LLPS-Drm-0147
csul
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein arginine N-methyltransferase 5; JBP1 homolog; Protein arginine N-methyltransferase capsuleen |
| Gene Name: | csul, DART5, CG3730 |
| Ensembl Gene: | FBgn0015925 |
| Ensembl Protein: | FBpp0088811 |
| Organism: | Drosophila melanogaster |
| Taxa ID: | 7227 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body, Postsynaptic density | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA) (By similarity). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3. Required for arginine symmetrical dimethylation of piwi family proteins, piwi, aub and AGO3, during germline development. Required during oogenesis for pole cell formation in the pathway controlled by oskar (osk) and for abdominal segments during early embryogenesis. Involved in nanos (nos) and germ cell mRNAs localization. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | FBtr0089872 | FBpp0088811 |
| Ensembl | FBtr0089871 | FBpp0088810 |
| UniProt | Q9U6Y9, ANM5_DROME, O46117, Q8MKK9, Q9V7L8 | |
| GeneBank | AE013599, AF167574, AY122153, AJ002740 | CAA05712.1, AAF58030.1, AAF04504.1, AAM52665.1, AAM68510.1 |
| RefSeq | NM_057836.4, NM_166158.2 | NP_477184.1, NP_725552.1 |
| Entrez | 36809 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNYYVCLHQE GVNSIPKLIE KAFANNYNVV STSINANMLP FEPHESDPTY PATILSGSDW 60 61 NSKVIFTMSD VNVDSPNDKL REHAKEVFMR DVAWAEHLQN VGNLMVRLRG PENENLASIV 120 121 LAKTKDDFPS GNWFIQVPIT NPELATFEHR KDATAEEVAE AESNDPWNWW NNLRMVTKHS 180 181 TKVKVVIELN DADRPSKETV RRWLGEPIEA IIIPSSLFVR NRSNYCVLKK EWQLIVGHFI 240 241 SVRANIIIST NPNDKALCQY ADYVNKLIND NCDKHMLNSY ENMLEIPLQP LCDNLDTYTY 300 301 EVFETDPVKY KLYQDAVQAA LLDRVSAAEA KTKLTVVMLL GGGRGPLARA VFNAAELTKR 360 361 KVRLYIIEKN PNAIRTLSNM VKTLWADKDV HIFSKDMRDF SPPELADIMV SELLGSFGDN 420 421 ELSPECLDGA LKLLKPDGIS IPYKSTSYIN PLMSAVLHQN VCQLLPTYPA FDYGYVSLLK 480 481 NIYHIDEPQA LFEFVHPNRA ENIDNTRCKT VSFKVNKDCV LHGIGGYFDT HLYKDICLSI 540 541 NPLTHTPGMF SWFPMFFATR PRTLREGQTI SIQFWRCVDA TKVWYEWQVV NSPDDWEHHN 600 601 TRGTGYNMRL 610 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAATTACT ACGTCTGTCT GCACCAGGAG GGTGTTAATA GCATACCCAA GTTAATCGAG 60 61 AAGGCCTTCG CGAACAACTA TAATGTGGTT TCCACCTCTA TCAACGCCAA TATGTTGCCC 120 121 TTCGAACCAC ACGAATCGGA TCCCACATAT CCGGCCACAA TTTTGAGCGG CAGCGACTGG 180 181 AATTCCAAGG TGATATTTAC CATGTCCGAC GTGAATGTGG ACTCGCCGAA TGACAAGCTG 240 241 CGCGAACACG CAAAGGAGGT ATTCATGAGG GACGTGGCCT GGGCGGAGCA CCTGCAAAAT 300 301 GTGGGCAACC TGATGGTACG GCTGCGCGGT CCGGAAAACG AGAATCTGGC CTCCATTGTG 360 361 CTGGCCAAAA CAAAGGATGA TTTTCCTTCA GGGAACTGGT TCATCCAAGT GCCCATCACC 420 421 AATCCAGAAC TGGCCACATT CGAGCACCGA AAGGATGCCA CCGCCGAGGA GGTGGCTGAA 480 481 GCGGAATCGA ATGACCCGTG GAACTGGTGG AATAACCTGC GCATGGTCAC CAAACACAGC 540 541 ACCAAAGTGA AGGTTGTGAT AGAGCTAAAC GATGCTGATC GACCCAGCAA GGAAACAGTG 600 601 CGTCGCTGGT TGGGCGAACC AATCGAGGCA ATCATCATTC CGTCTTCCCT GTTCGTCAGA 660 661 AACCGCTCCA ACTACTGTGT GCTGAAGAAG GAGTGGCAGC TCATCGTCGG GCACTTCATC 720 721 TCGGTACGGG CCAACATCAT CATCTCCACA AATCCCAACG ATAAGGCTTT GTGCCAGTAC 780 781 GCGGATTACG TAAATAAGCT AATTAATGAT AACTGCGATA AGCACATGCT AAACAGCTAT 840 841 GAAAACATGC TGGAAATTCC ACTGCAGCCT CTTTGCGATA ATCTGGACAC CTATACCTAT 900 901 GAGGTATTCG AAACTGATCC TGTCAAATAC AAACTCTATC AGGATGCCGT ACAAGCGGCC 960 961 CTGTTGGATC GAGTAAGCGC TGCGGAGGCT AAAACGAAAC TGACAGTTGT AATGCTACTG 1020 1021 GGTGGAGGAC GAGGTCCTTT AGCGAGAGCT GTTTTCAATG CTGCCGAGTT AACGAAGCGC 1080 1081 AAAGTTCGCC TCTACATCAT AGAAAAGAAT CCCAATGCCA TCCGCACCCT CTCCAACATG 1140 1141 GTTAAAACGC TTTGGGCCGA TAAGGATGTT CACATTTTTT CAAAGGACAT GCGGGACTTT 1200 1201 TCCCCTCCAG AGCTGGCTGA CATCATGGTT TCGGAGTTAC TTGGTTCCTT TGGCGATAAT 1260 1261 GAACTTTCGC CCGAGTGCCT TGATGGAGCA CTGAAGCTGC TCAAACCGGA TGGAATCAGT 1320 1321 ATACCCTACA AATCCACCTC CTACATTAAT CCACTGATGT CAGCAGTGCT GCACCAAAAT 1380 1381 GTCTGCCAAT TGTTACCAAC CTATCCTGCC TTCGACTACG GCTATGTGTC GCTGCTAAAG 1440 1441 AATATTTACC ATATTGACGA GCCGCAGGCT CTGTTTGAAT TCGTACATCC TAATCGAGCG 1500 1501 GAAAATATTG ACAATACTCG CTGCAAGACG GTTTCATTTA AAGTCAATAA AGATTGCGTG 1560 1561 CTGCACGGAA TCGGCGGATA CTTTGATACC CATTTGTACA AGGACATCTG CCTAAGCATC 1620 1621 AATCCTCTGA CCCATACGCC TGGCATGTTC TCCTGGTTCC CCATGTTCTT CGCAACGCGT 1680 1681 CCAAGAACTC TGAGGGAGGG ACAGACTATA TCCATCCAGT TTTGGCGATG CGTGGATGCA 1740 1741 ACCAAAGTGT GGTACGAATG GCAGGTGGTC AATTCTCCAG ACGATTGGGA GCACCATAAC 1800 1801 ACACGCGGGA CAGGTTACAA CATGCGATTG 1830 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Molecular Function | Histone-arginine N-methyltransferase activity | |
Molecular Function | Protein methyltransferase activity | |
Molecular Function | Protein-arginine N-methyltransferase activity | |
Molecular Function | Protein-arginine omega-N symmetric methyltransferase activity | |
Biological Process | Histone arginine methylation | |
Biological Process | Intracellular mRNA localization | |
Biological Process | P granule organization | |
Biological Process | Peptidyl-arginine methylation | |
Biological Process | Pole plasm assembly | |
Biological Process | Pole plasm protein localization |
▼ ANNOTATION
| Physicochemical | ||||
| AAindex | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | ||||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Coc-0442 | Corchorus capsularis | 56.82 | 7e-16 | 79.0 |
| LLPS-Orr-0037 | Oryza rufipogon | 49.55 | 8e-89 | 295 |
| LLPS-Orb-1542 | Oryza barthii | 49.55 | 1e-88 | 295 |
| LLPS-Orni-0479 | Oryza nivara | 49.55 | 1e-88 | 295 |
| LLPS-Orgl-1122 | Oryza glumaepatula | 47.26 | 2e-84 | 284 |
| LLPS-Meg-2279 | Meleagris gallopavo | 47.22 | 7e-14 | 72.8 |
| LLPS-Ora-2124 | Ornithorhynchus anatinus | 47.2 | 2e-49 | 184 |
| LLPS-Orm-0569 | Oryza meridionalis | 43.91 | 5e-91 | 300 |
| LLPS-Orp-0505 | Oryza punctata | 43.91 | 5e-91 | 300 |
| LLPS-Lac-0169 | Latimeria chalumnae | 41.67 | 3e-110 | 352 |
| LLPS-Sah-0320 | Sarcophilus harrisii | 41.21 | 6e-123 | 384 |
| LLPS-Myl-3059 | Myotis lucifugus | 41.2 | 9e-134 | 412 |
| LLPS-Mod-0908 | Monodelphis domestica | 41.09 | 5e-132 | 408 |
| LLPS-Otg-0110 | Otolemur garnettii | 41.06 | 1e-132 | 409 |
| LLPS-Bot-0625 | Bos taurus | 41.06 | 3e-133 | 411 |
| LLPS-Aim-2349 | Ailuropoda melanoleuca | 41.06 | 3e-132 | 409 |
| LLPS-Ova-0382 | Ovis aries | 41.06 | 3e-133 | 411 |
| LLPS-Ran-1579 | Rattus norvegicus | 41.06 | 1e-133 | 412 |
| LLPS-Caf-0303 | Canis familiaris | 40.89 | 2e-132 | 409 |
| LLPS-Ict-2113 | Ictidomys tridecemlineatus | 40.89 | 2e-132 | 409 |
| LLPS-Cas-0265 | Carlito syrichta | 40.89 | 3e-132 | 408 |
| LLPS-Man-2564 | Macaca nemestrina | 40.89 | 4e-132 | 409 |
| LLPS-Fec-0660 | Felis catus | 40.89 | 2e-132 | 409 |
| LLPS-Hos-0618 | Homo sapiens | 40.89 | 2e-132 | 409 |
| LLPS-Pat-0966 | Pan troglodytes | 40.89 | 3e-132 | 408 |
| LLPS-Urm-2098 | Ursus maritimus | 40.89 | 4e-132 | 408 |
| LLPS-Pap-1578 | Pan paniscus | 40.89 | 3e-132 | 408 |
| LLPS-Mup-3238 | Mustela putorius furo | 40.89 | 2e-132 | 409 |
| LLPS-Mal-1962 | Mandrillus leucophaeus | 40.89 | 3e-132 | 408 |
| LLPS-Paa-1254 | Papio anubis | 40.89 | 2e-132 | 409 |
| LLPS-Cea-0799 | Cercocebus atys | 40.89 | 3e-132 | 408 |
| LLPS-Maf-0042 | Macaca fascicularis | 40.89 | 3e-132 | 408 |
| LLPS-Gog-0149 | Gorilla gorilla | 40.89 | 2e-132 | 409 |
| LLPS-Mam-1811 | Macaca mulatta | 40.88 | 7e-130 | 402 |
| LLPS-Rhb-2129 | Rhinopithecus bieti | 40.88 | 6e-130 | 402 |
| LLPS-Chs-0486 | Chlorocebus sabaeus | 40.85 | 6e-133 | 410 |
| LLPS-Loa-1157 | Loxodonta africana | 40.72 | 4e-132 | 408 |
| LLPS-Tut-0450 | Tursiops truncatus | 40.72 | 5e-132 | 407 |
| LLPS-Mum-1487 | Mus musculus | 40.72 | 3e-132 | 408 |
| LLPS-Fud-1857 | Fukomys damarensis | 40.72 | 6e-132 | 408 |
| LLPS-Poa-1903 | Pongo abelii | 40.68 | 3e-132 | 409 |
| LLPS-Dio-2685 | Dipodomys ordii | 40.68 | 2e-132 | 409 |
| LLPS-Aon-2172 | Aotus nancymaae | 40.54 | 2e-132 | 409 |
| LLPS-Caj-2555 | Callithrix jacchus | 40.54 | 6e-132 | 408 |
| LLPS-Cap-3222 | Cavia porcellus | 40.51 | 1e-131 | 407 |
| LLPS-Eqc-0130 | Equus caballus | 40.51 | 1e-131 | 407 |
| LLPS-Orc-2162 | Oryctolagus cuniculus | 40.51 | 1e-131 | 407 |
| LLPS-Sus-2626 | Sus scrofa | 40.5 | 2e-125 | 392 |
| LLPS-Xim-0596 | Xiphophorus maculatus | 40.38 | 3e-126 | 393 |
| LLPS-Dar-2641 | Danio rerio | 40.34 | 3e-125 | 390 |
| LLPS-Pof-1963 | Poecilia formosa | 40.14 | 2e-130 | 404 |
| LLPS-Scf-2089 | Scleropages formosus | 40.07 | 4e-124 | 387 |
| LLPS-Nol-0930 | Nomascus leucogenys | 40.03 | 2e-124 | 388 |
| LLPS-Scm-0582 | Scophthalmus maximus | 39.9 | 1e-125 | 392 |
| LLPS-Asm-0720 | Astyanax mexicanus | 39.82 | 5e-124 | 387 |
| LLPS-Xet-2625 | Xenopus tropicalis | 39.66 | 4e-128 | 398 |
| LLPS-Ten-0432 | Tetraodon nigroviridis | 39.55 | 2e-127 | 396 |
| LLPS-Icp-2781 | Ictalurus punctatus | 39.47 | 1e-123 | 386 |
| LLPS-Anc-0448 | Anolis carolinensis | 39.4 | 4e-124 | 387 |
| LLPS-Tar-1160 | Takifugu rubripes | 39.34 | 3e-112 | 357 |
| LLPS-Orl-2141 | Oryzias latipes | 39.33 | 1e-125 | 392 |
| LLPS-Arl-1465 | Arabidopsis lyrata | 39.27 | 7e-115 | 363 |
| LLPS-Gaa-1151 | Gasterosteus aculeatus | 39.02 | 3e-126 | 393 |
| LLPS-Sem-0040 | Selaginella moellendorffii | 38.88 | 2e-113 | 360 |
| LLPS-Bro-0554 | Brassica oleracea | 38.82 | 2e-113 | 360 |
| LLPS-Art-2120 | Arabidopsis thaliana | 38.82 | 6e-116 | 366 |
| LLPS-Brn-1320 | Brassica napus | 38.82 | 1e-113 | 360 |
| LLPS-Orn-0808 | Oreochromis niloticus | 38.81 | 2e-125 | 391 |
| LLPS-Viv-0349 | Vitis vinifera | 38.66 | 1e-109 | 350 |
| LLPS-Brr-2383 | Brassica rapa | 38.65 | 7e-114 | 361 |
| LLPS-Prp-0360 | Prunus persica | 38.4 | 1e-112 | 358 |
| LLPS-Tra-2070 | Triticum aestivum | 38.4 | 6e-117 | 369 |
| LLPS-Mua-1482 | Musa acuminata | 38.39 | 8e-107 | 341 |
| LLPS-Via-0079 | Vigna angularis | 38.33 | 2e-114 | 362 |
| LLPS-Brd-0612 | Brachypodium distachyon | 38.23 | 4e-115 | 364 |
| LLPS-Tru-1384 | Triticum urartu | 38.08 | 2e-109 | 354 |
| LLPS-Glm-1858 | Glycine max | 38.02 | 4e-112 | 356 |
| LLPS-Orbr-1438 | Oryza brachyantha | 38.01 | 1e-115 | 365 |
| LLPS-Vir-0993 | Vigna radiata | 38.0 | 1e-108 | 347 |
| LLPS-Cii-1029 | Ciona intestinalis | 37.95 | 2e-113 | 359 |
| LLPS-Hov-0748 | Hordeum vulgare | 37.88 | 2e-113 | 360 |
| LLPS-Org-1142 | Oryza glaberrima | 37.84 | 3e-114 | 362 |
| LLPS-Ors-0541 | Oryza sativa | 37.84 | 3e-114 | 362 |
| LLPS-Lep-0834 | Leersia perrieri | 37.84 | 2e-114 | 363 |
| LLPS-Phv-1208 | Phaseolus vulgaris | 37.77 | 6e-112 | 356 |
| LLPS-Scp-0983 | Schizosaccharomyces pombe | 37.16 | 2e-73 | 254 |
| LLPS-Map-0456 | Magnaporthe poae | 36.89 | 1e-10 | 65.9 |
| LLPS-Osl-0306 | Ostreococcus lucimarinus | 36.85 | 5e-73 | 251 |
| LLPS-Nia-1149 | Nicotiana attenuata | 36.82 | 2e-107 | 344 |
| LLPS-Abg-1003 | Absidia glauca | 36.82 | 4e-104 | 335 |
| LLPS-Met-0698 | Medicago truncatula | 36.82 | 3e-106 | 341 |
| LLPS-Amt-0332 | Amborella trichopoda | 36.53 | 3e-110 | 352 |
| LLPS-Cus-0571 | Cucumis sativus | 36.52 | 1e-102 | 332 |
| LLPS-Ori-0676 | Oryza indica | 36.41 | 1e-94 | 309 |
| LLPS-Hea-1061 | Helianthus annuus | 36.26 | 2e-108 | 348 |
| LLPS-Mae-1072 | Manihot esculenta | 36.23 | 5e-107 | 343 |
| LLPS-Dac-0792 | Daucus carota | 36.22 | 5e-108 | 346 |
| LLPS-Sol-1680 | Solanum lycopersicum | 36.16 | 2e-104 | 336 |
| LLPS-Sei-0761 | Setaria italica | 36.15 | 4e-113 | 359 |
| LLPS-Php-1389 | Physcomitrella patens | 36.07 | 5e-110 | 351 |
| LLPS-Crn-0252 | Cryptococcus neoformans | 35.94 | 8e-75 | 262 |
| LLPS-Scj-0634 | Schizosaccharomyces japonicus | 35.62 | 2e-79 | 271 |
| LLPS-Usm-0303 | Ustilago maydis | 35.58 | 2e-74 | 259 |
| LLPS-Sob-0482 | Sorghum bicolor | 35.41 | 2e-109 | 350 |
| LLPS-Pot-0794 | Populus trichocarpa | 35.39 | 5e-106 | 340 |
| LLPS-Mel-0778 | Melampsora laricipopulina | 35.39 | 1e-61 | 223 |
| LLPS-Thc-0586 | Theobroma cacao | 35.27 | 1e-105 | 340 |
| LLPS-Chc-0345 | Chondrus crispus | 35.18 | 1e-101 | 329 |
| LLPS-Zem-0028 | Zea mays | 34.67 | 6e-100 | 326 |
| LLPS-Gor-0339 | Gossypium raimondii | 34.66 | 9e-105 | 337 |
| LLPS-Miv-0667 | Microbotryum violaceum | 34.27 | 1e-84 | 287 |
| LLPS-Gas-0383 | Galdieria sulphuraria | 34.24 | 8e-83 | 280 |
| LLPS-Scc-0416 | Schizosaccharomyces cryophilus | 34.24 | 2e-73 | 253 |
| LLPS-Put-0042 | Puccinia triticina | 34.15 | 2e-48 | 182 |
| LLPS-Phn-0208 | Phaeosphaeria nodorum | 34.02 | 2e-46 | 179 |
| LLPS-Pug-0420 | Puccinia graminis | 33.33 | 1e-64 | 233 |
| LLPS-Leo-1656 | Lepisosteus oculatus | 33.33 | 3e-10 | 63.5 |
| LLPS-Blg-0864 | Blumeria graminis | 33.18 | 8e-43 | 169 |
| LLPS-Chr-0175 | Chlamydomonas reinhardtii | 33.03 | 3e-87 | 292 |
| LLPS-Pyt-0374 | Pyrenophora teres | 32.69 | 3e-36 | 149 |
| LLPS-Scs-0480 | Sclerotinia sclerotiorum | 32.21 | 2e-41 | 164 |
| LLPS-Tum-0849 | Tuber melanosporum | 31.73 | 2e-70 | 246 |
| LLPS-Dos-0139 | Dothistroma septosporum | 31.2 | 3e-63 | 228 |
| LLPS-Cae-0617 | Caenorhabditis elegans | 31.01 | 2e-67 | 239 |
| LLPS-Nec-0518 | Neurospora crassa | 30.57 | 1e-55 | 206 |
| LLPS-Asni-0847 | Aspergillus niger | 30.49 | 2e-64 | 230 |
| LLPS-Mao-0881 | Magnaporthe oryzae | 30.43 | 2e-51 | 193 |
| LLPS-Spr-0978 | Sporisorium reilianum | 30.21 | 1e-76 | 268 |
| LLPS-Zyt-0742 | Zymoseptoria tritici | 29.85 | 6e-60 | 218 |
| LLPS-Yal-0367 | Yarrowia lipolytica | 29.85 | 1e-62 | 227 |
| LLPS-Sac-0321 | Saccharomyces cerevisiae | 29.78 | 3e-39 | 157 |
| LLPS-Beb-0007 | Beauveria bassiana | 29.74 | 9e-51 | 192 |
| LLPS-Asfu-0724 | Aspergillus fumigatus | 29.17 | 1e-50 | 192 |
| LLPS-Trv-0541 | Trichoderma virens | 28.84 | 1e-50 | 191 |
| LLPS-Fus-0097 | Fusarium solani | 28.81 | 4e-48 | 184 |
| LLPS-Cog-0105 | Colletotrichum gloeosporioides | 28.76 | 2e-50 | 190 |
| LLPS-Fuv-0193 | Fusarium verticillioides | 28.7 | 2e-48 | 185 |
| LLPS-Gag-0220 | Gaeumannomyces graminis | 28.68 | 4e-47 | 181 |
| LLPS-Asg-0253 | Ashbya gossypii | 28.66 | 5e-40 | 160 |
| LLPS-Nef-0257 | Neosartorya fischeri | 28.65 | 6e-50 | 190 |
| LLPS-Cogr-0495 | Colletotrichum graminicola | 28.36 | 1e-52 | 197 |
| LLPS-Fuo-0332 | Fusarium oxysporum | 28.3 | 9e-47 | 180 |
| LLPS-Lem-1201 | Leptosphaeria maculans | 28.21 | 3e-56 | 208 |
| LLPS-Trr-0450 | Trichoderma reesei | 28.2 | 2e-50 | 190 |
| LLPS-Ved-0647 | Verticillium dahliae | 28.02 | 9e-47 | 180 |
| LLPS-Kop-0391 | Komagataella pastoris | 27.85 | 2e-47 | 182 |
| LLPS-Asn-0377 | Aspergillus nidulans | 27.76 | 5e-55 | 205 |
| LLPS-Pytr-1046 | Pyrenophora triticirepentis | 27.42 | 3e-51 | 193 |
| LLPS-Aso-0504 | Aspergillus oryzae | 26.56 | 8e-49 | 186 |
| LLPS-Coo-0561 | Colletotrichum orbiculare | 26.54 | 2e-46 | 178 |
| LLPS-Asc-0280 | Aspergillus clavatus | 26.16 | 2e-51 | 194 |
| LLPS-Asf-1071 | Aspergillus flavus | 25.71 | 8e-49 | 186 |
| LLPS-Ast-0030 | Aspergillus terreus | 25.46 | 2e-37 | 152 |