LLPS-Dar-0985
katnb1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Katanin p80 WD40 repeat-containing subunit B1
Gene Name: katnb1, zgc:56071
Ensembl Gene: ENSDARG00000110223.1
Ensembl Protein: ENSDARP00000131168.2
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MALTNTTITS  WKLQEIVAHS  SNVSSLVLGK  SSGRLLATGG  EDCRVNIWAV  SKPNCIMSLT  60
61    GHTSAVGCIQ  FNSSEERVVA  GSLSGSLRLW  DLEAAKILRT  LMGHKASISS  LDFHPMGEYL  120
121   ASGSVDSNIK  LWDVRRKGCV  FRYKGHTQAV  RCLAFSPDGK  WLASASDDST  VKLWDLIAGK  180
181   MITEFTSHTS  AVNVVQFHPN  EYLLASGSAD  RTVKLWDLEK  FNMIGSSEGE  TGVVRSVLFN  240
241   PDGSCLYSGS  ENTLRVYGWE  PDRCFDVVHV  GWGKVSDLAI  SNNQMIAVSY  SHTNVSWYVV  300
301   DLNRVKKSGS  VIQGLIQDKP  IPAPSSALGT  TLRRNYERPT  TSCTGQEMKQ  SSEADRRSPE  360
361   GERRSPSSED  EKEDKESSAE  ITNPEDYKEI  FQPRSVISRT  PPKTTEPFPA  PLEHSLSESV  420
421   LEKPGPVVKI  VTPVIDRAGQ  LKGPITSSTP  VQRVEPTVIA  AAPRPVAVVT  TSASSPSRPV  480
481   VNTTKPKPST  GIILSTRNEP  IGLNAGDFLS  HARNAKASAM  GDEEALAQIR  KGHDTMCVML  540
541   SSRSKNLDSV  RSVWASGDVK  TSLDSAVSMN  DLSIVVDVLN  IINLKPSLWK  LDLCTSILPQ  600
601   IEELLQSRYE  SYVQTGCMSL  KLILKRFWPL  ISDTLNAPPS  VGVDITREER  HQKCKACYKQ  660
661   LKNLSNVVKN  RAEQVGRHGS  TFRELQLLMA  PLDY  694
Nucleotide CDS Sequence (FASTA)
1     ATGGCTCTCA  CCAACACCAC  TATAACATCA  TGGAAACTGC  AGGAGATAGT  GGCTCATTCC  60
61    AGCAATGTGT  CTTCACTGGT  GTTGGGGAAA  TCCTCTGGTC  GTCTACTGGC  CACAGGCGGC  120
121   GAGGACTGCA  GAGTCAATAT  CTGGGCTGTC  AGCAAACCAA  ACTGCATCAT  GAGTCTGACG  180
181   GGCCACACCA  GTGCTGTGGG  ATGCATCCAG  TTCAACAGTT  CTGAAGAGCG  TGTGGTGGCT  240
241   GGTTCTCTGT  CAGGTTCTCT  TCGGCTTTGG  GATTTGGAGG  CTGCTAAAAT  TCTACGCACG  300
301   TTGATGGGGC  ACAAGGCCAG  CATCAGCAGT  CTAGACTTTC  ACCCCATGGG  AGAATACCTG  360
361   GCATCTGGCT  CTGTGGACAG  CAATATTAAG  TTGTGGGATG  TGAGAAGGAA  AGGATGTGTG  420
421   TTCAGATACA  AGGGTCACAC  TCAGGCTGTG  CGCTGTCTAG  CATTCAGTCC  TGATGGGAAA  480
481   TGGCTTGCTT  CAGCCAGTGA  TGACAGTACA  GTAAAGCTAT  GGGATCTTAT  AGCAGGCAAG  540
541   ATGATCACTG  AATTCACATC  ACACACATCA  GCGGTTAATG  TTGTGCAGTT  CCACCCCAAT  600
601   GAATACCTGC  TTGCCTCTGG  GAGTGCAGAT  CGGACGGTTA  AGCTGTGGGA  CCTGGAGAAA  660
661   TTTAACATGA  TTGGCTCATC  GGAGGGTGAA  ACTGGAGTTG  TGAGAAGTGT  TTTATTTAAC  720
721   CCTGATGGTA  GCTGCTTGTA  CAGTGGCTCA  GAGAACACAC  TACGGGTGTA  CGGCTGGGAG  780
781   CCTGACCGCT  GCTTTGATGT  AGTGCATGTA  GGCTGGGGCA  AAGTGTCTGA  CCTGGCCATC  840
841   AGCAACAACC  AAATGATCGC  AGTATCCTAC  AGTCACACTA  ATGTGAGCTG  GTATGTTGTG  900
901   GATCTCAACC  GAGTGAAGAA  GTCTGGATCT  GTGATTCAAG  GGTTGATTCA  GGACAAACCT  960
961   ATTCCAGCAC  CTTCGTCTGC  ACTGGGAACA  ACACTTCGGC  GGAATTATGA  GCGGCCCACT  1020
1021  ACATCCTGCA  CTGGACAAGA  GATGAAGCAG  AGTTCAGAAG  CTGATCGGCG  CAGTCCAGAA  1080
1081  GGAGAGCGGA  GAAGTCCCAG  CAGTGAGGAT  GAGAAAGAAG  ACAAAGAGAG  CAGCGCAGAA  1140
1141  ATCACCAACC  CTGAAGATTA  TAAAGAGATC  TTTCAGCCCC  GCAGTGTCAT  CTCACGAACA  1200
1201  CCACCTAAAA  CAACAGAACC  CTTTCCAGCA  CCTCTAGAGC  ATTCTTTATC  AGAGAGTGTG  1260
1261  CTAGAGAAAC  CCGGTCCAGT  AGTTAAGATT  GTAACTCCAG  TAATAGACAG  GGCAGGACAG  1320
1321  TTGAAAGGTC  CCATTACATC  CTCTACTCCA  GTACAAAGAG  TGGAACCAAC  AGTGATCGCC  1380
1381  GCTGCTCCCC  GTCCAGTAGC  AGTGGTAACC  ACATCAGCGA  GCTCTCCATC  TCGACCTGTG  1440
1441  GTTAATACCA  CTAAACCCAA  ACCCTCCACA  GGAATCATCC  TCTCAACACG  CAACGAGCCA  1500
1501  ATTGGACTCA  ATGCAGGAGA  CTTCCTTTCT  CATGCACGAA  ATGCTAAAGC  CAGCGCAATG  1560
1561  GGAGATGAAG  AGGCCTTAGC  ACAGATCAGG  AAAGGGCACG  ACACCATGTG  CGTAATGCTG  1620
1621  AGCAGTCGAT  CTAAAAACCT  GGACAGTGTC  CGCTCCGTCT  GGGCCAGTGG  TGATGTAAAG  1680
1681  ACGTCCCTGG  ACTCAGCAGT  GTCTATGAAT  GATCTTTCTA  TTGTGGTGGA  CGTCCTCAAC  1740
1741  ATAATCAACC  TCAAGCCGTC  ACTGTGGAAA  CTGGACCTCT  GCACGTCCAT  CCTGCCACAG  1800
1801  ATTGAGGAGT  TGCTTCAGAG  CAGATATGAA  AGTTATGTGC  AGACTGGTTG  CATGTCTTTG  1860
1861  AAGCTGATTC  TCAAGCGTTT  CTGGCCATTA  ATCTCAGACA  CGCTTAACGC  TCCTCCATCT  1920
1921  GTCGGAGTGG  ACATTACTCG  AGAGGAGAGG  CATCAGAAGT  GTAAAGCGTG  CTACAAGCAG  1980
1981  TTGAAGAACC  TCAGTAATGT  AGTGAAGAAC  CGGGCGGAGC  AGGTTGGTCG  CCATGGCAGC  2040
2041  ACTTTCAGAG  AGCTACAGCT  ACTTATGGCC  CCTCTGGACT  ATTGA  2085

▼ KEYWORD

ID
Family
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Microtubule
Mitosis
Reference proteome
Repeat
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cytoplasm
Cellular Component
Katanin complex
Cellular Component
Microtubule
Cellular Component
Spindle
Cellular Component
Spindle pole
Molecular Function
Microtubule binding
Biological Process
Brain development
Biological Process
Cell cycle
Biological Process
Cell division
Biological Process
Microtubule depolymerization
Biological Process
Microtubule severing
Biological Process
Midbrain development

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-2887Astyanax mexicanus76.290.01007
LLPS-Scf-3191Scleropages formosus75.430.01016
LLPS-Leo-3707Lepisosteus oculatus73.210.0 972
LLPS-Icp-2932Ictalurus punctatus70.820.0 960
LLPS-Orn-2073Oreochromis niloticus66.90.0 898
LLPS-Gaa-3438Gasterosteus aculeatus66.330.0 888
LLPS-Xim-2259Xiphophorus maculatus65.711e-38 143
LLPS-Pof-2725Poecilia formosa64.60.0 875
LLPS-Lac-3569Latimeria chalumnae64.510.0 858
LLPS-Ora-1715Ornithorhynchus anatinus62.90.0 812
LLPS-Anc-3263Anolis carolinensis62.370.0 790
LLPS-Gog-4076Gorilla gorilla62.360.0 861
LLPS-Hos-1971Homo sapiens62.290.0 860
LLPS-Pat-2849Pan troglodytes62.290.0 861
LLPS-Pap-3047Pan paniscus62.290.0 861
LLPS-Cea-4778Cercocebus atys62.210.0 857
LLPS-Maf-2964Macaca fascicularis62.210.0 855
LLPS-Chs-1788Chlorocebus sabaeus62.210.0 844
LLPS-Paa-2698Papio anubis62.210.0 858
LLPS-Mup-1557Mustela putorius furo62.210.0 844
LLPS-Rhb-2382Rhinopithecus bieti62.210.0 858
LLPS-Mam-4089Macaca mulatta62.210.0 858
LLPS-Fec-4749Felis catus62.160.0 849
LLPS-Ran-2956Rattus norvegicus62.070.0 840
LLPS-Fia-3556Ficedula albicollis62.070.0 836
LLPS-Myl-0300Myotis lucifugus62.060.0 831
LLPS-Dio-0610Dipodomys ordii62.00.0 854
LLPS-Cap-2306Cavia porcellus61.980.0 851
LLPS-Loa-1995Loxodonta africana61.950.0 857
LLPS-Aon-1785Aotus nancymaae61.930.0 849
LLPS-Mea-2262Mesocricetus auratus61.930.0 843
LLPS-Eqc-4324Equus caballus61.930.0 852
LLPS-Tag-3269Taeniopygia guttata61.840.0 837
LLPS-Caj-2397Callithrix jacchus61.760.0 851
LLPS-Mum-4719Mus musculus61.640.0 833
LLPS-Ten-0323Tetraodon nigroviridis61.640.0 848
LLPS-Pes-3769Pelodiscus sinensis61.540.0 834
LLPS-Cas-2604Carlito syrichta61.510.0 849
LLPS-Orc-1929Oryctolagus cuniculus61.490.0 852
LLPS-Otg-2770Otolemur garnettii61.430.0 846
LLPS-Scm-3993Scophthalmus maximus61.370.0 796
LLPS-Fud-4157Fukomys damarensis61.260.0 840
LLPS-Ova-4000Ovis aries61.260.0 831
LLPS-Aim-3637Ailuropoda melanoleuca61.170.0 827
LLPS-Meg-1644Meleagris gallopavo60.870.0 822
LLPS-Anp-2415Anas platyrhynchos60.850.0 845
LLPS-Nol-0530Nomascus leucogenys60.830.0 816
LLPS-Tar-1911Takifugu rubripes60.740.0 835
LLPS-Gaga-0782Gallus gallus60.660.0 833
LLPS-Orl-3342Oryzias latipes60.540.0 818
LLPS-Poa-1503Pongo abelii60.420.0 738
LLPS-Mod-3752Monodelphis domestica60.110.0 815
LLPS-Xet-2036Xenopus tropicalis60.060.0 838
LLPS-Bot-1252Bos taurus59.730.0 758
LLPS-Sus-3357Sus scrofa58.60.0 759
LLPS-Man-1777Macaca nemestrina55.760.0 781
LLPS-Viv-1827Vitis vinifera53.824e-115 371
LLPS-Amt-2118Amborella trichopoda53.773e-111 361
LLPS-Php-0095Physcomitrella patens53.725e-113 367
LLPS-Mua-2209Musa acuminata53.43e-114 359
LLPS-Dac-2237Daucus carota53.311e-113 368
LLPS-Mal-4523Mandrillus leucophaeus53.270.0 650
LLPS-Nia-0167Nicotiana attenuata53.168e-113 365
LLPS-Brd-0887Brachypodium distachyon52.962e-112 367
LLPS-Sol-1379Solanum lycopersicum52.824e-112 363
LLPS-Pot-2211Populus trichocarpa52.821e-113 368
LLPS-Sei-1258Setaria italica52.631e-113 370
LLPS-Sob-2471Sorghum bicolor52.635e-113 369
LLPS-Sot-1681Solanum tuberosum52.568e-111 353
LLPS-Glm-2113Glycine max52.493e-114 368
LLPS-Met-1770Medicago truncatula52.491e-114 369
LLPS-Orm-1164Oryza meridionalis52.382e-109 359
LLPS-Orbr-1197Oryza brachyantha52.33e-113 370
LLPS-Orp-1927Oryza punctata52.38e-114 370
LLPS-Ori-1069Oryza indica52.224e-109 359
LLPS-Gor-1969Gossypium raimondii52.176e-111 362
LLPS-Orni-0058Oryza nivara51.973e-113 368
LLPS-Orb-1334Oryza barthii51.973e-113 368
LLPS-Org-2180Oryza glaberrima51.977e-113 369
LLPS-Orr-1290Oryza rufipogon51.973e-113 368
LLPS-Thc-1930Theobroma cacao51.836e-108 360
LLPS-Arl-0829Arabidopsis lyrata51.835e-111 362
LLPS-Art-2788Arabidopsis thaliana51.835e-111 362
LLPS-Coc-2057Corchorus capsularis51.832e-110 362
LLPS-Caf-2580Canis familiaris51.763e-170 508
LLPS-Zem-1388Zea mays51.641e-111 365
LLPS-Tru-1879Triticum urartu51.598e-92 312
LLPS-Brr-2105Brassica rapa51.134e-108 354
LLPS-Tra-1813Triticum aestivum50.792e-112 367
LLPS-Prp-1268Prunus persica50.468e-115 371
LLPS-Urm-3332Ursus maritimus50.230.0 567
LLPS-Brn-3138Brassica napus49.849e-108 353
LLPS-Bro-1649Brassica oleracea49.841e-107 352
LLPS-Cus-2188Cucumis sativus49.281e-115 374
LLPS-Hea-1687Helianthus annuus48.86e-99 332
LLPS-Sem-1919Selaginella moellendorffii48.665e-111 360
LLPS-Cis-2065Ciona savignyi48.269e-97 307
LLPS-Mae-1255Manihot esculenta47.832e-102 341
LLPS-Orgl-1541Oryza glumaepatula47.734e-100 333
LLPS-Ors-2384Oryza sativa47.732e-100 334
LLPS-Cii-1915Ciona intestinalis47.681e-100 330
LLPS-Lep-0914Leersia perrieri47.183e-100 329
LLPS-Via-0224Vigna angularis46.985e-101 335
LLPS-Phv-0207Phaseolus vulgaris46.893e-101 332
LLPS-Hov-2118Hordeum vulgare46.289e-99 332
LLPS-Abg-0236Absidia glauca37.899e-23 105
LLPS-Pug-1357Puccinia graminis34.161e-1790.1
LLPS-Ict-2797Ictidomys tridecemlineatus33.121e-21 102
LLPS-Tut-0269Tursiops truncatus31.71e-36 148
LLPS-Sah-2127Sarcophilus harrisii31.584e-35 144
LLPS-Scc-1401Schizosaccharomyces cryophilus30.172e-32 135
LLPS-Usm-0235Ustilago maydis29.239e-33 137
LLPS-Cae-1298Caenorhabditis elegans28.747e-33 137