• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Orl-3209
AK6

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Adenylate kinase isoenzyme 6
Gene Name: AK6, ak6, CINAP
Ensembl Gene: ENSORLG00000017342.2
Ensembl Protein: ENSORLP00000021690.1
Organism: Oryzias latipes
Taxa ID: 8090
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MTKRPNILLT  GTPGVGKTTL  GKELSSRTGL  TYVNVGDLAQ  EGQLYDGFDE  DYQCPILDED  60
61    RVVDELEDKM  EEGGVIVDYH  GCDLFPERWF  HIVFVLRTDN  TQLYNRLEAR  GYTGKKLQDN  120
121   VQCEIFQTIL  EEAMEAYSED  IVHQLPSNSP  EDLERNLEQM  SQWVEQWIKD  HN  172
Nucleotide CDS Sequence (FASTA)
1     ATGACGAAGC  GGCCAAACAT  TCTGCTGACT  GGAACCCCCG  GTGTGGGGAA  GACCACTCTT  60
61    GGGAAGGAGC  TCTCCAGTCG  CACTGGACTG  ACCTACGTGA  ACGTGGGGGA  CCTGGCACAG  120
121   GAAGGACAGC  TGTATGACGG  CTTTGATGAA  GACTACCAGT  GCCCCATCCT  GGATGAAGAC  180
181   AGGGTTGTGG  ATGAGCTGGA  GGATAAGATG  GAGGAAGGCG  GTGTGATCGT  GGACTACCAC  240
241   GGCTGTGACC  TGTTCCCCGA  GCGCTGGTTC  CACATCGTCT  TTGTCCTGCG  GACAGACAAC  300
301   ACCCAGCTGT  ACAACCGGCT  GGAGGCCAGG  GGTTACACGG  GAAAGAAGCT  GCAGGACAAC  360
361   GTACAGTGTG  AGATCTTCCA  GACCATCTTG  GAGGAGGCCA  TGGAGGCGTA  CAGCGAGGAC  420
421   ATCGTCCACC  AGCTGCCCAG  CAACAGTCCC  GAGGACCTGG  AGAGGAACCT  GGAGCAGATG  480
481   AGCCAGTGGG  TGGAGCAGTG  GATAAAAGAC  CACAACTAG  519

▼ KEYWORD


ID
Family
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Nucleus
Reference proteome
Transferase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cajal body
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
Adenylate kinase activity
Molecular Function
ATP binding
Molecular Function
ATPase activity

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tar-1733Takifugu rubripes86.883e-91 270
LLPS-Orn-2081Oreochromis niloticus86.474e-100 293
LLPS-Xim-2502Xiphophorus maculatus86.051e-101 296
LLPS-Pof-1575Poecilia formosa85.474e-100 293
LLPS-Dar-2416Danio rerio85.471e-99 292
LLPS-Gaa-0532Gasterosteus aculeatus85.473e-100 294
LLPS-Asm-1831Astyanax mexicanus84.881e-97 287
LLPS-Scf-4078Scleropages formosus84.129e-96 282
LLPS-Icp-0112Ictalurus punctatus83.142e-96 284
LLPS-Ten-3731Tetraodon nigroviridis81.982e-92 273
LLPS-Leo-1628Lepisosteus oculatus81.762e-94 279
LLPS-Pes-0512Pelodiscus sinensis80.594e-94 278
LLPS-Anp-1214Anas platyrhynchos79.761e-90 269
LLPS-Tag-1676Taeniopygia guttata79.51e-86 258
LLPS-Mod-0577Monodelphis domestica79.412e-89 266
LLPS-Gaga-0097Gallus gallus79.417e-92 272
LLPS-Fia-3080Ficedula albicollis78.828e-93 274
LLPS-Lac-2676Latimeria chalumnae78.821e-92 274
LLPS-Xet-2358Xenopus tropicalis78.826e-81 244
LLPS-Ran-3754Rattus norvegicus78.821e-88 264
LLPS-Loa-4312Loxodonta africana78.184e-87 260
LLPS-Ova-1954Ovis aries77.986e-88 262
LLPS-Orc-3214Oryctolagus cuniculus77.382e-89 266
LLPS-Fec-2200Felis catus77.382e-88 263
LLPS-Ict-4050Ictidomys tridecemlineatus76.791e-87 261
LLPS-Anc-1606Anolis carolinensis76.793e-89 266
LLPS-Caj-2413Callithrix jacchus76.798e-87 259
LLPS-Aon-1520Aotus nancymaae76.798e-87 259
LLPS-Myl-2484Myotis lucifugus76.796e-88 262
LLPS-Aim-4307Ailuropoda melanoleuca76.791e-87 261
LLPS-Mup-2037Mustela putorius furo76.793e-88 263
LLPS-Eqc-1324Equus caballus76.191e-86 260
LLPS-Sah-1480Sarcophilus harrisii76.198e-85 254
LLPS-Sus-2790Sus scrofa75.782e-82 248
LLPS-Rhb-2807Rhinopithecus bieti75.61e-85 256
LLPS-Pap-3103Pan paniscus75.61e-85 256
LLPS-Pat-3854Pan troglodytes75.61e-85 256
LLPS-Hos-4180Homo sapiens75.61e-85 256
LLPS-Nol-0874Nomascus leucogenys75.61e-85 256
LLPS-Poa-2369Pongo abelii75.61e-85 256
LLPS-Maf-0259Macaca fascicularis75.61e-85 256
LLPS-Paa-0410Papio anubis75.61e-85 256
LLPS-Mal-4631Mandrillus leucophaeus75.61e-85 256
LLPS-Man-3929Macaca nemestrina75.05e-82 247
LLPS-Cea-4312Cercocebus atys74.853e-81 245
LLPS-Dio-3986Dipodomys ordii74.711e-87 261
LLPS-Urm-2549Ursus maritimus74.72e-83 252
LLPS-Chs-2386Chlorocebus sabaeus74.691e-80 243
LLPS-Mea-4194Mesocricetus auratus74.622e-60 191
LLPS-Meg-1637Meleagris gallopavo73.842e-83 250
LLPS-Mam-2872Macaca mulatta73.658e-82 246
LLPS-Bot-4240Bos taurus73.656e-81 248
LLPS-Gog-2279Gorilla gorilla72.991e-82 248
LLPS-Otg-0771Otolemur garnettii71.435e-83 249
LLPS-Cap-3242Cavia porcellus71.436e-83 249
LLPS-Fud-3467Fukomys damarensis70.838e-83 249
LLPS-Cii-1862Ciona intestinalis59.881e-64 203
LLPS-Gor-0462Gossypium raimondii59.392e-55 179
LLPS-Prp-1779Prunus persica58.796e-52 170
LLPS-Nia-1991Nicotiana attenuata58.184e-52 171
LLPS-Thc-1463Theobroma cacao58.186e-53 173
LLPS-Sei-1470Setaria italica58.183e-53 174
LLPS-Mua-0988Musa acuminata57.932e-51 169
LLPS-Mae-0972Manihot esculenta57.582e-51 169
LLPS-Sot-0622Solanum tuberosum57.581e-50 167
LLPS-Tru-1316Triticum urartu57.063e-51 169
LLPS-Tra-2238Triticum aestivum57.062e-51 169
LLPS-Sob-1672Sorghum bicolor56.975e-51 170
LLPS-Phv-0744Phaseolus vulgaris56.971e-48 162
LLPS-Viv-0308Vitis vinifera56.978e-51 167
LLPS-Zem-1420Zea mays56.972e-51 169
LLPS-Coc-0439Corchorus capsularis56.979e-51 167
LLPS-Orbr-2272Oryza brachyantha56.368e-51 167
LLPS-Glm-2863Glycine max56.361e-48 162
LLPS-Met-1914Medicago truncatula56.361e-46 159
LLPS-Php-2386Physcomitrella patens56.253e-55 179
LLPS-Orp-1104Oryza punctata56.16e-50 165
LLPS-Amt-0330Amborella trichopoda56.023e-51 169
LLPS-Cus-2257Cucumis sativus55.763e-48 160
LLPS-Vir-2019Vigna radiata55.762e-45 157
LLPS-Via-1421Vigna angularis55.769e-48 160
LLPS-Hea-1467Helianthus annuus55.691e-51 169
LLPS-Ors-2033Oryza sativa55.492e-49 164
LLPS-Org-0699Oryza glaberrima55.492e-49 164
LLPS-Orr-1744Oryza rufipogon55.491e-49 164
LLPS-Orb-1255Oryza barthii55.492e-49 164
LLPS-Ori-1478Oryza indica55.491e-49 164
LLPS-Brd-1179Brachypodium distachyon55.492e-50 166
LLPS-Orgl-1539Oryza glumaepatula55.491e-49 164
LLPS-Orni-2232Oryza nivara54.886e-47 159
LLPS-Sem-0741Selaginella moellendorffii54.884e-58 186
LLPS-Lep-1201Leersia perrieri54.887e-49 162
LLPS-Dac-2417Daucus carota54.553e-49 163
LLPS-Pot-0442Populus trichocarpa54.493e-47 159
LLPS-Bro-0532Brassica oleracea52.732e-53 179
LLPS-Art-2564Arabidopsis thaliana51.522e-54 177
LLPS-Brn-0347Brassica napus51.525e-54 176
LLPS-Pytr-0319Pyrenophora triticirepentis51.183e-48 160
LLPS-Brr-1330Brassica rapa50.911e-53 175
LLPS-Pyt-1002Pyrenophora teres50.593e-47 158
LLPS-Chr-1316Chlamydomonas reinhardtii50.311e-41 144
LLPS-Cae-2042Caenorhabditis elegans49.717e-54 175
LLPS-Phn-0098Phaeosphaeria nodorum49.72e-47 159
LLPS-Abg-1967Absidia glauca49.71e-42 146
LLPS-Arl-0507Arabidopsis lyrata49.083e-39 142
LLPS-Sol-0385Solanum lycopersicum48.777e-37 131
LLPS-Ved-0506Verticillium dahliae48.59e-49 162
LLPS-Scj-1350Schizosaccharomyces japonicus47.931e-50 167
LLPS-Dos-0975Dothistroma septosporum47.653e-45 154
LLPS-Trv-0559Trichoderma virens47.377e-51 167
LLPS-Zyt-0957Zymoseptoria tritici47.347e-45 153
LLPS-Scp-0844Schizosaccharomyces pombe47.314e-44 150
LLPS-Cogr-1347Colletotrichum graminicola47.028e-51 167
LLPS-Beb-1293Beauveria bassiana46.518e-45 152
LLPS-Drm-0517Drosophila melanogaster46.342e-46 156
LLPS-Trr-1457Trichoderma reesei46.21e-49 164
LLPS-Scs-1128Sclerotinia sclerotiorum46.23e-48 160
LLPS-Blg-0496Blumeria graminis45.612e-48 161
LLPS-Gag-1432Gaeumannomyces graminis45.514e-45 153
LLPS-Cog-0942Colletotrichum gloeosporioides45.357e-50 165
LLPS-Coo-0012Colletotrichum orbiculare44.913e-41 142
LLPS-Mao-0651Magnaporthe oryzae44.913e-37 132
LLPS-Map-0029Magnaporthe poae44.913e-44 150
LLPS-Nec-1222Neurospora crassa44.792e-44 151
LLPS-Fuo-1376Fusarium oxysporum44.442e-2395.9
LLPS-Scc-1554Schizosaccharomyces cryophilus44.386e-43 147
LLPS-Fus-1264Fusarium solani44.193e-47 158
LLPS-Pug-0592Puccinia graminis43.352e-30 116
LLPS-Asfu-0194Aspergillus fumigatus42.868e-40 139
LLPS-Put-0092Puccinia triticina42.772e-30 115
LLPS-Miv-0719Microbotryum violaceum42.452e-32 120
LLPS-Fuv-1396Fusarium verticillioides42.352e-44 150
LLPS-Nef-0951Neosartorya fischeri42.269e-40 139
LLPS-Asg-0760Ashbya gossypii42.015e-37 133
LLPS-Gas-0892Galdieria sulphuraria41.982e-37 133
LLPS-Kop-0803Komagataella pastoris41.718e-38 134
LLPS-Asc-1238Aspergillus clavatus41.625e-41 142
LLPS-Ast-1149Aspergillus terreus41.281e-40 141
LLPS-Asn-0696Aspergillus nidulans41.043e-39 137
LLPS-Lem-0164Leptosphaeria maculans40.822e-0648.5
LLPS-Osl-1146Ostreococcus lucimarinus40.356e-32 118
LLPS-Crn-1064Cryptococcus neoformans39.898e-32 119
LLPS-Cym-0932Cyanidioschyzon merolae39.294e-31 117
LLPS-Sac-0202Saccharomyces cerevisiae39.296e-34 124
LLPS-Yal-1350Yarrowia lipolytica38.954e-41 142
LLPS-Mel-0169Melampsora laricipopulina37.241e-25 103
LLPS-Tum-1628Tuber melanosporum36.091e-25 102
LLPS-Spr-1267Sporisorium reilianum31.842e-25 102
LLPS-Usm-0966Ustilago maydis30.52e-25 102
LLPS-Aso-0600Aspergillus oryzae26.741e-1368.9