LLPS-Urm-3523
DSG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | desmoglein-1 |
| Gene Name: | DSG1 |
| Ensembl Gene: | ENSUMAG00000001090.1 |
| Ensembl Protein: | ENSUMAP00000001262.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000001591.1 | ENSUMAP00000001262.1 |
| Ensembl | ENSUMAT00000001598.1 | ENSUMAP00000001269.1 |
| Ensembl | ENSUMAT00000001586.1 | ENSUMAP00000001257.1 |
| UniProt | A0A384C2Q7, A0A384C2Q7_URSMA | |
| RefSeq | , XM_008690939.1 | , XP_008689161.1, XP_008689161.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 QVRDYNTKNG TIKWHSIRRQ KREWIKFAAA CREGEDNSKR NPIAKIHSDC AANQQVTYRI 60 61 SGVGIDQPPY GIFIINQKTG EINITSIVDR EVTPFFIIYC RALNSLGQDL ERPLELRVRV 120 121 LDINDNPPVF SMSTFVGQIE ENSNANTLVM RLNATDADEP NNLNSKIAFK IIRQEPSDSP 180 181 MFIINRNTGE IRTMNNFLDR EQYSQYSLAV RGSDRDGGAD GMSAECECNI KILDVNDNIP 240 241 YMELPSQSIS IEENALYSDL LQIRIIDLDE EYSANWMGVI FFISGNEGGW FDIEMNERTN 300 301 VGILKVIKPL DYEDVKNLQL SLGVRNKAEF HHSIMSQYKL TATAITVTVL NVIEGAVFRP 360 361 GSKTYVVTSN MGQNYKVGDF IAIDQDTGRA STTVRYVMGN NPANLLNVDS KTGIITLRNR 420 421 VTMEQYNMLG GKYQGTILSI DDTLRRTCTG TINIDLQGSG WVENGKVTDS TSTGSSGGTA 480 481 GGSAGTGTVG PAVTSTSVNG DDTDTNTDDK SNTGTPGTQP MVNGLNPSDN VHFGPAGIGL 540 541 LIMGFLVLGL VPFLLMCCDC GGAPGGGAGF EPVPECSDGA IHSWAVEGPQ PPPVDVTTVC 600 601 VPPIPPDNAN LIECIDTSGV YTNEYGGREM QDLGGGERTT GFELTEGVKT SGVPEICQEY 660 661 SGTLRRNSMR ECREGGLNMN FMESYFCQKA YAYADEDEGR PSNDCLLIYD IEGVGSPAGS 720 721 VGCCSFIGED VDDSFLDTLG PKFKKLADIS LGKEVELYPD PDPSWPPEST EPICPQQGTE 780 781 PISGGHPPIS PHFGTTTVIS ESTYPSGPGV QHPMPIPDPL GYGNVTVTES YTTSGTLKPS 840 841 VHVHDNRHAS NVVVTERVLG PISGTDLHGM LEMPDLRDGS NVIVTERVIA PSSSLPTSLT 900 901 MPDPRESSNV VVTERVIRPA SGMMGNLSIH PELSNTQNVI VTERVVSGSG ISGISGPAGM 960 961 SGGSGLVGSA AGVSGGGIGL SSLGGGGGLS SGMGGTATIG HMRSSSDHHF SQTLGSASPS 1020 1021 TARSRITKYS TVQYTK 1036 |
| Nucleotide CDS Sequence (FASTA) |
1 CAGGTAAGAG ATTACAACAC CAAAAATGGT ACCATCAAGT GGCATTCAAT CAGGAGGCAA 60 61 AAACGTGAAT GGATCAAGTT TGCTGCAGCC TGTCGTGAAG GTGAAGACAA TTCAAAGAGG 120 121 AACCCAATTG CCAAAATTCA CTCAGATTGT GCTGCAAACC AGCAAGTTAC ATACCGCATC 180 181 TCTGGAGTAG GAATTGATCA GCCACCTTAT GGAATCTTCA TCATTAATCA AAAAACTGGT 240 241 GAAATTAATA TTACATCCAT AGTTGATCGA GAGGTCACCC CTTTTTTCAT TATCTATTGC 300 301 CGAGCTCTTA ATTCACTGGG TCAAGATTTA GAGAGGCCTC TTGAGCTCAG AGTCAGGGTT 360 361 TTGGATATAA ATGACAACCC TCCAGTATTT TCTATGTCTA CTTTTGTAGG ACAAATAGAA 420 421 GAAAATTCTA ATGCAAATAC GCTGGTGATG AGACTCAATG CTACTGATGC AGATGAACCA 480 481 AATAATTTGA ACTCAAAAAT AGCCTTCAAG ATCATAAGAC AGGAACCTTC TGACTCACCA 540 541 ATGTTTATTA TCAACAGAAA CACTGGAGAA ATTCGAACAA TGAATAATTT TCTAGACAGA 600 601 GAGCAATATA GCCAGTATTC CCTTGCTGTG AGAGGCTCAG ACCGAGATGG TGGGGCAGAC 660 661 GGTATGTCAG CAGAGTGTGA GTGCAACATT AAAATCCTTG ATGTTAATGA TAACATCCCA 720 721 TACATGGAAC TGCCTTCGCA ATCCATTAGT ATTGAAGAAA ATGCTCTATA CTCAGATTTG 780 781 CTCCAGATTA GAATAATCGA TTTGGATGAA GAGTACTCAG CTAACTGGAT GGGAGTAATT 840 841 TTCTTTATCT CTGGAAATGA GGGAGGTTGG TTTGACATAG AAATGAATGA AAGGACAAAT 900 901 GTGGGAATTT TAAAGGTTAT TAAGCCACTA GATTATGAAG ATGTGAAGAA TCTGCAACTT 960 961 AGTCTCGGTG TCAGAAATAA AGCTGAATTT CACCATTCAA TTATGTCTCA ATACAAACTC 1020 1021 ACAGCAACTG CAATCACTGT GACTGTGTTA AACGTAATTG AAGGTGCGGT GTTCCGTCCA 1080 1081 GGTTCAAAGA CATATGTAGT AACTAGTAAC ATGGGACAGA ATTATAAAGT GGGAGACTTT 1140 1141 ATAGCTATTG ACCAGGACAC AGGTCGAGCT TCAACAACTG TTAGATATGT AATGGGAAAT 1200 1201 AATCCAGCTA ACCTACTCAA TGTTGACTCA AAAACAGGCA TAATAACTTT GAGAAATAGA 1260 1261 GTTACCATGG AACAGTACAA CATGCTTGGT GGAAAATACC AAGGAACAAT TTTATCTATA 1320 1321 GATGATACTC TTCGAAGAAC TTGTACTGGA ACAATTAATA TTGACCTTCA AGGTTCTGGC 1380 1381 TGGGTTGAGA ATGGAAAAGT TACTGATAGC ACCAGTACTG GAAGCAGCGG GGATGATACT 1440 1441 GATACTAACA CAGATGACAA AAGTAACACT GGCACCCCTG GCACCCAGCC AATGGTAAAT 1500 1501 GGATTAAATC CTTCAGATAA TGTCCATTTT GGTCCTGCCG GCATTGGACT GCTCATCATG 1560 1561 GGATTCTTGG TCCTAGGATT GGTCCCATTT TTGTTGATGT GCTGTGACTG TGGAGGTGCC 1620 1621 CCTGGTGGGG GAGCTGGCTT TGAGCCCGTC CCCGAATGTT CAGATGGAGC AATTCACTCA 1680 1681 TGGGCAGTAG AAGGCCCACA GCCGCCTCCC GTAGTAAGGG TTTACACAAA TGAGTATGGT 1740 1741 GGCAGAGAAA TGCAAGATCT GGGAGGAGGA GAAAGAACAA CAGGATTTGA ACTAACAGAA 1800 1801 GGAGTTAAAA CGTCAGGAGT ACCTGAGATA TGTCAAGAAT ATTCTGGAAC ATTAAGAAGA 1860 1861 AATTCTATGA GAGAATGTAG AGAAGGAGGT CTGAATATGA ACTTCATGGA AAGCTACTTC 1920 1921 TGTCAGAAAG CATATGCCTA TGCAGATGAA GATGAAGGAC GCCCATCCAA TGACTGTTTG 1980 1981 CTCATATATG ACATTGAAGG TGTAGGTTCC CCTGCTGGCT CCGTGGGTTG TTGTAGCTTC 2040 2041 ATTGGAGAAG ACGTGGATGA CAGCTTTTTG GACACACTGG GGCCTAAATT TAAGAAGTTG 2100 2101 GCAGATATCA GCCTGGGAAA AGAAGTTGAA CTATATCCAG ACCCTGATCC CTCTTGGCCA 2160 2161 CCTGAGAGCA CCGAACCGAT TTGCCCTCAG CAGGGAACAG AGCCCATCAG TGGTGGACAC 2220 2221 CCACCCATCT CCCCACATTT TGGCACCACC ACAGTCATTT CTGAGAGCAC CTACCCCTCA 2280 2281 GGACCTGGTG TACAGCATCC TATGCCTATT CCTGATCCTC TGGGCTATGG TAATGTCACT 2340 2341 GTGACCGAGT CTTACACCAC CTCTGGCACT CTGAAGCCCT CTGTCCATGT TCATGATAAT 2400 2401 CGACACGCAT CAAACGTAGT GGTGACCGAG AGAGTGCTAG GCCCAATCTC TGGCACTGAT 2460 2461 TTGCATGGAA TGTTAGAGAT GCCTGACTTG AGAGATGGGT CAAACGTTAT AGTCACAGAA 2520 2521 AGAGTAATAG CACCAAGTTC AAGTCTACCC ACCTCTTTGA CCATGCCTGA TCCTAGAGAG 2580 2581 TCATCAAATG TGGTAGTGAC AGAAAGAGTA ATCCGACCAG CTTCTGGCAT GATGGGCAAT 2640 2641 CTAAGTATAC ACCCTGAGTT ATCAAATACC CAAAATGTGA TTGTGACAGA GAGAGTTGTT 2700 2701 TCTGGCTCTG GCATAAGTGG AATTAGTGGC CCAGCTGGGA TGAGCGGAGG CAGTGGCCTG 2760 2761 GTTGGCAGTG CAGCTGGAGT AAGTGGTGGT GGCATTGGGC TGAGCAGCCT GGGAGGAGGT 2820 2821 GGAGGCCTGA GTAGTGGCAT GGGGGGCACA GCTACCATTG GTCACATGAG GAGCTCCTCT 2880 2881 GACCATCACT TTAGCCAGAC TCTTGGATCT GCCTCCCCTA GTACAGCCCG AAGTCGAATC 2940 2941 ACAAAGTACA GTACAGTACA ATACACGAAG TAG 2973 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Plasma membrane | |
Molecular Function | Calcium ion binding | |
Biological Process | Homophilic cell adhesion via plasma membrane adhesion molecules |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orc-2575 | Oryctolagus cuniculus | 97.56 | 8e-15 | 84.0 |
| LLPS-Caf-4388 | Canis familiaris | 95.89 | 0.0 | 788 |
| LLPS-Ict-3052 | Ictidomys tridecemlineatus | 95.12 | 2e-14 | 82.4 |
| LLPS-Fec-3059 | Felis catus | 95.11 | 0.0 | 796 |
| LLPS-Aim-3109 | Ailuropoda melanoleuca | 93.97 | 0.0 | 1698 |
| LLPS-Mup-1531 | Mustela putorius furo | 93.37 | 0.0 | 790 |
| LLPS-Caj-3601 | Callithrix jacchus | 92.68 | 3e-14 | 82.0 |
| LLPS-Cea-3022 | Cercocebus atys | 92.68 | 3e-14 | 82.0 |
| LLPS-Aon-4353 | Aotus nancymaae | 92.68 | 3e-14 | 81.6 |
| LLPS-Maf-0004 | Macaca fascicularis | 92.68 | 3e-14 | 82.0 |
| LLPS-Chs-3974 | Chlorocebus sabaeus | 92.68 | 3e-14 | 82.0 |
| LLPS-Paa-0902 | Papio anubis | 92.68 | 3e-14 | 82.0 |
| LLPS-Rhb-4147 | Rhinopithecus bieti | 92.68 | 3e-14 | 82.0 |
| LLPS-Man-3831 | Macaca nemestrina | 92.68 | 3e-14 | 81.6 |
| LLPS-Mam-1290 | Macaca mulatta | 92.68 | 3e-14 | 82.0 |
| LLPS-Eqc-4314 | Equus caballus | 91.76 | 0.0 | 851 |
| LLPS-Mal-3250 | Mandrillus leucophaeus | 91.47 | 0.0 | 840 |
| LLPS-Gog-0246 | Gorilla gorilla | 90.24 | 6e-14 | 80.9 |
| LLPS-Nol-4467 | Nomascus leucogenys | 90.24 | 9e-14 | 80.1 |
| LLPS-Cas-2839 | Carlito syrichta | 90.0 | 4e-13 | 78.2 |
| LLPS-Dio-3880 | Dipodomys ordii | 88.96 | 0.0 | 835 |
| LLPS-Hos-0130 | Homo sapiens | 88.48 | 0.0 | 820 |
| LLPS-Fud-2253 | Fukomys damarensis | 87.8 | 9e-13 | 77.0 |
| LLPS-Loa-3842 | Loxodonta africana | 86.33 | 0.0 | 798 |
| LLPS-Cap-3107 | Cavia porcellus | 85.56 | 0.0 | 792 |
| LLPS-Mea-4449 | Mesocricetus auratus | 84.42 | 0.0 | 796 |
| LLPS-Mum-3522 | Mus musculus | 84.2 | 0.0 | 786 |
| LLPS-Otg-2318 | Otolemur garnettii | 84.1 | 0.0 | 774 |
| LLPS-Sus-4850 | Sus scrofa | 81.86 | 0.0 | 1546 |
| LLPS-Bot-4744 | Bos taurus | 81.47 | 0.0 | 1526 |
| LLPS-Ova-2889 | Ovis aries | 81.42 | 0.0 | 1524 |
| LLPS-Pap-3004 | Pan paniscus | 81.15 | 0.0 | 1514 |
| LLPS-Pat-3131 | Pan troglodytes | 81.06 | 0.0 | 1514 |
| LLPS-Poa-1815 | Pongo abelii | 80.58 | 0.0 | 1512 |
| LLPS-Myl-4114 | Myotis lucifugus | 79.67 | 0.0 | 1481 |
| LLPS-Ran-2830 | Rattus norvegicus | 76.72 | 0.0 | 1452 |
| LLPS-Sah-0417 | Sarcophilus harrisii | 72.81 | 0.0 | 677 |
| LLPS-Mod-0557 | Monodelphis domestica | 72.04 | 0.0 | 564 |
| LLPS-Ora-2619 | Ornithorhynchus anatinus | 70.39 | 0.0 | 658 |
| LLPS-Gaga-3864 | Gallus gallus | 56.24 | 3e-150 | 479 |
| LLPS-Meg-1115 | Meleagris gallopavo | 55.77 | 3e-154 | 491 |
| LLPS-Pes-3237 | Pelodiscus sinensis | 54.21 | 1e-151 | 484 |
| LLPS-Dar-0415 | Danio rerio | 52.31 | 2e-11 | 72.4 |
| LLPS-Tar-3701 | Takifugu rubripes | 50.77 | 1e-09 | 67.0 |
| LLPS-Asm-3457 | Astyanax mexicanus | 49.3 | 9e-12 | 73.6 |
| LLPS-Scm-2666 | Scophthalmus maximus | 46.88 | 2e-08 | 62.8 |
| LLPS-Icp-3822 | Ictalurus punctatus | 45.98 | 5e-12 | 74.7 |
| LLPS-Pof-3672 | Poecilia formosa | 44.62 | 2e-06 | 56.2 |
| LLPS-Fia-3140 | Ficedula albicollis | 41.89 | 4e-07 | 58.5 |
| LLPS-Tag-2527 | Taeniopygia guttata | 41.89 | 4e-07 | 58.5 |
| LLPS-Orn-3559 | Oreochromis niloticus | 33.02 | 1e-06 | 57.0 |
| LLPS-Anp-1007 | Anas platyrhynchos | 32.07 | 2e-31 | 134 |
| LLPS-Xet-2003 | Xenopus tropicalis | 31.33 | 5e-43 | 172 |
| LLPS-Xim-0963 | Xiphophorus maculatus | 31.31 | 2e-36 | 152 |
| LLPS-Leo-3081 | Lepisosteus oculatus | 30.98 | 3e-36 | 151 |
| LLPS-Scf-0063 | Scleropages formosus | 30.67 | 2e-39 | 161 |
| LLPS-Orl-3817 | Oryzias latipes | 30.41 | 1e-35 | 149 |
| LLPS-Gaa-3618 | Gasterosteus aculeatus | 28.32 | 9e-15 | 82.0 |