DrLLPS - Data resource of LLPS

LLPS-Urm-0617
ARPC4

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Actin-related protein 2/3 complex subunit 4
Gene Name:	ARPC4
Ensembl Gene:	ENSUMAG00000018855.1
Ensembl Protein:	ENSUMAP00000025868.1
Organism:	Ursus maritimus
Taxa ID:	29073
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-0652	P59999	Client	Nucleolus, Postsynaptic density	100.00	3e-49	160
Homo sapiens	LLPS-Hos-0436	P59998	Client	Nucleolus	100.00	1e-48	160

▼ FUNCTION

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSUMAT00000030634.1	ENSUMAP00000025868.1
UniProt		A0A384CMQ6, A0A384CMQ6_URSMA
RefSeq	, XM_008697905.1	, XP_008696127.1, XP_008696127.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRFMMMRAEN FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK 60 61 LSVNARARIV AEEFLKNVSG GLPGVPPKVG GTVG 94
Nucleotide CDS Sequence (FASTA)
1 ATGCGCTTCA TGATGATGCG AGCAGAGAAC TTTTTTATCC TTCGAAGGAA ACCAGTAGAG 60 61 GGATATGACA TCAGTTTTCT GATCACCAAC TTCCACACAG AACAGATGTA CAAACACAAG 120 121 TTGGTGGACT TTGTGATCCA CTTTATGGAG GAGATTGACA AGGAGATCAG TGAGATGAAG 180 181 CTGTCGGTCA ATGCTCGTGC ACGCATCGTG GCCGAGGAAT TCCTCAAGAA TGTAAGTGGG 240 241 GGCCTTCCTG GTGTCCCTCC AAAGGTAGGA GGAACCGTGG GTTGA 285

▼ KEYWORD

ID	Family
KW-0009	Actin-binding
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005885	Cellular Component	Arp2/3 protein complex
GO:0005737	Cellular Component	Cytoplasm
GO:0003779	Molecular Function	Actin binding
GO:0030041	Biological Process	Actin filament polymerization
GO:0034314	Biological Process	Arp2/3 complex-mediated actin nucleation

▼ KEGG

umr:103669571

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Xet-1117	Xenopus tropicalis	100.0	4e-49	159
LLPS-Gaga-1582	Gallus gallus	100.0	1e-49	161
LLPS-Cas-0607	Carlito syrichta	100.0	5e-50	163
LLPS-Ict-2792	Ictidomys tridecemlineatus	100.0	2e-50	163
LLPS-Anc-1067	Anolis carolinensis	100.0	1e-49	161
LLPS-Nol-0161	Nomascus leucogenys	100.0	2e-50	163
LLPS-Tag-0915	Taeniopygia guttata	100.0	4e-49	159
LLPS-Caf-1084	Canis familiaris	100.0	3e-49	160
LLPS-Ten-2637	Tetraodon nigroviridis	100.0	1e-49	161
LLPS-Eqc-3509	Equus caballus	100.0	9e-50	163
LLPS-Cap-2149	Cavia porcellus	100.0	1e-50	163
LLPS-Otg-2944	Otolemur garnettii	100.0	7e-50	160
LLPS-Pes-0890	Pelodiscus sinensis	100.0	4e-50	162
LLPS-Fia-1423	Ficedula albicollis	100.0	4e-49	159
LLPS-Orc-1194	Oryctolagus cuniculus	100.0	6e-49	159
LLPS-Orn-2470	Oreochromis niloticus	100.0	6e-49	159
LLPS-Rhb-3486	Rhinopithecus bieti	100.0	4e-50	163
LLPS-Pof-3629	Poecilia formosa	100.0	6e-49	159
LLPS-Pat-0999	Pan troglodytes	100.0	2e-50	163
LLPS-Pap-1658	Pan paniscus	100.0	2e-50	163
LLPS-Hos-0436	Homo sapiens	100.0	5e-49	160
LLPS-Meg-0100	Meleagris gallopavo	100.0	1e-49	161
LLPS-Dar-1651	Danio rerio	100.0	4e-49	160
LLPS-Fec-3068	Felis catus	100.0	4e-49	159
LLPS-Mod-2781	Monodelphis domestica	100.0	7e-50	161
LLPS-Scm-0634	Scophthalmus maximus	100.0	6e-49	159
LLPS-Man-3207	Macaca nemestrina	100.0	7e-49	156
LLPS-Loa-2824	Loxodonta africana	100.0	6e-50	161
LLPS-Ran-0905	Rattus norvegicus	100.0	4e-49	159
LLPS-Paa-3233	Papio anubis	100.0	9e-50	164
LLPS-Aim-2262	Ailuropoda melanoleuca	100.0	5e-49	160
LLPS-Mup-2652	Mustela putorius furo	100.0	4e-49	159
LLPS-Ova-1183	Ovis aries	100.0	6e-50	161
LLPS-Myl-1916	Myotis lucifugus	100.0	6e-50	161
LLPS-Xim-1121	Xiphophorus maculatus	100.0	6e-49	159
LLPS-Tar-1751	Takifugu rubripes	100.0	2e-50	164
LLPS-Dio-0803	Dipodomys ordii	100.0	4e-49	159
LLPS-Bot-1400	Bos taurus	100.0	2e-50	163
LLPS-Scf-1779	Scleropages formosus	100.0	2e-48	159
LLPS-Gog-1013	Gorilla gorilla	100.0	3e-50	164
LLPS-Asm-0830	Astyanax mexicanus	100.0	9e-49	159
LLPS-Icp-0319	Ictalurus punctatus	100.0	6e-49	159
LLPS-Caj-0881	Callithrix jacchus	100.0	4e-49	160
LLPS-Mea-2361	Mesocricetus auratus	100.0	2e-49	164
LLPS-Maf-0350	Macaca fascicularis	100.0	1e-49	164
LLPS-Mum-0652	Mus musculus	100.0	4e-49	159
LLPS-Ora-0549	Ornithorhynchus anatinus	100.0	5e-49	159
LLPS-Chs-0190	Chlorocebus sabaeus	100.0	4e-49	159
LLPS-Orl-3442	Oryzias latipes	100.0	4e-48	160
LLPS-Aon-0826	Aotus nancymaae	100.0	3e-50	164
LLPS-Sah-3477	Sarcophilus harrisii	100.0	6e-50	161
LLPS-Cea-1031	Cercocebus atys	100.0	9e-50	165
LLPS-Leo-0404	Lepisosteus oculatus	100.0	4e-49	160
LLPS-Sus-4258	Sus scrofa	100.0	8e-49	159
LLPS-Mal-1894	Mandrillus leucophaeus	98.28	3e-34	120
LLPS-Anp-0158	Anas platyrhynchos	97.96	9e-28	101
LLPS-Gaa-2438	Gasterosteus aculeatus	97.4	2e-47	155
LLPS-Cii-0515	Ciona intestinalis	94.74	3e-45	149
LLPS-Cis-1894	Ciona savignyi	93.42	2e-44	147
LLPS-Fud-3935	Fukomys damarensis	89.71	1e-35	122
LLPS-Drm-0301	Drosophila melanogaster	89.33	1e-41	140
LLPS-Asni-0142	Aspergillus niger	82.43	2e-37	129
LLPS-Asfu-1463	Aspergillus fumigatus	81.08	2e-36	127
LLPS-Dos-1346	Dothistroma septosporum	81.08	3e-36	127
LLPS-Nef-0415	Neosartorya fischeri	81.08	1e-35	128
LLPS-Tum-0964	Tuber melanosporum	81.08	6e-36	127
LLPS-Lem-0494	Leptosphaeria maculans	81.08	1e-36	127
LLPS-Blg-0223	Blumeria graminis	81.08	2e-36	127
LLPS-Asc-0667	Aspergillus clavatus	81.08	2e-36	127
LLPS-Scs-0265	Sclerotinia sclerotiorum	81.08	2e-36	127
LLPS-Cogr-0360	Colletotrichum graminicola	79.73	2e-36	127
LLPS-Phn-0823	Phaeosphaeria nodorum	79.73	3e-36	126
LLPS-Pytr-0672	Pyrenophora triticirepentis	79.73	3e-36	126
LLPS-Fuo-1180	Fusarium oxysporum	79.73	2e-36	127
LLPS-Fus-0038	Fusarium solani	79.73	2e-36	127
LLPS-Nec-1345	Neurospora crassa	79.73	2e-36	127
LLPS-Pyt-0774	Pyrenophora teres	79.73	6e-36	127
LLPS-Asn-0348	Aspergillus nidulans	79.73	5e-36	126
LLPS-Coo-0401	Colletotrichum orbiculare	79.73	5e-36	127
LLPS-Mao-0976	Magnaporthe oryzae	79.73	2e-36	127
LLPS-Fuv-1406	Fusarium verticillioides	79.73	2e-36	127
LLPS-Abg-0612	Absidia glauca	79.49	2e-39	136
LLPS-Spr-0603	Sporisorium reilianum	78.95	1e-37	130
LLPS-Crn-0865	Cryptococcus neoformans	78.95	9e-38	130
LLPS-Cae-0810	Caenorhabditis elegans	78.67	2e-37	129
LLPS-Trv-1151	Trichoderma virens	78.38	3e-35	124
LLPS-Map-0902	Magnaporthe poae	78.38	9e-36	125
LLPS-Gag-0231	Gaeumannomyces graminis	78.38	9e-36	125
LLPS-Zyt-1383	Zymoseptoria tritici	78.21	8e-37	128
LLPS-Beb-1285	Beauveria bassiana	77.03	2e-35	124
LLPS-Asf-0180	Aspergillus flavus	77.03	2e-33	119
LLPS-Aso-0207	Aspergillus oryzae	77.03	2e-33	119
LLPS-Trr-0790	Trichoderma reesei	76.92	2e-36	127
LLPS-Ved-1164	Verticillium dahliae	75.68	1e-32	117
LLPS-Miv-0754	Microbotryum violaceum	75.68	3e-30	118
LLPS-Usm-0881	Ustilago maydis	75.0	6e-36	125
LLPS-Scp-0688	Schizosaccharomyces pombe	75.0	1e-35	125
LLPS-Scc-1192	Schizosaccharomyces cryophilus	75.0	2e-35	124
LLPS-Yal-0627	Yarrowia lipolytica	74.32	6e-33	118
LLPS-Org-0767	Oryza glaberrima	72.37	3e-35	124
LLPS-Tru-0576	Triticum urartu	72.37	2e-35	125
LLPS-Orr-1517	Oryza rufipogon	72.37	2e-35	124
LLPS-Orm-1096	Oryza meridionalis	72.37	2e-35	124
LLPS-Sob-1721	Sorghum bicolor	72.37	1e-35	125
LLPS-Amt-0286	Amborella trichopoda	72.37	6e-36	126
LLPS-Viv-0466	Vitis vinifera	72.37	3e-35	124
LLPS-Ors-1316	Oryza sativa	72.37	2e-35	124
LLPS-Sei-1004	Setaria italica	72.37	2e-35	124
LLPS-Brd-0359	Brachypodium distachyon	72.37	2e-35	125
LLPS-Tra-0642	Triticum aestivum	72.37	1e-35	125
LLPS-Orgl-0658	Oryza glumaepatula	72.37	2e-35	124
LLPS-Lep-0650	Leersia perrieri	72.37	2e-35	124
LLPS-Php-2172	Physcomitrella patens	72.37	2e-35	124
LLPS-Mua-1729	Musa acuminata	72.37	7e-36	125
LLPS-Orni-0006	Oryza nivara	72.37	2e-35	124
LLPS-Orb-0492	Oryza barthii	72.37	2e-35	124
LLPS-Ori-1906	Oryza indica	72.37	2e-35	124
LLPS-Orp-1386	Oryza punctata	71.43	3e-35	125
LLPS-Hov-1438	Hordeum vulgare	71.43	2e-35	126
LLPS-Phv-1822	Phaseolus vulgaris	71.05	7e-35	123
LLPS-Nia-0475	Nicotiana attenuata	71.05	1e-34	122
LLPS-Via-0610	Vigna angularis	71.05	7e-35	123
LLPS-Hea-1768	Helianthus annuus	71.05	6e-35	123
LLPS-Glm-2466	Glycine max	71.05	4e-35	124
LLPS-Sol-1177	Solanum lycopersicum	71.05	1e-31	121
LLPS-Kop-0007	Komagataella pastoris	70.27	5e-31	113
LLPS-Mel-0650	Melampsora laricipopulina	70.27	5e-31	113
LLPS-Sot-1011	Solanum tuberosum	70.13	3e-34	120
LLPS-Art-2385	Arabidopsis thaliana	70.0	9e-20	84.0
LLPS-Pot-0566	Populus trichocarpa	70.0	2e-19	83.2
LLPS-Bro-0020	Brassica oleracea	69.74	1e-33	120
LLPS-Prp-1352	Prunus persica	69.74	3e-34	121
LLPS-Cus-1588	Cucumis sativus	69.74	5e-34	120
LLPS-Thc-1854	Theobroma cacao	69.74	3e-34	121
LLPS-Sem-0422	Selaginella moellendorffii	69.74	4e-34	121
LLPS-Met-0054	Medicago truncatula	68.42	2e-33	119
LLPS-Brn-0819	Brassica napus	68.42	2e-30	112
LLPS-Sac-1404	Saccharomyces cerevisiae	67.57	2e-27	103
LLPS-Asg-0647	Ashbya gossypii	67.57	9e-28	105
LLPS-Mae-1150	Manihot esculenta	67.53	5e-34	120
LLPS-Scj-1302	Schizosaccharomyces japonicus	67.53	6e-33	118
LLPS-Dac-0306	Daucus carota	67.11	4e-32	117
LLPS-Gor-0531	Gossypium raimondii	66.23	4e-33	118
LLPS-Pug-0691	Puccinia graminis	66.22	3e-29	108
LLPS-Arl-1195	Arabidopsis lyrata	65.38	1e-29	109
LLPS-Cog-0381	Colletotrichum gloeosporioides	62.11	6e-32	117
LLPS-Vir-1271	Vigna radiata	60.67	3e-31	113
LLPS-Osl-0368	Ostreococcus lucimarinus	57.75	2e-22	91.3
LLPS-Zem-0225	Zea mays	56.7	4e-31	114
LLPS-Chr-0425	Chlamydomonas reinhardtii	51.9	8e-23	92.0

LLPS-Urm-0617ARPC4

Protein Sequence

Nucleotide Sequence

LLPS-Urm-0617
ARPC4