2536Mustela putorius furo84.266e-178 503
LLPS-Aim-3146Ailuropoda melanoleuca84.266e-178 503
LLPS-Bot-2293Bos taurus84.265e-178 503
LLPS-Gog-0691Gorilla gorilla84.265e-178 503
LLPS-Caj-2089Callithrix jacchus84.265e-178 503
LLPS-Mea-2644Mesocricetus auratus84.262e-178 504
LLPS-Chs-0510Chlorocebus sabaeus84.265e-178 503
LLPS-Sus-0896Sus scrofa84.265e-178 503
LLPS-Nol-1819Nomascus leucogenys84.265e-178 503
LLPS-Ict-3714Ictidomys tridecemlineatus84.266e-178 503
LLPS-Poa-1688Pongo abelii84.265e-178 503
LLPS-Mam-1127Macaca mulatta84.265e-178 503
LLPS-Hos-1869Homo sapiens84.265e-178 503
LLPS-Pap-2056Pan paniscus84.265e-178 503
LLPS-Mod-0503Monodelphis domestica84.260.0 521
LLPS-Eqc-2256Equus caballus84.233e-172 488
LLPS-Pat-2349Pan troglodytes84.235e-172 488
LLPS-Lac-0998Latimeria chalumnae84.195e-156 445
LLPS-Aon-4799Aotus nancymaae83.957e-176 499
LLPS-Caf-4330Canis familiaris83.950.0 521
LLPS-Cap-3956Cavia porcellus83.954e-177 501
LLPS-Otg-0759Otolemur garnettii83.959e-178 502
LLPS-Fec-0245Felis catus83.950.0 521
LLPS-Urm-2966Ursus maritimus83.723e-162 463
LLPS-Fud-0745Fukomys damarensis83.339e-176 497
LLPS-Myl-2213Myotis lucifugus82.725e-168 476
LLPS-Cas-1362Carlito syrichta82.451e-157 450
LLPS-Maf-3067Macaca fascicularis82.370.0 511
LLPS-Man-2591Macaca nemestrina82.370.0 511
LLPS-Paa-0442Papio anubis82.34e-175 496
LLPS-Mal-2108Mandrillus leucophaeus82.34e-175 496
LLPS-Cea-4111Cercocebus atys82.242e-173 491
LLPS-Rhb-1732Rhinopithecus bieti82.086e-172 488
LLPS-Loa-2880Loxodonta africana80.977e-133 386
LLPS-Anc-1822Anolis carolinensis80.850.0 537
LLPS-Sah-0346Sarcophilus harrisii80.257e-173 490
LLPS-Dio-3946Dipodomys ordii76.452e-135 394
LLPS-Xet-0825Xenopus tropicalis75.382e-163 466
LLPS-Pes-1425Pelodiscus sinensis75.244e-153 440
LLPS-Orl-1765Oryzias latipes73.252e-154 442
LLPS-Orn-3307Oreochromis niloticus73.172e-158 452
LLPS-Ora-1749Ornithorhynchus anatinus72.782e-74 233
LLPS-Gaa-3150Gasterosteus aculeatus72.568e-157 449
LLPS-Pof-0828Poecilia formosa72.566e-155 443
LLPS-Xim-2455Xiphophorus maculatus72.534e-153 439
LLPS-Scf-0020Scleropages formosus72.396e-158 451
LLPS-Icp-2563Ictalurus punctatus72.397e-159 453
LLPS-Dar-3972Danio rerio72.395e-157 448
LLPS-Leo-1814Lepisosteus oculatus72.311e-155 445
LLPS-Scm-3079Scophthalmus maximus71.963e-155 444
LLPS-Asm-3703Astyanax mexicanus71.748e-154 441
LLPS-Tar-0567Takifugu rubripes71.341e-156 447
LLPS-Ten-1748Tetraodon nigroviridis70.917e-156 447
LLPS-Chc-0680Chondrus crispus54.632e-29 119
LLPS-Cym-0809Cyanidioschyzon merolae45.453e-40 150
LLPS-Sem-0918Selaginella moellendorffii44.612e-54 186
LLPS-Mel-0013Melampsora laricipopulina44.344e-43 156
LLPS-Sot-0545Solanum tuberosum44.06e-0961.2
LLPS-Sol-0565Solanum lycopersicum42.677e-0961.2
LLPS-Cii-0445Ciona intestinalis42.598e-61 202
LLPS-Miv-1020Microbotryum violaceum42.155e-52 179
LLPS-Prp-2042Prunus persica41.646e-54 184
LLPS-Met-0522Medicago truncatula41.494e-53 182
LLPS-Coc-2291Corchorus capsularis41.23e-53 182
LLPS-Php-0266Physcomitrella patens41.131e-48 170
LLPS-Sei-1425Setaria italica41.072e-49 172
LLPS-Put-0827Puccinia triticina40.814e-53 183
LLPS-Viv-1958Vitis vinifera40.787e-51 177
LLPS-Amt-1362Amborella trichopoda40.743e-48 170
LLPS-Fus-1284Fusarium solani40.664e-49 172
LLPS-Brd-0746Brachypodium distachyon40.59e-49 171
LLPS-Tum-0960Tuber melanosporum40.52e-45 162
LLPS-Glm-1979Glycine max40.497e-51 176
LLPS-Mae-0971Manihot esculenta40.436e-50 174
LLPS-Asni-0724Aspergillus niger40.32e-52 180
LLPS-Usm-0297Ustilago maydis40.227e-53 182
LLPS-Zem-1321Zea mays40.149e-47 166
LLPS-Osl-1259Ostreococcus lucimarinus40.086e-55 186
LLPS-Drm-1251Drosophila melanogaster40.077e-60 199
LLPS-Fuv-0398Fusarium verticillioides40.071e-50 176
LLPS-Spr-0965Sporisorium reilianum40.071e-52 181
LLPS-Hea-0357Helianthus annuus40.04e-0856.6
LLPS-Dos-0545Dothistroma septosporum40.04e-1062.0
LLPS-Ast-0740Aspergillus terreus40.02e-53 183
LLPS-Lep-0479Leersia perrieri39.932e-49 173
LLPS-Fuo-0584Fusarium oxysporum39.932e-49 173
LLPS-Asn-0957Aspergillus nidulans39.925e-48 169
LLPS-Cus-1156Cucumis sativus39.862e-52 180
LLPS-Arl-1768Arabidopsis lyrata39.865e-49 172
LLPS-Asf-0051Aspergillus flavus39.866e-53 182
LLPS-Aso-0733Aspergillus oryzae39.866e-53 182
LLPS-Thc-0020Theobroma cacao39.867e-55 187
LLPS-Pot-2631Populus trichocarpa39.744e-0857.4
LLPS-Via-1891Vigna angularis39.642e-50 176
LLPS-Gor-0204Gossypium raimondii39.513e-55 188
LLPS-Brr-2763Brassica rapa39.494e-50 174
LLPS-Beb-0564Beauveria bassiana39.495e-48 169
LLPS-Tru-1850Triticum urartu39.469e-42 152
LLPS-Scj-1274Schizosaccharomyces japonicus39.372e-49 172
LLPS-Phv-1431Phaseolus vulgaris39.362e-50 176
LLPS-Asfu-0456Aspergillus fumigatus39.133e-50 175
LLPS-Mua-0901Musa acuminata38.792e-46 165
LLPS-Orgl-1278Oryza glumaepatula38.578e-46 169
LLPS-Orni-2064Oryza nivara38.576e-48 169
LLPS-Orb-0144Oryza barthii38.576e-48 169
LLPS-Ori-1924Oryza indica38.576e-48 169
LLPS-Orr-1041Oryza rufipogon38.576e-48 169
LLPS-Ors-1554Oryza sativa38.576e-48 169
LLPS-Orp-0250Oryza punctata38.575e-48 169
LLPS-Sob-1178Sorghum bicolor38.495e-46 164
LLPS-Nef-0813Neosartorya fischeri38.416e-50 174
LLPS-Nec-1329Neurospora crassa38.358e-43 157
LLPS-Orbr-1672Oryza brachyantha38.351e-48 170
LLPS-Nia-2153Nicotiana attenuata38.332e-45 162
LLPS-Cogr-0917Colletotrichum graminicola38.253e-47 167
LLPS-Org-1079Oryza glaberrima38.211e-46 166
LLPS-Blg-1178Blumeria graminis38.172e-46 164
LLPS-Brn-2442Brassica napus38.131e-50 176
LLPS-Bro-0120Brassica oleracea38.131e-50 176
LLPS-Trv-0510Trichoderma virens38.16e-48 169
LLPS-Dac-1504Daucus carota38.016e-49 171
LLPS-Ved-0715Verticillium dahliae37.991e-45 163
LLPS-Mao-0209Magnaporthe oryzae37.944e-44 160
LLPS-Cog-0260Colletotrichum gloeosporioides37.943e-43 164
LLPS-Phn-0462Phaeosphaeria nodorum37.731e-45 162
LLPS-Trr-0947Trichoderma reesei37.733e-45 162
LLPS-Pug-1355Puccinia graminis37.696e-51 177
LLPS-Scc-0623Schizosaccharomyces cryophilus37.683e-46 164
LLPS-Abg-1202Absidia glauca37.541e-53 184
LLPS-Chr-0896Chlamydomonas reinhardtii37.362e-38 143
LLPS-Lem-1004Leptosphaeria maculans37.361e-44 160
LLPS-Gas-0839Galdieria sulphuraria37.319e-42 152
LLPS-Art-2448Arabidopsis thaliana37.182e-50 176
LLPS-Coo-0769Colletotrichum orbiculare37.062e-42 155
LLPS-Crn-0077Cryptococcus neoformans36.944e-36 137
LLPS-Tra-1185Triticum aestivum36.924e-46 164
LLPS-Asc-0149Aspergillus clavatus36.753e-49 172
LLPS-Zyt-0868Zymoseptoria tritici36.737e-41 150
LLPS-Hov-0107Hordeum vulgare36.621e-44 161
LLPS-Pyt-1114Pyrenophora teres36.598e-44 157
LLPS-Scp-1443Schizosaccharomyces pombe36.597e-48 168
LLPS-Pytr-0136Pyrenophora triticirepentis36.591e-43 157
LLPS-Yal-0641Yarrowia lipolytica35.431e-33 130
LLPS-Tag-0591Taeniopygia guttata35.05e-0858.2
LLPS-Anp-1528Anas platyrhynchos35.04e-0858.2
LLPS-Sac-0178Saccharomyces cerevisiae31.844e-28 115
LLPS-Cae-1909Caenorhabditis elegans31.644e-32 125
LLPS-Gag-0282Gaeumannomyces graminis31.62e-1372.8
LLPS-Kop-0781Komagataella pastoris30.914e-28 115
LLPS-Asg-0979Ashbya gossypii29.61e-27 114