LLPS-Hos-0436
ARPC4
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Actin-related protein 2/3 complex subunit 4; Arp2/3 complex 20 kDa subunit; p20-ARC |
| Gene Name: | ARPC4, ARC20 |
| Ensembl Gene: | ENSG00000241553.12 |
| Ensembl Protein: | ENSP00000432235.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli." | HeLa cells | 15635413 |
| Postsynaptic density | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000498623.6 | ENSP00000432235.1 |
| Ensembl | ENST00000417500.5 | ENSP00000414751.1 |
| Ensembl | ENST00000433034.1 | ENSP00000388169.1 |
| Ensembl | ENST00000440787.5 | ENSP00000395085.1 |
| Ensembl | ENST00000485273.1 | ENSP00000473435.1 |
| Ensembl | ENST00000397261.7 | ENSP00000380431.2 |
| UniProt | P59998, ARPC4_HUMAN, C9JWM7, E7ETI0, F6TTL5, O15509, Q6P0W5, Q96QJ3 | |
| GeneBank | BC025289, AF006087, BX419672, AC022382, BC012596, AF019888 | AAH12596.3, AAB71548.1, AAB64192.1 |
| RefSeq | NM_001024959.2, NM_001024960.2, NM_001198780.1, NM_005718.4 | NP_001020130.1, NP_001020131.1, NP_001185709.1, NP_005709.1 |
| Entrez | 10093 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVREPGPRPG TPGCSASGQW TATLRPYLSA VRATLQAALC LENFSSQVVE RHNKPEVEVR 60 61 SSKELLLQPV TISRNEKEKV LIEGSINSVR VSIAVKQADE IEKILCHKFM RFMMMRAENF 120 121 FILRRKPVEG YDISFLITNF HTEQMYKHKL VDFVIHFMEE IDKEISEMKL SVNARARIVA 180 181 EEFLKNF 187 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACTGCCA CTCTCCGCCC CTACCTGAGT GCCGTGCGGG CCACATTGCA GGCTGCCCTC 60 61 TGCCTGGAGA ACTTCTCCTC CCAGGTTGTG GAACGACACA ACAAGCCGGA AGTGGAAGTC 120 121 AGTCCTCGCC AGTGA 135 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Arp2/3 protein complex | |
Cellular Component | Cell projection | |
Cellular Component | Cytosol | |
Cellular Component | Extracellular exosome | |
Cellular Component | Nucleus | |
Cellular Component | Site of double-strand break | |
Molecular Function | Actin binding | |
Molecular Function | Enzyme binding | |
Molecular Function | Structural constituent of cytoskeleton | |
Biological Process | Actin filament polymerization | |
Biological Process | Actin nucleation | |
Biological Process | Arp2/3 complex-mediated actin nucleation | |
Biological Process | Ephrin receptor signaling pathway | |
Biological Process | Fc-gamma receptor signaling pathway involved in phagocytosis | |
Biological Process | Membrane organization |
▼ ANNOTATION
| Disease | ||||
| OMIM | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CORUM | CellMarker | RaftProt | |
| Localization | ||||
| COMPARTMENTS | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fud-3935 | Fukomys damarensis | 100.0 | 2e-33 | 120 |
| LLPS-Mea-2361 | Mesocricetus auratus | 100.0 | 4e-114 | 333 |
| LLPS-Maf-0350 | Macaca fascicularis | 100.0 | 7e-115 | 335 |
| LLPS-Aon-0826 | Aotus nancymaae | 100.0 | 7e-116 | 335 |
| LLPS-Sah-3477 | Sarcophilus harrisii | 100.0 | 4e-117 | 337 |
| LLPS-Cea-1031 | Cercocebus atys | 100.0 | 7e-115 | 335 |
| LLPS-Ova-1183 | Ovis aries | 100.0 | 4e-117 | 337 |
| LLPS-Myl-1916 | Myotis lucifugus | 100.0 | 4e-117 | 337 |
| LLPS-Bot-1400 | Bos taurus | 100.0 | 4e-117 | 337 |
| LLPS-Otg-2944 | Otolemur garnettii | 100.0 | 2e-86 | 257 |
| LLPS-Rhb-3486 | Rhinopithecus bieti | 100.0 | 2e-116 | 336 |
| LLPS-Mod-2781 | Monodelphis domestica | 100.0 | 5e-117 | 336 |
| LLPS-Pap-1658 | Pan paniscus | 100.0 | 6e-117 | 336 |
| LLPS-Urm-0617 | Ursus maritimus | 100.0 | 1e-48 | 160 |
| LLPS-Pat-0999 | Pan troglodytes | 100.0 | 6e-117 | 336 |
| LLPS-Loa-2824 | Loxodonta africana | 100.0 | 4e-117 | 337 |
| LLPS-Man-3207 | Macaca nemestrina | 100.0 | 1e-49 | 161 |
| LLPS-Cas-0607 | Carlito syrichta | 100.0 | 1e-115 | 334 |
| LLPS-Ict-2792 | Ictidomys tridecemlineatus | 100.0 | 3e-116 | 335 |
| LLPS-Nol-0161 | Nomascus leucogenys | 100.0 | 3e-116 | 335 |
| LLPS-Eqc-3509 | Equus caballus | 100.0 | 2e-107 | 314 |
| LLPS-Caf-1084 | Canis familiaris | 100.0 | 4e-117 | 337 |
| LLPS-Gog-1013 | Gorilla gorilla | 99.4 | 9e-116 | 335 |
| LLPS-Chs-0190 | Chlorocebus sabaeus | 99.4 | 6e-118 | 338 |
| LLPS-Mum-0652 | Mus musculus | 99.4 | 6e-118 | 338 |
| LLPS-Ran-0905 | Rattus norvegicus | 99.4 | 6e-118 | 338 |
| LLPS-Mup-2652 | Mustela putorius furo | 99.4 | 6e-118 | 338 |
| LLPS-Paa-3233 | Papio anubis | 99.4 | 7e-115 | 335 |
| LLPS-Dio-0803 | Dipodomys ordii | 99.4 | 6e-118 | 338 |
| LLPS-Fec-3068 | Felis catus | 99.4 | 6e-118 | 338 |
| LLPS-Cap-2149 | Cavia porcellus | 99.4 | 6e-117 | 336 |
| LLPS-Sus-4258 | Sus scrofa | 98.82 | 4e-117 | 337 |
| LLPS-Ora-0549 | Ornithorhynchus anatinus | 98.81 | 7e-117 | 336 |
| LLPS-Fia-1423 | Ficedula albicollis | 98.8 | 1e-115 | 333 |
| LLPS-Meg-0100 | Meleagris gallopavo | 98.8 | 1e-115 | 333 |
| LLPS-Xet-1117 | Xenopus tropicalis | 98.8 | 2e-116 | 335 |
| LLPS-Gaga-1582 | Gallus gallus | 98.8 | 1e-114 | 331 |
| LLPS-Tag-0915 | Taeniopygia guttata | 98.19 | 3e-114 | 329 |
| LLPS-Anc-1067 | Anolis carolinensis | 98.19 | 3e-115 | 332 |
| LLPS-Ten-2637 | Tetraodon nigroviridis | 98.19 | 4e-115 | 332 |
| LLPS-Anp-0158 | Anas platyrhynchos | 97.96 | 3e-27 | 103 |
| LLPS-Caj-0881 | Callithrix jacchus | 97.86 | 6e-132 | 375 |
| LLPS-Icp-0319 | Ictalurus punctatus | 97.62 | 5e-116 | 333 |
| LLPS-Orn-2470 | Oreochromis niloticus | 97.62 | 6e-116 | 333 |
| LLPS-Scm-0634 | Scophthalmus maximus | 97.62 | 6e-116 | 333 |
| LLPS-Pof-3629 | Poecilia formosa | 97.62 | 5e-116 | 333 |
| LLPS-Dar-2259 | Danio rerio | 97.62 | 5e-116 | 333 |
| LLPS-Orl-2334 | Oryzias latipes | 97.6 | 2e-114 | 330 |
| LLPS-Tar-0782 | Takifugu rubripes | 97.59 | 2e-113 | 328 |
| LLPS-Orc-1194 | Oryctolagus cuniculus | 97.33 | 2e-130 | 371 |
| LLPS-Xim-1121 | Xiphophorus maculatus | 97.04 | 2e-116 | 335 |
| LLPS-Gaa-2438 | Gasterosteus aculeatus | 97.01 | 9e-115 | 330 |
| LLPS-Aim-2262 | Ailuropoda melanoleuca | 96.77 | 1e-126 | 361 |
| LLPS-Scf-1779 | Scleropages formosus | 96.49 | 4e-115 | 333 |
| LLPS-Lac-2605 | Latimeria chalumnae | 94.02 | 4e-64 | 214 |
| LLPS-Leo-0404 | Lepisosteus oculatus | 93.26 | 7e-118 | 339 |
| LLPS-Asm-0830 | Astyanax mexicanus | 92.74 | 1e-115 | 333 |
| LLPS-Cii-0515 | Ciona intestinalis | 85.71 | 7e-102 | 298 |
| LLPS-Cis-1894 | Ciona savignyi | 84.52 | 2e-100 | 294 |
| LLPS-Pes-0890 | Pelodiscus sinensis | 82.53 | 1e-91 | 271 |
| LLPS-Drm-0301 | Drosophila melanogaster | 82.14 | 3e-96 | 283 |
| LLPS-Mal-1894 | Mandrillus leucophaeus | 80.36 | 9e-86 | 256 |
| LLPS-Crn-0865 | Cryptococcus neoformans | 77.58 | 7e-90 | 267 |
| LLPS-Cae-0810 | Caenorhabditis elegans | 76.79 | 1e-92 | 274 |
| LLPS-Usm-0881 | Ustilago maydis | 73.94 | 6e-84 | 252 |
| LLPS-Spr-0603 | Sporisorium reilianum | 73.94 | 1e-85 | 256 |
| LLPS-Nef-0415 | Neosartorya fischeri | 73.05 | 1e-81 | 250 |
| LLPS-Asni-0142 | Aspergillus niger | 72.62 | 1e-83 | 251 |
| LLPS-Asfu-1463 | Aspergillus fumigatus | 72.62 | 4e-83 | 250 |
| LLPS-Asn-0348 | Aspergillus nidulans | 72.02 | 4e-82 | 248 |
| LLPS-Asc-0667 | Aspergillus clavatus | 72.02 | 1e-82 | 249 |
| LLPS-Nec-1345 | Neurospora crassa | 72.02 | 3e-85 | 255 |
| LLPS-Blg-0223 | Blumeria graminis | 71.86 | 2e-83 | 251 |
| LLPS-Abg-0612 | Absidia glauca | 71.59 | 1e-86 | 261 |
| LLPS-Zyt-1383 | Zymoseptoria tritici | 71.52 | 2e-82 | 249 |
| LLPS-Mao-0976 | Magnaporthe oryzae | 70.83 | 6e-84 | 252 |
| LLPS-Fuv-1406 | Fusarium verticillioides | 70.83 | 4e-83 | 250 |
| LLPS-Scs-0265 | Sclerotinia sclerotiorum | 70.83 | 5e-83 | 250 |
| LLPS-Fus-0038 | Fusarium solani | 70.83 | 4e-83 | 250 |
| LLPS-Dos-1346 | Dothistroma septosporum | 70.83 | 6e-82 | 247 |
| LLPS-Cogr-0360 | Colletotrichum graminicola | 70.83 | 2e-83 | 251 |
| LLPS-Fuo-1180 | Fusarium oxysporum | 70.83 | 4e-83 | 250 |
| LLPS-Lem-0494 | Leptosphaeria maculans | 70.66 | 4e-81 | 245 |
| LLPS-Yal-0627 | Yarrowia lipolytica | 70.24 | 9e-79 | 239 |
| LLPS-Asf-0180 | Aspergillus flavus | 70.24 | 1e-79 | 241 |
| LLPS-Aso-0207 | Aspergillus oryzae | 70.24 | 1e-79 | 241 |
| LLPS-Miv-0754 | Microbotryum violaceum | 70.12 | 5e-70 | 234 |
| LLPS-Pyt-0774 | Pyrenophora teres | 70.06 | 2e-80 | 244 |
| LLPS-Phn-0823 | Phaeosphaeria nodorum | 70.06 | 2e-80 | 244 |
| LLPS-Pytr-0672 | Pyrenophora triticirepentis | 70.06 | 1e-80 | 244 |
| LLPS-Mua-1729 | Musa acuminata | 69.8 | 3e-72 | 222 |
| LLPS-Php-2172 | Physcomitrella patens | 69.7 | 3e-81 | 245 |
| LLPS-Map-0902 | Magnaporthe poae | 69.64 | 2e-83 | 251 |
| LLPS-Gag-0231 | Gaeumannomyces graminis | 69.64 | 2e-83 | 251 |
| LLPS-Sot-1011 | Solanum tuberosum | 69.53 | 2e-58 | 186 |
| LLPS-Trr-0790 | Trichoderma reesei | 69.51 | 1e-78 | 239 |
| LLPS-Orni-0006 | Oryza nivara | 69.09 | 4e-80 | 243 |
| LLPS-Ori-1906 | Oryza indica | 69.09 | 4e-80 | 243 |
| LLPS-Orb-0492 | Oryza barthii | 69.09 | 5e-80 | 243 |
| LLPS-Sei-1004 | Setaria italica | 69.09 | 4e-80 | 243 |
| LLPS-Orgl-0658 | Oryza glumaepatula | 69.09 | 5e-80 | 243 |
| LLPS-Lep-0650 | Leersia perrieri | 69.09 | 4e-80 | 243 |
| LLPS-Sob-1721 | Sorghum bicolor | 69.09 | 4e-80 | 243 |
| LLPS-Amt-0286 | Amborella trichopoda | 69.09 | 9e-81 | 244 |
| LLPS-Ors-1316 | Oryza sativa | 69.09 | 4e-80 | 243 |
| LLPS-Orm-1096 | Oryza meridionalis | 69.09 | 4e-80 | 243 |
| LLPS-Orr-1517 | Oryza rufipogon | 69.09 | 4e-80 | 243 |
| LLPS-Coo-0401 | Colletotrichum orbiculare | 68.89 | 4e-83 | 252 |
| LLPS-Kop-0007 | Komagataella pastoris | 68.86 | 3e-79 | 240 |
| LLPS-Glm-2466 | Glycine max | 68.48 | 2e-79 | 241 |
| LLPS-Brd-0359 | Brachypodium distachyon | 68.48 | 5e-80 | 242 |
| LLPS-Tra-0642 | Triticum aestivum | 68.48 | 2e-80 | 243 |
| LLPS-Tru-0576 | Triticum urartu | 68.48 | 5e-80 | 242 |
| LLPS-Scc-1192 | Schizosaccharomyces cryophilus | 68.45 | 3e-79 | 240 |
| LLPS-Sac-1404 | Saccharomyces cerevisiae | 68.45 | 2e-74 | 228 |
| LLPS-Beb-1285 | Beauveria bassiana | 68.45 | 2e-81 | 246 |
| LLPS-Trv-1151 | Trichoderma virens | 68.45 | 3e-79 | 240 |
| LLPS-Sol-1177 | Solanum lycopersicum | 68.42 | 8e-39 | 145 |
| LLPS-Tum-0964 | Tuber melanosporum | 68.42 | 1e-80 | 245 |
| LLPS-Asg-0647 | Ashbya gossypii | 67.86 | 5e-74 | 227 |
| LLPS-Scp-0688 | Schizosaccharomyces pombe | 67.86 | 8e-79 | 239 |
| LLPS-Phv-1822 | Phaseolus vulgaris | 67.86 | 3e-80 | 243 |
| LLPS-Ved-1164 | Verticillium dahliae | 67.86 | 7e-79 | 239 |
| LLPS-Bro-0020 | Brassica oleracea | 67.68 | 9e-77 | 234 |
| LLPS-Thc-1854 | Theobroma cacao | 67.47 | 1e-76 | 234 |
| LLPS-Viv-0466 | Vitis vinifera | 67.27 | 3e-77 | 235 |
| LLPS-Via-0610 | Vigna angularis | 67.26 | 2e-79 | 241 |
| LLPS-Brn-0819 | Brassica napus | 67.07 | 1e-73 | 226 |
| LLPS-Mel-0650 | Melampsora laricipopulina | 66.67 | 1e-72 | 223 |
| LLPS-Sem-0422 | Selaginella moellendorffii | 66.67 | 6e-77 | 234 |
| LLPS-Scj-1302 | Schizosaccharomyces japonicus | 66.67 | 1e-77 | 236 |
| LLPS-Nia-0475 | Nicotiana attenuata | 66.67 | 2e-77 | 235 |
| LLPS-Prp-1352 | Prunus persica | 66.67 | 2e-78 | 238 |
| LLPS-Met-0054 | Medicago truncatula | 66.47 | 1e-77 | 236 |
| LLPS-Art-2385 | Arabidopsis thaliana | 66.42 | 1e-61 | 195 |
| LLPS-Cus-1588 | Cucumis sativus | 66.27 | 6e-78 | 237 |
| LLPS-Hea-1768 | Helianthus annuus | 65.48 | 3e-77 | 235 |
| LLPS-Mae-1150 | Manihot esculenta | 65.48 | 2e-78 | 238 |
| LLPS-Gor-0531 | Gossypium raimondii | 65.48 | 2e-77 | 236 |
| LLPS-Pot-0566 | Populus trichocarpa | 65.22 | 3e-60 | 192 |
| LLPS-Org-0767 | Oryza glaberrima | 64.77 | 1e-76 | 234 |
| LLPS-Coc-0446 | Corchorus capsularis | 64.71 | 3e-13 | 71.2 |
| LLPS-Arl-1195 | Arabidopsis lyrata | 64.67 | 1e-72 | 224 |
| LLPS-Hov-1438 | Hordeum vulgare | 64.29 | 2e-80 | 245 |
| LLPS-Pug-0691 | Puccinia graminis | 64.24 | 5e-71 | 219 |
| LLPS-Orp-1386 | Oryza punctata | 60.94 | 2e-77 | 238 |
| LLPS-Zem-0225 | Zea mays | 60.54 | 3e-54 | 178 |
| LLPS-Dac-0306 | Daucus carota | 60.0 | 4e-75 | 231 |
| LLPS-Cog-0381 | Colletotrichum gloeosporioides | 59.15 | 8e-79 | 242 |
| LLPS-Vir-1271 | Vigna radiata | 54.49 | 1e-58 | 187 |
| LLPS-Brr-0943 | Brassica rapa | 53.66 | 3e-50 | 165 |
| LLPS-Chr-0425 | Chlamydomonas reinhardtii | 50.29 | 1e-53 | 176 |
| LLPS-Osl-0368 | Ostreococcus lucimarinus | 46.67 | 6e-43 | 147 |