LLPS-Ova-3346
CNN2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Calponin |
| Gene Name: | CNN2 |
| Ensembl Gene: | ENSOARG00000010489.1 |
| Ensembl Protein: | ENSOARP00000011258.1 |
| Organism: | Ovis aries |
| Taxa ID: | 9940 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOART00000011418.1 | ENSOARP00000011258.1 |
| UniProt | W5PLD5, W5PLD5_SHEEP | |
| GeneBank | AMGL01092732, AMGL01092731 | |
| RefSeq | XM_004008768.3 | XP_004008817.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSTQFNKGP SYGLSAEVKN RLQSKYDPQK EAELRSWIEG LTGLSVGPDF QKGLKDGIIL 60 61 CTLMNKLQPG SIPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNLTQV 120 121 QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATMK AGQCVIGLQM GTNKCASQSG 180 181 MTAYGTRRHL YDPKNHILPP MDHSTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC 240 241 DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGPAA DGAPAAAGDG PGPGEPSECP 300 301 PYYQEEAGY 309 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCTCCA CGCAGTTCAA CAAGGGGCCT TCGTACGGGC TCTCGGCCGA GGTCAAGAAC 60 61 CGGCTGCAAT CCAAATATGA CCCTCAAAAG GAGGCGGAAC TCCGAAGCTG GATTGAGGGA 120 121 CTCACTGGCC TCTCTGTTGG CCCAGACTTC CAGAAGGGTC TGAAGGATGG GATCATATTG 180 181 TGCACACTCA TGAATAAACT GCAGCCGGGC TCAATCCCTA AGATCAACCG CTCCATGCAG 240 241 AACTGGCACC AGCTAGAAAA CCTCTCCAAC TTCATCAAGG CCATGGTGAG CTACGGCATG 300 301 AATCCTGTTG ACCTGTTCGA GGCCAACGAC CTGTTTGAAA GTGGGAACTT GACTCAGGTG 360 361 CAGGTGTCTC TTCTTGCCCT GGCTGGGAAG GCCAAGACAA AGGGGCTGCA GAGTGGTGTG 420 421 GACATTGGCG TCAAATACTC AGAGAAGCAG GAGCGAAACT TTGATGATGC CACCATGAAG 480 481 GCGGGCCAGT GCGTCATTGG GCTCCAGATG GGCACCAACA AATGTGCCAG CCAGTCTGGC 540 541 ATGACAGCTT ACGGCACCAG ACGGCATCTG TACGACCCCA AAAACCATAT CCTGCCCCCC 600 601 ATGGACCACT CGACCATCAG CCTCCAGATG GGCACAAACA AGTGTGCCAG CCAGGTGGGC 660 661 ATGACAGCTC CAGGGACTCG GCGGCACATT TACGACACAA AGCTGGGGAC AGACAAATGT 720 721 GATAATTCCT CCATGTCCCT GCAGATGGGC TACACACAGG GTGCCAACCA GAGTGGTCAG 780 781 GTCTTTGGCC TGGGCCGGCA GATATACGAC CCCAAGTACT GCCCTCAAGG TCCAGCGGCC 840 841 GACGGGGCTC CAGCAGCTGC TGGAGATGGC CCAGGCCCAG GGGAGCCCTC AGAGTGCCCT 900 901 CCCTACTACC AGGAGGAGGC AGGCTACTGA 930 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoskeleton | |
Molecular Function | Actin binding | |
Molecular Function | Calmodulin binding | |
Biological Process | Actomyosin structure organization | |
Biological Process | Hemopoiesis | |
Biological Process | Negative regulation of cell migration | |
Biological Process | Negative regulation of phagocytosis | |
Biological Process | Positive regulation of gene expression | |
Biological Process | Regulation of cell population proliferation | |
Biological Process | Wound healing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bot-2542 | Bos taurus | 99.68 | 0.0 | 601 |
| LLPS-Sus-3562 | Sus scrofa | 97.83 | 0.0 | 563 |
| LLPS-Ran-3229 | Rattus norvegicus | 97.26 | 5e-158 | 447 |
| LLPS-Eqc-0556 | Equus caballus | 97.09 | 0.0 | 584 |
| LLPS-Tut-2044 | Tursiops truncatus | 96.76 | 0.0 | 583 |
| LLPS-Gog-1510 | Gorilla gorilla | 95.15 | 0.0 | 582 |
| LLPS-Pap-2847 | Pan paniscus | 95.12 | 2e-162 | 459 |
| LLPS-Aim-0226 | Ailuropoda melanoleuca | 94.83 | 0.0 | 533 |
| LLPS-Myl-3478 | Myotis lucifugus | 94.82 | 0.0 | 581 |
| LLPS-Poa-1776 | Pongo abelii | 94.82 | 0.0 | 582 |
| LLPS-Mam-4569 | Macaca mulatta | 94.82 | 0.0 | 580 |
| LLPS-Man-3778 | Macaca nemestrina | 94.82 | 0.0 | 577 |
| LLPS-Urm-3882 | Ursus maritimus | 94.74 | 3e-157 | 447 |
| LLPS-Maf-0569 | Macaca fascicularis | 94.17 | 0.0 | 575 |
| LLPS-Caf-3498 | Canis familiaris | 94.17 | 0.0 | 577 |
| LLPS-Otg-4470 | Otolemur garnettii | 94.17 | 0.0 | 576 |
| LLPS-Paa-4487 | Papio anubis | 93.2 | 0.0 | 570 |
| LLPS-Chs-3005 | Chlorocebus sabaeus | 93.2 | 0.0 | 568 |
| LLPS-Mup-0951 | Mustela putorius furo | 93.01 | 0.0 | 518 |
| LLPS-Mal-2861 | Mandrillus leucophaeus | 92.57 | 0.0 | 540 |
| LLPS-Cap-4251 | Cavia porcellus | 92.53 | 0.0 | 577 |
| LLPS-Rhb-2051 | Rhinopithecus bieti | 92.23 | 0.0 | 565 |
| LLPS-Mum-3671 | Mus musculus | 91.91 | 0.0 | 570 |
| LLPS-Mea-3883 | Mesocricetus auratus | 91.26 | 0.0 | 566 |
| LLPS-Fud-4088 | Fukomys damarensis | 90.91 | 0.0 | 574 |
| LLPS-Mod-1971 | Monodelphis domestica | 89.97 | 0.0 | 556 |
| LLPS-Tag-2789 | Taeniopygia guttata | 89.29 | 4e-169 | 478 |
| LLPS-Sah-3081 | Sarcophilus harrisii | 89.0 | 0.0 | 547 |
| LLPS-Hos-2473 | Homo sapiens | 88.79 | 0.0 | 569 |
| LLPS-Caj-3905 | Callithrix jacchus | 88.35 | 0.0 | 523 |
| LLPS-Meg-2232 | Meleagris gallopavo | 87.89 | 9e-169 | 477 |
| LLPS-Ict-3721 | Ictidomys tridecemlineatus | 87.54 | 0.0 | 543 |
| LLPS-Loa-3740 | Loxodonta africana | 86.55 | 2e-169 | 479 |
| LLPS-Ere-0885 | Erinaceus europaeus | 86.03 | 2e-102 | 304 |
| LLPS-Xet-3311 | Xenopus tropicalis | 85.71 | 1e-176 | 498 |
| LLPS-Fec-2436 | Felis catus | 85.67 | 0.0 | 555 |
| LLPS-Cea-3915 | Cercocebus atys | 84.84 | 1e-165 | 470 |
| LLPS-Dio-1820 | Dipodomys ordii | 84.45 | 2e-167 | 473 |
| LLPS-Pes-3500 | Pelodiscus sinensis | 83.41 | 2e-132 | 383 |
| LLPS-Fia-0296 | Ficedula albicollis | 83.28 | 0.0 | 526 |
| LLPS-Gaga-3196 | Gallus gallus | 82.32 | 0.0 | 521 |
| LLPS-Aon-2279 | Aotus nancymaae | 82.12 | 1e-174 | 493 |
| LLPS-Scf-2637 | Scleropages formosus | 80.73 | 1e-168 | 478 |
| LLPS-Leo-2165 | Lepisosteus oculatus | 78.99 | 6e-163 | 463 |
| LLPS-Pat-2662 | Pan troglodytes | 78.64 | 9e-171 | 482 |
| LLPS-Dar-4155 | Danio rerio | 78.47 | 1e-164 | 468 |
| LLPS-Xim-1529 | Xiphophorus maculatus | 77.49 | 6e-157 | 449 |
| LLPS-Nol-2012 | Nomascus leucogenys | 77.27 | 1e-159 | 456 |
| LLPS-Gaa-2418 | Gasterosteus aculeatus | 76.75 | 3e-154 | 442 |
| LLPS-Cas-3742 | Carlito syrichta | 76.7 | 1e-157 | 449 |
| LLPS-Lac-3308 | Latimeria chalumnae | 76.45 | 4e-157 | 449 |
| LLPS-Orl-4083 | Oryzias latipes | 76.38 | 4e-155 | 444 |
| LLPS-Pof-2795 | Poecilia formosa | 76.36 | 5e-157 | 449 |
| LLPS-Orn-2963 | Oreochromis niloticus | 76.09 | 2e-155 | 445 |
| LLPS-Tar-2768 | Takifugu rubripes | 74.81 | 5e-149 | 428 |
| LLPS-Ten-3716 | Tetraodon nigroviridis | 74.35 | 1e-148 | 427 |
| LLPS-Scm-1948 | Scophthalmus maximus | 73.91 | 2e-153 | 441 |
| LLPS-Anc-0650 | Anolis carolinensis | 41.84 | 2e-39 | 143 |
| LLPS-Anp-1601 | Anas platyrhynchos | 41.84 | 8e-37 | 136 |
| LLPS-Orc-3135 | Oryctolagus cuniculus | 41.49 | 2e-33 | 127 |
| LLPS-Ora-3025 | Ornithorhynchus anatinus | 41.33 | 1e-40 | 147 |
| LLPS-Cii-0957 | Ciona intestinalis | 41.18 | 5e-38 | 139 |
| LLPS-Asm-1639 | Astyanax mexicanus | 38.27 | 5e-34 | 129 |
| LLPS-Icp-2696 | Ictalurus punctatus | 38.27 | 4e-35 | 132 |
| LLPS-Ved-0923 | Verticillium dahliae | 36.36 | 5e-09 | 61.2 |
| LLPS-Usm-1144 | Ustilago maydis | 35.16 | 3e-06 | 53.1 |
| LLPS-Drm-1949 | Drosophila melanogaster | 35.0 | 1e-29 | 117 |
| LLPS-Cae-1089 | Caenorhabditis elegans | 34.39 | 3e-27 | 110 |