• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ten-3646

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: S-adenosylmethionine synthase
Ensembl Gene: ENSTNIG00000008664.1
Ensembl Protein: ENSTNIP00000011512.1
Organism: Tetraodon nigroviridis
Taxa ID: 99883
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSTNIT00000011694.1ENSTNIP00000011512.1
UniProtH3CTC8, H3CTC8_TETNG

▼ SEQUENCE

Protein Sequence (FASTA)
1     PQGKKKVTMS  DQLEDSSFIF  TSESVGEGHP  DKICDQISDA  VLDAHLKQDP  DAKVACETVC  60
61    KTGMVLLCGE  ITSRANVDYQ  KVVRDAVKQI  GYDSSDKGFD  YKTCNVLVAL  EQQSPDIAQG  120
121   VHVDRKEEDI  GAGDQGLMFG  YATDETEECM  PLTIVLAHKL  NAKMAELRRN  GTIPWLRPDS  180
181   KTQVTVHYEQ  KDGAVIPKRV  HTIVISVQHD  DNISLEEQKK  VLKEKVINSV  VPAKYLDDKT  240
241   VYHLQPSGRF  VIGGPQGDAG  VTGRKIIVDT  YGGWGAHGGG  AFSGKDFSKV  DRSAAYAARW  300
301   VAKSLVKAKL  CKRVLVQLSY  AIGVAHPLSI  SVFTYGSSKK  TEAELLQIVN  KNFDLRPGVI  360
361   VRELNLKRPI  YQQTAAYGHF  GRDGFSWEVP  KQLVF  395
Nucleotide CDS Sequence (FASTA)
1     CCCCAGGGAA  AAAAAAAAGT  CACAATGAGT  GATCAGCTGG  AAGATAGCTC  CTTCATATTC  60
61    ACTTCAGAGT  CTGTGGGAGA  GGGACATCCA  GACAAGATCT  GTGATCAGAT  CAGTGACGCC  120
121   GTCCTGGATG  CTCACCTGAA  GCAGGACCCA  GATGCAAAGG  TGGCCTGTGA  AACGGTTTGT  180
181   AAGACTGGCA  TGGTGCTGCT  CTGCGGTGAG  ATCACATCCC  GGGCCAATGT  GGACTACCAG  240
241   AAGGTGGTGA  GGGACGCCGT  CAAACAAATC  GGTTACGACA  GCTCTGACAA  AGGCTTTGAC  300
301   TACAAGACGT  GCAACGTGCT  GGTGGCTCTG  GAGCAGCAGA  GCCCCGACAT  TGCTCAGGGA  360
361   GTCCACGTTG  ACAGGAAGGA  GGAGGACATT  GGAGCTGGAG  ACCAGGGTCT  GATGTTCGGC  420
421   TACGCCACGG  ACGAAACAGA  GGAATGCATG  CCTCTCACCA  TCGTCCTAGC  CCACAAACTC  480
481   AACGCAAAGA  TGGCCGAACT  CAGACGTAAC  GGCACCATTC  CCTGGCTGCG  TCCCGACTCC  540
541   AAAACACAGG  TGACCGTGCA  CTATGAGCAG  AAAGACGGAG  CGGTGATCCC  CAAAAGAGTT  600
601   CACACCATCG  TGATCTCGGT  GCAGCACGAC  GACAACATCT  CCCTGGAGGA  GCAGAAGAAG  660
661   GTGCTCAAAG  AGAAGGTGAT  CAATTCAGTT  GTCCCCGCTA  AATATTTGGA  CGACAAGACT  720
721   GTTTACCACC  TCCAGCCGAG  CGGCCGCTTT  GTTATCGGAG  GACCCCAGGG  GGACGCTGGA  780
781   GTAACAGGCA  GGAAAATCAT  CGTCGACACG  TACGGAGGCT  GGGGAGCTCA  CGGAGGCGGA  840
841   GCGTTCTCCG  GCAAAGACTT  CTCAAAGGTG  GACCGCTCCG  CCGCCTACGC  CGCCCGCTGG  900
901   GTGGCCAAAT  CTCTGGTCAA  GGCCAAACTG  TGCAAGAGAG  TTCTGGTGCA  GCTGTCCTAT  960
961   GCCATCGGGG  TGGCCCATCC  TCTCTCCATC  TCTGTGTTCA  CTTATGGCTC  TTCCAAGAAA  1020
1021  ACAGAGGCAG  AGTTGCTCCA  GATTGTCAAC  AAGAACTTTG  ACCTACGGCC  AGGAGTCATT  1080
1081  GTCAGGGAAC  TGAATCTGAA  GAGGCCCATC  TACCAGCAGA  CAGCCGCATA  CGGCCACTTT  1140
1141  GGTCGAGATG  GGTTTTCATG  GGAGGTGCCC  AAACAGCTCG  TCTTTTAA  1188

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Potassium
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Methionine adenosyltransferase activity
Biological Process
One-carbon metabolic process
Biological Process
S-adenosylmethionine biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tar-3031Takifugu rubripes96.120.0 715
LLPS-Orl-1702Oryzias latipes91.990.0 692
LLPS-Orn-3785Oreochromis niloticus89.920.0 680
LLPS-Scf-0778Scleropages formosus88.220.0 662
LLPS-Dar-3894Danio rerio88.050.0 663
LLPS-Gaa-3338Gasterosteus aculeatus87.140.0 654
LLPS-Lac-0321Latimeria chalumnae86.880.0 641
LLPS-Leo-0546Lepisosteus oculatus86.650.0 647
LLPS-Asm-0204Astyanax mexicanus86.430.0 658
LLPS-Xet-2137Xenopus tropicalis85.220.0 638
LLPS-Fia-2232Ficedula albicollis85.080.0 640
LLPS-Eqc-1225Equus caballus84.530.0 571
LLPS-Pes-0133Pelodiscus sinensis84.250.0 631
LLPS-Anp-0170Anas platyrhynchos84.030.0 637
LLPS-Cas-3062Carlito syrichta83.790.0 596
LLPS-Meg-1498Meleagris gallopavo83.770.0 632
LLPS-Fud-4116Fukomys damarensis83.770.0 633
LLPS-Myl-2273Myotis lucifugus83.770.0 633
LLPS-Pap-1644Pan paniscus83.550.0 630
LLPS-Pat-1352Pan troglodytes83.550.0 630
LLPS-Hos-1410Homo sapiens83.550.0 630
LLPS-Rhb-2929Rhinopithecus bieti83.550.0 630
LLPS-Mam-2050Macaca mulatta83.550.0 630
LLPS-Poa-1460Pongo abelii83.550.0 630
LLPS-Tag-1753Taeniopygia guttata83.550.0 628
LLPS-Cea-1338Cercocebus atys83.550.0 630
LLPS-Aon-3122Aotus nancymaae83.550.0 630
LLPS-Chs-3280Chlorocebus sabaeus83.550.0 630
LLPS-Maf-1148Macaca fascicularis83.550.0 630
LLPS-Gog-1123Gorilla gorilla83.550.0 630
LLPS-Paa-2923Papio anubis83.550.0 630
LLPS-Cap-4494Cavia porcellus83.510.0 633
LLPS-Man-3151Macaca nemestrina83.290.0 612
LLPS-Otg-1686Otolemur garnettii83.290.0 629
LLPS-Caf-1423Canis familiaris83.290.0 629
LLPS-Caj-0295Callithrix jacchus83.290.0 611
LLPS-Aim-0592Ailuropoda melanoleuca83.290.0 629
LLPS-Gaga-0823Gallus gallus83.250.0 630
LLPS-Orc-3083Oryctolagus cuniculus83.120.0 514
LLPS-Loa-1113Loxodonta africana83.030.0 628
LLPS-Fec-4399Felis catus83.030.0 628
LLPS-Ict-1511Ictidomys tridecemlineatus83.030.0 628
LLPS-Mea-0384Mesocricetus auratus83.030.0 629
LLPS-Mum-3166Mus musculus83.030.0 629
LLPS-Dio-1975Dipodomys ordii83.030.0 629
LLPS-Mup-0096Mustela putorius furo83.030.0 628
LLPS-Ran-3799Rattus norvegicus83.030.0 628
LLPS-Mod-2718Monodelphis domestica82.980.0 629
LLPS-Icp-2063Ictalurus punctatus82.770.0 627
LLPS-Ova-3481Ovis aries82.770.0 624
LLPS-Sus-4034Sus scrofa82.760.0 609
LLPS-Bot-3022Bos taurus82.760.0 609
LLPS-Nol-0149Nomascus leucogenys82.720.0 624
LLPS-Mal-2151Mandrillus leucophaeus82.720.0 624
LLPS-Ora-3195Ornithorhynchus anatinus82.530.0 534
LLPS-Urm-3561Ursus maritimus82.460.0 624
LLPS-Sah-2557Sarcophilus harrisii81.940.0 626
LLPS-Pof-2477Poecilia formosa81.410.0 616
LLPS-Anc-1589Anolis carolinensis81.410.0 621
LLPS-Xim-1770Xiphophorus maculatus81.140.0 617
LLPS-Scm-1553Scophthalmus maximus77.810.0 568
LLPS-Drm-1266Drosophila melanogaster72.580.0 552
LLPS-Cae-0591Caenorhabditis elegans71.810.0 535
LLPS-Aso-0972Aspergillus oryzae71.770.0 535
LLPS-Scj-1316Schizosaccharomyces japonicus71.770.0 551
LLPS-Asf-0281Aspergillus flavus71.770.0 535
LLPS-Beb-1295Beauveria bassiana71.580.0 516
LLPS-Asni-0550Aspergillus niger71.580.0 532
LLPS-Fuo-1211Fusarium oxysporum71.20.0 538
LLPS-Fuv-0294Fusarium verticillioides71.20.0 538
LLPS-Scp-1449Schizosaccharomyces pombe70.980.0 538
LLPS-Fus-0472Fusarium solani70.940.0 541
LLPS-Trr-1346Trichoderma reesei70.790.0 529
LLPS-Yal-1099Yarrowia lipolytica70.710.0 535
LLPS-Cogr-1222Colletotrichum graminicola70.680.0 531
LLPS-Coo-1398Colletotrichum orbiculare70.673e-178 513
LLPS-Blg-1155Blumeria graminis70.450.0 537
LLPS-Tum-0534Tuber melanosporum70.260.0 536
LLPS-Pyt-1142Pyrenophora teres70.00.0 528
LLPS-Zyt-1323Zymoseptoria tritici69.660.0 524
LLPS-Trv-0078Trichoderma virens69.473e-177 506
LLPS-Cog-1285Colletotrichum gloeosporioides69.370.0 522
LLPS-Ved-1434Verticillium dahliae69.370.0 535
LLPS-Gag-0692Gaeumannomyces graminis69.370.0 520
LLPS-Asn-1459Aspergillus nidulans69.292e-180 514
LLPS-Usm-0593Ustilago maydis69.270.0 523
LLPS-Asfu-1142Aspergillus fumigatus68.992e-174 499
LLPS-Lem-1484Leptosphaeria maculans68.960.0 540
LLPS-Scc-1206Schizosaccharomyces cryophilus68.870.0 531
LLPS-Map-0958Magnaporthe poae68.851e-180 516
LLPS-Nef-1047Neosartorya fischeri68.737e-176 503
LLPS-Asc-1638Aspergillus clavatus68.730.0 523
LLPS-Spr-0242Sporisorium reilianum68.670.0 517
LLPS-Pytr-1152Pyrenophora triticirepentis68.613e-168 483
LLPS-Phn-0147Phaeosphaeria nodorum68.618e-164 473
LLPS-Miv-1180Microbotryum violaceum68.319e-163 470
LLPS-Asg-0492Ashbya gossypii68.250.0 524
LLPS-Mao-1555Magnaporthe oryzae67.80.0 521
LLPS-Sac-0497Saccharomyces cerevisiae67.280.0 527
LLPS-Gas-0809Galdieria sulphuraria67.278e-179 511
LLPS-Kop-0411Komagataella pastoris67.114e-176 503
LLPS-Dos-1282Dothistroma septosporum66.934e-178 509
LLPS-Coc-0758Corchorus capsularis64.581e-159 462
LLPS-Gor-1480Gossypium raimondii64.327e-160 462
LLPS-Hea-0846Helianthus annuus64.327e-158 460
LLPS-Chr-1223Chlamydomonas reinhardtii64.322e-160 464
LLPS-Prp-1969Prunus persica64.34e-159 461
LLPS-Brd-0192Brachypodium distachyon64.081e-160 465
LLPS-Viv-1749Vitis vinifera64.067e-158 459
LLPS-Thc-0683Theobroma cacao63.829e-158 461
LLPS-Brr-2331Brassica rapa63.82e-159 462
LLPS-Brn-3239Brassica napus63.82e-159 462
LLPS-Glm-1320Glycine max63.84e-158 458
LLPS-Via-0955Vigna angularis63.85e-157 455
LLPS-Mae-0443Manihot esculenta63.712e-157 456
LLPS-Pot-0114Populus trichocarpa63.541e-157 457
LLPS-Amt-1643Amborella trichopoda63.545e-157 456
LLPS-Bro-0473Brassica oleracea63.548e-159 460
LLPS-Sem-2050Selaginella moellendorffii63.541e-158 459
LLPS-Dac-1368Daucus carota63.541e-159 462
LLPS-Mua-1889Musa acuminata63.43e-156 453
LLPS-Zem-1761Zea mays63.381e-157 457
LLPS-Hov-0917Hordeum vulgare63.315e-158 458
LLPS-Art-1556Arabidopsis thaliana63.281e-158 459
LLPS-Sol-0656Solanum lycopersicum63.282e-157 456
LLPS-Arl-1236Arabidopsis lyrata63.281e-158 459
LLPS-Cus-1530Cucumis sativus63.282e-158 459
LLPS-Met-1039Medicago truncatula63.285e-158 458
LLPS-Tru-0315Triticum urartu63.052e-157 459
LLPS-Tra-0476Triticum aestivum63.051e-158 459
LLPS-Phv-1976Phaseolus vulgaris63.024e-156 453
LLPS-Sob-1371Sorghum bicolor63.021e-156 454
LLPS-Sei-0614Setaria italica63.025e-157 457
LLPS-Ors-1298Oryza sativa62.761e-156 454
LLPS-Orbr-1919Oryza brachyantha62.762e-156 454
LLPS-Orm-2003Oryza meridionalis62.765e-157 456
LLPS-Orr-0057Oryza rufipogon62.765e-157 456
LLPS-Orb-0310Oryza barthii62.765e-157 456
LLPS-Orni-1417Oryza nivara62.761e-156 454
LLPS-Orgl-1775Oryza glumaepatula62.765e-157 456
LLPS-Sot-1272Solanum tuberosum62.244e-156 453
LLPS-Php-2391Physcomitrella patens61.522e-157 457