• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scm-2058
ELOVL7

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Elongation of very long chain fatty acids protein 7; 3-keto acyl-CoA synthase ELOVL7; ELOVL fatty acid elongase 7; ELOVL FA elongase 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7
Gene Name: ELOVL7, SMAX5B_010506
Ensembl Gene: ENSSMAG00000001693.1
Ensembl Protein: ENSSMAP00000002738.1
Organism: Scophthalmus maximus
Taxa ID: 52904
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEFSDIKSSA  ALMYDEFIQN  ADWRTGNWFL  MSSPVPQALI  IVAYIYFVTS  LGPRIMENRK  60
61    AFDLKGVLIV  YNFGVVALSL  YMCYEFVMSG  WGTGYNFHCD  LIDFSDSPQG  VRMAATCWLY  120
121   YFSKFIEMLD  TVFFVLRKKN  TQVTFLHVYH  HSIMPFTWWF  GVRFAGGGMG  TFHALLNCIV  180
181   HVIMYSYYGL  TAMGPKYQKY  LWWKKYLTTI  QLIQFVMVTS  HISQYFFMDC  PYQFPIFIYI  240
241   IGLYGLIFLF  LFLNFWYHAY  TKGKRLPKVL  QAQRWAHHSN  GVMNGNANHD  KDE  293
Nucleotide CDS Sequence (FASTA)
1     ATGGAATTCA  GCGATATAAA  GTCCTCGGCC  GCGCTCATGT  ACGATGAGTT  CATCCAAAAT  60
61    GCAGACTGGC  GCACGGGGAA  CTGGTTCCTC  ATGTCGTCCC  CTGTGCCCCA  AGCGCTCATC  120
121   ATTGTAGCAT  ACATTTACTT  TGTCACGTCA  CTGGGGCCCC  GGATAATGGA  GAACCGCAAA  180
181   GCCTTCGACC  TCAAGGGAGT  TCTCATCGTC  TACAACTTTG  GCGTGGTCGC  TCTGTCGCTC  240
241   TACATGTGCT  ACGAGTTTGT  GATGTCGGGA  TGGGGCACAG  GATACAATTT  TCACTGTGAC  300
301   CTGATTGACT  TCTCTGATTC  ACCACAGGGC  GTGAGGATGG  CAGCAACATG  CTGGCTTTAC  360
361   TACTTCTCAA  AGTTCATCGA  GATGTTGGAC  ACAGTCTTCT  TTGTCCTGAG  GAAGAAAAAC  420
421   ACCCAGGTGA  CATTTCTCCA  CGTCTACCAT  CACTCCATCA  TGCCCTTCAC  CTGGTGGTTT  480
481   GGCGTTCGTT  TTGCCGGAGG  CGGCATGGGT  ACATTCCACG  CCCTGCTCAA  CTGCATCGTC  540
541   CATGTCATCA  TGTACTCGTA  CTACGGCCTC  ACCGCCATGG  GCCCCAAATA  CCAGAAGTAC  600
601   CTGTGGTGGA  AGAAATACCT  CACTACCATT  CAGCTCATCC  AGTTTGTCAT  GGTGACGAGC  660
661   CACATCTCCC  AGTATTTCTT  CATGGATTGC  CCCTACCAGT  TCCCCATCTT  CATATACATC  720
721   ATCGGCCTGT  ACGGCCTGAT  TTTCCTGTTC  CTCTTCCTCA  ACTTCTGGTA  CCACGCCTAC  780
781   ACCAAGGGCA  AGAGGCTGCC  GAAAGTTCTG  CAGGCTCAGA  GATGGGCACA  CCACAGCAAT  840
841   GGGGTTATGA  ATGGAAACGC  CAATCATGAT  AAGGACGAGT  GA  882

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Molecular Function
3-oxo-arachidoyl-CoA synthase activity
Molecular Function
3-oxo-cerotoyl-CoA synthase activity
Molecular Function
3-oxo-lignoceronyl-CoA synthase activity
Molecular Function
Fatty acid elongase activity
Molecular Function
Very-long-chain 3-ketoacyl-CoA synthase activity
Biological Process
Fatty acid elongation, monounsaturated fatty acid
Biological Process
Fatty acid elongation, polyunsaturated fatty acid
Biological Process
Fatty acid elongation, saturated fatty acid
Biological Process
Long-chain fatty-acyl-CoA biosynthetic process
Biological Process
Unsaturated fatty acid biosynthetic process
Biological Process
Very long-chain fatty acid biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-2673Oreochromis niloticus89.88e-170 480
LLPS-Pof-1943Poecilia formosa87.338e-164 464
LLPS-Orl-2064Oryzias latipes86.397e-165 467
LLPS-Xim-3398Xiphophorus maculatus85.962e-162 461
LLPS-Gaa-2823Gasterosteus aculeatus84.782e-158 451
LLPS-Tar-0772Takifugu rubripes84.694e-163 462
LLPS-Ten-0487Tetraodon nigroviridis81.852e-159 453
LLPS-Scf-1851Scleropages formosus78.316e-137 396
LLPS-Lac-0488Latimeria chalumnae73.332e-121 356
LLPS-Leo-2154Lepisosteus oculatus73.245e-129 376
LLPS-Icp-0705Ictalurus punctatus73.018e-138 398
LLPS-Ran-0090Rattus norvegicus72.494e-78 243
LLPS-Xet-1331Xenopus tropicalis71.326e-120 354
LLPS-Ict-1785Ictidomys tridecemlineatus70.264e-117 345
LLPS-Pes-0924Pelodiscus sinensis69.499e-123 360
LLPS-Dio-0697Dipodomys ordii69.126e-118 347
LLPS-Mea-2739Mesocricetus auratus69.126e-119 350
LLPS-Dar-4122Danio rerio69.054e-129 376
LLPS-Tag-2264Taeniopygia guttata68.892e-119 351
LLPS-Eqc-0639Equus caballus68.382e-119 351
LLPS-Fia-3464Ficedula albicollis68.387e-119 351
LLPS-Myl-0317Myotis lucifugus68.382e-119 351
LLPS-Bot-2334Bos taurus68.381e-118 349
LLPS-Caj-2439Callithrix jacchus68.382e-119 351
LLPS-Mum-3743Mus musculus68.388e-118 347
LLPS-Asm-3393Astyanax mexicanus68.372e-127 372
LLPS-Otg-4381Otolemur garnettii68.253e-119 351
LLPS-Loa-4302Loxodonta africana68.252e-119 351
LLPS-Gaga-3029Gallus gallus68.012e-117 346
LLPS-Cas-3030Carlito syrichta68.011e-117 346
LLPS-Urm-0069Ursus maritimus68.013e-119 351
LLPS-Nol-4159Nomascus leucogenys67.652e-118 348
LLPS-Poa-0713Pongo abelii67.652e-119 351
LLPS-Hos-0704Homo sapiens67.654e-118 348
LLPS-Pat-4467Pan troglodytes67.656e-118 347
LLPS-Pap-0758Pan paniscus67.656e-118 347
LLPS-Aim-4304Ailuropoda melanoleuca67.522e-119 351
LLPS-Rhb-1647Rhinopithecus bieti67.285e-119 350
LLPS-Mup-4033Mustela putorius furo67.286e-120 352
LLPS-Gog-2803Gorilla gorilla67.281e-117 347
LLPS-Mod-1614Monodelphis domestica67.138e-120 352
LLPS-Ova-0319Ovis aries66.911e-117 347
LLPS-Sus-1867Sus scrofa66.913e-116 343
LLPS-Sah-3965Sarcophilus harrisii66.789e-120 352
LLPS-Orc-3806Oryctolagus cuniculus66.541e-117 347
LLPS-Mam-2056Macaca mulatta65.841e-119 352
LLPS-Paa-4664Papio anubis65.843e-119 351
LLPS-Mal-2730Mandrillus leucophaeus65.841e-119 352
LLPS-Cea-4116Cercocebus atys65.842e-119 351
LLPS-Maf-3765Macaca fascicularis65.841e-119 352
LLPS-Ere-0868Erinaceus europaeus65.539e-119 350
LLPS-Fud-3866Fukomys damarensis65.445e-112 332
LLPS-Tut-1667Tursiops truncatus65.294e-118 348
LLPS-Fec-1625Felis catus65.173e-119 350
LLPS-Cap-0988Cavia porcellus65.112e-113 336
LLPS-Anp-1606Anas platyrhynchos65.075e-110 327
LLPS-Anc-1450Anolis carolinensis64.514e-117 345
LLPS-Caf-3712Canis familiaris64.361e-119 352
LLPS-Man-4744Macaca nemestrina60.422e-100 303
LLPS-Meg-0638Meleagris gallopavo58.062e-95 290
LLPS-Ora-1454Ornithorhynchus anatinus52.591e-35 133
LLPS-Cii-1615Ciona intestinalis49.621e-70 226
LLPS-Drm-0956Drosophila melanogaster46.693e-62 208
LLPS-Chs-1691Chlorocebus sabaeus43.527e-45 160
LLPS-Phv-1880Phaseolus vulgaris40.744e-0960.5
LLPS-Nia-2575Nicotiana attenuata40.263e-0857.8
LLPS-Aon-2626Aotus nancymaae39.519e-45 159
LLPS-Met-2317Medicago truncatula38.382e-1063.9
LLPS-Sol-2156Solanum lycopersicum37.56e-0650.8
LLPS-Asn-1531Aspergillus nidulans35.522e-1270.9
LLPS-Php-0292Physcomitrella patens35.56e-1989.0
LLPS-Gas-0729Galdieria sulphuraria34.731e-0960.8
LLPS-Fus-1472Fusarium solani34.23e-1270.1
LLPS-Ast-1576Aspergillus terreus33.154e-1063.9
LLPS-Blg-1546Blumeria graminis32.962e-0961.6
LLPS-Zyt-1149Zymoseptoria tritici32.461e-0756.6
LLPS-Asf-0757Aspergillus flavus32.319e-1062.8
LLPS-Aso-0317Aspergillus oryzae32.319e-1062.8
LLPS-Brr-0788Brassica rapa31.188e-0856.6
LLPS-Dos-1426Dothistroma septosporum31.094e-0857.8
LLPS-Cogr-0789Colletotrichum graminicola30.822e-0858.9
LLPS-Brn-2958Brassica napus29.675e-0754.3
LLPS-Mae-1673Manihot esculenta29.521e-0652.8
LLPS-Bro-2458Brassica oleracea29.413e-0857.8
LLPS-Arl-2581Arabidopsis lyrata29.125e-0754.3
LLPS-Art-2236Arabidopsis thaliana28.84e-0754.3
LLPS-Pot-1549Populus trichocarpa25.654e-0857.4