LLPS-Sac-0497
SAM2

▼ OVERVIEW

Status: Reviewed
Protein Name: S-adenosylmethionine synthase 2
Gene Name: SAM2, ETH2, YDR502C, D9719.8
Ensembl Gene: YDR502C
Ensembl Protein: YDR502C_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...To the list of proteins identified and validated in stress granules, we added proteins known to be in stress granules but not enriched in our mass spectrometric analysis to create an initial list of yeast stress granule proteins."
Saccharomyces cerevisiae26777405
Stress granule
"...Statistical analysis allowed us to rigorously conclude that at least 39 of these 59 overlap with Ded1 and are thus stress granule proteins."
Saccharomyces cerevisiae26777405
Others
"...We have carried out extensive proteomic studies to quantify heat-triggered aggregation and subsequent disaggregation in budding yeast, identifying more than 170 endogenous proteins aggregating within minutes of heat shock in multiple subcellular compartments."
Saccharomyces cerevisiae26359986

▼ FUNCTION

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSKSKTFLFT  SESVGEGHPD  KICDQVSDAI  LDACLEQDPF  SKVACETAAK  TGMIMVFGEI  60
61    TTKARLDYQQ  IVRDTIKKIG  YDDSAKGFDY  KTCNVLVAIE  QQSPDIAQGL  HYEKSLEDLG  120
121   AGDQGIMFGY  ATDETPEGLP  LTILLAHKLN  MAMADARRDG  SLPWLRPDTK  TQVTVEYEDD  180
181   NGRWVPKRID  TVVISAQHAD  EISTADLRTQ  LQKDIVEKVI  PKDMLDENTK  YFIQPSGRFV  240
241   IGGPQGDAGL  TGRKIIVDAY  GGASSVGGGA  FSGKDYSKVD  RSAAYAARWV  AKSLVAAGLC  300
301   KRVQVQFSYA  IGIAEPLSLH  VDTYGTATKS  DDEIIEIIKK  NFDLRPGVLV  KELDLARPIY  360
361   LPTASYGHFT  NQEYSWEKPK  KLEF  384
Nucleotide CDS Sequence (FASTA)
1     ATGTCCAAGA  GCAAAACTTT  CTTATTTACC  TCTGAATCCG  TCGGTGAAGG  TCACCCAGAC  60
61    AAGATTTGTG  ACCAAGTTTC  TGATGCTATT  TTGGACGCTT  GTTTAGAACA  AGATCCATTC  120
121   TCCAAGGTTG  CCTGTGAAAC  AGCTGCCAAA  ACTGGTATGA  TTATGGTTTT  CGGTGAAATT  180
181   ACCACCAAAG  CTAGACTTGA  CTACCAACAA  ATAGTAAGAG  ATACCATCAA  GAAGATTGGT  240
241   TATGACGATT  CTGCCAAGGG  TTTCGACTAC  AAGACATGTA  ATGTTTTAGT  AGCTATCGAA  300
301   CAACAATCTC  CAGATATCGC  TCAAGGTCTG  CACTATGAAA  AGAGCTTAGA  AGACTTAGGT  360
361   GCTGGTGACC  AAGGTATAAT  GTTTGGTTAC  GCTACAGACG  AAACTCCAGA  AGGGTTACCA  420
421   TTGACCATTC  TTTTGGCTCA  CAAATTGAAC  ATGGCTATGG  CAGATGCTAG  AAGAGATGGT  480
481   TCTCTCCCAT  GGTTGAGACC  AGACACAAAG  ACTCAAGTCA  CTGTCGAATA  CGAAGACGAC  540
541   AATGGTAGAT  GGGTTCCAAA  GAGGATAGAT  ACCGTTGTTA  TTTCTGCTCA  ACATGCTGAT  600
601   GAAATTTCCA  CCGCTGACTT  GAGAACTCAA  CTTCAAAAAG  ATATTGTTGA  AAAGGTCATA  660
661   CCAAAGGATA  TGTTAGACGA  AAATACCAAA  TATTTCATCC  AACCATCCGG  TAGATTCGTC  720
721   ATCGGTGGTC  CTCAAGGTGA  CGCTGGTTTG  ACCGGTAGAA  AGATTATTGT  CGACGCTTAC  780
781   GGTGGTGCCT  CATCCGTCGG  TGGTGGTGCC  TTCTCCGGTA  AGGACTATTC  CAAGGTCGAT  840
841   CGTTCCGCTG  CTTACGCTGC  TAGATGGGTT  GCCAAGTCTC  TAGTTGCCGC  TGGTTTGTGT  900
901   AAGAGAGTCC  AAGTCCAATT  TTCATATGCT  ATTGGTATTG  CTGAACCATT  GTCTTTACAT  960
961   GTGGACACCT  ATGGTACAGC  TACAAAATCA  GATGACGAAA  TCATTGAAAT  TATTAAGAAG  1020
1021  AACTTCGACT  TGAGACCAGG  TGTGTTAGTA  AAGGAATTAG  ATTTGGCTAG  ACCAATTTAC  1080
1081  TTACCAACCG  CTTCTTATGG  TCACTTCACT  AATCAAGAGT  ACTCATGGGA  AAAACCAAAG  1140
1141  AAATTGGAAT  TTTAA  1155

▼ KEYWORD

ID
Family
Acetylation
ATP-binding
Complete proteome
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Potassium
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasmic stress granule
Cellular Component
Cytosol
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Methionine adenosyltransferase activity
Biological Process
Methionine metabolic process
Biological Process
One-carbon metabolic process
Biological Process
S-adenosylmethionine biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-0492Ashbya gossypii88.680.0 663
LLPS-Yal-1099Yarrowia lipolytica79.210.0 587
LLPS-Scj-1316Schizosaccharomyces japonicus79.170.0 607
LLPS-Asc-1638Aspergillus clavatus76.820.0 583
LLPS-Scp-1449Schizosaccharomyces pombe76.640.0 594
LLPS-Usm-0593Ustilago maydis76.460.0 566
LLPS-Nef-1047Neosartorya fischeri76.30.0 553
LLPS-Asfu-1142Aspergillus fumigatus76.30.0 541
LLPS-Pyt-1142Pyrenophora teres76.250.0 565
LLPS-Spr-0242Sporisorium reilianum76.190.0 566
LLPS-Scc-1206Schizosaccharomyces cryophilus76.050.0 580
LLPS-Kop-0411Komagataella pastoris75.780.0 577
LLPS-Asn-1459Aspergillus nidulans75.730.0 565
LLPS-Dos-1282Dothistroma septosporum75.660.0 556
LLPS-Tum-0534Tuber melanosporum75.20.0 567
LLPS-Phn-0147Phaeosphaeria nodorum75.140.0 518
LLPS-Blg-1155Blumeria graminis75.130.0 572
LLPS-Zyt-1323Zymoseptoria tritici74.930.0 567
LLPS-Pytr-1152Pyrenophora triticirepentis74.720.0 514
LLPS-Trv-0078Trichoderma virens74.550.0 544
LLPS-Asf-0281Aspergillus flavus74.480.0 580
LLPS-Aso-0972Aspergillus oryzae74.480.0 580
LLPS-Map-0958Magnaporthe poae74.470.0 559
LLPS-Fuv-0294Fusarium verticillioides74.470.0 556
LLPS-Cogr-1222Colletotrichum graminicola74.470.0 565
LLPS-Fuo-1211Fusarium oxysporum74.470.0 556
LLPS-Mao-1555Magnaporthe oryzae74.210.0 570
LLPS-Gag-0692Gaeumannomyces graminis73.950.0 567
LLPS-Cog-1285Colletotrichum gloeosporioides73.950.0 563
LLPS-Ved-1434Verticillium dahliae73.950.0 561
LLPS-Fus-0472Fusarium solani73.680.0 565
LLPS-Lem-1484Leptosphaeria maculans73.630.0 565
LLPS-Coo-1398Colletotrichum orbiculare73.60.0 546
LLPS-Trr-1346Trichoderma reesei73.510.0 559
LLPS-Asni-0550Aspergillus niger73.440.0 575
LLPS-Beb-1295Beauveria bassiana72.630.0 535
LLPS-Miv-1180Microbotryum violaceum71.23e-172 493
LLPS-Icp-0087Ictalurus punctatus70.90.0 534
LLPS-Xet-0456Xenopus tropicalis69.942e-168 483
LLPS-Gaa-1397Gasterosteus aculeatus69.580.0 518
LLPS-Ten-3561Tetraodon nigroviridis69.310.0 526
LLPS-Dar-0069Danio rerio69.282e-165 475
LLPS-Orn-1635Oreochromis niloticus69.050.0 523
LLPS-Lac-0166Latimeria chalumnae68.870.0 527
LLPS-Tar-2950Takifugu rubripes68.780.0 516
LLPS-Fia-2232Ficedula albicollis68.520.0 522
LLPS-Abg-1295Absidia glauca68.452e-147 429
LLPS-Gog-4609Gorilla gorilla68.340.0 525
LLPS-Mup-0096Mustela putorius furo68.340.0 521
LLPS-Pap-4513Pan paniscus68.340.0 525
LLPS-Pat-4232Pan troglodytes68.340.0 525
LLPS-Hos-2216Homo sapiens68.340.0 525
LLPS-Fec-4399Felis catus68.340.0 521
LLPS-Loa-1113Loxodonta africana68.340.0 521
LLPS-Asm-3207Astyanax mexicanus68.251e-176 505
LLPS-Leo-3580Lepisosteus oculatus68.250.0 518
LLPS-Xim-1770Xiphophorus maculatus68.250.0 516
LLPS-Pes-0133Pelodiscus sinensis68.250.0 518
LLPS-Pof-2477Poecilia formosa68.250.0 516
LLPS-Meg-1498Meleagris gallopavo68.250.0 520
LLPS-Anc-1589Anolis carolinensis68.250.0 522
LLPS-Mea-4440Mesocricetus auratus68.230.0 528
LLPS-Fud-2583Fukomys damarensis68.070.0 518
LLPS-Mum-3166Mus musculus68.070.0 520
LLPS-Ova-3481Ovis aries68.070.0 516
LLPS-Aim-0592Ailuropoda melanoleuca68.070.0 520
LLPS-Dio-1975Dipodomys ordii68.070.0 520
LLPS-Scf-0619Scleropages formosus68.070.0 519
LLPS-Otg-1686Otolemur garnettii68.070.0 520
LLPS-Caf-1423Canis familiaris68.070.0 520
LLPS-Cap-1493Cavia porcellus68.070.0 517
LLPS-Orl-1999Oryzias latipes67.990.0 518
LLPS-Ict-1419Ictidomys tridecemlineatus67.970.0 528
LLPS-Maf-1148Macaca fascicularis67.810.0 519
LLPS-Chs-3280Chlorocebus sabaeus67.810.0 519
LLPS-Aon-3122Aotus nancymaae67.810.0 519
LLPS-Cea-1338Cercocebus atys67.810.0 519
LLPS-Ran-3799Rattus norvegicus67.810.0 521
LLPS-Paa-2923Papio anubis67.810.0 519
LLPS-Myl-2236Myotis lucifugus67.810.0 516
LLPS-Rhb-2929Rhinopithecus bieti67.810.0 519
LLPS-Poa-1460Pongo abelii67.810.0 519
LLPS-Mam-2050Macaca mulatta67.810.0 519
LLPS-Anp-0170Anas platyrhynchos67.720.0 517
LLPS-Gaga-0823Gallus gallus67.720.0 518
LLPS-Sah-2557Sarcophilus harrisii67.710.0 525
LLPS-Sus-4713Sus scrofa67.710.0 516
LLPS-Mal-2151Mandrillus leucophaeus67.710.0 526
LLPS-Urm-3561Ursus maritimus67.710.0 526
LLPS-Mod-2718Monodelphis domestica67.710.0 522
LLPS-Man-0202Macaca nemestrina67.710.0 526
LLPS-Cas-2015Carlito syrichta67.710.0 527
LLPS-Eqc-1225Equus caballus67.523e-164 474
LLPS-Caj-1404Callithrix jacchus67.450.0 525
LLPS-Nol-0149Nomascus leucogenys67.450.0 525
LLPS-Orc-1026Oryctolagus cuniculus67.440.0 523
LLPS-Tag-1753Taeniopygia guttata67.289e-179 510
LLPS-Bot-3022Bos taurus67.198e-178 508
LLPS-Ora-3195Ornithorhynchus anatinus65.662e-150 436
LLPS-Gas-0809Galdieria sulphuraria65.125e-170 488
LLPS-Drm-1266Drosophila melanogaster64.582e-164 474
LLPS-Cae-0591Caenorhabditis elegans64.296e-171 491
LLPS-Scm-1553Scophthalmus maximus63.768e-162 467
LLPS-Hea-1820Helianthus annuus61.086e-152 444
LLPS-Sot-1272Solanum tuberosum60.884e-149 435
LLPS-Sol-0656Solanum lycopersicum60.623e-148 432
LLPS-Nia-1483Nicotiana attenuata60.621e-148 434
LLPS-Thc-1689Theobroma cacao60.361e-147 431
LLPS-Glm-2331Glycine max60.212e-146 428
LLPS-Pot-0414Populus trichocarpa60.055e-146 427
LLPS-Prp-1969Prunus persica60.052e-148 433
LLPS-Mae-2077Manihot esculenta59.954e-146 427
LLPS-Brn-3239Brassica napus59.791e-147 431
LLPS-Phv-0916Phaseolus vulgaris59.796e-146 427
LLPS-Brr-2331Brassica rapa59.791e-147 431
LLPS-Bro-0473Brassica oleracea59.796e-148 432
LLPS-Cus-1272Cucumis sativus59.691e-147 431
LLPS-Tru-0315Triticum urartu59.697e-149 437
LLPS-Via-0842Vigna angularis59.591e-145 426
LLPS-Amt-0874Amborella trichopoda59.592e-146 428
LLPS-Sei-0614Setaria italica59.345e-147 432
LLPS-Hov-0917Hordeum vulgare59.342e-149 436
LLPS-Brd-0192Brachypodium distachyon59.343e-149 435
LLPS-Tra-0476Triticum aestivum59.345e-150 437
LLPS-Dac-1368Daucus carota59.336e-145 424
LLPS-Arl-1236Arabidopsis lyrata59.332e-145 426
LLPS-Art-1556Arabidopsis thaliana59.332e-145 426
LLPS-Zem-0594Zea mays59.183e-147 430
LLPS-Gor-1480Gossypium raimondii59.172e-147 430
LLPS-Mua-0437Musa acuminata59.088e-147 429
LLPS-Viv-1749Vitis vinifera59.082e-146 429
LLPS-Coc-0758Corchorus capsularis59.074e-145 424
LLPS-Met-1039Medicago truncatula59.027e-146 426
LLPS-Chr-1223Chlamydomonas reinhardtii58.977e-148 431
LLPS-Sob-1371Sorghum bicolor58.934e-146 427
LLPS-Ors-2336Oryza sativa58.915e-145 424
LLPS-Orp-1778Oryza punctata58.911e-145 426
LLPS-Orr-1047Oryza rufipogon58.915e-145 424
LLPS-Lep-1398Leersia perrieri58.822e-146 430
LLPS-Orb-1302Oryza barthii58.576e-148 432
LLPS-Org-2200Oryza glaberrima58.576e-148 432
LLPS-Cym-0405Cyanidioschyzon merolae58.332e-151 441
LLPS-Orni-1417Oryza nivara58.313e-145 425
LLPS-Orgl-1775Oryza glumaepatula58.312e-145 426
LLPS-Orbr-1919Oryza brachyantha58.314e-145 425
LLPS-Orm-2003Oryza meridionalis58.312e-145 426