LLPS-Cea-4116
ELOVL7
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Elongation of very long chain fatty acids protein 7; 3-keto acyl-CoA synthase ELOVL7; ELOVL fatty acid elongase 7; ELOVL FA elongase 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7 |
| Gene Name: | ELOVL7 |
| Ensembl Gene: | ENSCATG00000036926.1 |
| Ensembl Protein: | ENSCATP00000027059.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCATT00000051301.1 | ENSCATP00000027059.1 |
| Ensembl | ENSCATT00000051297.1 | ENSCATP00000027055.1 |
| UniProt | A0A2K5MPM6, A0A2K5MPM6_CERAT | |
| RefSeq | XM_012030118.1, XM_012030119.1, XM_012030120.1, XM_012030121.1 | XP_011885508.1, XP_011885509.1, XP_011885510.1, XP_011885511.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAFSDLTSRT VHLYDNWIKD ADPRVEDWLL MSSPLPQTIL LGFYVYFVTS LGPKLMENRK 60 61 PFELKKVMIT YNFLIVLFSV YMCYEFVMSG WGIGYSFRCE IVDYSQSPTA LRMARTCWLY 120 121 YFSKFIELLD TIFFVLRKKN NQVTFLHVFH HTIMPWTWWF GVKFAAGGLG TFHALLNTAV 180 181 HVVMYSYYGL SALGPAYHKY LWWKKYLTSL QLVQFVIVTI HISQFFFMED CKYQFPVFAC 240 241 IIMSYSCMFL LLFLHFWYLA YTKGQRLPKT VKNGTCKYKD N 281 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTTCA GTGATCTTAC ATCGAGGACT GTGCATCTTT ATGATAATTG GATCAAAGAT 60 61 GCTGATCCAA GAGTTGAAGA TTGGCTCCTC ATGTCCTCGC CTCTGCCGCA AACCATCCTT 120 121 CTAGGATTCT ATGTCTATTT TGTCACTTCT CTGGGACCAA AGCTCATGGA AAATCGCAAG 180 181 CCCTTTGAAC TCAAGAAAGT GATGATAACG TACAATTTTT TAATAGTACT CTTTTCTGTG 240 241 TATATGTGTT ATGAGTTTGT GATGTCTGGC TGGGGTATAG GTTATTCATT TCGATGTGAA 300 301 ATTGTTGACT ATTCACAGTC ACCCACAGCT TTGAGGATGG CACGTACCTG CTGGCTTTAT 360 361 TACTTCTCCA AATTTATTGA GCTATTAGAT ACGATCTTTT TTGTTCTGCG CAAGAAAAAT 420 421 AACCAAGTGA CTTTCCTTCA TGTATTCCAT CATACCATCA TGCCGTGGAC CTGGTGGTTT 480 481 GGAGTCAAAT TTGCTGCAGG TGGTTTGGGA ACATTCCATG CCCTTCTAAA TACAGCTGTA 540 541 CATGTAGTCA TGTATTCCTA CTACGGACTC TCTGCACTGG GACCAGCCTA CCATAAGTAT 600 601 TTGTGGTGGA AAAAATATTT GACATCATTA CAGCTTGTCC AGTTTGTTAT TGTCACCATC 660 661 CACATAAGCC AGTTCTTTTT CATGGAGGAT TGCAAGTATC AGTTTCCAGT CTTTGCGTGC 720 721 ATCATAATGA GTTACAGTTG CATGTTTCTG CTGCTCTTTC TCCATTTTTG GTACCTTGCT 780 781 TACACCAAAG GTCAGAGGTT GCCCAAAACT GTGAAAAATG GAACTTGCAA ATACAAAGAT 840 841 AACTGA 846 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | 3-oxo-arachidoyl-CoA synthase activity | |
Molecular Function | 3-oxo-cerotoyl-CoA synthase activity | |
Molecular Function | 3-oxo-lignoceronyl-CoA synthase activity | |
Molecular Function | Fatty acid elongase activity | |
Molecular Function | Very-long-chain 3-ketoacyl-CoA synthase activity | |
Biological Process | Fatty acid elongation, monounsaturated fatty acid | |
Biological Process | Fatty acid elongation, polyunsaturated fatty acid | |
Biological Process | Fatty acid elongation, saturated fatty acid | |
Biological Process | Long-chain fatty-acyl-CoA biosynthetic process | |
Biological Process | Unsaturated fatty acid biosynthetic process | |
Biological Process | Very long-chain fatty acid biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-2056 | Macaca mulatta | 98.93 | 0.0 | 578 |
| LLPS-Maf-3765 | Macaca fascicularis | 98.93 | 0.0 | 578 |
| LLPS-Mal-2730 | Mandrillus leucophaeus | 98.93 | 0.0 | 578 |
| LLPS-Paa-4664 | Papio anubis | 98.93 | 0.0 | 578 |
| LLPS-Rhb-1647 | Rhinopithecus bieti | 97.51 | 0.0 | 570 |
| LLPS-Nol-4159 | Nomascus leucogenys | 97.15 | 0.0 | 546 |
| LLPS-Poa-0713 | Pongo abelii | 96.8 | 0.0 | 551 |
| LLPS-Hos-0704 | Homo sapiens | 96.44 | 0.0 | 543 |
| LLPS-Pat-4467 | Pan troglodytes | 96.44 | 0.0 | 541 |
| LLPS-Pap-0758 | Pan paniscus | 96.44 | 0.0 | 541 |
| LLPS-Gog-2803 | Gorilla gorilla | 96.44 | 0.0 | 543 |
| LLPS-Caj-2439 | Callithrix jacchus | 93.59 | 0.0 | 545 |
| LLPS-Fec-1625 | Felis catus | 92.17 | 0.0 | 540 |
| LLPS-Tut-1667 | Tursiops truncatus | 92.17 | 0.0 | 538 |
| LLPS-Myl-0317 | Myotis lucifugus | 92.17 | 0.0 | 540 |
| LLPS-Caf-3712 | Canis familiaris | 91.81 | 0.0 | 538 |
| LLPS-Cas-3030 | Carlito syrichta | 91.81 | 0.0 | 535 |
| LLPS-Urm-0069 | Ursus maritimus | 91.46 | 0.0 | 537 |
| LLPS-Loa-4302 | Loxodonta africana | 91.46 | 0.0 | 534 |
| LLPS-Otg-4381 | Otolemur garnettii | 91.46 | 0.0 | 534 |
| LLPS-Aim-4304 | Ailuropoda melanoleuca | 91.1 | 0.0 | 535 |
| LLPS-Bot-2334 | Bos taurus | 90.75 | 0.0 | 533 |
| LLPS-Man-4744 | Macaca nemestrina | 90.46 | 0.0 | 519 |
| LLPS-Mup-4033 | Mustela putorius furo | 90.39 | 0.0 | 535 |
| LLPS-Ere-0868 | Erinaceus europaeus | 90.11 | 0.0 | 529 |
| LLPS-Eqc-0639 | Equus caballus | 90.04 | 0.0 | 526 |
| LLPS-Sus-1867 | Sus scrofa | 89.32 | 0.0 | 525 |
| LLPS-Orc-3806 | Oryctolagus cuniculus | 88.61 | 0.0 | 522 |
| LLPS-Ict-1785 | Ictidomys tridecemlineatus | 88.61 | 3e-177 | 497 |
| LLPS-Ova-0319 | Ovis aries | 88.26 | 0.0 | 525 |
| LLPS-Mum-3743 | Mus musculus | 87.54 | 0.0 | 516 |
| LLPS-Dio-0697 | Dipodomys ordii | 87.46 | 0.0 | 515 |
| LLPS-Mea-2739 | Mesocricetus auratus | 86.83 | 0.0 | 516 |
| LLPS-Sah-3965 | Sarcophilus harrisii | 85.05 | 0.0 | 509 |
| LLPS-Mod-1614 | Monodelphis domestica | 84.7 | 2e-179 | 503 |
| LLPS-Fud-3866 | Fukomys damarensis | 83.63 | 1e-176 | 496 |
| LLPS-Cap-0988 | Cavia porcellus | 83.51 | 2e-175 | 493 |
| LLPS-Ran-0090 | Rattus norvegicus | 82.93 | 5e-123 | 357 |
| LLPS-Leo-2154 | Lepisosteus oculatus | 76.28 | 6e-156 | 444 |
| LLPS-Lac-0488 | Latimeria chalumnae | 76.25 | 1e-149 | 427 |
| LLPS-Fia-3464 | Ficedula albicollis | 75.09 | 2e-159 | 453 |
| LLPS-Tag-2264 | Taeniopygia guttata | 74.73 | 9e-160 | 453 |
| LLPS-Xet-1331 | Xenopus tropicalis | 74.38 | 1e-152 | 436 |
| LLPS-Gaga-3029 | Gallus gallus | 74.37 | 7e-157 | 446 |
| LLPS-Scf-1851 | Scleropages formosus | 73.31 | 2e-156 | 445 |
| LLPS-Pes-0924 | Pelodiscus sinensis | 72.95 | 8e-156 | 443 |
| LLPS-Anp-1606 | Anas platyrhynchos | 72.92 | 2e-152 | 434 |
| LLPS-Asm-3393 | Astyanax mexicanus | 72.46 | 1e-151 | 432 |
| LLPS-Icp-0705 | Ictalurus punctatus | 71.53 | 4e-155 | 442 |
| LLPS-Xim-3398 | Xiphophorus maculatus | 70.11 | 1e-143 | 412 |
| LLPS-Anc-1450 | Anolis carolinensis | 69.68 | 5e-144 | 413 |
| LLPS-Pof-1943 | Poecilia formosa | 69.4 | 1e-141 | 408 |
| LLPS-Orn-2673 | Oreochromis niloticus | 67.62 | 2e-140 | 405 |
| LLPS-Ten-0487 | Tetraodon nigroviridis | 67.26 | 3e-136 | 394 |
| LLPS-Scm-2058 | Scophthalmus maximus | 65.84 | 3e-134 | 389 |
| LLPS-Orl-2064 | Oryzias latipes | 65.84 | 4e-137 | 396 |
| LLPS-Dar-4122 | Danio rerio | 65.48 | 8e-144 | 413 |
| LLPS-Tar-0772 | Takifugu rubripes | 65.48 | 5e-142 | 409 |
| LLPS-Gaa-2823 | Gasterosteus aculeatus | 65.48 | 4e-136 | 394 |
| LLPS-Meg-0638 | Meleagris gallopavo | 56.88 | 4e-118 | 348 |
| LLPS-Ora-1454 | Ornithorhynchus anatinus | 55.46 | 3e-39 | 142 |
| LLPS-Cii-1615 | Ciona intestinalis | 48.52 | 3e-91 | 279 |
| LLPS-Drm-0956 | Drosophila melanogaster | 47.2 | 1e-79 | 253 |
| LLPS-Chs-1691 | Chlorocebus sabaeus | 42.86 | 2e-56 | 189 |
| LLPS-Aon-2626 | Aotus nancymaae | 42.86 | 4e-56 | 189 |
| LLPS-Met-2317 | Medicago truncatula | 36.63 | 1e-12 | 69.7 |
| LLPS-Mae-1673 | Manihot esculenta | 36.54 | 5e-08 | 57.0 |
| LLPS-Phv-1880 | Phaseolus vulgaris | 36.19 | 1e-10 | 64.7 |
| LLPS-Brn-2958 | Brassica napus | 35.64 | 2e-08 | 58.5 |
| LLPS-Pug-0786 | Puccinia graminis | 35.61 | 4e-13 | 72.0 |
| LLPS-Orp-2129 | Oryza punctata | 35.51 | 1e-06 | 52.8 |
| LLPS-Gas-0729 | Galdieria sulphuraria | 35.5 | 4e-19 | 87.8 |
| LLPS-Tum-0999 | Tuber melanosporum | 34.46 | 5e-12 | 68.9 |
| LLPS-Viv-1949 | Vitis vinifera | 33.96 | 7e-08 | 56.6 |
| LLPS-Dos-1426 | Dothistroma septosporum | 33.7 | 3e-13 | 72.8 |
| LLPS-Sol-2156 | Solanum lycopersicum | 33.33 | 3e-13 | 72.0 |
| LLPS-Abg-1267 | Absidia glauca | 33.33 | 1e-11 | 68.2 |
| LLPS-Php-0292 | Physcomitrella patens | 32.67 | 3e-20 | 92.8 |
| LLPS-Crn-0928 | Cryptococcus neoformans | 32.23 | 1e-12 | 70.5 |
| LLPS-Zyt-1149 | Zymoseptoria tritici | 30.84 | 2e-10 | 64.7 |
| LLPS-Cogr-0789 | Colletotrichum graminicola | 30.43 | 1e-14 | 76.6 |
| LLPS-Asn-1531 | Aspergillus nidulans | 30.04 | 3e-17 | 83.6 |
| LLPS-Blg-1546 | Blumeria graminis | 29.77 | 2e-14 | 76.3 |
| LLPS-Fus-1472 | Fusarium solani | 29.71 | 1e-14 | 76.6 |
| LLPS-Ast-1576 | Aspergillus terreus | 29.6 | 1e-12 | 71.2 |
| LLPS-Aso-0317 | Aspergillus oryzae | 29.32 | 3e-12 | 69.7 |
| LLPS-Asf-0757 | Aspergillus flavus | 29.32 | 3e-12 | 69.7 |
| LLPS-Nia-2575 | Nicotiana attenuata | 29.17 | 1e-12 | 70.5 |
| LLPS-Brr-0788 | Brassica rapa | 28.49 | 2e-09 | 61.2 |
| LLPS-Bro-2458 | Brassica oleracea | 28.0 | 4e-09 | 60.5 |
| LLPS-Arl-2581 | Arabidopsis lyrata | 26.82 | 9e-10 | 62.0 |
| LLPS-Pot-1549 | Populus trichocarpa | 26.6 | 8e-09 | 59.7 |
| LLPS-Art-2236 | Arabidopsis thaliana | 26.5 | 2e-09 | 60.8 |