• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tut-0450
PRMT5

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein arginine N-methyltransferase 5
Gene Name: PRMT5
Ensembl Gene: ENSTTRG00000001501.1
Ensembl Protein: ENSTTRP00000001417.1
Organism: Tursiops truncatus
Taxa ID: 9739
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     FDFLCMPVFH  PRFKREFTQE  PAKNRPGPQT  RSDLLLSGRD  WNTLIVGKLS  PWIRPDSKVE  60
61    KIRRNSEAAM  LQELNFGAYL  GLPAFLLPLN  QEDNTNLARV  LTNHIHTGHH  SSMFWMRVPL  120
121   VAPEDLRDDI  IENAPTSHTE  EYSGEEKTWM  WWHNFRTLCD  YSKRIAVALE  IGADLPSNHV  180
181   IDRWLGEPIK  AAILPTSIFL  TNKKGFPVLS  KMHQRLIFRL  LKLEVQFIIT  GTNHHSEKEF  240
241   CSYLQYLEYL  SQNRPPPNAY  ELFAKGYEDY  LQSPLQPLMD  NLESQTYEVF  EKDPIKYSQY  300
301   QQAIYKCLLD  RVPEEEKDTN  VQVLMVLGAG  RGPLVNASLR  AAKQADRRIK  LYAVEKNPNA  360
361   VVTLENWQFE  EWGSQVTVVS  SDMREWVAPE  KADIIVSELL  GSFADNELSP  ECLDGTQHFL  420
421   KDDGVSIPGE  YTSFLAPISS  SKLYNEVRAC  REKDRDPEAQ  FEMPYVVRLH  NFHQLSAPQP  480
481   CFTFSHPNRD  PMIDNNRYCT  LEFPVEVNTV  LHGFAGYFET  VLYQDITLSI  RPETHSPGMF  540
541   SWFPILFPIK  QPITVREGQT  ICVRFWRCSN  SKKVWYEWAV  TAPVCSAIHN  PTGRSYTIGL  600
Nucleotide CDS Sequence (FASTA)
1     TTTGATTTCC  TCTGCATGCC  TGTGTTCCAC  CCGCGTTTCA  AGAGGGAGTT  CACTCAGGAA  60
61    CCTGCTAAGA  ATCGGCCGGG  CCCCCAGACA  CGATCAGACC  TACTGCTGTC  AGGAAGGGAC  120
121   TGGAATACAC  TAATTGTGGG  AAAGCTTTCT  CCATGGATTC  GTCCAGACTC  AAAAGTGGAA  180
181   AAGATCCGCA  GGAACTCCGA  GGCGGCTATG  TTACAGGAGC  TGAATTTTGG  GGCATATTTG  240
241   GGTCTTCCAG  CTTTCCTGCT  GCCCCTAAAT  CAGGAAGATA  ACACAAACTT  GGCGCGAGTT  300
301   TTGACCAACC  ACATCCACAC  TGGCCACCAC  TCCTCCATGT  TCTGGATGCG  GGTGCCATTG  360
361   GTGGCACCAG  AGGACCTGAG  AGATGATATA  ATTGAGAATG  CGCCAACTTC  ACACACAGAG  420
421   GAGTACAGTG  GAGAGGAGAA  GACATGGATG  TGGTGGCACA  ACTTCCGGAC  CTTGTGTGAT  480
481   TATAGCAAGA  GGATTGCGGT  GGCTCTCGAA  ATTGGTGCTG  ACCTCCCATC  TAATCATGTC  540
541   ATTGACCGTT  GGCTTGGGGA  GCCCATCAAA  GCAGCCATTC  TCCCCACCAG  CATTTTCCTG  600
601   ACCAATAAGA  AGGGATTTCC  TGTTCTTTCT  AAGATGCACC  AGAGGCTGAT  CTTCCGACTC  660
661   CTCAAGTTGG  AGGTGCAGTT  CATCATCACA  GGCACCAACC  ACCACTCAGA  GAAAGAGTTC  720
721   TGCTCCTACC  TCCAGTACTT  GGAATACTTG  AGCCAGAATC  GACCTCCACC  CAATGCCTAC  780
781   GAACTCTTTG  CCAAGGGCTA  TGAAGACTAC  CTGCAATCCC  CACTCCAGCC  ACTGATGGAT  840
841   AATCTGGAAT  CTCAGACATA  CGAAGTGTTT  GAAAAGGACC  CTATCAAATA  CTCTCAATAC  900
901   CAACAGGCCA  TCTATAAATG  TCTGTTAGAC  CGAGTGCCAG  AGGAAGAGAA  GGACACCAAT  960
961   GTCCAAGTGC  TGATGGTGCT  GGGAGCAGGC  CGGGGGCCCC  TGGTGAATGC  TTCCCTGAGG  1020
1021  GCAGCCAAGC  AGGCTGACCG  GCGGATAAAG  CTGTATGCTG  TGGAGAAGAA  CCCAAATGCT  1080
1081  GTGGTGACGC  TGGAGAATTG  GCAGTTTGAA  GAATGGGGAA  GCCAGGTGAC  AGTAGTCTCA  1140
1141  TCGGACATGC  GGGAGTGGGT  GGCTCCAGAG  AAAGCGGATA  TCATTGTCAG  TGAGCTTCTG  1200
1201  GGGTCCTTCG  CTGATAATGA  GCTGTCACCG  GAATGCCTGG  ATGGAACCCA  GCACTTCCTT  1260
1261  AAAGATGATG  GCGTGAGCAT  CCCTGGGGAG  TACACCTCCT  TTCTAGCTCC  CATCTCCTCC  1320
1321  TCCAAGCTGT  ACAATGAGGT  CCGAGCCTGT  CGGGAAAAGG  ACCGCGACCC  TGAGGCCCAG  1380
1381  TTTGAAATGC  CTTATGTGGT  ACGACTGCAC  AATTTCCACC  AGCTGTCTGC  GCCCCAGCCC  1440
1441  TGTTTTACCT  TCAGCCATCC  CAACAGAGAT  CCTATGATTG  ACAACAACCG  CTACTGCACC  1500
1501  TTGGAGTTTC  CCGTGGAGGT  GAACACGGTG  CTGCATGGCT  TTGCAGGCTA  CTTTGAGACT  1560
1561  GTGCTTTATC  AGGACATCAC  TCTGAGTATC  CGCCCAGAGA  CTCACTCTCC  TGGGATGTTT  1620
1621  TCATGGTTTC  CCATCCTCTT  CCCCATTAAG  CAGCCCATTA  CCGTGCGTGA  AGGCCAGACC  1680
1681  ATCTGTGTGC  GTTTCTGGCG  ATGCAGCAAT  TCCAAGAAGG  TGTGGTATGA  GTGGGCTGTG  1740
1741  ACAGCACCAG  TCTGTTCTGC  TATTCACAAC  CCCACAGGCC  GCTCTTACAC  CATTGGCCTC  1800
1801  TAG  1803

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Methyltransferase
Nucleus
Reference proteome
S-adenosyl-L-methionine
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Histone-arginine N-methyltransferase activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cea-0799Cercocebus atys99.50.01250
LLPS-Maf-0042Macaca fascicularis99.50.01250
LLPS-Gog-0149Gorilla gorilla99.50.01252
LLPS-Bot-0625Bos taurus99.50.01253
LLPS-Ova-0382Ovis aries99.50.01253
LLPS-Paa-1254Papio anubis99.50.01252
LLPS-Mal-1962Mandrillus leucophaeus99.50.01250
LLPS-Man-2564Macaca nemestrina99.50.01254
LLPS-Hos-0618Homo sapiens99.50.01252
LLPS-Pap-1578Pan paniscus99.50.01250
LLPS-Pat-0966Pan troglodytes99.50.01250
LLPS-Cas-0265Carlito syrichta99.50.01250
LLPS-Chs-0486Chlorocebus sabaeus99.330.01250
LLPS-Mup-3238Mustela putorius furo99.330.01252
LLPS-Fec-0660Felis catus99.330.01252
LLPS-Urm-2098Ursus maritimus99.330.01252
LLPS-Poa-1903Pongo abelii99.330.01251
LLPS-Ict-2113Ictidomys tridecemlineatus99.330.01249
LLPS-Sus-2626Sus scrofa99.30.01194
LLPS-Otg-0110Otolemur garnettii99.170.01251
LLPS-Eqc-0130Equus caballus99.170.01250
LLPS-Caf-0303Canis familiaris99.170.01252
LLPS-Aon-2172Aotus nancymaae99.00.01248
LLPS-Caj-2555Callithrix jacchus99.00.01247
LLPS-Aim-2349Ailuropoda melanoleuca99.00.01249
LLPS-Loa-1157Loxodonta africana99.00.01247
LLPS-Cap-3222Cavia porcellus99.00.01247
LLPS-Dio-2685Dipodomys ordii98.830.01244
LLPS-Myl-3059Myotis lucifugus98.830.01249
LLPS-Fud-1857Fukomys damarensis98.50.01241
LLPS-Orc-2162Oryctolagus cuniculus98.50.01243
LLPS-Rhb-2129Rhinopithecus bieti97.870.01241
LLPS-Mam-1811Macaca mulatta97.870.01241
LLPS-Mum-1487Mus musculus97.330.01228
LLPS-Ran-1579Rattus norvegicus97.330.01228
LLPS-Nol-0930Nomascus leucogenys97.330.01209
LLPS-Mod-0908Monodelphis domestica95.50.01208
LLPS-Sah-0320Sarcophilus harrisii94.420.01142
LLPS-Ora-2124Ornithorhynchus anatinus89.04e-129 395
LLPS-Anc-0448Anolis carolinensis85.020.01078
LLPS-Xet-2625Xenopus tropicalis84.190.01095
LLPS-Lac-0169Latimeria chalumnae83.550.0 942
LLPS-Leo-1656Lepisosteus oculatus79.834e-59 199
LLPS-Asm-0720Astyanax mexicanus79.830.01029
LLPS-Scf-2089Scleropages formosus79.50.01028
LLPS-Orn-0808Oreochromis niloticus79.170.01022
LLPS-Xim-0596Xiphophorus maculatus78.830.01023
LLPS-Dar-2641Danio rerio78.830.01014
LLPS-Icp-2781Ictalurus punctatus78.50.01014
LLPS-Pof-1963Poecilia formosa78.50.01024
LLPS-Orl-2141Oryzias latipes78.330.01009
LLPS-Scm-0582Scophthalmus maximus78.00.01008
LLPS-Gaa-1151Gasterosteus aculeatus77.830.01004
LLPS-Ten-0432Tetraodon nigroviridis77.830.01015
LLPS-Tar-1160Takifugu rubripes72.270.0 930
LLPS-Meg-2279Meleagris gallopavo72.221e-31 122
LLPS-Coc-0442Corchorus capsularis69.322e-34 130
LLPS-Gaga-0042Gallus gallus56.122e-2195.9
LLPS-Cii-1029Ciona intestinalis52.440.0 641
LLPS-Via-0079Vigna angularis49.280.0 579
LLPS-Vir-0993Vigna radiata49.070.0 541
LLPS-Phv-1208Phaseolus vulgaris48.630.0 570
LLPS-Lep-0834Leersia perrieri48.560.0 578
LLPS-Orbr-1438Oryza brachyantha48.40.0 578
LLPS-Sob-0482Sorghum bicolor48.320.0 570
LLPS-Glm-1282Glycine max48.310.0 568
LLPS-Sei-0761Setaria italica48.240.0 577
LLPS-Ors-0541Oryza sativa48.240.0 575
LLPS-Org-1142Oryza glaberrima48.240.0 575
LLPS-Tra-0128Triticum aestivum48.170.0 580
LLPS-Php-0614Physcomitrella patens48.110.0 568
LLPS-Mua-1482Musa acuminata47.90.0 548
LLPS-Hov-0748Hordeum vulgare47.850.0 568
LLPS-Brd-0612Brachypodium distachyon47.760.0 566
LLPS-Nia-1149Nicotiana attenuata47.460.0 571
LLPS-Art-2120Arabidopsis thaliana47.420.0 559
LLPS-Prp-0360Prunus persica47.370.0 574
LLPS-Viv-0349Vitis vinifera47.280.0 567
LLPS-Sem-0040Selaginella moellendorffii47.230.0 554
LLPS-Tru-1384Triticum urartu47.190.0 551
LLPS-Arl-1465Arabidopsis lyrata47.180.0 555
LLPS-Brn-1320Brassica napus46.940.0 562
LLPS-Brr-2383Brassica rapa46.940.0 567
LLPS-Bro-0554Brassica oleracea46.940.0 562
LLPS-Chc-0345Chondrus crispus46.60.0 534
LLPS-Mae-1072Manihot esculenta46.570.0 559
LLPS-Amt-0332Amborella trichopoda46.360.0 543
LLPS-Met-0698Medicago truncatula46.250.0 547
LLPS-Sol-1680Solanum lycopersicum46.190.0 554
LLPS-Abg-1003Absidia glauca46.190.0 548
LLPS-Pot-0794Populus trichocarpa45.850.0 547
LLPS-Gor-0339Gossypium raimondii45.770.0 543
LLPS-Hea-1061Helianthus annuus45.580.0 553
LLPS-Thc-0586Theobroma cacao45.450.0 540
LLPS-Ori-0676Oryza indica45.253e-164 489
LLPS-Cus-0571Cucumis sativus45.143e-180 532
LLPS-Orp-0505Oryza punctata45.141e-170 506
LLPS-Orm-0569Oryza meridionalis44.822e-169 503
LLPS-Dac-0792Daucus carota44.753e-180 532
LLPS-Zem-0028Zea mays44.731e-179 532
LLPS-Usm-0303Ustilago maydis43.556e-119 377
LLPS-Map-0456Magnaporthe poae42.865e-1887.4
LLPS-Crn-0252Cryptococcus neoformans42.82e-114 368
LLPS-Orb-1542Oryza barthii42.649e-164 489
LLPS-Orni-0479Oryza nivara42.649e-164 489
LLPS-Orr-0037Oryza rufipogon42.491e-163 489
LLPS-Phn-0208Phaeosphaeria nodorum41.984e-87 294
LLPS-Chr-0175Chlamydomonas reinhardtii41.912e-156 473
LLPS-Orgl-1122Oryza glumaepatula41.633e-159 479
LLPS-Miv-0667Microbotryum violaceum40.916e-133 414
LLPS-Blg-0864Blumeria graminis40.693e-81 278
LLPS-Drm-0147Drosophila melanogaster40.411e-138 424
LLPS-Osl-0306Ostreococcus lucimarinus39.382e-121 377
LLPS-Put-0042Puccinia triticina39.331e-82 275
LLPS-Asni-0847Aspergillus niger39.241e-109 352
LLPS-Tum-0849Tuber melanosporum39.056e-125 390
LLPS-Pug-0420Puccinia graminis38.386e-105 342
LLPS-Gas-0383Galdieria sulphuraria38.027e-132 408
LLPS-Mel-0778Melampsora laricipopulina37.72e-108 348
LLPS-Yal-0367Yarrowia lipolytica37.583e-109 353
LLPS-Scp-0983Schizosaccharomyces pombe37.379e-118 371
LLPS-Scc-0416Schizosaccharomyces cryophilus37.331e-113 359
LLPS-Spr-0978Sporisorium reilianum37.126e-122 390
LLPS-Scj-0634Schizosaccharomyces japonicus36.925e-123 385
LLPS-Dos-0139Dothistroma septosporum35.446e-111 356
LLPS-Fuo-0332Fusarium oxysporum34.981e-91 305
LLPS-Fus-0097Fusarium solani34.678e-95 314
LLPS-Asn-0377Aspergillus nidulans34.595e-99 327
LLPS-Aso-0504Aspergillus oryzae34.551e-96 320
LLPS-Nef-0257Neosartorya fischeri34.555e-108 351
LLPS-Asfu-0724Aspergillus fumigatus34.552e-106 347
LLPS-Asf-1071Aspergillus flavus34.412e-96 320
LLPS-Asc-0280Aspergillus clavatus34.362e-97 323
LLPS-Ved-0647Verticillium dahliae34.271e-93 311
LLPS-Pytr-1046Pyrenophora triticirepentis34.212e-101 332
LLPS-Pyt-0374Pyrenophora teres34.13e-91 304
LLPS-Cae-0617Caenorhabditis elegans34.063e-97 319
LLPS-Fuv-0193Fusarium verticillioides33.81e-93 311
LLPS-Zyt-0742Zymoseptoria tritici33.755e-101 330
LLPS-Beb-0007Beauveria bassiana33.542e-97 321
LLPS-Trr-0450Trichoderma reesei33.332e-95 315
LLPS-Nec-0518Neurospora crassa32.885e-94 312
LLPS-Coo-0561Colletotrichum orbiculare32.812e-87 293
LLPS-Scs-0480Sclerotinia sclerotiorum32.663e-94 313
LLPS-Asg-0253Ashbya gossypii32.514e-66 236
LLPS-Cogr-0495Colletotrichum graminicola32.498e-96 317
LLPS-Trv-0541Trichoderma virens32.312e-94 313
LLPS-Lem-1201Leptosphaeria maculans32.292e-98 324
LLPS-Mao-0881Magnaporthe oryzae31.944e-85 288
LLPS-Cog-0105Colletotrichum gloeosporioides31.845e-97 320
LLPS-Ast-0030Aspergillus terreus31.555e-74 258
LLPS-Gag-0220Gaeumannomyces graminis31.113e-87 294
LLPS-Kop-0391Komagataella pastoris29.842e-73 256
LLPS-Sac-0321Saccharomyces cerevisiae27.291e-68 244
LLPS-Sot-0117Solanum tuberosum26.777e-0755.8