• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gog-1123

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: S-adenosylmethionine synthase
Ensembl Gene: ENSGGOG00000004936.3
Ensembl Protein: ENSGGOP00000035433.1
Organism: Gorilla gorilla
Taxa ID: 9595
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNGQLNGFHE  AFIEEGTFLF  TSESVGEGHP  DKICDQISDA  VLDAHLQQDP  DAKVACETVA  60
61    KTGMILLAGE  ITSRAAVDYQ  KVVREAVKHI  GYDDSSKGFD  YKTCNVLVAL  EQQSPDIAQG  120
121   VHLDRNEEDI  GAGDQGLMFG  YATDETEECM  PLTIVLAHKL  NAKLAELRRN  GTLPWLRPDS  180
181   KTQVTVQYMQ  DRGAVLPIRV  HTIVISVQHD  EEVCLDEMRD  ALKEKVIKAV  VPAKYLDEDT  240
241   IYHLQPSGRF  VIGGPQGDAG  LTGRKIIVDT  YGGWGAHGGG  AFSGKDYTKV  DRSAAYAARW  300
301   VAKSLVKGGL  CRRVLVQVSY  AIGVSHPLSI  SIFHYGTSQK  SERELLEIVK  KNFDLRPGVI  360
361   VRDLDLKKPI  YQRTAAYGHF  GRDSFPWEVP  KKLKY  395
Nucleotide CDS Sequence (FASTA)
1     ATGAACGGAC  AGCTCAACGG  CTTCCACGAG  GCGTTCATCG  AGGAGGGCAC  GTTCCTTTTC  60
61    ACCTCAGAGT  CGGTCGGGGA  AGGCCACCCA  GATAAGATTT  GTGACCAGAT  CAGTGATGCT  120
121   GTCCTTGATG  CCCACCTTCA  GCAGGATCCT  GATGCCAAAG  TAGCTTGTGA  AACTGTTGCT  180
181   AAAACTGGAA  TGATCCTTCT  TGCTGGGGAA  ATTACATCCA  GAGCTGCTGT  TGACTACCAG  240
241   AAAGTGGTTC  GTGAAGCTGT  TAAACACATT  GGATATGATG  ATTCTTCCAA  AGGTTTTGAC  300
301   TACAAGACTT  GTAATGTGCT  GGTAGCCTTG  GAGCAACAGT  CACCAGATAT  TGCTCAAGGT  360
361   GTTCATCTTG  ACAGAAATGA  AGAAGACATT  GGTGCTGGAG  ACCAGGGCTT  AATGTTTGGC  420
421   TATGCCACTG  ATGAAACTGA  GGAGTGTATG  CCTTTAACCA  TTGTCTTGGC  ACACAAGCTA  480
481   AATGCCAAAC  TGGCAGAACT  ACGCCGTAAT  GGCACTTTGC  CTTGGTTACG  CCCTGATTCG  540
541   AAAACTCAAG  TTACTGTGCA  GTATATGCAG  GATAGAGGTG  CTGTGCTTCC  CATCAGAGTC  600
601   CACACAATCG  TTATATCTGT  TCAGCATGAT  GAAGAGGTTT  GTCTTGATGA  GATGAGGGAT  660
661   GCCCTAAAGG  AGAAAGTCAT  CAAAGCAGTT  GTGCCTGCGA  AATACCTTGA  TGAGGATACA  720
721   ATCTACCACC  TACAGCCAAG  TGGCAGATTT  GTTATTGGTG  GGCCTCAGGG  TGATGCTGGT  780
781   TTGACTGGAC  GGAAAATCAT  TGTGGACACT  TATGGCGGTT  GGGGTGCTCA  TGGAGGAGGT  840
841   GCCTTTTCAG  GAAAGGATTA  TACCAAGGTC  GACCGTTCAG  CTGCTTATGC  TGCTCGTTGG  900
901   GTGGCAAAAT  CCCTTGTTAA  AGGAGGTCTG  TGCCGGAGGG  TTCTTGTTCA  GGTCTCTTAT  960
961   GCTATTGGAG  TTTCTCATCC  ATTATCTATC  TCCATTTTCC  ATTATGGTAC  CTCTCAGAAG  1020
1021  AGTGAGAGAG  AGCTATTAGA  GATTGTGAAG  AAGAATTTCG  ATCTCCGCCC  TGGGGTCATT  1080
1081  GTCAGGGATC  TGGATCTGAA  GAAGCCAATT  TATCAGAGGA  CTGCAGCCTA  TGGCCACTTT  1140
1141  GGTAGGGACA  GCTTCCCATG  GGAAGTGCCC  AAAAAGCTTA  AATATTGA  1188

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Potassium
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Methionine adenosyltransferase complex
Molecular Function
ATP binding
Molecular Function
Identical protein binding
Molecular Function
Metal ion binding
Molecular Function
Methionine adenosyltransferase activity
Biological Process
Cellular response to leukemia inhibitory factor
Biological Process
One-carbon metabolic process
Biological Process
Protein heterooligomerization
Biological Process
Protein hexamerization
Biological Process
S-adenosylmethionine biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-2050Macaca mulatta100.00.0 784
LLPS-Poa-1460Pongo abelii100.00.0 784
LLPS-Pap-1644Pan paniscus100.00.0 784
LLPS-Pat-1352Pan troglodytes100.00.0 784
LLPS-Hos-1410Homo sapiens100.00.0 784
LLPS-Paa-2923Papio anubis100.00.0 784
LLPS-Cea-1338Cercocebus atys100.00.0 784
LLPS-Aon-3122Aotus nancymaae100.00.0 784
LLPS-Chs-3280Chlorocebus sabaeus100.00.0 784
LLPS-Maf-1148Macaca fascicularis100.00.0 784
LLPS-Caf-1423Canis familiaris99.750.0 784
LLPS-Rhb-2929Rhinopithecus bieti99.750.0 781
LLPS-Otg-1686Otolemur garnettii99.750.0 784
LLPS-Aim-0592Ailuropoda melanoleuca99.750.0 784
LLPS-Cas-3062Carlito syrichta99.730.0 716
LLPS-Loa-1113Loxodonta africana99.490.0 782
LLPS-Fec-4399Felis catus99.490.0 782
LLPS-Mup-0096Mustela putorius furo99.490.0 782
LLPS-Dio-1975Dipodomys ordii99.490.0 783
LLPS-Mea-0384Mesocricetus auratus99.490.0 783
LLPS-Mum-3166Mus musculus99.490.0 783
LLPS-Man-3151Macaca nemestrina99.480.0 756
LLPS-Caj-0295Callithrix jacchus99.480.0 755
LLPS-Ict-1511Ictidomys tridecemlineatus98.990.0 780
LLPS-Ova-3481Ovis aries98.990.0 777
LLPS-Ran-3799Rattus norvegicus98.990.0 780
LLPS-Bot-3022Bos taurus98.70.0 751
LLPS-Sus-4034Sus scrofa98.70.0 752
LLPS-Ora-3195Ornithorhynchus anatinus98.490.0 646
LLPS-Cap-1493Cavia porcellus98.480.0 775
LLPS-Fud-2583Fukomys damarensis98.480.0 776
LLPS-Orc-3083Oryctolagus cuniculus98.450.0 620
LLPS-Eqc-0767Equus caballus98.180.0 748
LLPS-Mod-1707Monodelphis domestica97.720.0 771
LLPS-Myl-2236Myotis lucifugus97.720.0 769
LLPS-Urm-2060Ursus maritimus97.220.0 756
LLPS-Mal-2612Mandrillus leucophaeus97.110.0 724
LLPS-Fia-1380Ficedula albicollis95.950.0 759
LLPS-Nol-3893Nomascus leucogenys95.140.0 729
LLPS-Pes-2077Pelodiscus sinensis95.030.0 603
LLPS-Scf-0619Scleropages formosus93.670.0 748
LLPS-Leo-3580Lepisosteus oculatus93.160.0 739
LLPS-Xet-0456Xenopus tropicalis92.840.0 674
LLPS-Asm-3207Astyanax mexicanus92.660.0 720
LLPS-Orn-1473Oreochromis niloticus91.650.0 733
LLPS-Lac-0166Latimeria chalumnae90.540.0 716
LLPS-Ten-3792Tetraodon nigroviridis90.380.0 719
LLPS-Anc-3057Anolis carolinensis90.280.0 716
LLPS-Tar-2330Takifugu rubripes90.130.0 723
LLPS-Dar-0069Danio rerio90.060.0 657
LLPS-Gaa-0123Gasterosteus aculeatus89.870.0 721
LLPS-Icp-2063Ictalurus punctatus89.370.0 721
LLPS-Pof-2477Poecilia formosa88.890.0 698
LLPS-Xim-1770Xiphophorus maculatus88.890.0 700
LLPS-Orl-1999Oryzias latipes88.780.0 694
LLPS-Scm-1553Scophthalmus maximus86.330.0 671
LLPS-Gaga-0823Gallus gallus84.090.0 668
LLPS-Meg-1498Meleagris gallopavo83.840.0 668
LLPS-Anp-0170Anas platyrhynchos83.590.0 666
LLPS-Sah-2557Sarcophilus harrisii82.830.0 671
LLPS-Tag-1753Taeniopygia guttata82.620.0 655
LLPS-Drm-1266Drosophila melanogaster74.410.0 573
LLPS-Cae-0549Caenorhabditis elegans74.270.0 566
LLPS-Yal-1099Yarrowia lipolytica72.030.0 555
LLPS-Scj-1316Schizosaccharomyces japonicus71.240.0 557
LLPS-Blg-1155Blumeria graminis70.790.0 557
LLPS-Asfu-1142Aspergillus fumigatus70.685e-180 514
LLPS-Nef-1047Neosartorya fischeri70.680.0 530
LLPS-Asf-0281Aspergillus flavus70.420.0 550
LLPS-Aso-0972Aspergillus oryzae70.420.0 550
LLPS-Tum-0534Tuber melanosporum70.180.0 543
LLPS-Spr-0242Sporisorium reilianum70.050.0 538
LLPS-Usm-0593Ustilago maydis70.050.0 540
LLPS-Scp-1449Schizosaccharomyces pombe69.920.0 545
LLPS-Asc-1638Aspergillus clavatus69.90.0 546
LLPS-Asni-0550Aspergillus niger69.660.0 542
LLPS-Beb-1295Beauveria bassiana69.570.0 528
LLPS-Trr-1346Trichoderma reesei69.470.0 536
LLPS-Cogr-1222Colletotrichum graminicola69.450.0 544
LLPS-Scc-1206Schizosaccharomyces cryophilus69.390.0 540
LLPS-Coo-1398Colletotrichum orbiculare69.330.0 523
LLPS-Lem-1484Leptosphaeria maculans69.210.0 534
LLPS-Asn-1459Aspergillus nidulans69.030.0 521
LLPS-Trv-0078Trichoderma virens68.930.0 518
LLPS-Gag-0692Gaeumannomyces graminis68.670.0 541
LLPS-Fus-0472Fusarium solani68.430.0 553
LLPS-Cog-1285Colletotrichum gloeosporioides68.410.0 538
LLPS-Ved-1434Verticillium dahliae68.350.0 550
LLPS-Kop-0411Komagataella pastoris68.250.0 515
LLPS-Pyt-1142Pyrenophora teres68.240.0 523
LLPS-Sac-0627Saccharomyces cerevisiae68.160.0 539
LLPS-Map-0958Magnaporthe poae68.150.0 527
LLPS-Asg-0492Ashbya gossypii67.720.0 529
LLPS-Fuo-1211Fusarium oxysporum67.680.0 533
LLPS-Fuv-0294Fusarium verticillioides67.680.0 533
LLPS-Prp-1969Prunus persica67.625e-172 493
LLPS-Zyt-1323Zymoseptoria tritici67.260.0 535
LLPS-Mao-1555Magnaporthe oryzae67.260.0 544
LLPS-Met-0236Medicago truncatula66.753e-169 486
LLPS-Glm-1767Glycine max66.754e-169 486
LLPS-Gor-1480Gossypium raimondii66.581e-169 488
LLPS-Dac-2229Daucus carota66.581e-169 488
LLPS-Zem-0594Zea mays66.491e-168 485
LLPS-Sob-1371Sorghum bicolor66.499e-168 483
LLPS-Gas-0809Galdieria sulphuraria66.490.0 518
LLPS-Coc-0758Corchorus capsularis66.321e-168 485
LLPS-Amt-1643Amborella trichopoda66.325e-168 483
LLPS-Lep-1398Leersia perrieri66.326e-168 485
LLPS-Mae-0443Manihot esculenta66.237e-169 485
LLPS-Brr-1228Brassica rapa66.233e-168 484
LLPS-Brd-0192Brachypodium distachyon66.067e-168 483
LLPS-Tra-0476Triticum aestivum66.062e-168 484
LLPS-Hov-0917Hordeum vulgare66.069e-168 483
LLPS-Thc-1689Theobroma cacao66.064e-168 483
LLPS-Hea-0846Helianthus annuus65.982e-166 481
LLPS-Pot-0414Populus trichocarpa65.971e-167 482
LLPS-Orr-0057Oryza rufipogon65.87e-168 483
LLPS-Orm-2003Oryza meridionalis65.87e-168 483
LLPS-Orbr-1919Oryza brachyantha65.89e-168 483
LLPS-Ors-1298Oryza sativa65.84e-167 481
LLPS-Sei-0614Setaria italica65.82e-167 484
LLPS-Orgl-1775Oryza glumaepatula65.87e-168 483
LLPS-Orni-1417Oryza nivara65.84e-167 481
LLPS-Mua-0437Musa acuminata65.86e-167 481
LLPS-Orb-0310Oryza barthii65.87e-168 483
LLPS-Viv-1749Vitis vinifera65.756e-169 487
LLPS-Org-0993Oryza glaberrima65.711e-167 482
LLPS-Orp-1778Oryza punctata65.713e-168 484
LLPS-Art-1132Arabidopsis thaliana65.713e-166 479
LLPS-Via-1976Vigna angularis65.626e-166 478
LLPS-Bro-2313Brassica oleracea65.455e-166 478
LLPS-Arl-1090Arabidopsis lyrata65.455e-166 478
LLPS-Cus-1272Cucumis sativus65.283e-167 481
LLPS-Tru-0896Triticum urartu65.194e-169 486
LLPS-Brn-1898Brassica napus65.191e-166 480
LLPS-Dos-1282Dothistroma septosporum65.144e-178 509
LLPS-Sem-0265Selaginella moellendorffii65.035e-167 481