LLPS-Urm-3882
CNN2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Calponin |
| Gene Name: | CNN2 |
| Ensembl Gene: | ENSUMAG00000005540.1 |
| Ensembl Protein: | ENSUMAP00000007129.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000008556.1 | ENSUMAP00000007129.1 |
| UniProt | A0A384DRG1, A0A384DRG1_URSMA | |
| RefSeq | , XM_008711356.1 | , XP_008709578.1, XP_008709578.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNKLQPGSVP KINRSMQNWH QLENLSTFIK AMVSYGMNPV DLFEANDLFE SGNMTQVQVS 60 61 LLALAGKAKT KGLQSGVDIG VKYSEKQERN FDDATMKAGQ CVIGLQMGTN KCASQSGMTA 120 121 YGTRRHLYDP KNHILPPMDH STISLQMGTN KCASQVGMTA PGTRRHIYDT KLGTDKCDNS 180 181 SMSLQMGYSQ GANQSGQVFG LGRQIYDPKY CPQGPVADGA SAAAGDCPGP GEAPEYPPYH 240 241 HQEEADY 247 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAATAAGC TACAGCCCGG CTCTGTCCCC AAGATCAACC GCTCCATGCA GAACTGGCAC 60 61 CAGCTGGAAA ACCTGTCCAC CTTCATCAAG GCCATGGTCA GCTACGGCAT GAACCCCGTG 120 121 GACCTGTTCG AGGCCAACGA CCTGTTTGAG AGCGGGAACA TGACACAGGT GCAAGTGTCC 180 181 CTTCTTGCCC TGGCCGGGAA GGCCAAAACA AAGGGGCTGC AGAGTGGCGT GGACATTGGC 240 241 GTCAAATACT CAGAAAAGCA GGAGCGCAAC TTTGATGATG CCACCATGAA GGCGGGCCAG 300 301 TGCGTCATCG GGCTCCAGAT GGGCACAAAC AAGTGCGCCA GCCAGTCGGG CATGACAGCT 360 361 TACGGCACCA GAAGGCATCT GTACGACCCC AAGAACCATA TCCTGCCCCC CATGGACCAC 420 421 TCAACCATCA GCCTCCAGAT GGGCACAAAC AAGTGTGCCA GCCAGGTGGG CATGACGGCT 480 481 CCGGGGACGC GGCGGCACAT CTACGATACC AAGCTGGGGA CGGACAAGTG TGACAACTCC 540 541 TCCATGTCCC TGCAGATGGG CTACTCGCAG GGCGCCAACC AGAGCGGCCA GGTCTTTGGC 600 601 TTAGGCCGGC AGATCTACGA CCCCAAGTAC TGCCCGCAAG GCCCCGTGGC CGATGGGGCT 660 661 TCGGCGGCTG CAGGCGACTG CCCAGGCCCC GGGGAGGCCC CAGAGTACCC CCCCTACCAC 720 721 CACCAGGAGG AGGCAGACTA CTGA 744 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoskeleton | |
Molecular Function | Actin binding | |
Molecular Function | Calmodulin binding | |
Biological Process | Actomyosin structure organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-0226 | Ailuropoda melanoleuca | 100.0 | 3e-162 | 458 |
| LLPS-Ran-3229 | Rattus norvegicus | 98.72 | 6e-110 | 323 |
| LLPS-Bot-2542 | Bos taurus | 98.59 | 1e-155 | 442 |
| LLPS-Caf-3498 | Canis familiaris | 98.59 | 6e-156 | 443 |
| LLPS-Eqc-0556 | Equus caballus | 98.23 | 2e-164 | 465 |
| LLPS-Sus-3562 | Sus scrofa | 98.12 | 1e-153 | 438 |
| LLPS-Ova-3346 | Ovis aries | 98.12 | 2e-155 | 442 |
| LLPS-Tut-2044 | Tursiops truncatus | 98.12 | 3e-155 | 441 |
| LLPS-Mal-2861 | Mandrillus leucophaeus | 97.36 | 2e-162 | 461 |
| LLPS-Mam-4569 | Macaca mulatta | 97.36 | 5e-164 | 464 |
| LLPS-Myl-3478 | Myotis lucifugus | 96.92 | 2e-164 | 464 |
| LLPS-Man-3778 | Macaca nemestrina | 96.92 | 9e-164 | 463 |
| LLPS-Pap-2847 | Pan paniscus | 96.92 | 5e-164 | 461 |
| LLPS-Poa-1776 | Pongo abelii | 96.92 | 3e-163 | 462 |
| LLPS-Gog-1510 | Gorilla gorilla | 96.48 | 4e-163 | 461 |
| LLPS-Mum-3671 | Mus musculus | 96.44 | 5e-160 | 453 |
| LLPS-Maf-0569 | Macaca fascicularis | 96.04 | 2e-161 | 457 |
| LLPS-Cap-4251 | Cavia porcellus | 96.02 | 1e-159 | 452 |
| LLPS-Mea-3883 | Mesocricetus auratus | 95.98 | 2e-159 | 452 |
| LLPS-Mup-0951 | Mustela putorius furo | 95.95 | 4e-156 | 446 |
| LLPS-Chs-3005 | Chlorocebus sabaeus | 95.59 | 2e-159 | 452 |
| LLPS-Otg-4470 | Otolemur garnettii | 95.59 | 5e-161 | 456 |
| LLPS-Paa-4487 | Papio anubis | 95.15 | 2e-160 | 454 |
| LLPS-Rhb-2051 | Rhinopithecus bieti | 95.15 | 2e-161 | 457 |
| LLPS-Fud-4088 | Fukomys damarensis | 95.13 | 7e-160 | 453 |
| LLPS-Mod-1971 | Monodelphis domestica | 94.84 | 5e-150 | 428 |
| LLPS-Ere-0885 | Erinaceus europaeus | 94.63 | 4e-102 | 301 |
| LLPS-Sah-3081 | Sarcophilus harrisii | 94.37 | 6e-147 | 420 |
| LLPS-Ict-3721 | Ictidomys tridecemlineatus | 91.15 | 3e-153 | 436 |
| LLPS-Fia-0296 | Ficedula albicollis | 90.13 | 6e-146 | 418 |
| LLPS-Fec-2436 | Felis catus | 90.09 | 2e-149 | 427 |
| LLPS-Gaga-3196 | Gallus gallus | 89.69 | 4e-146 | 418 |
| LLPS-Tag-2789 | Taeniopygia guttata | 89.64 | 9e-146 | 416 |
| LLPS-Pes-3500 | Pelodiscus sinensis | 89.16 | 1e-132 | 382 |
| LLPS-Meg-2232 | Meleagris gallopavo | 88.79 | 4e-145 | 415 |
| LLPS-Hos-2473 | Homo sapiens | 88.71 | 5e-158 | 449 |
| LLPS-Caj-3905 | Callithrix jacchus | 87.9 | 4e-156 | 444 |
| LLPS-Dio-1820 | Dipodomys ordii | 86.73 | 6e-139 | 399 |
| LLPS-Xet-3311 | Xenopus tropicalis | 86.24 | 5e-137 | 394 |
| LLPS-Aon-2279 | Aotus nancymaae | 85.02 | 1e-132 | 384 |
| LLPS-Pat-2662 | Pan troglodytes | 83.48 | 7e-133 | 384 |
| LLPS-Loa-3740 | Loxodonta africana | 82.66 | 5e-135 | 389 |
| LLPS-Leo-2165 | Lepisosteus oculatus | 82.16 | 2e-126 | 368 |
| LLPS-Scf-2637 | Scleropages formosus | 81.61 | 2e-132 | 383 |
| LLPS-Dar-4155 | Danio rerio | 81.17 | 1e-130 | 379 |
| LLPS-Pof-2795 | Poecilia formosa | 79.72 | 6e-121 | 354 |
| LLPS-Tar-2768 | Takifugu rubripes | 78.77 | 3e-118 | 348 |
| LLPS-Cas-3742 | Carlito syrichta | 78.41 | 2e-123 | 360 |
| LLPS-Nol-2012 | Nomascus leucogenys | 78.22 | 6e-120 | 352 |
| LLPS-Cea-3915 | Cercocebus atys | 77.73 | 3e-123 | 360 |
| LLPS-Xim-1529 | Xiphophorus maculatus | 77.23 | 8e-122 | 357 |
| LLPS-Orl-4083 | Oryzias latipes | 76.34 | 5e-122 | 357 |
| LLPS-Gaa-2418 | Gasterosteus aculeatus | 76.34 | 1e-119 | 351 |
| LLPS-Ten-3716 | Tetraodon nigroviridis | 75.8 | 7e-116 | 341 |
| LLPS-Lac-3308 | Latimeria chalumnae | 75.45 | 3e-124 | 362 |
| LLPS-Orn-2963 | Oreochromis niloticus | 74.22 | 5e-119 | 350 |
| LLPS-Scm-1948 | Scophthalmus maximus | 73.89 | 4e-117 | 346 |
| LLPS-Orc-2710 | Oryctolagus cuniculus | 44.26 | 3e-21 | 92.8 |
| LLPS-Cii-0957 | Ciona intestinalis | 43.08 | 6e-26 | 105 |
| LLPS-Anp-1601 | Anas platyrhynchos | 42.11 | 6e-20 | 89.4 |
| LLPS-Ora-3025 | Ornithorhynchus anatinus | 41.35 | 2e-22 | 96.3 |
| LLPS-Anc-0650 | Anolis carolinensis | 40.6 | 2e-21 | 93.6 |
| LLPS-Cae-1089 | Caenorhabditis elegans | 38.89 | 8e-17 | 80.5 |
| LLPS-Icp-2696 | Ictalurus punctatus | 36.09 | 2e-17 | 82.0 |
| LLPS-Drm-1949 | Drosophila melanogaster | 35.94 | 9e-18 | 83.2 |
| LLPS-Asm-1639 | Astyanax mexicanus | 35.34 | 9e-18 | 83.2 |