• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaa-2438

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2/3 complex subunit 4
Ensembl Gene: ENSGACG00000009846.1
Ensembl Protein: ENSGACP00000012999.1
Organism: Gasterosteus aculeatus
Taxa ID: 69293
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSGACT00000013024.1ENSGACP00000012999.1
UniProtG3P5X6, G3P5X6_GASAC

▼ SEQUENCE

Protein Sequence (FASTA)
1     QTATLRPYLN  AVRATLQAAL  CLENFSSQVV  ERHNKPEVEV  RSSKELLLQP  VVISRNDKEK  60
61    VLIEGSINSV  RVSIAVKQAD  EIEKILCHKF  MRFMMMRAEN  FFILRRKAVE  GYDISFLITN  120
121   FHTEQMYKHK  LVDYVIHFME  EIDKEISEMK  LSVNARARIV  AEEFLKNF  168
Nucleotide CDS Sequence (FASTA)
1     CAGACAGCGA  CTCTGCGCCC  CTACTTGAAC  GCGGTGAGGG  CCACCCTGCA  GGCGGCCCTC  60
61    TGTCTGGAGA  ACTTCTCCTC  TCAGGTGGTG  GAGCGTCACA  ACAAGCCCGA  GGTGGAGGTC  120
121   AGGAGCAGTA  AGGAGCTGCT  GCTTCAACCT  GTGGTCATCA  GCCGTAATGA  CAAGGAGAAG  180
181   GTTCTCATCG  AGGGATCCAT  CAACTCCGTC  AGAGTCAGCA  TTGCTGTCAA  GCAGGCTGAT  240
241   GAGATCGAGA  AGATCCTTTG  CCACAAGTTC  ATGCGCTTCA  TGATGATGAG  AGCGGAGAAC  300
301   TTCTTCATTC  TGAGGAGGAA  AGCAGTGGAG  GGGTACGATA  TTAGCTTCTT  GATTACCAAC  360
361   TTCCACACGG  AGCAGATGTA  CAAACACAAG  CTGGTGGACT  ACGTCATCCA  CTTCATGGAG  420
421   GAGATCGACA  AGGAGATCAG  CGAGATGAAG  CTGTCCGTTA  ACGCCAGGGC  CCGTATCGTC  480
481   GCTGAGGAAT  TCCTCAAGAA  CTTCTGA  507

▼ KEYWORD

ID
Family
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Cytoplasm
Molecular Function
Actin binding
Biological Process
Actin filament polymerization
Biological Process
Arp2/3 complex-mediated actin nucleation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pof-3629Poecilia formosa98.85e-117 335
LLPS-Dar-1651Danio rerio98.84e-117 337
LLPS-Xim-1121Xiphophorus maculatus98.84e-117 336
LLPS-Asm-0830Astyanax mexicanus98.88e-117 336
LLPS-Icp-0319Ictalurus punctatus98.85e-117 335
LLPS-Orl-3442Oryzias latipes98.84e-116 337
LLPS-Xet-1117Xenopus tropicalis98.213e-117 336
LLPS-Ten-2637Tetraodon nigroviridis98.27e-117 335
LLPS-Orn-2470Oreochromis niloticus98.27e-117 335
LLPS-Scm-0634Scophthalmus maximus98.27e-117 335
LLPS-Fia-1423Ficedula albicollis97.64e-116 333
LLPS-Meg-0100Meleagris gallopavo97.64e-116 333
LLPS-Scf-1779Scleropages formosus97.62e-115 332
LLPS-Gaga-1582Gallus gallus97.597e-115 330
LLPS-Tar-1751Takifugu rubripes97.595e-115 332
LLPS-Leo-0404Lepisosteus oculatus97.592e-115 332
LLPS-Eqc-3509Equus caballus97.456e-106 309
LLPS-Man-3207Macaca nemestrina97.445e-48 157
LLPS-Urm-0617Ursus maritimus97.47e-48 157
LLPS-Lac-2605Latimeria chalumnae97.273e-66 219
LLPS-Sus-4258Sus scrofa97.021e-115 332
LLPS-Anc-1067Anolis carolinensis97.018e-116 332
LLPS-Caf-1084Canis familiaris97.016e-115 330
LLPS-Loa-2824Loxodonta africana97.016e-115 330
LLPS-Hos-0436Homo sapiens97.018e-115 330
LLPS-Fec-3068Felis catus97.014e-115 330
LLPS-Mup-2652Mustela putorius furo97.014e-115 330
LLPS-Myl-1916Myotis lucifugus97.016e-115 330
LLPS-Ova-1183Ovis aries97.016e-115 330
LLPS-Ran-0905Rattus norvegicus97.014e-115 330
LLPS-Dio-0803Dipodomys ordii97.014e-115 330
LLPS-Caj-0881Callithrix jacchus97.018e-115 330
LLPS-Sah-3477Sarcophilus harrisii97.016e-115 330
LLPS-Mum-0652Mus musculus97.014e-115 330
LLPS-Chs-0190Chlorocebus sabaeus97.014e-115 330
LLPS-Ora-0549Ornithorhynchus anatinus97.012e-115 331
LLPS-Ict-2792Ictidomys tridecemlineatus96.999e-114 327
LLPS-Nol-0161Nomascus leucogenys96.995e-114 328
LLPS-Tag-0915Taeniopygia guttata96.991e-113 327
LLPS-Cas-0607Carlito syrichta96.998e-114 329
LLPS-Cap-2149Cavia porcellus96.993e-114 328
LLPS-Rhb-3486Rhinopithecus bieti96.996e-114 328
LLPS-Pat-0999Pan troglodytes96.994e-114 328
LLPS-Pap-1658Pan paniscus96.994e-114 328
LLPS-Mod-2781Monodelphis domestica96.994e-114 328
LLPS-Paa-3233Papio anubis96.995e-113 329
LLPS-Aim-2262Ailuropoda melanoleuca96.999e-114 328
LLPS-Bot-1400Bos taurus96.992e-114 329
LLPS-Gog-1013Gorilla gorilla96.991e-113 329
LLPS-Cea-1031Cercocebus atys96.993e-113 330
LLPS-Aon-0826Aotus nancymaae96.996e-114 330
LLPS-Mea-2361Mesocricetus auratus96.991e-112 328
LLPS-Maf-0350Macaca fascicularis96.994e-113 330
LLPS-Otg-2944Otolemur garnettii96.851e-83 249
LLPS-Orc-1194Oryctolagus cuniculus96.412e-114 330
LLPS-Anp-0158Anas platyrhynchos95.927e-27 102
LLPS-Fud-3935Fukomys damarensis87.882e-33 120
LLPS-Cii-0515Ciona intestinalis85.632e-101 296
LLPS-Cis-1894Ciona savignyi84.433e-100 293
LLPS-Pes-0890Pelodiscus sinensis82.041e-92 273
LLPS-Drm-0301Drosophila melanogaster81.939e-96 281
LLPS-Mal-1894Mandrillus leucophaeus78.443e-84 251
LLPS-Cae-0810Caenorhabditis elegans76.652e-92 273
LLPS-Crn-0865Cryptococcus neoformans76.361e-90 269
LLPS-Spr-0603Sporisorium reilianum70.918e-83 249
LLPS-Usm-0881Ustilago maydis70.914e-81 244
LLPS-Nef-0415Neosartorya fischeri70.833e-81 248
LLPS-Asfu-1463Aspergillus fumigatus70.662e-81 245
LLPS-Asni-0142Aspergillus niger70.669e-82 246
LLPS-Abg-0612Absidia glauca70.451e-85 257
LLPS-Miv-0754Microbotryum violaceum70.371e-66 223
LLPS-Nec-1345Neurospora crassa70.061e-83 251
LLPS-Asn-0348Aspergillus nidulans70.062e-80 242
LLPS-Asc-0667Aspergillus clavatus70.066e-81 244
LLPS-Coo-0401Colletotrichum orbiculare69.74e-81 246
LLPS-Zyt-1383Zymoseptoria tritici69.512e-80 243
LLPS-Blg-0223Blumeria graminis69.466e-82 246
LLPS-Scc-1192Schizosaccharomyces cryophilus69.091e-79 241
LLPS-Cogr-0360Colletotrichum graminicola68.861e-81 246
LLPS-Dos-1346Dothistroma septosporum68.863e-80 242
LLPS-Fuo-1180Fusarium oxysporum68.861e-81 245
LLPS-Fus-0038Fusarium solani68.861e-81 245
LLPS-Tum-0964Tuber melanosporum68.869e-81 244
LLPS-Mao-0976Magnaporthe oryzae68.863e-82 247
LLPS-Scs-0265Sclerotinia sclerotiorum68.862e-81 245
LLPS-Fuv-1406Fusarium verticillioides68.861e-81 245
LLPS-Trr-0790Trichoderma reesei68.483e-79 240
LLPS-Scp-0688Schizosaccharomyces pombe68.483e-79 239
LLPS-Asf-0180Aspergillus flavus68.265e-78 236
LLPS-Aso-0207Aspergillus oryzae68.265e-78 236
LLPS-Lem-0494Leptosphaeria maculans68.262e-79 240
LLPS-Yal-0627Yarrowia lipolytica68.269e-77 233
LLPS-Php-2172Physcomitrella patens67.882e-80 243
LLPS-Mua-1729Musa acuminata67.791e-71 219
LLPS-Phn-0823Phaeosphaeria nodorum67.667e-79 238
LLPS-Trv-1151Trichoderma virens67.663e-79 239
LLPS-Pytr-0672Pyrenophora triticirepentis67.666e-79 239
LLPS-Kop-0007Komagataella pastoris67.661e-77 235
LLPS-Pyt-0774Pyrenophora teres67.661e-78 239
LLPS-Map-0902Magnaporthe poae67.661e-81 246
LLPS-Gag-0231Gaeumannomyces graminis67.661e-81 246
LLPS-Orm-1096Oryza meridionalis67.277e-79 239
LLPS-Orr-1517Oryza rufipogon67.277e-79 239
LLPS-Amt-0286Amborella trichopoda67.272e-79 239
LLPS-Sob-1721Sorghum bicolor67.275e-79 239
LLPS-Ors-1316Oryza sativa67.277e-79 239
LLPS-Sei-1004Setaria italica67.277e-79 239
LLPS-Lep-0650Leersia perrieri67.277e-79 239
LLPS-Orgl-0658Oryza glumaepatula67.279e-79 238
LLPS-Orni-0006Oryza nivara67.277e-79 239
LLPS-Orb-0492Oryza barthii67.279e-79 238
LLPS-Ori-1906Oryza indica67.277e-79 239
LLPS-Ved-1164Verticillium dahliae67.075e-79 239
LLPS-Tru-0576Triticum urartu66.671e-78 238
LLPS-Sac-1404Saccharomyces cerevisiae66.671e-72 223
LLPS-Brd-0359Brachypodium distachyon66.671e-78 238
LLPS-Tra-0642Triticum aestivum66.677e-79 238
LLPS-Asg-0647Ashbya gossypii66.673e-73 224
LLPS-Glm-2466Glycine max66.673e-78 237
LLPS-Phv-1822Phaseolus vulgaris66.473e-79 239
LLPS-Beb-1285Beauveria bassiana66.471e-79 241
LLPS-Sot-1011Solanum tuberosum66.412e-56 180
LLPS-Via-0610Vigna angularis66.272e-78 237
LLPS-Hov-1438Hordeum vulgare66.075e-79 241
LLPS-Prp-1352Prunus persica66.064e-77 234
LLPS-Bro-0020Brassica oleracea65.852e-75 230
LLPS-Thc-1854Theobroma cacao65.662e-75 230
LLPS-Viv-0466Vitis vinifera65.454e-76 231
LLPS-Hea-1768Helianthus annuus65.063e-76 232
LLPS-Sol-1177Solanum lycopersicum64.951e-37 141
LLPS-Nia-0475Nicotiana attenuata64.853e-76 232
LLPS-Scj-1302Schizosaccharomyces japonicus64.852e-76 233
LLPS-Mel-0650Melampsora laricipopulina64.854e-71 219
LLPS-Sem-0422Selaginella moellendorffii64.851e-75 230
LLPS-Coc-0446Corchorus capsularis64.719e-1472.4
LLPS-Met-0054Medicago truncatula64.671e-76 233
LLPS-Dac-0306Daucus carota64.637e-75 229
LLPS-Mae-1150Manihot esculenta64.463e-77 234
LLPS-Gor-0531Gossypium raimondii64.462e-76 232
LLPS-Cus-1588Cucumis sativus64.461e-76 233
LLPS-Brn-0819Brassica napus64.296e-73 223
LLPS-Art-2385Arabidopsis thaliana64.235e-60 191
LLPS-Org-0767Oryza glaberrima63.073e-75 230
LLPS-Pot-0566Populus trichocarpa63.046e-59 188
LLPS-Pug-0691Puccinia graminis63.034e-70 216
LLPS-Arl-1195Arabidopsis lyrata62.874e-71 219
LLPS-Orp-1386Oryza punctata62.151e-74 230
LLPS-Cog-0381Colletotrichum gloeosporioides61.72e-76 235
LLPS-Zem-0225Zea mays58.52e-53 175
LLPS-Vir-1271Vigna radiata52.787e-58 185
LLPS-Brr-0943Brassica rapa51.797e-50 164
LLPS-Chr-0425Chlamydomonas reinhardtii49.142e-53 174
LLPS-Osl-0368Ostreococcus lucimarinus45.452e-41 143