LLPS-Hos-0618
PRMT5
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein arginine N-methyltransferase 5; 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog; SKB1 homolog; SKB1Hs |
| Gene Name: | PRMT5, HRMT1L5, IBP72, JBP1, SKB1 |
| Ensembl Gene: | ENSG00000100462.15 |
| Ensembl Protein: | ENSP00000452218.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Depletion of PRMT5 caused decreased symmetric arginine dimethylation of WT Lsm4, as monitored with the Sym10 antibody. When HeLa cells were depleted of PRMT5 with two different siRNAs, visible PBs were strongly reduced, as monitored with two different PB markers, compared to those in cells treated with a control siRNA. This demonstrates that PRMT5 is important for PB accumulation and, together with the Lsm4 mutational studies, suggests that symmetric arginine dimethylation of the Lsm4 C-terminal RGG domain contributes to this effect." | HeLa cells | 27247266 |
| Stress granule | "...Here, we examined the potent SG-nucleating protein Ras-GAP SH3-binding protein 1, and found that G3BP1 is differentially methylated on specific arginine residues by protein arginine methyltransferase 1 and PRMT5 in its RGG domain. Several genetic and biochemical interventions that increased methylation repressed SG assembly, whereas interventions that decreased methylation promoted SG assembly." | U2OS cells | 27601476 |
| Stress granule | "...PRMT5 helps eliminate stress granules by autophagy." | HeLa cells | 30022074 |
| Stress granule | "...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell." | U2OS cells | 26777405 |
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates TP53; methylation might possibly affect TP53 target gene specificity (PubMed:19011621). |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK 60 61 NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP 120 121 AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS 180 181 GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK 240 241 KGFPVLSKMH QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 300 301 AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKDTNVQV 360 361 LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM 420 421 REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL 480 481 YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF 540 541 PVEVNTVLHG FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV 600 601 RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL 637 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCGGGGTC CGAACTCGGG GACGGAGAAG GGCAGACTAG TCATCCCGGA GAAGCAGGGG 60 61 TTTGATTTCC TCTGCATGCC TGTCTTCCAT CCGCGTTTCA AGAGGGAGTT CATTCAGGAA 120 121 CCTGCTAAGA ATCGGCCCGG TCCCCAGACA CGATCAGACC TACTGCTGTC AGGAAGGGCT 180 181 TTCCTGCTGC CCCTTAATCA GGAAGATAAC ACCAACCTGG CCAGAGTTTT GACCAACCAC 240 241 ATCCACACTG GCCATCACTC TTCCATGTTC TGGATGCGGG TACCCTTGGT GGCACCAGAG 300 301 GACCTGAGAG ATGATATAAT TGAGAATGCA CCAACTACAC ACACAGAGGA GTACAGTGGG 360 361 GAGGAGAAAA CGTGGATGTG GTGGCACAAC TTCCGGACTT TGTGTGACTA TAGTAAGAGG 420 421 ATTGCAGTGG CTCTTGAAAT TGGGGCTGAC CTCCCATCTA ATCATGTCAT TGATCGCTGG 480 481 CTTGGGGAGC CCATCAAAGC AGCCATTCTC CCCACTAGCA TTTTCCTGAC CAATAAGAAG 540 541 GGATTTCCTG TTCTTTCTAA GATGCACCAG AGGCTCATCT TCCGGCTCCT CAAGTTGGAG 600 601 GTGCAGTTCA TCATCACAGG CACCAACCAC CACTCAGAGA AGGAGTTCTG CTCCTACCTC 660 661 CAATACCTGG AATACTTAAG CCAGAACCGT CCTCCACCTA ATGCCTATGA ACTCTTTGCC 720 721 AAGGGCTATG AAGACTATCT GCAGTCCCCG CTTCAGCCAC TGATGGACAA TCTGGAATCT 780 781 CAGACATATG AAGTGTTTGA AAAGGACCCC ATCAAATACT CTCAGTACCA GCAGGCCATC 840 841 TATAAATGTC TGCTAGACCG AGTACCAGAA GAGGAGAAGG ATACCAATGT CCAGGTACTG 900 901 ATGGTGCTGG GAGCAGGACG GGGACCCCTG GTGAACGCTT CCCTGCGGGC AGCCAAGCAG 960 961 GCCGACCGGC GGATAAAGCT GTATGCTGTG GAGAAAAACC CAAATGCCGT GGTGACGCTA 1020 1021 GAGAACTGGC AGTTTGAAGA ATGGGGAAGC CAAGTGACCG TAGTCTCATC AGACATGAGG 1080 1081 GAATGGGTGG CTCCAGAGAA AGCAGACATC ATTGTCAGTG AGCTTCTGGG CTCATTTGCT 1140 1141 GACAATGAAT TGTCGCCTGA GTGCCTGGAT GGAGCCCAGC ACTTCCTAAA AGATGATGGT 1200 1201 GTGAGCATCC CCGGGGAGTA CACTTCCTTT CTGGCTCCCA TCTCTTCCTC CAAGCTGTAC 1260 1261 AATGAGGTCC GAGCCTGTAG GGAGAAGGAC CGTGACCCTG AGGCCCAGTT TGAGATGCCT 1320 1321 TATGTGGTAC GGCTGCACAA CTTCCACCAG CTCTCTGCAC CCCAGCCCTG TTTCACCTTC 1380 1381 AGCCATCCCA ACAGAGATCC TATGATTGAC AACAACCGCT ATTGCACCTT GGAATTTCCT 1440 1441 GTGGAGGTGA ACACAGTACT ACATGGCTTT GCCGGCTACT TTGAGACTGT GCTTTATCAG 1500 1501 GACATCACTC TGAGTATCCG TCCAGAGACT CACTCTCCTG GGATGTTCTC ATGGTTTCCC 1560 1561 ATCCTCTTCC CTATTAAGCA GCCCATAACG GTACGTGAAG GCCAAACCAT CTGTGTGCGT 1620 1621 TTCTGGCGAT GCAGCAATTC CAAGAAGGTG TGGTATGAGT GGGCTGTGAC AGCACCAGTC 1680 1681 TGTTCTGCTA TTCATAACCC CACAGGCCGC TCATATACCA TTGGCCTCTA G 1731 |
▼ KEYWORD
ID | Family |
3D-structure | |
Acetylation | |
Alternative splicing | |
Biological rhythms | |
Chromatin regulator | |
Complete proteome | |
Cytoplasm | |
Direct protein sequencing | |
Golgi apparatus | |
Methyltransferase | |
Nucleus | |
Reference proteome | |
Repressor | |
S-adenosyl-L-methionine | |
Transcription | |
Transcription regulation | |
Transferase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Golgi apparatus | |
Cellular Component | Histone methyltransferase complex | |
Cellular Component | Methylosome | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | E-box binding | |
Molecular Function | Histone methyltransferase activity (H4-R3 specific) | |
Molecular Function | Histone-arginine N-methyltransferase activity | |
Molecular Function | Identical protein binding | |
Molecular Function | Methyl-CpG binding | |
Molecular Function | Methyltransferase activity | |
Molecular Function | P53 binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Protein-arginine N-methyltransferase activity | |
Molecular Function | Protein-arginine omega-N symmetric methyltransferase activity | |
Molecular Function | Ribonucleoprotein complex binding | |
Molecular Function | Transcription corepressor activity | |
Biological Process | Circadian regulation of gene expression | |
Biological Process | DNA-templated transcription, termination | |
Biological Process | Endothelial cell activation | |
Biological Process | Golgi ribbon formation | |
Biological Process | Histone arginine methylation | |
Biological Process | Histone H4-R3 methylation | |
Biological Process | Liver regeneration | |
Biological Process | Negative regulation of cell differentiation | |
Biological Process | Peptidyl-arginine methylation | |
Biological Process | Peptidyl-arginine N-methylation | |
Biological Process | Positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway | |
Biological Process | Positive regulation of oligodendrocyte differentiation | |
Biological Process | Regulation of DNA methylation | |
Biological Process | Regulation of ERK1 and ERK2 cascade | |
Biological Process | Regulation of mitotic nuclear division | |
Biological Process | Regulation of signal transduction by p53 class mediator | |
Biological Process | Spliceosomal snRNP assembly |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Paa-1254 | Papio anubis | 100.0 | 0.0 | 1296 |
| LLPS-Gog-0149 | Gorilla gorilla | 100.0 | 0.0 | 1296 |
| LLPS-Cas-0265 | Carlito syrichta | 100.0 | 0.0 | 1261 |
| LLPS-Pap-1578 | Pan paniscus | 100.0 | 0.0 | 1261 |
| LLPS-Pat-0966 | Pan troglodytes | 100.0 | 0.0 | 1261 |
| LLPS-Man-2564 | Macaca nemestrina | 100.0 | 0.0 | 1297 |
| LLPS-Chs-0486 | Chlorocebus sabaeus | 99.84 | 0.0 | 1295 |
| LLPS-Poa-1903 | Pongo abelii | 99.84 | 0.0 | 1295 |
| LLPS-Mal-1962 | Mandrillus leucophaeus | 99.83 | 0.0 | 1258 |
| LLPS-Maf-0042 | Macaca fascicularis | 99.83 | 0.0 | 1258 |
| LLPS-Cea-0799 | Cercocebus atys | 99.83 | 0.0 | 1258 |
| LLPS-Mup-3238 | Mustela putorius furo | 99.52 | 0.0 | 1291 |
| LLPS-Aon-2172 | Aotus nancymaae | 99.52 | 0.0 | 1293 |
| LLPS-Caj-2555 | Callithrix jacchus | 99.52 | 0.0 | 1291 |
| LLPS-Ict-2113 | Ictidomys tridecemlineatus | 99.52 | 0.0 | 1290 |
| LLPS-Fec-0660 | Felis catus | 99.52 | 0.0 | 1291 |
| LLPS-Urm-2098 | Ursus maritimus | 99.52 | 0.0 | 1291 |
| LLPS-Tut-0450 | Tursiops truncatus | 99.5 | 0.0 | 1250 |
| LLPS-Bot-0625 | Bos taurus | 99.35 | 0.0 | 1291 |
| LLPS-Ova-0382 | Ovis aries | 99.35 | 0.0 | 1291 |
| LLPS-Eqc-0130 | Equus caballus | 99.35 | 0.0 | 1290 |
| LLPS-Caf-0303 | Canis familiaris | 99.35 | 0.0 | 1291 |
| LLPS-Otg-0110 | Otolemur garnettii | 99.35 | 0.0 | 1291 |
| LLPS-Aim-2349 | Ailuropoda melanoleuca | 99.19 | 0.0 | 1290 |
| LLPS-Cap-3222 | Cavia porcellus | 99.19 | 0.0 | 1287 |
| LLPS-Loa-1157 | Loxodonta africana | 99.19 | 0.0 | 1287 |
| LLPS-Sus-2626 | Sus scrofa | 99.16 | 0.0 | 1232 |
| LLPS-Myl-3059 | Myotis lucifugus | 99.03 | 0.0 | 1289 |
| LLPS-Dio-2685 | Dipodomys ordii | 98.87 | 0.0 | 1283 |
| LLPS-Fud-1857 | Fukomys damarensis | 98.71 | 0.0 | 1281 |
| LLPS-Orc-2162 | Oryctolagus cuniculus | 98.55 | 0.0 | 1283 |
| LLPS-Mam-1811 | Macaca mulatta | 98.21 | 0.0 | 1251 |
| LLPS-Rhb-2129 | Rhinopithecus bieti | 98.21 | 0.0 | 1251 |
| LLPS-Mum-1487 | Mus musculus | 97.9 | 0.0 | 1271 |
| LLPS-Nol-0930 | Nomascus leucogenys | 97.9 | 0.0 | 1254 |
| LLPS-Ran-1579 | Rattus norvegicus | 97.74 | 0.0 | 1271 |
| LLPS-Mod-0908 | Monodelphis domestica | 95.64 | 0.0 | 1247 |
| LLPS-Sah-0320 | Sarcophilus harrisii | 94.59 | 0.0 | 1183 |
| LLPS-Ora-2124 | Ornithorhynchus anatinus | 89.47 | 2e-129 | 397 |
| LLPS-Anc-0448 | Anolis carolinensis | 85.16 | 0.0 | 1116 |
| LLPS-Xet-2625 | Xenopus tropicalis | 84.19 | 0.0 | 1129 |
| LLPS-Lac-0169 | Latimeria chalumnae | 83.58 | 0.0 | 976 |
| LLPS-Leo-1656 | Lepisosteus oculatus | 79.83 | 7e-59 | 199 |
| LLPS-Scf-2089 | Scleropages formosus | 79.81 | 0.0 | 1061 |
| LLPS-Asm-0720 | Astyanax mexicanus | 79.81 | 0.0 | 1060 |
| LLPS-Orn-0808 | Oreochromis niloticus | 79.48 | 0.0 | 1056 |
| LLPS-Xim-0596 | Xiphophorus maculatus | 79.32 | 0.0 | 1058 |
| LLPS-Pof-1963 | Poecilia formosa | 79.0 | 0.0 | 1058 |
| LLPS-Dar-2641 | Danio rerio | 79.0 | 0.0 | 1046 |
| LLPS-Icp-2781 | Ictalurus punctatus | 78.68 | 0.0 | 1045 |
| LLPS-Gaa-1151 | Gasterosteus aculeatus | 78.35 | 0.0 | 1040 |
| LLPS-Orl-2141 | Oryzias latipes | 78.35 | 0.0 | 1039 |
| LLPS-Ten-0432 | Tetraodon nigroviridis | 78.35 | 0.0 | 1050 |
| LLPS-Scm-0582 | Scophthalmus maximus | 78.19 | 0.0 | 1040 |
| LLPS-Tar-1160 | Takifugu rubripes | 72.78 | 0.0 | 962 |
| LLPS-Meg-2279 | Meleagris gallopavo | 72.22 | 2e-31 | 122 |
| LLPS-Coc-0442 | Corchorus capsularis | 69.32 | 3e-34 | 130 |
| LLPS-Gaga-0042 | Gallus gallus | 58.12 | 3e-31 | 123 |
| LLPS-Cii-1029 | Ciona intestinalis | 51.82 | 0.0 | 651 |
| LLPS-Via-0079 | Vigna angularis | 49.44 | 0.0 | 583 |
| LLPS-Vir-0993 | Vigna radiata | 49.24 | 0.0 | 543 |
| LLPS-Phv-1208 | Phaseolus vulgaris | 48.79 | 0.0 | 573 |
| LLPS-Glm-1282 | Glycine max | 48.63 | 0.0 | 572 |
| LLPS-Sob-0482 | Sorghum bicolor | 48.56 | 0.0 | 574 |
| LLPS-Sei-0761 | Setaria italica | 48.33 | 0.0 | 578 |
| LLPS-Lep-0834 | Leersia perrieri | 48.28 | 0.0 | 581 |
| LLPS-Tra-0128 | Triticum aestivum | 48.1 | 0.0 | 581 |
| LLPS-Mua-1482 | Musa acuminata | 48.07 | 0.0 | 549 |
| LLPS-Brd-0612 | Brachypodium distachyon | 47.85 | 0.0 | 568 |
| LLPS-Hov-0748 | Hordeum vulgare | 47.78 | 0.0 | 570 |
| LLPS-Org-1142 | Oryza glaberrima | 47.72 | 0.0 | 578 |
| LLPS-Ors-0541 | Oryza sativa | 47.72 | 0.0 | 578 |
| LLPS-Orbr-1438 | Oryza brachyantha | 47.72 | 0.0 | 582 |
| LLPS-Php-0614 | Physcomitrella patens | 47.61 | 0.0 | 571 |
| LLPS-Nia-1149 | Nicotiana attenuata | 47.54 | 0.0 | 576 |
| LLPS-Art-2120 | Arabidopsis thaliana | 47.36 | 0.0 | 565 |
| LLPS-Viv-0349 | Vitis vinifera | 47.29 | 0.0 | 572 |
| LLPS-Prp-0360 | Prunus persica | 47.15 | 0.0 | 577 |
| LLPS-Arl-1465 | Arabidopsis lyrata | 47.12 | 0.0 | 561 |
| LLPS-Brn-0505 | Brassica napus | 47.12 | 0.0 | 574 |
| LLPS-Tru-1384 | Triticum urartu | 47.12 | 0.0 | 553 |
| LLPS-Brr-2383 | Brassica rapa | 47.12 | 0.0 | 572 |
| LLPS-Bro-0554 | Brassica oleracea | 46.88 | 0.0 | 569 |
| LLPS-Sem-0040 | Selaginella moellendorffii | 46.62 | 0.0 | 561 |
| LLPS-Met-0698 | Medicago truncatula | 46.57 | 0.0 | 551 |
| LLPS-Mae-1072 | Manihot esculenta | 46.52 | 0.0 | 566 |
| LLPS-Sol-1680 | Solanum lycopersicum | 46.28 | 0.0 | 558 |
| LLPS-Chc-0345 | Chondrus crispus | 46.08 | 0.0 | 543 |
| LLPS-Amt-0332 | Amborella trichopoda | 45.89 | 0.0 | 550 |
| LLPS-Abg-1003 | Absidia glauca | 45.85 | 0.0 | 551 |
| LLPS-Hea-1061 | Helianthus annuus | 45.82 | 0.0 | 558 |
| LLPS-Gor-0339 | Gossypium raimondii | 45.57 | 0.0 | 549 |
| LLPS-Pot-0794 | Populus trichocarpa | 45.48 | 0.0 | 548 |
| LLPS-Thc-0586 | Theobroma cacao | 45.25 | 0.0 | 546 |
| LLPS-Cus-0571 | Cucumis sativus | 44.86 | 0.0 | 538 |
| LLPS-Ori-0676 | Oryza indica | 44.78 | 8e-165 | 492 |
| LLPS-Orp-0505 | Oryza punctata | 44.69 | 2e-171 | 509 |
| LLPS-Zem-0028 | Zea mays | 44.59 | 3e-179 | 532 |
| LLPS-Dac-0792 | Daucus carota | 44.46 | 0.0 | 535 |
| LLPS-Orm-0569 | Oryza meridionalis | 44.38 | 5e-170 | 506 |
| LLPS-Usm-0303 | Ustilago maydis | 43.76 | 5e-119 | 379 |
| LLPS-Crn-0252 | Cryptococcus neoformans | 43.0 | 1e-114 | 370 |
| LLPS-Map-0456 | Magnaporthe poae | 42.86 | 5e-18 | 87.8 |
| LLPS-Orb-1542 | Oryza barthii | 42.26 | 4e-164 | 492 |
| LLPS-Orni-0479 | Oryza nivara | 42.26 | 4e-164 | 492 |
| LLPS-Orr-0037 | Oryza rufipogon | 42.11 | 5e-164 | 491 |
| LLPS-Blg-0864 | Blumeria graminis | 42.05 | 8e-14 | 79.0 |
| LLPS-Pytr-1046 | Pyrenophora triticirepentis | 42.0 | 3e-88 | 298 |
| LLPS-Phn-0208 | Phaeosphaeria nodorum | 41.75 | 9e-87 | 294 |
| LLPS-Chr-0175 | Chlamydomonas reinhardtii | 41.7 | 4e-158 | 479 |
| LLPS-Orgl-1122 | Oryza glumaepatula | 41.28 | 8e-160 | 481 |
| LLPS-Miv-0667 | Microbotryum violaceum | 40.91 | 4e-132 | 413 |
| LLPS-Drm-0147 | Drosophila melanogaster | 40.58 | 8e-139 | 426 |
| LLPS-Osl-0306 | Ostreococcus lucimarinus | 39.55 | 1e-121 | 379 |
| LLPS-Put-0042 | Puccinia triticina | 39.33 | 4e-82 | 275 |
| LLPS-Pug-0420 | Puccinia graminis | 38.38 | 2e-104 | 342 |
| LLPS-Gas-0383 | Galdieria sulphuraria | 37.84 | 5e-135 | 417 |
| LLPS-Scp-0983 | Schizosaccharomyces pombe | 37.71 | 4e-117 | 370 |
| LLPS-Mel-0778 | Melampsora laricipopulina | 37.7 | 6e-108 | 348 |
| LLPS-Scc-0416 | Schizosaccharomyces cryophilus | 37.33 | 5e-113 | 359 |
| LLPS-Spr-0978 | Sporisorium reilianum | 37.28 | 7e-122 | 391 |
| LLPS-Tum-0849 | Tuber melanosporum | 37.27 | 6e-126 | 394 |
| LLPS-Asni-0847 | Aspergillus niger | 37.18 | 7e-109 | 351 |
| LLPS-Scj-0634 | Schizosaccharomyces japonicus | 36.93 | 3e-124 | 389 |
| LLPS-Yal-0367 | Yarrowia lipolytica | 35.64 | 4e-110 | 357 |
| LLPS-Fuo-0332 | Fusarium oxysporum | 34.92 | 1e-91 | 306 |
| LLPS-Fus-0097 | Fusarium solani | 34.82 | 8e-95 | 315 |
| LLPS-Aso-0504 | Aspergillus oryzae | 34.64 | 2e-96 | 321 |
| LLPS-Asf-1071 | Aspergillus flavus | 34.64 | 4e-96 | 321 |
| LLPS-Asfu-0724 | Aspergillus fumigatus | 34.55 | 6e-106 | 347 |
| LLPS-Nef-0257 | Neosartorya fischeri | 34.55 | 3e-107 | 350 |
| LLPS-Ved-0647 | Verticillium dahliae | 34.27 | 2e-93 | 311 |
| LLPS-Pyt-0374 | Pyrenophora teres | 34.1 | 8e-91 | 304 |
| LLPS-Cae-0617 | Caenorhabditis elegans | 34.06 | 1e-96 | 319 |
| LLPS-Dos-0139 | Dothistroma septosporum | 33.85 | 3e-112 | 360 |
| LLPS-Fuv-0193 | Fusarium verticillioides | 33.8 | 3e-93 | 311 |
| LLPS-Beb-0007 | Beauveria bassiana | 33.38 | 2e-96 | 320 |
| LLPS-Trr-0450 | Trichoderma reesei | 33.33 | 8e-95 | 315 |
| LLPS-Coo-0561 | Colletotrichum orbiculare | 32.81 | 8e-87 | 293 |
| LLPS-Asn-0377 | Aspergillus nidulans | 32.81 | 8e-99 | 328 |
| LLPS-Asc-0280 | Aspergillus clavatus | 32.69 | 4e-97 | 323 |
| LLPS-Asg-0253 | Ashbya gossypii | 32.51 | 7e-66 | 236 |
| LLPS-Cogr-0495 | Colletotrichum graminicola | 32.41 | 1e-96 | 320 |
| LLPS-Zyt-0742 | Zymoseptoria tritici | 32.39 | 4e-102 | 334 |
| LLPS-Lem-1201 | Leptosphaeria maculans | 32.25 | 6e-99 | 327 |
| LLPS-Cog-0105 | Colletotrichum gloeosporioides | 31.81 | 6e-98 | 323 |
| LLPS-Scs-0480 | Sclerotinia sclerotiorum | 31.49 | 2e-93 | 312 |
| LLPS-Ast-0030 | Aspergillus terreus | 31.4 | 2e-73 | 258 |
| LLPS-Gag-0220 | Gaeumannomyces graminis | 31.35 | 6e-88 | 297 |
| LLPS-Nec-0518 | Neurospora crassa | 31.2 | 3e-94 | 314 |
| LLPS-Trv-0541 | Trichoderma virens | 30.8 | 1e-93 | 312 |
| LLPS-Mao-0881 | Magnaporthe oryzae | 30.78 | 7e-86 | 291 |
| LLPS-Kop-0391 | Komagataella pastoris | 30.19 | 2e-73 | 257 |
| LLPS-Sac-0321 | Saccharomyces cerevisiae | 27.25 | 3e-68 | 244 |
| LLPS-Sot-0117 | Solanum tuberosum | 27.1 | 8e-07 | 55.8 |