• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tag-1676
AK6

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Adenylate kinase isoenzyme 6
Gene Name: AK6, CINAP
Ensembl Gene: ENSTGUG00000017529.1
Ensembl Protein: ENSTGUP00000017810.1
Organism: Taeniopygia guttata
Taxa ID: 59729
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSTGUT00000018215.1ENSTGUP00000017810.1
UniProtH1A4J4, H1A4J4_TAEGU
GeneBankABQF01062714, ABQF01062713

▼ SEQUENCE

Protein Sequence (FASTA)
1     TPGVGKTTLG  KELASRAGLS  YVNVGDLAKE  GELYEGFDEE  YDCPILDEDR  VVDELEPRMS  60
61    EGGVVVDYHG  CDFFPERWFH  IVFVLRTDNS  CLYQRLESRG  YTGKKLQDNI  QCEIFQTLYE  120
121   EAVLSYRKEI  VHQLPSNTPE  DLERNLDQIM  QWIEQWMKDN  N  161
Nucleotide CDS Sequence (FASTA)
1     ACGCCGGGAG  TCGGGAAAAC  CACGCTGGGG  AAGGAGCTGG  CCTCCAGAGC  TGGGCTGAGC  60
61    TACGTCAACG  TGGGGGACCT  GGCCAAGGAA  GGAGAGCTCT  ACGAGGGCTT  CGACGAGGAG  120
121   TACGACTGCC  CCATCCTGGA  TGAGGACAGG  GTGGTGGACG  AGCTGGAGCC  CCGGATGAGC  180
181   GAGGGAGGGG  TGGTTGTGGA  TTACCACGGC  TGTGACTTTT  TCCCCGAGCG  CTGGTTCCAC  240
241   ATCGTGTTCG  TGCTGCGCAC  TGACAACTCC  TGTCTGTACC  AGCGGCTGGA  GAGCAGGGGC  300
301   TACACGGGCA  AGAAGCTGCA  GGACAACATT  CAGTGCGAGA  TTTTTCAGAC  TCTGTATGAG  360
361   GAGGCTGTGC  TGTCCTACAG  AAAGGAAATT  GTACACCAGC  TACCCAGCAA  CACTCCAGAG  420
421   GACCTGGAGA  GAAATTTGGA  CCAGATTATG  CAGTGGATTG  AGCAGTGGAT  GAAGGACAAC  480
481   AAC  483

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Nucleus
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cajal body
Cellular Component
Cytosol
Molecular Function
Adenylate kinase activity
Molecular Function
ATP binding
Molecular Function
ATPase activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fia-3080Ficedula albicollis95.653e-111 321
LLPS-Anp-1214Anas platyrhynchos90.061e-106 309
LLPS-Gaga-0097Gallus gallus88.21e-103 301
LLPS-Pes-0512Pelodiscus sinensis86.968e-104 302
LLPS-Meg-1637Meleagris gallopavo86.344e-102 298
LLPS-Leo-1628Lepisosteus oculatus85.097e-101 295
LLPS-Lac-2676Latimeria chalumnae84.471e-101 296
LLPS-Anc-1606Anolis carolinensis83.851e-99 292
LLPS-Dar-2416Danio rerio83.858e-101 294
LLPS-Xet-2358Xenopus tropicalis83.232e-90 268
LLPS-Loa-4312Loxodonta africana81.993e-97 285
LLPS-Eqc-1324Equus caballus81.379e-97 285
LLPS-Mod-0577Monodelphis domestica81.373e-96 283
LLPS-Ran-3754Rattus norvegicus81.374e-96 282
LLPS-Sah-1480Sarcophilus harrisii81.371e-96 283
LLPS-Ict-4050Ictidomys tridecemlineatus80.753e-95 280
LLPS-Fec-2200Felis catus80.753e-97 285
LLPS-Orn-2081Oreochromis niloticus80.751e-97 286
LLPS-Scf-4078Scleropages formosus80.752e-98 288
LLPS-Asm-1831Astyanax mexicanus80.752e-97 286
LLPS-Sus-2790Sus scrofa80.626e-96 282
LLPS-Urm-2549Ursus maritimus80.124e-96 284
LLPS-Aim-4307Ailuropoda melanoleuca80.122e-96 283
LLPS-Myl-2484Myotis lucifugus80.123e-97 285
LLPS-Ova-1954Ovis aries80.125e-96 282
LLPS-Icp-0112Ictalurus punctatus80.125e-96 282
LLPS-Orc-3214Oryctolagus cuniculus79.53e-95 280
LLPS-Bot-4240Bos taurus79.54e-93 278
LLPS-Dio-3986Dipodomys ordii79.51e-95 281
LLPS-Gaa-0532Gasterosteus aculeatus79.51e-95 281
LLPS-Mup-2037Mustela putorius furo79.54e-96 282
LLPS-Orl-3209Oryzias latipes79.54e-96 282
LLPS-Tar-1733Takifugu rubripes79.388e-94 276
LLPS-Mea-4194Mesocricetus auratus79.238e-73 222
LLPS-Poa-2369Pongo abelii78.268e-94 276
LLPS-Mam-2872Macaca mulatta78.265e-94 277
LLPS-Nol-0874Nomascus leucogenys78.268e-94 276
LLPS-Hos-4180Homo sapiens78.268e-94 276
LLPS-Pat-3854Pan troglodytes78.268e-94 276
LLPS-Pap-3103Pan paniscus78.268e-94 276
LLPS-Man-3929Macaca nemestrina78.262e-93 276
LLPS-Rhb-2807Rhinopithecus bieti78.268e-94 276
LLPS-Paa-0410Papio anubis78.268e-94 276
LLPS-Mal-4631Mandrillus leucophaeus78.268e-94 276
LLPS-Chs-2386Chlorocebus sabaeus78.262e-93 276
LLPS-Maf-0259Macaca fascicularis78.268e-94 276
LLPS-Cea-4312Cercocebus atys78.261e-93 276
LLPS-Gog-2279Gorilla gorilla78.263e-93 275
LLPS-Ten-3731Tetraodon nigroviridis77.643e-90 267
LLPS-Aon-1520Aotus nancymaae77.644e-93 275
LLPS-Caj-2413Callithrix jacchus77.644e-93 275
LLPS-Cap-3242Cavia porcellus76.47e-92 271
LLPS-Pof-1575Poecilia formosa76.42e-93 276
LLPS-Xim-2502Xiphophorus maculatus76.41e-93 276
LLPS-Otg-0771Otolemur garnettii75.161e-90 268
LLPS-Fud-3467Fukomys damarensis74.532e-90 268
LLPS-Cii-1862Ciona intestinalis59.627e-68 210
LLPS-Orbr-2272Oryza brachyantha58.332e-55 179
LLPS-Tru-1316Triticum urartu57.643e-56 181
LLPS-Orp-1104Oryza punctata57.649e-55 177
LLPS-Tra-2238Triticum aestivum57.643e-56 181
LLPS-Brd-1179Brachypodium distachyon57.644e-56 181
LLPS-Orr-1744Oryza rufipogon56.942e-54 176
LLPS-Org-0699Oryza glaberrima56.946e-54 175
LLPS-Ors-2033Oryza sativa56.944e-54 176
LLPS-Sob-1672Sorghum bicolor56.943e-54 177
LLPS-Orgl-1539Oryza glumaepatula56.942e-54 176
LLPS-Lep-1201Leersia perrieri56.949e-55 177
LLPS-Ori-1478Oryza indica56.942e-54 176
LLPS-Orb-1255Oryza barthii56.946e-54 175
LLPS-Orni-2232Oryza nivara56.944e-53 175
LLPS-Mua-0988Musa acuminata56.254e-54 175
LLPS-Sem-0741Selaginella moellendorffii55.843e-52 171
LLPS-Zem-1420Zea mays55.567e-54 175
LLPS-Sei-1470Setaria italica55.569e-55 177
LLPS-Amt-0330Amborella trichopoda55.178e-52 170
LLPS-Mae-0972Manihot esculenta54.865e-52 170
LLPS-Met-1914Medicago truncatula54.868e-49 164
LLPS-Hea-1467Helianthus annuus54.862e-53 174
LLPS-Thc-1463Theobroma cacao54.862e-51 169
LLPS-Art-2564Arabidopsis thaliana54.491e-57 184
LLPS-Coc-0439Corchorus capsularis54.172e-51 168
LLPS-Viv-0308Vitis vinifera54.171e-52 172
LLPS-Nia-1991Nicotiana attenuata54.172e-51 169
LLPS-Phv-0744Phaseolus vulgaris54.174e-50 165
LLPS-Cus-2257Cucumis sativus54.171e-49 164
LLPS-Php-2386Physcomitrella patens53.956e-55 178
LLPS-Prp-1779Prunus persica53.741e-51 169
LLPS-Gor-0462Gossypium raimondii53.473e-52 171
LLPS-Via-1421Vigna angularis53.471e-49 164
LLPS-Glm-2863Glycine max53.479e-50 164
LLPS-Bro-0532Brassica oleracea53.214e-55 183
LLPS-Sot-0622Solanum tuberosum52.782e-49 163
LLPS-Vir-2019Vigna radiata52.086e-46 157
LLPS-Brn-0347Brassica napus51.922e-55 179
LLPS-Brr-1330Brassica rapa51.285e-55 178
LLPS-Chr-1316Chlamydomonas reinhardtii51.061e-48 161
LLPS-Dac-2417Daucus carota50.681e-49 164
LLPS-Pot-0442Populus trichocarpa50.344e-48 160
LLPS-Abg-1967Absidia glauca50.05e-48 160
LLPS-Arl-0507Arabidopsis lyrata49.682e-42 150
LLPS-Pytr-0319Pyrenophora triticirepentis49.071e-49 164
LLPS-Pyt-1002Pyrenophora teres49.071e-49 164
LLPS-Phn-0098Phaeosphaeria nodorum48.775e-50 165
LLPS-Drm-0517Drosophila melanogaster48.731e-50 167
LLPS-Beb-1293Beauveria bassiana47.21e-45 153
LLPS-Cae-2042Caenorhabditis elegans46.632e-49 163
LLPS-Ved-0506Verticillium dahliae45.919e-49 162
LLPS-Trv-0559Trichoderma virens45.625e-48 160
LLPS-Scp-0844Schizosaccharomyces pombe45.622e-45 153
LLPS-Scs-1128Sclerotinia sclerotiorum45.623e-47 157
LLPS-Map-0029Magnaporthe poae45.624e-46 155
LLPS-Fus-1264Fusarium solani45.342e-48 160
LLPS-Nec-1222Neurospora crassa45.341e-46 156
LLPS-Lem-0164Leptosphaeria maculans45.12e-0648.5
LLPS-Trr-1457Trichoderma reesei45.04e-47 157
LLPS-Gag-1432Gaeumannomyces graminis45.05e-46 155
LLPS-Miv-0719Microbotryum violaceum44.61e-38 136
LLPS-Mao-0651Magnaporthe oryzae44.599e-43 146
LLPS-Fuo-1376Fusarium oxysporum44.442e-25 100
LLPS-Cogr-1347Colletotrichum graminicola44.13e-48 160
LLPS-Fuv-1396Fusarium verticillioides44.16e-47 157
LLPS-Scj-1350Schizosaccharomyces japonicus43.757e-48 159
LLPS-Scc-1554Schizosaccharomyces cryophilus43.752e-44 150
LLPS-Cog-0942Colletotrichum gloeosporioides43.481e-47 159
LLPS-Pug-0592Puccinia graminis43.247e-38 135
LLPS-Sol-0385Solanum lycopersicum43.158e-37 131
LLPS-Dos-0975Dothistroma septosporum42.943e-40 140
LLPS-Put-0092Puccinia triticina42.672e-38 135
LLPS-Zyt-0957Zymoseptoria tritici42.597e-41 142
LLPS-Asn-0696Aspergillus nidulans42.593e-39 137
LLPS-Kop-0803Komagataella pastoris42.179e-42 144
LLPS-Coo-0012Colletotrichum orbiculare42.144e-39 137
LLPS-Asg-0760Ashbya gossypii41.611e-38 137
LLPS-Ast-1149Aspergillus terreus41.253e-40 140
LLPS-Sac-0202Saccharomyces cerevisiae40.889e-37 131
LLPS-Asfu-0194Aspergillus fumigatus40.767e-37 131
LLPS-Nef-0951Neosartorya fischeri40.764e-37 132
LLPS-Cym-0932Cyanidioschyzon merolae40.745e-37 132
LLPS-Blg-0496Blumeria graminis40.621e-44 151
LLPS-Asc-1238Aspergillus clavatus40.124e-38 134
LLPS-Yal-1350Yarrowia lipolytica39.755e-41 142
LLPS-Crn-1064Cryptococcus neoformans39.662e-33 123
LLPS-Aso-0600Aspergillus oryzae38.66e-0646.6
LLPS-Osl-1146Ostreococcus lucimarinus37.972e-28 109
LLPS-Mel-0169Melampsora laricipopulina37.933e-34 125
LLPS-Gas-0892Galdieria sulphuraria35.715e-33 121
LLPS-Usm-0966Ustilago maydis34.363e-28 109
LLPS-Spr-1267Sporisorium reilianum33.163e-27 107
LLPS-Tum-1628Tuber melanosporum32.723e-2498.2