LLPS-Urm-3332
KATNB1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Katanin p80 WD40 repeat-containing subunit B1 |
| Gene Name: | KATNB1 |
| Ensembl Gene: | ENSUMAG00000021407.1 |
| Ensembl Protein: | ENSUMAP00000029808.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body | Predicted from orthologs | (View) |
▼ FUNCTION
| Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000035226.1 | ENSUMAP00000029808.1 |
| Ensembl | ENSUMAT00000035213.1 | ENSUMAP00000029797.1 |
| Ensembl | ENSUMAT00000035235.1 | ENSUMAP00000029817.1 |
| Ensembl | ENSUMAT00000035227.1 | ENSUMAP00000029809.1 |
| Ensembl | ENSUMAT00000035182.1 | ENSUMAP00000029769.1 |
| Ensembl | ENSUMAT00000035217.1 | ENSUMAP00000029799.1 |
| UniProt | A0A384D2F8, A0A384D2F8_URSMA | |
| RefSeq | , XM_008702742.1 | , XP_008700964.1, XP_008700964.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 IIRDPDGHTQ AVAVAAVNDL KPGGSPGLRE EAFPLPGCVG TPCQLDWRIW GGSTPTPGAK 60 61 CRLFSGWSFR CQPTEGWPPL WSPRRPGNYS LTGHTSPVES VRLNTPEELI VAGSQSGSIR 120 121 VWDLEAAKIL RTLMGHKANI CSLDFHPYGE FVASGSQDTN IKVRRCLCPL SPGHSQAVRC 180 181 LRWLASAADD HTVKLWDLTA GKMMSEFPGH TGPVNVVEFH PNEYLLASGG SDRTIRFWDL 240 241 EKFQVVSCIE GEPGPVRYAG SWVAALDPPP GRLDVGMGYG RDSRPLAQQP AHPSAPLRRI 300 301 YERPSTACSK PQRVKQNSEG ERRSPSSEDD RDERESRAEI QNAEEYNEIF QPKNSISRTP 360 361 PRRSEPFPAP PEDDMVSAKE AAKPSPAMDL QFPVPNLEVP PRPPAVTSTP EPKAEPAIIP 420 421 ATRNEPIGLK ASDFLPAVKI PQQVELVDED AMSQIRKGHD TMCVVLTSRH KNLDTVRAVW 480 481 TTGDIKTSVD SAVAINDLSV VVDLLNIVNQ KASLWKLDLC TTVLPQIEKL LQSKYESYVQ 540 541 TGCTSLKLIL QRFLPLITDI LAAPPSVGVD ISREERLHKC RLCYKQLKSI SGLVKSKSGL 600 601 SGRHGSAFRE LHLLMASLD 619 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCACCC CTGTGGTCAC CAAGACGGCC TGGAAATTAC AGGAGATTGT CGCCCACGCC 60 61 AGCAATGTGT CCTCGCTGGT GCTGGGCAAG GCCTCCGGGC GGCTGCTGGC TACTGGTGGG 120 121 GATGACTGCC GTGTCAACCT GTGGTCCATC AACAAACCCA ACTGCATCAT GAGCCTGACG 180 181 GGTCACACGT CCCCAGTGGA GAGTGTCCGA CTCAACACCC CGGAGGAGCT CATCGTGGCC 240 241 GGCTCCCAGT CGGGCTCCAT CCGCGTCTGG GACCTAGAAG CCGCCAAAAT TCTGCGTACG 300 301 CTTATGGGCC ACAAAGCCAA CATCTGCAGC CTGGACTTCC ACCCGTACGG CGAGTTCGTA 360 361 GCCTCGGGCT CCCAGGACAC GAACATCAAG GTGAGACGCT GTCTGTGCCC TCTGTCCCCC 420 421 GGACACAGCC AGGCCGTGCG GTGCCTCCGG TGGCTGGCGT CGGCCGCCGA TGACCACACA 480 481 GTGAAGCTCT GGGATCTGAC TGCTGGCAAG ATGATGTCCG AGTTCCCTGG CCACACAGGG 540 541 CCTGTCAACG TGGTGGAGTT TCACCCCAAT GAGTACCTCC TGGCTTCTGG CGGCTCAGAC 600 601 AGGACCATCC GGTTCTGGGA TCTGGAGAAG TTCCAGGTGG TGAGCTGCAT CGAAGGAGAG 660 661 CCAGGGCCCG TCAGGTACGC AGGCAGCTGG GTGGCGGCTC TGGACCCTCC TCCCGGGCGG 720 721 TTGGATGACA GCCGGCCCCT GGCGCAGCAG CCAGCCCACC CCAGTGCCCC TCTTCGGCGC 780 781 ATCTATGAGC GGCCCAGCAC AGCCTGCAGC AAGCCTCAGA GGGTGAAGCA GAATTCGGAG 840 841 GGCGAGCGCC GCAGCCCCAG CAGCGAGGAC GACCGGGATG AGCGGGAGTC TCGGGCCGAG 900 901 ATCCAGAACG CTGAGGAGTA CAACGAGATC TTCCAGCCCA AGAACAGCAT CAGTCGGACA 960 961 CCACCCCGAA GAAGTGAGCC CTTCCCGGCA CCACCCGAGG ACGACATGGT CTCAGCCAAG 1020 1021 GAGGCAGCCA AGCCCAGCCC AGCCATGGAC TTGCAGTTCC CGGTGCCAAA TGTAAGTCTA 1080 1081 GGTGGAGAGG GCACGCTCGA GGTCCCACCC CGGCCCCCGG CTGTCACTTC CACTCCTGAG 1140 1141 CCCAAGGCCG AGCCTGCCAT CATCCCTGCC ACCCGGAACG AGCCCATTGG GCTGAAGGCT 1200 1201 TCCGACTTCC TGCCCGCTGT GAAGATCCCG CAGCAGGTGG AGCTGGTCGA CGAGGACGCC 1260 1261 ATGTCACAGA TCCGCAAAGG CCATGACACC ATGTGCGTGG TACTCACCAG CCGTCACAAG 1320 1321 AACCTGGACA CCGTGCGGGC CGTGTGGACC ACGGGCGACA TCAAGACGTC GGTGGACTCG 1380 1381 GCTGTGGCCA TCAATGACCT GTCGGTGGTA GTGGACCTCC TGAACATTGT CAACCAGAAA 1440 1441 GCCTCCCTAT GGAAGCTGGA CTTGTGCACC ACGGTCTTGC CACAGATTGA GAAGCTTCTG 1500 1501 CAGAGCAAGT ATGAGAGCTA TGTGCAGACT GGCTGCACCT CGCTGAAGCT GATCCTGCAG 1560 1561 CGTTTTCTGC CCCTGATCAC GGACATCCTG GCGGCGCCCC CCTCTGTGGG TGTGGACATC 1620 1621 AGCCGGGAGG AGAGGCTACA CAAGTGCCGG CTCTGCTACA AGCAGCTTAA GAGCATCAGT 1680 1681 GGCCTCGTCA AGAGCAAGTC GGGTTTGAGT GGCCGCCACG GCAGTGCCTT CCGAGAACTG 1740 1741 CACCTGCTCA TGGCCAGTTT GGACTGA 1767 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centrosome | |
Cellular Component | Katanin complex | |
Cellular Component | Microtubule | |
Cellular Component | Spindle pole | |
Molecular Function | Microtubule binding | |
Biological Process | Cell division | |
Biological Process | Microtubule severing | |
Biological Process | Mitotic chromosome movement towards spindle pole | |
Biological Process | Positive regulation of microtubule depolymerization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-3637 | Ailuropoda melanoleuca | 97.98 | 1e-110 | 354 |
| LLPS-Caj-2397 | Callithrix jacchus | 97.98 | 2e-110 | 354 |
| LLPS-Man-1777 | Macaca nemestrina | 94.1 | 7e-154 | 467 |
| LLPS-Caf-2580 | Canis familiaris | 83.02 | 6e-107 | 341 |
| LLPS-Scf-3191 | Scleropages formosus | 78.28 | 3e-88 | 295 |
| LLPS-Mup-1557 | Mustela putorius furo | 77.34 | 0.0 | 694 |
| LLPS-Fec-4749 | Felis catus | 76.52 | 0.0 | 692 |
| LLPS-Eqc-4324 | Equus caballus | 76.03 | 0.0 | 693 |
| LLPS-Myl-0300 | Myotis lucifugus | 75.86 | 0.0 | 681 |
| LLPS-Gog-4076 | Gorilla gorilla | 75.86 | 0.0 | 683 |
| LLPS-Paa-2698 | Papio anubis | 75.7 | 0.0 | 680 |
| LLPS-Maf-2964 | Macaca fascicularis | 75.7 | 0.0 | 679 |
| LLPS-Cea-4778 | Cercocebus atys | 75.7 | 0.0 | 679 |
| LLPS-Mam-4089 | Macaca mulatta | 75.7 | 0.0 | 680 |
| LLPS-Orc-1929 | Oryctolagus cuniculus | 75.7 | 0.0 | 689 |
| LLPS-Pat-2849 | Pan troglodytes | 75.7 | 0.0 | 679 |
| LLPS-Pap-3047 | Pan paniscus | 75.7 | 0.0 | 679 |
| LLPS-Rhb-2382 | Rhinopithecus bieti | 75.53 | 0.0 | 679 |
| LLPS-Hos-1971 | Homo sapiens | 75.53 | 0.0 | 678 |
| LLPS-Ova-4000 | Ovis aries | 75.2 | 0.0 | 689 |
| LLPS-Cas-2604 | Carlito syrichta | 74.39 | 0.0 | 659 |
| LLPS-Loa-1995 | Loxodonta africana | 74.35 | 0.0 | 678 |
| LLPS-Otg-2770 | Otolemur garnettii | 74.06 | 0.0 | 673 |
| LLPS-Dio-0610 | Dipodomys ordii | 73.89 | 0.0 | 673 |
| LLPS-Sus-3357 | Sus scrofa | 73.84 | 0.0 | 782 |
| LLPS-Aon-1785 | Aotus nancymaae | 73.81 | 0.0 | 675 |
| LLPS-Nol-0530 | Nomascus leucogenys | 73.73 | 0.0 | 658 |
| LLPS-Cap-2306 | Cavia porcellus | 73.56 | 0.0 | 677 |
| LLPS-Fud-4157 | Fukomys damarensis | 73.23 | 0.0 | 666 |
| LLPS-Chs-1788 | Chlorocebus sabaeus | 73.07 | 0.0 | 643 |
| LLPS-Leo-3707 | Lepisosteus oculatus | 71.72 | 8e-82 | 278 |
| LLPS-Poa-1503 | Pongo abelii | 71.51 | 0.0 | 553 |
| LLPS-Ran-2956 | Rattus norvegicus | 70.61 | 0.0 | 631 |
| LLPS-Mea-2262 | Mesocricetus auratus | 70.61 | 0.0 | 624 |
| LLPS-Ora-1715 | Ornithorhynchus anatinus | 70.12 | 0.0 | 613 |
| LLPS-Mum-4719 | Mus musculus | 70.1 | 0.0 | 619 |
| LLPS-Bot-1252 | Bos taurus | 70.09 | 0.0 | 732 |
| LLPS-Dar-0985 | Danio rerio | 69.19 | 4e-81 | 276 |
| LLPS-Pes-3769 | Pelodiscus sinensis | 68.13 | 0.0 | 667 |
| LLPS-Mal-4523 | Mandrillus leucophaeus | 67.0 | 0.0 | 556 |
| LLPS-Fia-3556 | Ficedula albicollis | 66.56 | 0.0 | 639 |
| LLPS-Mod-3752 | Monodelphis domestica | 66.39 | 0.0 | 578 |
| LLPS-Meg-1644 | Meleagris gallopavo | 66.23 | 0.0 | 619 |
| LLPS-Gaga-0782 | Gallus gallus | 65.69 | 0.0 | 619 |
| LLPS-Tag-3269 | Taeniopygia guttata | 64.84 | 0.0 | 637 |
| LLPS-Anp-2415 | Anas platyrhynchos | 64.14 | 0.0 | 632 |
| LLPS-Orn-2073 | Oreochromis niloticus | 61.93 | 2e-68 | 241 |
| LLPS-Anc-3263 | Anolis carolinensis | 61.79 | 0.0 | 552 |
| LLPS-Orl-3342 | Oryzias latipes | 57.14 | 5e-60 | 218 |
| LLPS-Lac-3569 | Latimeria chalumnae | 57.1 | 0.0 | 560 |
| LLPS-Xet-2036 | Xenopus tropicalis | 55.22 | 4e-169 | 505 |
| LLPS-Asm-2887 | Astyanax mexicanus | 50.54 | 3e-167 | 502 |
| LLPS-Icp-2932 | Ictalurus punctatus | 50.0 | 1e-161 | 486 |
| LLPS-Pof-2725 | Poecilia formosa | 49.68 | 3e-148 | 452 |
| LLPS-Cis-2065 | Ciona savignyi | 49.39 | 3e-45 | 167 |
| LLPS-Sei-1258 | Setaria italica | 49.2 | 2e-51 | 195 |
| LLPS-Sot-1681 | Solanum tuberosum | 49.2 | 5e-52 | 193 |
| LLPS-Sol-1379 | Solanum lycopersicum | 49.2 | 2e-51 | 194 |
| LLPS-Dac-2237 | Daucus carota | 48.68 | 2e-51 | 194 |
| LLPS-Nia-0167 | Nicotiana attenuata | 48.68 | 1e-51 | 194 |
| LLPS-Php-0095 | Physcomitrella patens | 48.66 | 2e-49 | 188 |
| LLPS-Ten-0323 | Tetraodon nigroviridis | 48.4 | 6e-154 | 465 |
| LLPS-Cus-2188 | Cucumis sativus | 48.15 | 1e-50 | 192 |
| LLPS-Mua-2209 | Musa acuminata | 48.15 | 2e-51 | 190 |
| LLPS-Orni-0058 | Oryza nivara | 48.15 | 9e-51 | 192 |
| LLPS-Orb-1334 | Oryza barthii | 48.15 | 9e-51 | 192 |
| LLPS-Ori-1069 | Oryza indica | 48.15 | 1e-50 | 193 |
| LLPS-Org-2180 | Oryza glaberrima | 48.15 | 1e-50 | 193 |
| LLPS-Zem-1388 | Zea mays | 48.15 | 2e-50 | 192 |
| LLPS-Orm-1164 | Oryza meridionalis | 48.15 | 1e-50 | 192 |
| LLPS-Orr-1290 | Oryza rufipogon | 48.15 | 9e-51 | 192 |
| LLPS-Sob-2471 | Sorghum bicolor | 48.15 | 2e-50 | 192 |
| LLPS-Amt-2118 | Amborella trichopoda | 48.15 | 3e-50 | 191 |
| LLPS-Orp-1927 | Oryza punctata | 48.15 | 9e-51 | 192 |
| LLPS-Glm-2113 | Glycine max | 48.13 | 7e-51 | 192 |
| LLPS-Prp-1268 | Prunus persica | 48.13 | 1e-50 | 192 |
| LLPS-Sem-1919 | Selaginella moellendorffii | 47.92 | 4e-51 | 193 |
| LLPS-Scm-3993 | Scophthalmus maximus | 47.72 | 1e-143 | 438 |
| LLPS-Gor-1969 | Gossypium raimondii | 47.62 | 1e-49 | 189 |
| LLPS-Pot-2211 | Populus trichocarpa | 47.62 | 9e-51 | 192 |
| LLPS-Met-1770 | Medicago truncatula | 47.59 | 8e-51 | 192 |
| LLPS-Brd-0887 | Brachypodium distachyon | 47.59 | 1e-49 | 190 |
| LLPS-Tra-1813 | Triticum aestivum | 47.59 | 1e-49 | 189 |
| LLPS-Tru-1879 | Triticum urartu | 47.59 | 2e-49 | 189 |
| LLPS-Coc-2057 | Corchorus capsularis | 47.59 | 1e-49 | 189 |
| LLPS-Hea-1687 | Helianthus annuus | 47.09 | 2e-47 | 183 |
| LLPS-Orbr-1197 | Oryza brachyantha | 47.09 | 1e-49 | 190 |
| LLPS-Art-2788 | Arabidopsis thaliana | 47.09 | 1e-48 | 186 |
| LLPS-Brr-2105 | Brassica rapa | 47.09 | 4e-49 | 187 |
| LLPS-Thc-1930 | Theobroma cacao | 47.06 | 7e-48 | 186 |
| LLPS-Brn-3138 | Brassica napus | 46.56 | 2e-48 | 185 |
| LLPS-Bro-1649 | Brassica oleracea | 46.56 | 3e-48 | 184 |
| LLPS-Phv-0207 | Phaseolus vulgaris | 46.07 | 4e-45 | 174 |
| LLPS-Via-0224 | Vigna angularis | 46.03 | 4e-49 | 187 |
| LLPS-Arl-0829 | Arabidopsis lyrata | 46.0 | 7e-49 | 187 |
| LLPS-Lep-0914 | Leersia perrieri | 45.99 | 4e-49 | 186 |
| LLPS-Gaa-3438 | Gasterosteus aculeatus | 45.84 | 1e-135 | 418 |
| LLPS-Hov-2118 | Hordeum vulgare | 45.76 | 2e-46 | 181 |
| LLPS-Mae-1255 | Manihot esculenta | 45.5 | 1e-46 | 181 |
| LLPS-Viv-1827 | Vitis vinifera | 45.45 | 1e-50 | 192 |
| LLPS-Tar-1911 | Takifugu rubripes | 45.3 | 1e-144 | 443 |
| LLPS-Orgl-1541 | Oryza glumaepatula | 42.2 | 1e-49 | 189 |
| LLPS-Ors-2384 | Oryza sativa | 42.2 | 7e-50 | 190 |
| LLPS-Vir-0260 | Vigna radiata | 35.2 | 2e-22 | 103 |
| LLPS-Cii-1915 | Ciona intestinalis | 34.64 | 8e-95 | 312 |
| LLPS-Osl-0039 | Ostreococcus lucimarinus | 33.72 | 1e-20 | 97.4 |
| LLPS-Abg-0147 | Absidia glauca | 33.5 | 1e-23 | 106 |
| LLPS-Sah-3483 | Sarcophilus harrisii | 32.47 | 3e-07 | 57.0 |
| LLPS-Ict-3692 | Ictidomys tridecemlineatus | 32.47 | 3e-07 | 57.0 |
| LLPS-Scj-0368 | Schizosaccharomyces japonicus | 32.29 | 2e-20 | 96.7 |
| LLPS-Drm-0977 | Drosophila melanogaster | 30.49 | 5e-20 | 98.2 |