LLPS-Dar-4155
cnn2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Calponin
Gene Name: cnn2
Ensembl Gene: ENSDARG00000035858.7
Ensembl Protein: ENSDARP00000052060.5
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSDART00000052061.6ENSDARP00000052060.5
UniProtQ4F876, Q4F876_DANRE
GeneBankDQ104245, BX530024, AAZ14863.1
Entrez406658

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSQFNRGPA  YGFSAEVKSK  IAQKYDPQRE  EELRIWIENT  TGRSIGDDFQ  KGLKNGVILC  60
61    ELINKLQPGS  VKKINQSSQN  WHQLENLTNF  IKAITTYGLK  PHDIFEANDL  FENGNMTQVQ  120
121   TTLLALAGMA  KTKGIHSSVD  IGVKYAERQE  RAFDDEKMKA  GQCVIGLQMG  TNKCASQAGM  180
181   NAYGTRRHLY  DPKSHILPPM  DHSTISLQMG  TNKGASQAGM  TAPGTRRAIY  DQKTGTDKCD  240
241   NSTMSLQMGY  SQGANQSGQN  FGLGRQIYDA  KYCPKGGAVA  AGEGNDGQYT  DYQDEGYQGY  300
301   QDDGQDY  307
Nucleotide CDS Sequence (FASTA)
1     ATGTCTTCGC  AGTTTAACAG  AGGCCCGGCG  TACGGGTTTT  CAGCGGAAGT  GAAAAGCAAG  60
61    ATTGCACAGA  AATATGACCC  ACAGAGAGAG  GAAGAATTAC  GAATCTGGAT  TGAGAATACT  120
121   ACAGGGCGAT  CGATTGGAGA  CGACTTCCAG  AAAGGATTAA  AAAATGGTGT  GATTCTCTGC  180
181   GAGCTCATAA  ACAAACTTCA  GCCAGGCTCT  GTAAAGAAGA  TTAACCAGTC  TTCCCAAAAC  240
241   TGGCATCAGC  TAGAGAACCT  GACCAACTTC  ATTAAAGCGA  TCACCACCTA  TGGACTCAAG  300
301   CCTCATGACA  TCTTTGAGGC  CAATGATCTG  TTCGAGAATG  GAAATATGAC  ACAGGTTCAG  360
361   ACCACCCTCC  TGGCACTCGC  TGGCATGGCT  AAAACCAAGG  GCATTCATTC  GAGTGTGGAC  420
421   ATAGGGGTGA  AATATGCCGA  AAGACAGGAG  AGGGCATTTG  ATGATGAGAA  AATGAAGGCT  480
481   GGCCAATGTG  TCATCGGACT  ACAGATGGGA  ACAAATAAAT  GTGCAAGTCA  GGCTGGAATG  540
541   AACGCCTATG  GCACTCGAAG  ACATCTGTAT  GATCCCAAGT  CACACATTCT  GCCACCAATG  600
601   GACCATTCAA  CCATCAGTCT  GCAGATGGGC  ACCAATAAGG  GTGCTAGTCA  AGCTGGTATG  660
661   ACAGCTCCAG  GCACTCGCCG  TGCCATCTAC  GACCAGAAAA  CTGGCACAGA  CAAGTGTGAC  720
721   AACTCCACCA  TGTCTTTGCA  AATGGGATAT  TCTCAAGGTG  CCAACCAGAG  CGGGCAAAAC  780
781   TTCGGTCTTG  GCCGTCAGAT  CTACGATGCC  AAATACTGTC  CTAAAGGTGG  CGCTGTTGCA  840
841   GCTGGAGAAG  GAAACGATGG  TCAGTACACA  GATTACCAAG  ACGAGGGTTA  CCAGGGCTAT  900
901   CAGGACGACG  GCCAAGATTA  CTAA  924

▼ KEYWORD

ID
Family
Actin-binding
Calmodulin-binding
Complete proteome
Proteomics identification
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoskeleton
Molecular Function
Actin binding
Molecular Function
Calmodulin binding
Biological Process
Actomyosin structure organization
Biological Process
Regulation of blood vessel endothelial cell migration
Biological Process
Regulation of MAPK cascade
Biological Process
Response to steroid hormone

▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINMIST
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Leo-2165Lepisosteus oculatus91.240.0 536
LLPS-Orl-4083Oryzias latipes88.770.0 518
LLPS-Scf-2637Scleropages formosus88.730.0 520
LLPS-Pof-2795Poecilia formosa87.872e-179 505
LLPS-Xim-1529Xiphophorus maculatus87.360.0 511
LLPS-Gaa-2418Gasterosteus aculeatus85.142e-177 500
LLPS-Orn-2963Oreochromis niloticus85.054e-180 508
LLPS-Scm-1948Scophthalmus maximus84.361e-175 497
LLPS-Ten-3716Tetraodon nigroviridis83.271e-170 483
LLPS-Urm-3882Ursus maritimus82.713e-130 378
LLPS-Ere-0885Erinaceus europaeus82.551e-86 264
LLPS-Pap-2847Pan paniscus81.821e-130 379
LLPS-Pes-3500Pelodiscus sinensis80.619e-114 336
LLPS-Tar-2768Takifugu rubripes80.432e-167 475
LLPS-Aim-0226Ailuropoda melanoleuca80.162e-154 441
LLPS-Mup-0951Mustela putorius furo79.845e-150 433
LLPS-Eqc-0556Equus caballus79.561e-165 470
LLPS-Tag-2789Taeniopygia guttata79.452e-153 438
LLPS-Tut-2044Tursiops truncatus79.23e-165 469
LLPS-Sus-3562Sus scrofa79.21e-164 469
LLPS-Caf-3498Canis familiaris79.23e-164 467
LLPS-Lac-3308Latimeria chalumnae79.088e-168 476
LLPS-Poa-1776Pongo abelii79.02e-166 472
LLPS-Bot-2542Bos taurus78.835e-165 469
LLPS-Otg-4470Otolemur garnettii78.786e-166 471
LLPS-Gog-1510Gorilla gorilla78.653e-166 472
LLPS-Mam-4569Macaca mulatta78.652e-165 470
LLPS-Ova-3346Ovis aries78.479e-165 468
LLPS-Man-3778Macaca nemestrina78.292e-165 469
LLPS-Xet-3311Xenopus tropicalis78.261e-165 469
LLPS-Meg-2232Meleagris gallopavo77.991e-155 444
LLPS-Mum-3671Mus musculus77.974e-167 474
LLPS-Gaga-3196Gallus gallus77.973e-167 474
LLPS-Fia-0296Ficedula albicollis77.973e-168 477
LLPS-Fud-4088Fukomys damarensis77.941e-164 468
LLPS-Maf-0569Macaca fascicularis77.941e-163 465
LLPS-Ran-3229Rattus norvegicus77.883e-126 367
LLPS-Mal-2861Mandrillus leucophaeus77.781e-154 444
LLPS-Mea-3883Mesocricetus auratus77.782e-167 474
LLPS-Sah-3081Sarcophilus harrisii77.744e-158 451
LLPS-Mod-1971Monodelphis domestica77.741e-160 457
LLPS-Chs-3005Chlorocebus sabaeus77.582e-161 460
LLPS-Rhb-2051Rhinopithecus bieti77.582e-163 464
LLPS-Cap-4251Cavia porcellus77.391e-165 470
LLPS-Paa-4487Papio anubis77.229e-162 461
LLPS-Myl-3478Myotis lucifugus77.114e-166 472
LLPS-Ict-3721Ictidomys tridecemlineatus77.086e-165 468
LLPS-Fec-2436Felis catus74.741e-161 461
LLPS-Loa-3740Loxodonta africana74.321e-137 398
LLPS-Hos-2473Homo sapiens73.513e-161 460
LLPS-Caj-3905Callithrix jacchus73.146e-148 425
LLPS-Dio-1820Dipodomys ordii72.692e-137 397
LLPS-Cea-3915Cercocebus atys69.095e-134 390
LLPS-Pat-2662Pan troglodytes68.731e-138 400
LLPS-Aon-2279Aotus nancymaae66.552e-135 393
LLPS-Nol-2012Nomascus leucogenys65.096e-127 373
LLPS-Cas-3742Carlito syrichta64.732e-125 368
LLPS-Ora-0907Ornithorhynchus anatinus43.85e-24 100
LLPS-Anc-0650Anolis carolinensis43.723e-42 150
LLPS-Anp-1601Anas platyrhynchos43.374e-41 147
LLPS-Orc-3135Oryctolagus cuniculus42.026e-37 137
LLPS-Asm-1639Astyanax mexicanus40.822e-37 138
LLPS-Icp-2696Ictalurus punctatus39.82e-37 138
LLPS-Cii-0957Ciona intestinalis39.585e-34 129
LLPS-Drm-1949Drosophila melanogaster37.141e-31 122
LLPS-Cae-1089Caenorhabditis elegans36.322e-29 116
LLPS-Usm-1144Ustilago maydis34.071e-0654.3
LLPS-Ved-0923Verticillium dahliae33.641e-1169.3
LLPS-Scj-1352Schizosaccharomyces japonicus27.321e-0654.3