LLPS-Xim-0252
SUCLG2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase subunit beta; G-SCS; GTPSCS; Succinyl-CoA synthetase beta-G chain; SCS-betaG |
| Gene Name: | SUCLG2 |
| Ensembl Gene: | ENSXMAG00000010534.2 |
| Ensembl Protein: | ENSXMAP00000034895.1 |
| Organism: | Xiphophorus maculatus |
| Taxa ID: | 8083 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Mitochondrial RNA granule | Predicted from orthologs | (View) |
▼ FUNCTION
| GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSXMAT00000029529.1 | ENSXMAP00000034895.1 |
| Ensembl | ENSXMAT00000010567.2 | ENSXMAP00000010553.2 |
| UniProt | A0A3B5QX28, A0A3B5QX28_XIPMA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAASMASQAA VRGLRTTATK RVLLDKLQCS WLTPRRWLNL QEYQSKKLMQ DSGVAVQRFY 60 61 VADTASEAQE AAKRLNAKEI VLKAQILAGG RGKGVFDSGL KGGVHLTKDP AVVGELAKRM 120 121 LGFNLITKQT PKDGVKVKTV MVAEALDISR ETYFAILMDR ACNGPVMVGS PQGGMDIEEV 180 181 AASTPELIFK EVIDIYKGVQ DDQALRMAAN LGFKGPLQRQ AADQIKRLYD LFLKVDATQV 240 241 EVNPLGETPE GQVVCFDAKI NFDDNAEFRQ KDVFAMDDMT ESDATEMEAA KWDLKYIGMD 300 301 GNIACFVNGA GLAMATCDII DLHGGKPANF LDLGGGVKER QVYEAFKLLT ADPKVEAILV 360 361 NIFGGIVNCA IIANGITKAC RELELKVPLV VRLEGTNVHE AKRILTESGL PITAADNLDD 420 421 AAKKAVAAIR K 431 |
| Nucleotide CDS Sequence (FASTA) |
1 ATCGAACTTA TTCTCCCGCT GTCTTGTTCG TCCTTCCAGT GCAGCTGGCT GACGCCCAGG 60 61 AGATGGCTGA ACCTACAGGA GTACCAGAGC AAGAAGCTGA TGCAGGACAG CGGCGTGGCG 120 121 GTCCAACGCT TCTACGTGGC CGACACAGCG TCTGAGGCGC AAGAGGCGGC AAAAAGACTC 180 181 AATGCCAAGG AAATAGTCCT GAAAGCTCAG ATTCTGGCTG GTGGGAGAGG CAAGGGTGTG 240 241 TTCGACAGTG GCCTCAAAGG GGGAGTGCAC TTAACTAAGG ACCCCGCAGT TGTTGGCGAG 300 301 CTGGCTAAAA GGATGCTCGG CTTCAACCTG ATTACCAAGC AGACGCCCAA AGATGGAGTG 360 361 AAAGTGAAAA CGGTGATGGT CGCTGAGGCT CTGGATATAA GCAGAGAGAC GTATTTTGCC 420 421 ATCCTAATGG ACCGGGCCTG TAATGGTCCA GTAATGGTGG GAAGCCCCCA GGGAGGGATG 480 481 GACATCGAAG AGGTGGCCGC CTCCACCCCA GAGCTCATCT TTAAGGAAGT CATAGATATA 540 541 TATAAAGGCG TGCAAGACGA CCAGGCGCTT CGCATGGCAG CTAATTTGGG TTTCAAAGGA 600 601 CCTCTGCAAA GACAGGCAGC GGATCAGATT AAGAGGCTCT ATGATCTGTT CCTGAAAGTC 660 661 GACGCCACTC AAGTTGAAGT CAATCCGCTC GGAGAGACTC CCGAAGGACA AGTGGTCTGC 720 721 TTTGATGCCA AGATCAACTT TGACGACAAC GCCGAGTTCC GTCAGAAAGA TGTGTTCGCC 780 781 ATGGATGACA TGACGGAGAG CGACGCCACG GAGATGGAGG CAGCCAAGTG GGATCTTAAA 840 841 TACATCGGAA TGGACGGAAA CATTGCCTGC TTTGTGAACG GAGCCGGTCT GGCCATGGCA 900 901 ACATGTGACA TCATTGACCT CCATGGAGGA AAGCCGGCTA ATTTCCTGGA CCTCGGGGGC 960 961 GGTGTCAAAG AGAGGCAGGT GTATGAGGCT TTTAAGCTGC TGACTGCTGA CCCAAAGGTC 1020 1021 GAAGCCATCT TGGTCAACAT ATTTGGAGGT ATTGTCAACT GTGCCATCAT TGCCAACGGC 1080 1081 ATCACCAAAG CCTGTCGAGA GCTGGAGCTC AAGGTCCCGC TGGTGGTCAG GCTCGAAGGC 1140 1141 ACCAACGTTC ACGAAGCTAA GAGGATCCTG ACCGAGAGCG GCCTGCCCAT CACAGCAGCC 1200 1201 GACAACCTGG ATGACGCCGC CAAGAAAGCG GTGGCCGCCA TCAGGAAATG A 1251 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | Succinate-CoA ligase (GDP-forming) activity | |
Biological Process | Succinyl-CoA metabolic process | |
Biological Process | Tricarboxylic acid cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pof-3972 | Poecilia formosa | 98.45 | 0.0 | 784 |
| LLPS-Gaa-1267 | Gasterosteus aculeatus | 94.81 | 0.0 | 743 |
| LLPS-Orn-1384 | Oreochromis niloticus | 94.52 | 0.0 | 749 |
| LLPS-Scm-3874 | Scophthalmus maximus | 93.77 | 0.0 | 779 |
| LLPS-Tar-1659 | Takifugu rubripes | 91.29 | 0.0 | 754 |
| LLPS-Ten-0508 | Tetraodon nigroviridis | 89.97 | 0.0 | 738 |
| LLPS-Dar-1599 | Danio rerio | 89.8 | 0.0 | 746 |
| LLPS-Asm-2536 | Astyanax mexicanus | 86.68 | 0.0 | 720 |
| LLPS-Lac-2314 | Latimeria chalumnae | 86.03 | 0.0 | 657 |
| LLPS-Leo-1344 | Lepisosteus oculatus | 85.82 | 0.0 | 733 |
| LLPS-Sus-2016 | Sus scrofa | 85.79 | 0.0 | 691 |
| LLPS-Urm-1457 | Ursus maritimus | 84.82 | 0.0 | 669 |
| LLPS-Pes-1317 | Pelodiscus sinensis | 84.66 | 0.0 | 649 |
| LLPS-Xet-1415 | Xenopus tropicalis | 84.62 | 0.0 | 637 |
| LLPS-Scf-3637 | Scleropages formosus | 84.07 | 0.0 | 710 |
| LLPS-Meg-2722 | Meleagris gallopavo | 84.01 | 0.0 | 687 |
| LLPS-Fia-2214 | Ficedula albicollis | 83.72 | 0.0 | 682 |
| LLPS-Fud-0525 | Fukomys damarensis | 83.56 | 0.0 | 637 |
| LLPS-Myl-2055 | Myotis lucifugus | 83.21 | 9e-171 | 488 |
| LLPS-Cap-2900 | Cavia porcellus | 83.2 | 0.0 | 664 |
| LLPS-Anp-0344 | Anas platyrhynchos | 82.97 | 0.0 | 564 |
| LLPS-Cas-4072 | Carlito syrichta | 82.81 | 4e-174 | 499 |
| LLPS-Ora-1945 | Ornithorhynchus anatinus | 82.75 | 2e-173 | 494 |
| LLPS-Tag-3335 | Taeniopygia guttata | 82.41 | 0.0 | 565 |
| LLPS-Pat-0223 | Pan troglodytes | 81.86 | 0.0 | 660 |
| LLPS-Nol-4033 | Nomascus leucogenys | 81.61 | 0.0 | 659 |
| LLPS-Hos-1303 | Homo sapiens | 81.61 | 0.0 | 658 |
| LLPS-Mal-3938 | Mandrillus leucophaeus | 81.61 | 0.0 | 659 |
| LLPS-Paa-4441 | Papio anubis | 81.61 | 0.0 | 659 |
| LLPS-Gog-2081 | Gorilla gorilla | 81.61 | 0.0 | 658 |
| LLPS-Fec-2272 | Felis catus | 81.4 | 0.0 | 687 |
| LLPS-Ova-0560 | Ovis aries | 81.4 | 0.0 | 684 |
| LLPS-Bot-4226 | Bos taurus | 81.4 | 0.0 | 684 |
| LLPS-Eqc-0466 | Equus caballus | 81.16 | 0.0 | 686 |
| LLPS-Chs-2072 | Chlorocebus sabaeus | 81.16 | 0.0 | 682 |
| LLPS-Aon-3163 | Aotus nancymaae | 81.11 | 0.0 | 654 |
| LLPS-Mup-0050 | Mustela putorius furo | 80.92 | 0.0 | 681 |
| LLPS-Gaga-1412 | Gallus gallus | 80.87 | 0.0 | 687 |
| LLPS-Orc-3988 | Oryctolagus cuniculus | 80.87 | 0.0 | 681 |
| LLPS-Caf-0774 | Canis familiaris | 80.63 | 0.0 | 676 |
| LLPS-Ran-1334 | Rattus norvegicus | 80.6 | 0.0 | 660 |
| LLPS-Caj-4169 | Callithrix jacchus | 80.55 | 0.0 | 657 |
| LLPS-Loa-3665 | Loxodonta africana | 80.43 | 0.0 | 679 |
| LLPS-Mum-3368 | Mus musculus | 80.24 | 0.0 | 673 |
| LLPS-Anc-1400 | Anolis carolinensis | 80.1 | 0.0 | 675 |
| LLPS-Otg-4308 | Otolemur garnettii | 79.9 | 0.0 | 671 |
| LLPS-Icp-1132 | Ictalurus punctatus | 79.74 | 0.0 | 611 |
| LLPS-Mod-3573 | Monodelphis domestica | 79.33 | 0.0 | 670 |
| LLPS-Ict-4345 | Ictidomys tridecemlineatus | 79.16 | 0.0 | 606 |
| LLPS-Mam-4070 | Macaca mulatta | 78.59 | 0.0 | 642 |
| LLPS-Pap-2675 | Pan paniscus | 77.73 | 0.0 | 646 |
| LLPS-Cea-3119 | Cercocebus atys | 77.51 | 0.0 | 641 |
| LLPS-Man-4745 | Macaca nemestrina | 77.06 | 0.0 | 673 |
| LLPS-Maf-2753 | Macaca fascicularis | 77.06 | 0.0 | 673 |
| LLPS-Dio-0963 | Dipodomys ordii | 75.49 | 0.0 | 620 |
| LLPS-Mea-0877 | Mesocricetus auratus | 75.0 | 9e-160 | 462 |
| LLPS-Rhb-0508 | Rhinopithecus bieti | 74.87 | 0.0 | 577 |
| LLPS-Poa-1729 | Pongo abelii | 74.15 | 0.0 | 603 |
| LLPS-Orl-2776 | Oryzias latipes | 71.35 | 0.0 | 521 |
| LLPS-Cis-1802 | Ciona savignyi | 68.56 | 0.0 | 544 |
| LLPS-Cii-1441 | Ciona intestinalis | 67.08 | 0.0 | 548 |
| LLPS-Cae-1164 | Caenorhabditis elegans | 57.33 | 5e-152 | 445 |
| LLPS-Drm-0441 | Drosophila melanogaster | 57.25 | 2e-157 | 458 |
| LLPS-Aim-0250 | Ailuropoda melanoleuca | 54.38 | 6e-140 | 416 |
| LLPS-Sah-1082 | Sarcophilus harrisii | 54.38 | 2e-138 | 412 |
| LLPS-Zem-1047 | Zea mays | 53.59 | 2e-121 | 369 |
| LLPS-Php-0392 | Physcomitrella patens | 53.03 | 1e-122 | 370 |
| LLPS-Trr-0933 | Trichoderma reesei | 52.91 | 1e-131 | 394 |
| LLPS-Org-0003 | Oryza glaberrima | 52.51 | 4e-130 | 389 |
| LLPS-Orr-0425 | Oryza rufipogon | 52.51 | 4e-130 | 389 |
| LLPS-Orm-1033 | Oryza meridionalis | 52.51 | 4e-130 | 389 |
| LLPS-Ors-0677 | Oryza sativa | 52.51 | 4e-130 | 389 |
| LLPS-Orgl-0621 | Oryza glumaepatula | 52.51 | 4e-130 | 389 |
| LLPS-Orni-0252 | Oryza nivara | 52.51 | 4e-130 | 389 |
| LLPS-Orb-0232 | Oryza barthii | 52.51 | 4e-130 | 389 |
| LLPS-Ori-0269 | Oryza indica | 52.51 | 4e-130 | 389 |
| LLPS-Orbr-0971 | Oryza brachyantha | 52.24 | 4e-129 | 387 |
| LLPS-Sei-1329 | Setaria italica | 52.24 | 2e-131 | 392 |
| LLPS-Lep-1662 | Leersia perrieri | 52.24 | 1e-129 | 388 |
| LLPS-Spr-0468 | Sporisorium reilianum | 51.98 | 7e-129 | 386 |
| LLPS-Sob-0565 | Sorghum bicolor | 51.98 | 1e-131 | 393 |
| LLPS-Hov-0503 | Hordeum vulgare | 51.98 | 2e-128 | 385 |
| LLPS-Chc-0582 | Chondrus crispus | 51.84 | 1e-128 | 386 |
| LLPS-Sem-0805 | Selaginella moellendorffii | 51.83 | 1e-126 | 380 |
| LLPS-Cogr-0335 | Colletotrichum graminicola | 51.59 | 8e-124 | 374 |
| LLPS-Osl-0712 | Ostreococcus lucimarinus | 51.59 | 1e-122 | 370 |
| LLPS-Trv-0404 | Trichoderma virens | 51.59 | 3e-127 | 382 |
| LLPS-Beb-0661 | Beauveria bassiana | 51.59 | 3e-128 | 385 |
| LLPS-Coo-0852 | Colletotrichum orbiculare | 51.59 | 4e-123 | 372 |
| LLPS-Tru-1306 | Triticum urartu | 51.45 | 4e-127 | 381 |
| LLPS-Tra-0273 | Triticum aestivum | 51.45 | 4e-127 | 381 |
| LLPS-Brd-0292 | Brachypodium distachyon | 51.45 | 2e-127 | 382 |
| LLPS-Mua-1569 | Musa acuminata | 51.19 | 3e-129 | 387 |
| LLPS-Abg-1138 | Absidia glauca | 51.12 | 3e-135 | 403 |
| LLPS-Fus-1060 | Fusarium solani | 51.06 | 6e-127 | 382 |
| LLPS-Art-0725 | Arabidopsis thaliana | 50.99 | 3e-131 | 392 |
| LLPS-Dos-0292 | Dothistroma septosporum | 50.93 | 2e-130 | 390 |
| LLPS-Thc-1032 | Theobroma cacao | 50.92 | 6e-125 | 376 |
| LLPS-Chr-1285 | Chlamydomonas reinhardtii | 50.9 | 3e-121 | 367 |
| LLPS-Phv-0767 | Phaseolus vulgaris | 50.86 | 1e-131 | 393 |
| LLPS-Ved-0064 | Verticillium dahliae | 50.79 | 2e-119 | 363 |
| LLPS-Fuo-0481 | Fusarium oxysporum | 50.79 | 6e-127 | 382 |
| LLPS-Fuv-1001 | Fusarium verticillioides | 50.79 | 4e-127 | 382 |
| LLPS-Gor-1977 | Gossypium raimondii | 50.66 | 2e-124 | 374 |
| LLPS-Lem-1324 | Leptosphaeria maculans | 50.63 | 1e-134 | 401 |
| LLPS-Miv-0055 | Microbotryum violaceum | 50.53 | 2e-123 | 372 |
| LLPS-Kop-0056 | Komagataella pastoris | 50.53 | 3e-122 | 369 |
| LLPS-Asn-0084 | Aspergillus nidulans | 50.53 | 8e-125 | 376 |
| LLPS-Asc-0544 | Aspergillus clavatus | 50.52 | 9e-129 | 387 |
| LLPS-Pot-0936 | Populus trichocarpa | 50.4 | 2e-124 | 375 |
| LLPS-Asf-0373 | Aspergillus flavus | 50.4 | 6e-120 | 365 |
| LLPS-Hea-2340 | Helianthus annuus | 50.4 | 1e-126 | 380 |
| LLPS-Cus-0361 | Cucumis sativus | 50.37 | 5e-130 | 389 |
| LLPS-Via-0769 | Vigna angularis | 50.37 | 5e-131 | 391 |
| LLPS-Glm-2497 | Glycine max | 50.37 | 8e-131 | 391 |
| LLPS-Asfu-0213 | Aspergillus fumigatus | 50.26 | 5e-128 | 384 |
| LLPS-Pytr-1104 | Pyrenophora triticirepentis | 50.26 | 1e-130 | 391 |
| LLPS-Phn-1291 | Phaeosphaeria nodorum | 50.13 | 7e-127 | 381 |
| LLPS-Usm-0563 | Ustilago maydis | 50.12 | 1e-129 | 388 |
| LLPS-Viv-0627 | Vitis vinifera | 50.12 | 4e-128 | 384 |
| LLPS-Arl-0713 | Arabidopsis lyrata | 50.12 | 1e-130 | 390 |
| LLPS-Nef-0014 | Neosartorya fischeri | 50.0 | 1e-128 | 386 |
| LLPS-Yal-0561 | Yarrowia lipolytica | 50.0 | 3e-126 | 380 |
| LLPS-Brr-3031 | Brassica rapa | 49.88 | 3e-130 | 389 |
| LLPS-Brn-0002 | Brassica napus | 49.88 | 4e-130 | 389 |
| LLPS-Pug-0329 | Puccinia graminis | 49.87 | 2e-117 | 357 |
| LLPS-Cog-0826 | Colletotrichum gloeosporioides | 49.85 | 4e-104 | 322 |
| LLPS-Gag-0432 | Gaeumannomyces graminis | 49.75 | 4e-132 | 395 |
| LLPS-Sot-0874 | Solanum tuberosum | 49.74 | 1e-125 | 378 |
| LLPS-Bro-1681 | Brassica oleracea | 49.63 | 3e-129 | 387 |
| LLPS-Tum-0021 | Tuber melanosporum | 49.61 | 5e-123 | 372 |
| LLPS-Zyt-1202 | Zymoseptoria tritici | 49.6 | 4e-127 | 382 |
| LLPS-Map-0662 | Magnaporthe poae | 49.51 | 7e-126 | 379 |
| LLPS-Crn-1328 | Cryptococcus neoformans | 49.51 | 1e-133 | 398 |
| LLPS-Dac-0483 | Daucus carota | 49.5 | 5e-128 | 384 |
| LLPS-Ast-0056 | Aspergillus terreus | 49.49 | 3e-128 | 385 |
| LLPS-Blg-0257 | Blumeria graminis | 49.47 | 3e-125 | 377 |
| LLPS-Coc-0369 | Corchorus capsularis | 49.38 | 5e-127 | 381 |
| LLPS-Pyt-0414 | Pyrenophora teres | 49.38 | 1e-130 | 391 |
| LLPS-Prp-0831 | Prunus persica | 49.26 | 5e-125 | 376 |
| LLPS-Sol-1002 | Solanum lycopersicum | 49.21 | 4e-124 | 374 |
| LLPS-Nec-0832 | Neurospora crassa | 48.99 | 2e-127 | 383 |
| LLPS-Asg-1061 | Ashbya gossypii | 48.68 | 6e-117 | 355 |
| LLPS-Mae-2353 | Manihot esculenta | 48.64 | 1e-124 | 375 |
| LLPS-Met-0285 | Medicago truncatula | 48.64 | 1e-124 | 375 |
| LLPS-Asni-1111 | Aspergillus niger | 48.61 | 1e-125 | 378 |
| LLPS-Nia-1866 | Nicotiana attenuata | 48.4 | 1e-125 | 378 |
| LLPS-Mel-1187 | Melampsora laricipopulina | 48.32 | 4e-115 | 350 |
| LLPS-Amt-1300 | Amborella trichopoda | 48.28 | 2e-110 | 337 |
| LLPS-Scc-1115 | Schizosaccharomyces cryophilus | 48.18 | 1e-114 | 350 |
| LLPS-Gas-0957 | Galdieria sulphuraria | 48.15 | 8e-124 | 374 |
| LLPS-Aso-0415 | Aspergillus oryzae | 48.14 | 2e-121 | 368 |
| LLPS-Put-0845 | Puccinia triticina | 48.12 | 6e-92 | 288 |
| LLPS-Scp-1401 | Schizosaccharomyces pombe | 48.04 | 6e-116 | 353 |
| LLPS-Mao-1359 | Magnaporthe oryzae | 48.04 | 3e-125 | 377 |
| LLPS-Vir-0194 | Vigna radiata | 47.65 | 3e-122 | 369 |
| LLPS-Sac-1451 | Saccharomyces cerevisiae | 47.14 | 7e-122 | 368 |
| LLPS-Cym-0027 | Cyanidioschyzon merolae | 46.37 | 3e-118 | 360 |
| LLPS-Scj-0526 | Schizosaccharomyces japonicus | 45.86 | 3e-115 | 352 |