• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
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  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Urm-0069
ELOVL7

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Elongation of very long chain fatty acids protein 7; 3-keto acyl-CoA synthase ELOVL7; ELOVL fatty acid elongase 7; ELOVL FA elongase 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7
Gene Name: ELOVL7
Ensembl Gene: ENSUMAG00000008913.1
Ensembl Protein: ENSUMAP00000011903.1
Organism: Ursus maritimus
Taxa ID: 29073
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAFSDLTSRT  VRLYDNWIKD  ADPRVEDWFL  MSSPLPQTFI  LGLYVYFVTS  LGPKLMENRK  60
61    PFELKKAMIT  YNFSIVLFSV  YMCYEFVMSG  WGTGYSLRCE  IVDYSQSPSA  LRMARTCWLY  120
121   YFSKFIELLD  TIFFVLRKKN  SQVTFLHVFH  HTIMPWTWWF  GVKFAAGGLG  TFHAFLNTAV  180
181   HVVMYSYYGL  SALGPAFQKY  LWWKKYLTSL  QLAQFIIVTI  HIGQFFFMED  CKYQFPVFLY  240
241   IIMSYGCIFL  LLFLHFWYRA  YTKGQRLPKT  VKNGTCKNKD  H  281
Nucleotide CDS Sequence (FASTA)
1     ATGGCCTTCA  GTGATCTTAC  ATCAAGAACC  GTGCGTCTTT  ATGATAATTG  GATCAAAGAT  60
61    GCTGATCCAA  GAGTTGAAGA  CTGGTTCCTC  ATGTCCTCAC  CTCTGCCACA  AACCTTCATC  120
121   CTGGGACTCT  ATGTCTATTT  TGTCACTTCT  CTAGGACCAA  AGCTCATGGA  GAATCGAAAG  180
181   CCCTTTGAAC  TCAAGAAAGC  GATGATAACA  TACAATTTTT  CCATAGTTCT  CTTTTCTGTG  240
241   TATATGTGTT  ACGAGTTTGT  GATGTCTGGC  TGGGGTACAG  GTTATTCACT  TCGATGCGAA  300
301   ATTGTTGACT  ACTCACAGTC  ACCTTCAGCA  TTGAGGATGG  CACGCACCTG  CTGGCTTTAT  360
361   TACTTCTCCA  AATTTATTGA  GCTATTAGAT  ACTATCTTTT  TTGTTCTGCG  TAAGAAAAAT  420
421   AGCCAAGTGA  CTTTCCTGCA  TGTCTTCCAT  CATACCATCA  TGCCATGGAC  CTGGTGGTTT  480
481   GGAGTCAAAT  TTGCCGCAGG  TGGTTTGGGA  ACATTCCACG  CCTTTCTAAA  TACAGCTGTA  540
541   CACGTAGTCA  TGTATTCCTA  CTATGGGCTA  TCTGCACTGG  GGCCAGCCTT  CCAGAAGTAT  600
601   CTGTGGTGGA  AAAAATATTT  GACATCATTA  CAGCTTGCCC  AGTTCATTAT  TGTCACCATC  660
661   CATATAGGCC  AGTTCTTTTT  CATGGAAGAT  TGCAAGTACC  AGTTTCCGGT  CTTTCTATAC  720
721   ATCATTATGA  GTTATGGGTG  CATCTTTCTG  CTGCTCTTTC  TCCATTTTTG  GTACCGTGCT  780
781   TACACCAAAG  GCCAGCGGCT  GCCCAAAACT  GTGAAAAATG  GAACCTGCAA  AAACAAAGAT  840
841   CACTGA  846

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Molecular Function
3-oxo-arachidoyl-CoA synthase activity
Molecular Function
3-oxo-cerotoyl-CoA synthase activity
Molecular Function
3-oxo-lignoceronyl-CoA synthase activity
Molecular Function
Fatty acid elongase activity
Molecular Function
Very-long-chain 3-ketoacyl-CoA synthase activity
Biological Process
Fatty acid elongation, monounsaturated fatty acid
Biological Process
Fatty acid elongation, polyunsaturated fatty acid
Biological Process
Fatty acid elongation, saturated fatty acid
Biological Process
Long-chain fatty-acyl-CoA biosynthetic process
Biological Process
Unsaturated fatty acid biosynthetic process
Biological Process
Very long-chain fatty acid biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-4304Ailuropoda melanoleuca98.930.0 577
LLPS-Caf-3712Canis familiaris97.490.0 566
LLPS-Myl-0317Myotis lucifugus96.440.0 566
LLPS-Fec-1625Felis catus96.090.0 565
LLPS-Mup-4033Mustela putorius furo96.090.0 568
LLPS-Tut-1667Tursiops truncatus95.730.0 561
LLPS-Caj-2439Callithrix jacchus95.370.0 563
LLPS-Otg-4381Otolemur garnettii94.660.0 557
LLPS-Cas-3030Carlito syrichta93.590.0 553
LLPS-Loa-4302Loxodonta africana93.590.0 551
LLPS-Ere-0868Erinaceus europaeus93.290.0 550
LLPS-Eqc-0639Equus caballus92.880.0 546
LLPS-Poa-0713Pongo abelii92.530.0 530
LLPS-Nol-4159Nomascus leucogenys92.530.0 524
LLPS-Orc-3806Oryctolagus cuniculus92.170.0 548
LLPS-Bot-2334Bos taurus92.170.0 546
LLPS-Sus-1867Sus scrofa92.170.0 544
LLPS-Mam-2056Macaca mulatta91.810.0 542
LLPS-Hos-0704Homo sapiens91.810.0 521
LLPS-Pat-4467Pan troglodytes91.810.0 520
LLPS-Pap-0758Pan paniscus91.810.0 520
LLPS-Mal-2730Mandrillus leucophaeus91.810.0 542
LLPS-Maf-3765Macaca fascicularis91.810.0 542
LLPS-Gog-2803Gorilla gorilla91.810.0 521
LLPS-Ova-0319Ovis aries91.760.0 544
LLPS-Paa-4664Papio anubis91.460.0 538
LLPS-Cea-4116Cercocebus atys91.460.0 537
LLPS-Ict-1785Ictidomys tridecemlineatus91.10.0 517
LLPS-Rhb-1647Rhinopithecus bieti91.10.0 539
LLPS-Mum-3743Mus musculus90.750.0 539
LLPS-Dio-0697Dipodomys ordii88.970.0 530
LLPS-Mea-2739Mesocricetus auratus88.970.0 533
LLPS-Fud-3866Fukomys damarensis86.830.0 514
LLPS-Cap-0988Cavia porcellus86.380.0 510
LLPS-Sah-3965Sarcophilus harrisii86.120.0 511
LLPS-Ran-0090Rattus norvegicus85.372e-129 374
LLPS-Mod-1614Monodelphis domestica85.051e-179 503
LLPS-Man-4744Macaca nemestrina83.392e-171 483
LLPS-Lac-0488Latimeria chalumnae77.394e-152 433
LLPS-Leo-2154Lepisosteus oculatus76.71e-161 458
LLPS-Xet-1331Xenopus tropicalis76.163e-156 446
LLPS-Fia-3464Ficedula albicollis74.195e-161 457
LLPS-Tag-2264Taeniopygia guttata73.843e-161 457
LLPS-Gaga-3029Gallus gallus73.846e-159 451
LLPS-Asm-3393Astyanax mexicanus73.843e-158 449
LLPS-Anp-1606Anas platyrhynchos73.027e-155 440
LLPS-Scf-1851Scleropages formosus72.734e-155 442
LLPS-Xim-3398Xiphophorus maculatus72.367e-147 421
LLPS-Icp-0705Ictalurus punctatus72.263e-157 447
LLPS-Pes-0924Pelodiscus sinensis72.246e-157 446
LLPS-Pof-1943Poecilia formosa70.917e-144 413
LLPS-Ten-0487Tetraodon nigroviridis70.181e-139 402
LLPS-Anc-1450Anolis carolinensis69.613e-144 414
LLPS-Orn-2673Oreochromis niloticus68.731e-141 407
LLPS-Scm-2058Scophthalmus maximus68.017e-137 395
LLPS-Tar-0772Takifugu rubripes68.016e-146 419
LLPS-Gaa-2823Gasterosteus aculeatus67.774e-138 398
LLPS-Orl-2064Oryzias latipes67.647e-139 400
LLPS-Dar-4122Danio rerio66.192e-144 414
LLPS-Meg-0638Meleagris gallopavo60.071e-122 359
LLPS-Ora-1454Ornithorhynchus anatinus56.36e-40 144
LLPS-Drm-0956Drosophila melanogaster48.252e-78 250
LLPS-Cii-1615Ciona intestinalis48.24e-94 286
LLPS-Zyt-1149Zymoseptoria tritici41.759e-1062.8
LLPS-Aon-2626Aotus nancymaae41.74e-57 191
LLPS-Chs-1691Chlorocebus sabaeus41.72e-57 192
LLPS-Abg-1267Absidia glauca39.183e-0961.2
LLPS-Phv-1880Phaseolus vulgaris35.925e-1062.8
LLPS-Gas-0729Galdieria sulphuraria34.54e-1885.1
LLPS-Mae-1673Manihot esculenta34.312e-0755.5
LLPS-Pot-1549Populus trichocarpa34.023e-0857.8
LLPS-Tum-0999Tuber melanosporum33.77e-1062.8
LLPS-Met-2317Medicago truncatula33.662e-1167.0
LLPS-Brn-2958Brassica napus33.661e-0756.2
LLPS-Viv-1949Vitis vinifera33.332e-0755.1
LLPS-Pug-0786Puccinia graminis33.331e-1270.5
LLPS-Sol-2156Solanum lycopersicum33.338e-1267.8
LLPS-Dos-1426Dothistroma septosporum32.621e-1270.9
LLPS-Crn-0928Cryptococcus neoformans32.081e-1270.9
LLPS-Nia-2575Nicotiana attenuata31.133e-1166.6
LLPS-Php-0292Physcomitrella patens30.25e-1989.0
LLPS-Cogr-0789Colletotrichum graminicola29.738e-1679.7
LLPS-Asn-1531Aspergillus nidulans29.574e-1475.1
LLPS-Blg-1546Blumeria graminis29.151e-1373.6
LLPS-Ast-1576Aspergillus terreus28.681e-1065.1
LLPS-Bro-2458Brassica oleracea28.493e-0960.5
LLPS-Fus-1472Fusarium solani28.191e-1270.9
LLPS-Aso-0317Aspergillus oryzae27.915e-1063.5
LLPS-Asf-0757Aspergillus flavus27.915e-1063.5
LLPS-Brr-0788Brassica rapa27.472e-0858.5
LLPS-Art-2236Arabidopsis thaliana26.01e-0858.9
LLPS-Arl-2581Arabidopsis lyrata25.07e-0959.7