LLPS-Man-3831
DSG1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Uncharacterized protein |
| Gene Name: | DSG1 |
| Ensembl Gene: | ENSMNEG00000014657.1 |
| Ensembl Protein: | ENSMNEP00000003181.1 |
| Organism: | Macaca nemestrina |
| Taxa ID: | 9545 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMNET00000015999.1 | ENSMNEP00000003181.1 |
| Ensembl | ENSMNET00000016037.1 | ENSMNEP00000003193.1 |
| UniProt | A0A2K6AVK4, A0A2K6AVK4_MACNE |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDWRFFRVAA VLFIFLVRDY NTKNGTIKWH SIRRQKREWI KFAAACREGE DNSKRNPIAK 60 61 IHSDCAANQQ VTYRISGVGI DQPPYGIFVI NQKTGEINIT SIVDREVTPF FIIYCRALNS 120 121 MGQDLERPLE LRVRVLDIND NPPVFSMATF VGQIEENSNA NTLVMILNAT DADEPNNLNS 180 181 KIAFKIIRQE PSDSPMFIIN RNTGEIRTMN NFLDREQYGQ YSLAVRGSDR DGGADGMSAE 240 241 CECNIKILDV NDNIPYMERS SYDISIEENT LNSNMLEIRV IDLDEEFSAN WMAVIFFISG 300 301 NEGNWFDIEM NERTNVGILK VVKPLDYEAM QNLQLSIGVR NKAEFHHSIM SQYKLTATAI 360 361 TVTVLNVIEG AVFRPGSKTY VVTGNMGSNY KVGDFVATDL DTGGPSTTVR YVMGNNPADL 420 421 LAVDSRTGII TLKNKVTREQ YNMLGGKYQG TILSIDDALQ RTCTGTINID IQNVDGDDRT 480 481 NTQASTEVTN TGREESTSST DYETSTIYTQ SAGSTSYENG GHAPLFADNV HFGPAGIGLL 540 541 IMGFLVLGLV PFLMICCDCG GAPRSAAGFE PVPECSDGAI HSWAVEGPQP EPGVMTTIIP 600 601 QIPPDNANII ECIDNSGVYT NEYGGREMQD LGGGERMTGF ELTEGVKTSG MPEICQEYSG 660 661 TLRRNSMREC REGGLNMNFM ESYFCQKAYA YADEDEGRPS NDCLLIYDIE GVGSPAGSVG 720 721 CCSFIGEDPD DSFLDTLGPK FKKLADISLG KEIESYPDPD PFWPPQSTEP VCLPQETEPI 780 781 VSGHPPISPH FGTTTVISES TYPSGPGVQH PKPILDPLGY GNVTVTESYT TSDTLKPSVH 840 841 FHDNRQASNV VVTERVVGPI SGTDLHGMLE MPDLRDGSNV IVTERVIAPS SSLPASLTIH 900 901 HPRESSNVVV TERVIQPTSG MIGSLSMHPE LTNAHNVIVT ERVVSGAGVT GISGTTGISG 960 961 GIGSSGLVGT SMGAGGGALS GAGISGGGIG LSSLGGTATI GHMRSSSDHH FNQTIGSASP 1020 1021 STARSRITKY STVQYSK 1037 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAAGATC TGGGAGGAGG AGAGAGAATG ACAGGATTTG AACTAACAGA GGGAGTTAAA 60 61 ACATCAGGAA TGCCTGAGAT ATGTCAAGAA TACTCTGGAA CATTAAGAAG AAATTCTATG 120 121 AGGGAATGTA GAGAAGGAGG TCTGAATATG AATTTCATGG AAAGCTACTT CTGTCAGAAA 180 181 GCATATGCTT ATGCAGATGA AGATGAAGGA CGCCCATCCA ATGACTGTTT GCTCATATAT 240 241 GACATCGAAG GTGTAGGTTC CCCTGCTGGC TCTGTGGGTT GCTGTAGCTT CATTGGAGAA 300 301 GATCCAGATG ACAGCTTCTT GGATACTCTG GGACCTAAAT TTAAGAAGTT GGCAGACATC 360 361 AGCCTAGGAA AAGAAATTGA ATCATATCCA GACCCTGATC CTTTTTGGCC ACCCCAAAGC 420 421 ACTGAACCAG TTTGCCTTCC TCAGGAAACA GAGCCCATCG TTAGTGGACA CCCACCAATC 480 481 TCCCCACATT TCGGCACTAC CACAGTAATT TCTGAGAGCA CCTATCCCTC GGGACCTGGT 540 541 GTGCAGCATC CTAAGCCTAT TCTCGATCCT CTGGGCTATG GTAATGTCAC TGTGACCGAG 600 601 TCTTACACCA CCTCTGACAC TCTGAAGCCC TCTGTACACT TTCACGATAA CCGACAAGCA 660 661 TCAAACGTGG TGGTGACAGA GAGAGTGGTC GGCCCAATCT CTGGCACTGA TTTGCATGGA 720 721 ATGTTAGAGA TGCCTGACTT GCGAGATGGG TCAAATGTCA TAGTGACAGA AAGGGTAATA 780 781 GCACCAAGCT CTAGTCTACC TGCCTCTCTG ACTATTCATC ATCCTAGAGA GTCTTCAAAT 840 841 GTGGTAGTGA CAGAAAGAGT AATCCAACCA ACTTCCGGCA TGATAGGTAG TCTTAGTATG 900 901 CACCCCGAGT TAACCAATGC CCACAATGTG ATTGTGACAG AGAGGGTTGT TTCTGGTGCT 960 961 GGCGTAACTG GAATTAGTGG CACCACTGGG ATCAGCGGTG GCATAGGCAG CAGTGGCCTG 1020 1021 GTTGGCACCA GCATGGGTGC TGGGGGTGGG GCCCTGAGTG GAGCTGGCAT AAGTGGTGGT 1080 1081 GGCATTGGCC TGAGCAGCTT GGGAGGGACA GCCACCATTG GCCACATGAG GAGTTCCTCT 1140 1141 GACCATCACT TTAACCAAAC CATTGGGTCC GCCTCCCCTA GCACAGCTCG AAGTCGAATC 1200 1201 ACAAAGTACA GTACCGTGCA ATATAGCAAG TAG 1233 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell-cell junction | |
Cellular Component | Cytoplasmic side of plasma membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | Calcium ion binding | |
Molecular Function | Gamma-catenin binding | |
Biological Process | Homophilic cell adhesion via plasma membrane adhesion molecules | |
Biological Process | Protein stabilization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cea-3022 | Cercocebus atys | 99.8 | 0.0 | 889 |
| LLPS-Maf-0004 | Macaca fascicularis | 98.05 | 0.0 | 1891 |
| LLPS-Mal-3250 | Mandrillus leucophaeus | 97.43 | 0.0 | 1914 |
| LLPS-Paa-0902 | Papio anubis | 97.24 | 0.0 | 1906 |
| LLPS-Mam-1290 | Macaca mulatta | 96.76 | 0.0 | 1897 |
| LLPS-Chs-3974 | Chlorocebus sabaeus | 96.49 | 0.0 | 1900 |
| LLPS-Rhb-4147 | Rhinopithecus bieti | 96.0 | 0.0 | 1887 |
| LLPS-Nol-4467 | Nomascus leucogenys | 92.85 | 0.0 | 1806 |
| LLPS-Pap-3004 | Pan paniscus | 92.67 | 0.0 | 1811 |
| LLPS-Pat-3131 | Pan troglodytes | 92.67 | 0.0 | 1813 |
| LLPS-Aim-3109 | Ailuropoda melanoleuca | 92.31 | 3e-13 | 78.6 |
| LLPS-Mup-1531 | Mustela putorius furo | 92.31 | 3e-13 | 78.6 |
| LLPS-Mum-3522 | Mus musculus | 92.31 | 8e-13 | 77.0 |
| LLPS-Urm-3523 | Ursus maritimus | 92.31 | 3e-13 | 78.6 |
| LLPS-Fec-3059 | Felis catus | 92.31 | 3e-13 | 78.6 |
| LLPS-Hos-0130 | Homo sapiens | 92.29 | 0.0 | 1797 |
| LLPS-Poa-1815 | Pongo abelii | 92.21 | 0.0 | 1800 |
| LLPS-Gog-0246 | Gorilla gorilla | 92.11 | 0.0 | 1800 |
| LLPS-Caf-4388 | Canis familiaris | 89.74 | 1e-12 | 76.6 |
| LLPS-Eqc-4314 | Equus caballus | 89.74 | 1e-12 | 77.0 |
| LLPS-Otg-2318 | Otolemur garnettii | 89.74 | 6e-13 | 77.4 |
| LLPS-Orc-2575 | Oryctolagus cuniculus | 89.74 | 1e-12 | 76.6 |
| LLPS-Ran-2830 | Rattus norvegicus | 87.53 | 0.0 | 754 |
| LLPS-Dio-3880 | Dipodomys ordii | 87.18 | 9e-10 | 67.4 |
| LLPS-Myl-4114 | Myotis lucifugus | 87.18 | 2e-12 | 75.5 |
| LLPS-Ict-3052 | Ictidomys tridecemlineatus | 87.18 | 3e-12 | 75.5 |
| LLPS-Aon-4353 | Aotus nancymaae | 87.14 | 0.0 | 1675 |
| LLPS-Caj-3601 | Callithrix jacchus | 86.22 | 0.0 | 1670 |
| LLPS-Cas-2839 | Carlito syrichta | 84.4 | 0.0 | 1607 |
| LLPS-Sus-4850 | Sus scrofa | 83.12 | 0.0 | 1578 |
| LLPS-Ova-2889 | Ovis aries | 82.05 | 0.0 | 1550 |
| LLPS-Fud-2253 | Fukomys damarensis | 82.05 | 7e-11 | 70.9 |
| LLPS-Bot-4744 | Bos taurus | 81.67 | 0.0 | 1566 |
| LLPS-Cap-3107 | Cavia porcellus | 78.56 | 0.0 | 1432 |
| LLPS-Mod-0557 | Monodelphis domestica | 77.78 | 3e-06 | 55.8 |
| LLPS-Loa-3842 | Loxodonta africana | 77.29 | 0.0 | 1531 |
| LLPS-Mea-4449 | Mesocricetus auratus | 76.64 | 0.0 | 1538 |
| LLPS-Ora-2619 | Ornithorhynchus anatinus | 63.38 | 0.0 | 1169 |
| LLPS-Sah-0417 | Sarcophilus harrisii | 63.3 | 0.0 | 1123 |
| LLPS-Dar-0415 | Danio rerio | 52.31 | 2e-11 | 72.8 |
| LLPS-Tar-3701 | Takifugu rubripes | 50.77 | 8e-10 | 67.4 |
| LLPS-Gaga-3864 | Gallus gallus | 50.68 | 0.0 | 827 |
| LLPS-Pes-3237 | Pelodiscus sinensis | 50.26 | 0.0 | 857 |
| LLPS-Asm-3457 | Astyanax mexicanus | 49.3 | 6e-12 | 74.3 |
| LLPS-Meg-1115 | Meleagris gallopavo | 49.29 | 0.0 | 804 |
| LLPS-Scm-2666 | Scophthalmus maximus | 46.88 | 1e-08 | 63.5 |
| LLPS-Icp-3822 | Ictalurus punctatus | 45.98 | 3e-12 | 75.1 |
| LLPS-Pof-3672 | Poecilia formosa | 44.62 | 1e-06 | 57.0 |
| LLPS-Tag-2527 | Taeniopygia guttata | 41.89 | 2e-07 | 59.3 |
| LLPS-Fia-3140 | Ficedula albicollis | 41.89 | 3e-07 | 58.9 |
| LLPS-Anp-1007 | Anas platyrhynchos | 33.24 | 2e-34 | 143 |
| LLPS-Orn-3559 | Oreochromis niloticus | 33.02 | 2e-06 | 56.6 |
| LLPS-Xet-2003 | Xenopus tropicalis | 32.23 | 1e-47 | 186 |
| LLPS-Scf-0063 | Scleropages formosus | 32.16 | 6e-43 | 172 |
| LLPS-Leo-3081 | Lepisosteus oculatus | 32.03 | 9e-40 | 162 |
| LLPS-Xim-0963 | Xiphophorus maculatus | 31.72 | 8e-39 | 159 |
| LLPS-Orl-3817 | Oryzias latipes | 31.07 | 6e-39 | 159 |
| LLPS-Gaa-3618 | Gasterosteus aculeatus | 29.62 | 7e-19 | 94.4 |