LLPS-Tra-1921
FEN1
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Flap endonuclease 1 |
Gene Name: | FEN1 |
Ensembl Gene: | TraesCS1B02G377800 |
Ensembl Protein: | TraesCS1B02G377800.1 |
Organism: | Triticum aestivum |
Taxa ID: | 4565 |
LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | TraesCS1B02G377800.1 | TraesCS1B02G377800.1 |
UniProt | A0A3B5Z3P0, A0A3B5Z3P0_WHEAT |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MGVKGLTKLL ADNAPKSMRE QKFESYFGRR IAVDASMCIY QFLIVVGRTG METLTNEAGD 60 61 ITSHLQGMFS RTIRLLEAGI KPVYVFDGKP PEMKKDELLK RHAKRNEATE ELTKAVEAGD 120 121 TDAIEKFSKR TVKVTKQHND DCKRLLRLMG VPVVEAPCEA ESQCAALCKN DKVYAVASED 180 181 MDSLTFGATR FVRHLMDPSS RKIPVMEFEV AKILEELEFT MDQFIDLCIL CGCDYCDSIK 240 241 GIGGLTALKL IRQHGSIEGI LENINKDKYQ IPEDWPYQEA RRMFKEPDVT LDIPELKWTA 300 301 PDEEGLVNFL VKENGFNQDR VTKAIEKIKS AKNKSSQGRL ESFFKPTVST SVPLKRKETA 360 361 EKPASAAASK KTKSTRGRKK 380 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGGGGTCA AGGGTTTGAC GAAGCTACTG GCGGACAACG CGCCCAAGTC GATGAGGGAG 60 61 CAGAAGTTCG AGAGCTACTT CGGCCGCCGC ATCGCCGTCG ACGCCAGCAT GTGCATCTAC 120 121 CAGTTCCTCA TTGTAGTTGG AAGGACAGGG ATGGAAACCC TTACAAACGA AGCCGGTGAT 180 181 ATCACCAGTC ATTTGCAAGG CATGTTCAGC CGGACAATAA GGTTGCTCGA GGCAGGAATT 240 241 AAACCAGTAT ATGTTTTTGA TGGCAAGCCT CCTGAAATGA AGAAGGACGA GCTTTTAAAA 300 301 AGACACGCAA AGAGGAATGA AGCAACAGAA GAGCTGACGA AGGCAGTAGA GGCAGGAGAT 360 361 ACGGATGCAA TTGAAAAATT CAGCAAGAGA ACTGTAAAGG TCACGAAGCA GCACAATGAT 420 421 GATTGTAAGC GTCTACTAAG ACTGATGGGT GTTCCTGTTG TGGAGGCTCC TTGTGAAGCA 480 481 GAATCACAAT GTGCTGCCCT TTGCAAGAAT GACAAGGTGT ATGCTGTTGC ATCCGAAGAT 540 541 ATGGACTCAC TTACTTTTGG AGCTACACGG TTTGTTCGTC ATTTGATGGA TCCAAGTTCC 600 601 AGGAAAATAC CTGTTATGGA ATTTGAAGTT GCGAAAATTC TTGAGGAGCT TGAATTCACT 660 661 ATGGACCAAT TCATTGACTT GTGCATCCTC TGTGGATGTG ACTACTGTGA TAGCATTAAA 720 721 GGCATTGGTG GTCTTACAGC TCTGAAGCTC ATTCGTCAGC ACGGGTCCAT TGAGGGCATT 780 781 CTGGAAAATA TTAATAAAGA CAAATATCAA ATTCCTGAGG ACTGGCCTTA TCAAGAGGCT 840 841 CGGCGCATGT TCAAGGAACC CGATGTAACA CTGGATATTC CCGAGCTCAA ATGGACTGCA 900 901 CCTGATGAGG AGGGCCTCGT GAACTTTCTG GTGAAAGAAA ATGGTTTCAA TCAAGATCGT 960 961 GTGACAAAGG CCATAGAGAA GATTAAATCA GCGAAGAATA AATCATCCCA AGGAAGGCTC 1020 1021 GAGTCATTTT TCAAGCCAAC TGTTAGCACA TCAGTGCCAT TGAAGCGGAA GGAAACTGCA 1080 1081 GAGAAACCAG CCAGTGCAGC CGCTAGCAAG AAGACGAAGT CAACCCGCGG AAGGAAGAAA 1140 1141 TAA 1143 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleoplasm | |
Molecular Function | 5'-3' exonuclease activity | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | Magnesium ion binding | |
Biological Process | Base-excision repair | |
Biological Process | DNA replication | |
Biological Process | DNA replication, removal of RNA primer |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Hov-1098 | Hordeum vulgare | 98.23 | 0.0 | 695 |
LLPS-Brd-0390 | Brachypodium distachyon | 93.54 | 0.0 | 701 |
LLPS-Ori-0397 | Oryza indica | 88.76 | 0.0 | 667 |
LLPS-Ors-1482 | Oryza sativa | 88.76 | 0.0 | 667 |
LLPS-Orbr-0792 | Oryza brachyantha | 88.76 | 0.0 | 669 |
LLPS-Org-0494 | Oryza glaberrima | 88.76 | 0.0 | 667 |
LLPS-Sei-1775 | Setaria italica | 87.92 | 0.0 | 669 |
LLPS-Sob-0247 | Sorghum bicolor | 85.96 | 0.0 | 657 |
LLPS-Lep-0111 | Leersia perrieri | 84.55 | 0.0 | 626 |
LLPS-Orp-1394 | Oryza punctata | 84.27 | 0.0 | 619 |
LLPS-Zem-0587 | Zea mays | 83.56 | 0.0 | 654 |
LLPS-Mua-0298 | Musa acuminata | 82.3 | 0.0 | 635 |
LLPS-Glm-1176 | Glycine max | 81.84 | 0.0 | 619 |
LLPS-Prp-0732 | Prunus persica | 81.84 | 0.0 | 620 |
LLPS-Arl-0879 | Arabidopsis lyrata | 81.01 | 0.0 | 613 |
LLPS-Met-0011 | Medicago truncatula | 81.01 | 0.0 | 613 |
LLPS-Art-0221 | Arabidopsis thaliana | 81.01 | 0.0 | 609 |
LLPS-Orgl-1200 | Oryza glumaepatula | 80.85 | 0.0 | 585 |
LLPS-Brn-0901 | Brassica napus | 80.73 | 0.0 | 610 |
LLPS-Brr-1381 | Brassica rapa | 80.73 | 0.0 | 610 |
LLPS-Nia-0211 | Nicotiana attenuata | 80.39 | 0.0 | 606 |
LLPS-Mae-0099 | Manihot esculenta | 80.17 | 0.0 | 616 |
LLPS-Coc-1602 | Corchorus capsularis | 80.17 | 0.0 | 608 |
LLPS-Bro-2245 | Brassica oleracea | 80.17 | 0.0 | 610 |
LLPS-Via-0889 | Vigna angularis | 79.89 | 0.0 | 604 |
LLPS-Cus-0532 | Cucumis sativus | 79.89 | 0.0 | 607 |
LLPS-Pot-0330 | Populus trichocarpa | 79.89 | 0.0 | 606 |
LLPS-Viv-0328 | Vitis vinifera | 79.89 | 0.0 | 615 |
LLPS-Sot-1640 | Solanum tuberosum | 79.78 | 2e-99 | 301 |
LLPS-Hea-1035 | Helianthus annuus | 79.61 | 0.0 | 611 |
LLPS-Thc-1819 | Theobroma cacao | 79.05 | 0.0 | 602 |
LLPS-Phv-1094 | Phaseolus vulgaris | 79.05 | 0.0 | 597 |
LLPS-Amt-0816 | Amborella trichopoda | 78.77 | 0.0 | 598 |
LLPS-Sem-1082 | Selaginella moellendorffii | 77.52 | 0.0 | 578 |
LLPS-Dac-1311 | Daucus carota | 77.03 | 0.0 | 608 |
LLPS-Gor-0173 | Gossypium raimondii | 76.82 | 0.0 | 592 |
LLPS-Vir-1643 | Vigna radiata | 73.39 | 0.0 | 557 |
LLPS-Php-0223 | Physcomitrella patens | 73.37 | 0.0 | 555 |
LLPS-Sol-0104 | Solanum lycopersicum | 72.27 | 0.0 | 557 |
LLPS-Orr-1696 | Oryza rufipogon | 67.32 | 2e-134 | 392 |
LLPS-Chr-0596 | Chlamydomonas reinhardtii | 62.82 | 1e-164 | 474 |
LLPS-Osl-0082 | Ostreococcus lucimarinus | 59.72 | 4e-146 | 427 |
LLPS-Orm-1176 | Oryza meridionalis | 59.59 | 1e-137 | 414 |
LLPS-Dar-1793 | Danio rerio | 57.7 | 3e-148 | 432 |
LLPS-Xim-1841 | Xiphophorus maculatus | 57.67 | 3e-144 | 421 |
LLPS-Orl-1540 | Oryzias latipes | 57.42 | 9e-145 | 425 |
LLPS-Scm-0534 | Scophthalmus maximus | 57.39 | 7e-144 | 421 |
LLPS-Pof-0073 | Poecilia formosa | 57.3 | 2e-142 | 417 |
LLPS-Orn-3509 | Oreochromis niloticus | 57.14 | 3e-145 | 424 |
LLPS-Cis-0672 | Ciona savignyi | 56.98 | 2e-149 | 434 |
LLPS-Icp-0514 | Ictalurus punctatus | 56.86 | 1e-146 | 427 |
LLPS-Scf-2853 | Scleropages formosus | 56.86 | 2e-146 | 427 |
LLPS-Gaa-0922 | Gasterosteus aculeatus | 56.82 | 2e-142 | 417 |
LLPS-Lac-1368 | Latimeria chalumnae | 56.64 | 4e-114 | 342 |
LLPS-Asm-0753 | Astyanax mexicanus | 56.58 | 6e-144 | 422 |
LLPS-Sah-0179 | Sarcophilus harrisii | 56.03 | 3e-136 | 401 |
LLPS-Xet-0658 | Xenopus tropicalis | 55.97 | 7e-137 | 403 |
LLPS-Cii-0087 | Ciona intestinalis | 55.59 | 2e-144 | 422 |
LLPS-Orb-1513 | Oryza barthii | 55.46 | 5e-128 | 379 |
LLPS-Orni-0004 | Oryza nivara | 55.46 | 4e-123 | 378 |
LLPS-Anp-0270 | Anas platyrhynchos | 55.4 | 3e-141 | 414 |
LLPS-Pes-0376 | Pelodiscus sinensis | 55.4 | 3e-141 | 415 |
LLPS-Mod-2146 | Monodelphis domestica | 55.17 | 4e-139 | 409 |
LLPS-Meg-1791 | Meleagris gallopavo | 55.11 | 1e-140 | 412 |
LLPS-Gaga-0195 | Gallus gallus | 55.11 | 7e-141 | 413 |
LLPS-Drm-0311 | Drosophila melanogaster | 54.99 | 3e-133 | 394 |
LLPS-Tag-2635 | Taeniopygia guttata | 54.55 | 1e-134 | 397 |
LLPS-Fia-1618 | Ficedula albicollis | 54.26 | 4e-133 | 395 |
LLPS-Fud-0817 | Fukomys damarensis | 54.11 | 2e-129 | 384 |
LLPS-Aon-3219 | Aotus nancymaae | 53.82 | 3e-130 | 386 |
LLPS-Dio-2286 | Dipodomys ordii | 53.82 | 1e-132 | 392 |
LLPS-Aim-0403 | Ailuropoda melanoleuca | 53.82 | 5e-135 | 398 |
LLPS-Myl-2294 | Myotis lucifugus | 53.82 | 4e-135 | 398 |
LLPS-Urm-0409 | Ursus maritimus | 53.82 | 2e-135 | 399 |
LLPS-Orc-0575 | Oryctolagus cuniculus | 53.82 | 2e-129 | 384 |
LLPS-Otg-1768 | Otolemur garnettii | 53.82 | 4e-129 | 383 |
LLPS-Cap-2194 | Cavia porcellus | 53.82 | 1e-135 | 400 |
LLPS-Cas-1133 | Carlito syrichta | 53.82 | 3e-131 | 389 |
LLPS-Cae-1279 | Caenorhabditis elegans | 53.62 | 2e-137 | 404 |
LLPS-Mea-0852 | Mesocricetus auratus | 53.54 | 5e-136 | 400 |
LLPS-Mum-1654 | Mus musculus | 53.54 | 1e-135 | 400 |
LLPS-Mup-3097 | Mustela putorius furo | 53.54 | 6e-128 | 380 |
LLPS-Caf-1324 | Canis familiaris | 53.54 | 2e-128 | 381 |
LLPS-Ict-0100 | Ictidomys tridecemlineatus | 53.54 | 3e-135 | 399 |
LLPS-Nol-2261 | Nomascus leucogenys | 53.54 | 2e-130 | 386 |
LLPS-Chs-0899 | Chlorocebus sabaeus | 53.45 | 1e-129 | 383 |
LLPS-Crn-0475 | Cryptococcus neoformans | 53.41 | 1e-94 | 297 |
LLPS-Put-0960 | Puccinia triticina | 53.31 | 9e-89 | 277 |
LLPS-Cea-1265 | Cercocebus atys | 53.26 | 1e-129 | 384 |
LLPS-Maf-0185 | Macaca fascicularis | 53.26 | 1e-129 | 384 |
LLPS-Gog-2575 | Gorilla gorilla | 53.26 | 3e-130 | 386 |
LLPS-Bot-2572 | Bos taurus | 53.26 | 1e-130 | 387 |
LLPS-Paa-0443 | Papio anubis | 53.26 | 1e-129 | 384 |
LLPS-Mal-0375 | Mandrillus leucophaeus | 53.26 | 3e-129 | 383 |
LLPS-Ran-3939 | Rattus norvegicus | 53.26 | 1e-136 | 402 |
LLPS-Man-2691 | Macaca nemestrina | 53.26 | 1e-129 | 384 |
LLPS-Fec-2873 | Felis catus | 53.26 | 3e-131 | 389 |
LLPS-Pat-0485 | Pan troglodytes | 53.26 | 3e-130 | 386 |
LLPS-Pap-0468 | Pan paniscus | 53.26 | 3e-130 | 386 |
LLPS-Hos-0295 | Homo sapiens | 53.26 | 3e-130 | 386 |
LLPS-Rhb-4199 | Rhinopithecus bieti | 53.26 | 8e-130 | 385 |
LLPS-Mam-1545 | Macaca mulatta | 53.26 | 1e-129 | 384 |
LLPS-Poa-0768 | Pongo abelii | 53.26 | 3e-130 | 386 |
LLPS-Gas-0144 | Galdieria sulphuraria | 53.14 | 4e-128 | 380 |
LLPS-Sus-0666 | Sus scrofa | 53.12 | 2e-131 | 389 |
LLPS-Blg-0124 | Blumeria graminis | 53.12 | 4e-112 | 339 |
LLPS-Scj-0941 | Schizosaccharomyces japonicus | 53.12 | 3e-133 | 393 |
LLPS-Eqc-3248 | Equus caballus | 53.12 | 1e-128 | 382 |
LLPS-Pyt-0008 | Pyrenophora teres | 52.98 | 6e-105 | 320 |
LLPS-Tut-1192 | Tursiops truncatus | 52.97 | 9e-130 | 385 |
LLPS-Tar-1215 | Takifugu rubripes | 52.84 | 1e-138 | 409 |
LLPS-Asfu-0800 | Aspergillus fumigatus | 52.81 | 1e-105 | 323 |
LLPS-Mel-0715 | Melampsora laricipopulina | 52.59 | 1e-125 | 374 |
LLPS-Scc-0387 | Schizosaccharomyces cryophilus | 52.42 | 2e-132 | 392 |
LLPS-Ova-0866 | Ovis aries | 52.41 | 2e-126 | 375 |
LLPS-Fuo-0424 | Fusarium oxysporum | 52.38 | 2e-72 | 233 |
LLPS-Tum-0928 | Tuber melanosporum | 52.3 | 5e-117 | 356 |
LLPS-Tru-1605 | Triticum urartu | 52.3 | 1e-134 | 399 |
LLPS-Fuv-1008 | Fusarium verticillioides | 52.25 | 2e-126 | 377 |
LLPS-Abg-0288 | Absidia glauca | 52.1 | 6e-131 | 388 |
LLPS-Fus-0361 | Fusarium solani | 51.97 | 1e-125 | 375 |
LLPS-Aso-1382 | Aspergillus oryzae | 51.88 | 1e-105 | 322 |
LLPS-Nec-0556 | Neurospora crassa | 51.85 | 2e-124 | 371 |
LLPS-Anc-0569 | Anolis carolinensis | 51.85 | 9e-132 | 390 |
LLPS-Asc-0727 | Aspergillus clavatus | 51.71 | 1e-120 | 362 |
LLPS-Lem-0965 | Leptosphaeria maculans | 51.69 | 3e-123 | 370 |
LLPS-Nef-0948 | Neosartorya fischeri | 51.69 | 3e-121 | 363 |
LLPS-Pug-0221 | Puccinia graminis | 51.56 | 2e-127 | 379 |
LLPS-Asn-0735 | Aspergillus nidulans | 51.4 | 7e-127 | 378 |
LLPS-Cym-0423 | Cyanidioschyzon merolae | 51.12 | 2e-120 | 361 |
LLPS-Trv-0220 | Trichoderma virens | 51.12 | 8e-126 | 375 |
LLPS-Coo-0055 | Colletotrichum orbiculare | 51.0 | 1e-123 | 369 |
LLPS-Cog-0632 | Colletotrichum gloeosporioides | 51.0 | 6e-125 | 373 |
LLPS-Map-0262 | Magnaporthe poae | 50.99 | 2e-125 | 374 |
LLPS-Yal-0929 | Yarrowia lipolytica | 50.97 | 2e-125 | 374 |
LLPS-Scp-0251 | Schizosaccharomyces pombe | 50.85 | 6e-133 | 393 |
LLPS-Asf-0676 | Aspergillus flavus | 50.84 | 1e-119 | 359 |
LLPS-Beb-0696 | Beauveria bassiana | 50.71 | 5e-122 | 365 |
LLPS-Gag-0290 | Gaeumannomyces graminis | 50.7 | 6e-126 | 375 |
LLPS-Trr-0609 | Trichoderma reesei | 50.56 | 4e-124 | 371 |
LLPS-Kop-0554 | Komagataella pastoris | 50.43 | 3e-126 | 375 |
LLPS-Zyt-0203 | Zymoseptoria tritici | 50.43 | 8e-123 | 367 |
LLPS-Mao-0135 | Magnaporthe oryzae | 50.28 | 4e-123 | 368 |
LLPS-Asni-1077 | Aspergillus niger | 50.28 | 8e-123 | 367 |
LLPS-Pytr-0753 | Pyrenophora triticirepentis | 50.14 | 2e-119 | 359 |
LLPS-Cogr-0326 | Colletotrichum graminicola | 50.14 | 4e-120 | 360 |
LLPS-Ved-0019 | Verticillium dahliae | 50.0 | 9e-121 | 362 |
LLPS-Dos-1012 | Dothistroma septosporum | 49.71 | 1e-120 | 362 |
LLPS-Miv-0171 | Microbotryum violaceum | 49.58 | 6e-122 | 365 |
LLPS-Ast-0208 | Aspergillus terreus | 49.31 | 1e-120 | 362 |
LLPS-Usm-0027 | Ustilago maydis | 48.9 | 2e-121 | 363 |
LLPS-Spr-0902 | Sporisorium reilianum | 48.77 | 1e-119 | 359 |
LLPS-Chc-0557 | Chondrus crispus | 47.89 | 5e-105 | 322 |
LLPS-Phn-0829 | Phaeosphaeria nodorum | 47.62 | 7e-110 | 333 |
LLPS-Sac-1364 | Saccharomyces cerevisiae | 47.46 | 3e-115 | 348 |
LLPS-Asg-1164 | Ashbya gossypii | 46.63 | 2e-111 | 338 |
LLPS-Scs-0771 | Sclerotinia sclerotiorum | 46.2 | 9e-102 | 313 |
LLPS-Ten-1024 | Tetraodon nigroviridis | 42.98 | 5e-90 | 282 |
LLPS-Leo-1061 | Lepisosteus oculatus | 35.99 | 4e-50 | 178 |