DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
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Orthology
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LLPS-Sus-3197
ELOVL1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Elongation of very long chain fatty acids protein 1; 3-keto acyl-CoA synthase ELOVL1; ELOVL fatty acid elongase 1; ELOVL FA elongase 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1
Gene Name:	ELOVL1
Ensembl Gene:	ENSSSCG00000035238.1
Ensembl Protein:	ENSSSCP00000050099.1
Organism:	Sus scrofa
Taxa ID:	9823
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1066	Q9BW60	Client	Nucleolus	91.40	0.0	539

▼ FUNCTION

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSSSCT00000056080.1	ENSSSCP00000050099.1
Ensembl	ENSSSCT00000042346.1	ENSSSCP00000055731.1
Ensembl	ENSSSCT00000055979.1	ENSSSCP00000044094.1
Ensembl	ENSSSCT00000049082.1	ENSSSCP00000051328.1
UniProt		A0A287B122, A0A287B122_PIG
GeneBank	AEMK02000049

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRKWQAGRPW GLLSGPAPSE PSATARLAPA EPLAGMEAVV NLYQEMMKHA DPRIQNYPLM 60 61 GSPLLMTSIL LSYVYFVLSL GPRLMANRKP FQLRGFMVVY NFSLVALSLY IVYEFLMSGW 120 121 LSTYTWRCDP VDFSNSPEAL RMVRVAWLFL FSKFIELMDT VIFILRKKDG QVTFLHVFHH 180 181 SVLPWSWWWG VKIAPGGMGS FHAMINSSVH VVMYLYYGLS ALGPVAQPYL WWKKHMTAIQ 240 241 LVQFVLVSLH VSQYYFVPAC DYQFPVIIHL IWVYGTVFFA LFSNFWYQAY TKGKRLPRVL 300 301 PQNGAPGTAR VKAN 314
Nucleotide CDS Sequence (FASTA)
1 ATGGAGGCTG TGGTGAACTT GTACCAGGAG ATGATGAAGC ACGCAGATCC TCGGATCCAG 60 61 AACTACCCTC TGATGGGGTC CCCCCTGCTA ATGACCTCCA TCCTCCTAAG CTACGTGTAC 120 121 TTCGTTCTCT CACTTGGGCC TCGCCTCATG GCCAATCGGA AGCCCTTCCA GCTCCGAGGC 180 181 TTCATGGTTG TCTACAACTT CTCACTGGTG GCACTTTCCC TCTACATCGT CTATGAGTTC 240 241 CTGATGTCAG GCTGGCTGAG TACCTACACC TGGCGCTGCG ATCCAGTGGA CTTTTCCAAC 300 301 AGCCCGGAGG CCCTGAGGAT GGTTCGAGTG GCCTGGCTCT TCCTCTTCTC CAAGTTCATT 360 361 GAGCTGATGG ACACAGTGAT CTTTATTCTC CGGAAAAAGG ACGGACAGGT GACCTTCCTC 420 421 CACGTCTTCC ACCACTCGGT GCTCCCCTGG AGCTGGTGGT GGGGCGTCAA AATTGCCCCA 480 481 GGAGGAATGG GCTCTTTCCA CGCCATGATA AACTCCTCTG TGCACGTCGT CATGTACCTG 540 541 TACTACGGGT TGTCCGCCCT GGGCCCTGTG GCCCAGCCCT ACCTTTGGTG GAAAAAGCAC 600 601 ATGACAGCCA TCCAGCTGGT CCAGTTCGTG CTGGTGTCCC TGCACGTCTC CCAGTACTAC 660 661 TTCGTGCCGG CCTGCGACTA CCAGTTCCCG GTCATCATCC ACCTCATCTG GGTGTACGGC 720 721 ACGGTCTTCT TCGCGCTCTT CTCCAACTTC TGGTATCAGG CGTACACCAA GGGCAAGCGG 780 781 CTGCCCCGCG TCCTTCCGCA GAATGGAGCT CCAGGGACCG CCAGAGTCAA GGCCAACTGA 840

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0256	Endoplasmic reticulum
KW-0275	Fatty acid biosynthesis
KW-0276	Fatty acid metabolism
KW-0444	Lipid biosynthesis
KW-0443	Lipid metabolism
KW-0472	Membrane
KW-1267	Proteomics identification
KW-1185	Reference proteome
KW-0808	Transferase
KW-0812	Transmembrane
KW-1133	Transmembrane helix

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005789	Cellular Component	Endoplasmic reticulum membrane
GO:0016021	Cellular Component	Integral component of membrane
GO:0102336	Molecular Function	3-oxo-arachidoyl-CoA synthase activity
GO:0102337	Molecular Function	3-oxo-cerotoyl-CoA synthase activity
GO:0102338	Molecular Function	3-oxo-lignoceronyl-CoA synthase activity
GO:0009922	Molecular Function	Fatty acid elongase activity
GO:0102756	Molecular Function	Very-long-chain 3-ketoacyl-CoA synthase activity
GO:0034625	Biological Process	Fatty acid elongation, monounsaturated fatty acid
GO:0019367	Biological Process	Fatty acid elongation, saturated fatty acid
GO:0035338	Biological Process	Long-chain fatty-acyl-CoA biosynthetic process
GO:0030148	Biological Process	Sphingolipid biosynthetic process
GO:0006636	Biological Process	Unsaturated fatty acid biosynthetic process
GO:0042761	Biological Process	Very long-chain fatty acid biosynthetic process

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Eqc-3785	Equus caballus	94.71	2e-141	411
LLPS-Caf-2392	Canis familiaris	93.19	0.0	543
LLPS-Loa-0499	Loxodonta africana	92.83	0.0	547
LLPS-Tut-1384	Tursiops truncatus	92.11	0.0	544
LLPS-Orc-4061	Oryctolagus cuniculus	91.76	0.0	541
LLPS-Poa-3190	Pongo abelii	91.76	0.0	541
LLPS-Hos-1066	Homo sapiens	91.4	0.0	539
LLPS-Caj-4705	Callithrix jacchus	91.4	0.0	540
LLPS-Ere-0362	Erinaceus europaeus	91.4	0.0	540
LLPS-Otg-4046	Otolemur garnettii	91.04	0.0	537
LLPS-Rhb-4018	Rhinopithecus bieti	91.04	0.0	539
LLPS-Mam-3860	Macaca mulatta	91.04	0.0	537
LLPS-Dio-3591	Dipodomys ordii	91.04	0.0	538
LLPS-Cas-3266	Carlito syrichta	90.68	0.0	536
LLPS-Ova-3904	Ovis aries	90.45	0.0	599
LLPS-Mup-0442	Mustela putorius furo	90.43	0.0	541
LLPS-Fud-4155	Fukomys damarensis	90.32	0.0	535
LLPS-Bot-0831	Bos taurus	89.49	0.0	601
LLPS-Aim-2666	Ailuropoda melanoleuca	89.21	0.0	577
LLPS-Myl-4228	Myotis lucifugus	88.85	0.0	582
LLPS-Ict-1573	Ictidomys tridecemlineatus	88.53	0.0	523
LLPS-Mum-3945	Mus musculus	88.53	0.0	531
LLPS-Mea-3928	Mesocricetus auratus	88.53	0.0	529
LLPS-Ran-1974	Rattus norvegicus	88.53	0.0	527
LLPS-Man-0644	Macaca nemestrina	88.46	0.0	524
LLPS-Nol-3699	Nomascus leucogenys	88.46	0.0	526
LLPS-Cea-3674	Cercocebus atys	88.11	0.0	523
LLPS-Mal-4147	Mandrillus leucophaeus	88.11	0.0	524
LLPS-Paa-4047	Papio anubis	88.11	0.0	523
LLPS-Urm-0291	Ursus maritimus	87.92	0.0	546
LLPS-Mod-3136	Monodelphis domestica	87.81	0.0	513
LLPS-Maf-1123	Macaca fascicularis	87.76	0.0	521
LLPS-Cap-2723	Cavia porcellus	87.58	0.0	576
LLPS-Fec-4540	Felis catus	86.5	0.0	552
LLPS-Pat-4378	Pan troglodytes	85.62	0.0	515
LLPS-Pap-0614	Pan paniscus	85.62	0.0	515
LLPS-Gog-2065	Gorilla gorilla	85.27	0.0	514
LLPS-Sah-4051	Sarcophilus harrisii	80.83	0.0	521
LLPS-Anc-3159	Anolis carolinensis	75.26	2e-162	462
LLPS-Lac-4014	Latimeria chalumnae	74.16	2e-150	431
LLPS-Tag-1368	Taeniopygia guttata	74.06	8e-143	411
LLPS-Xet-2587	Xenopus tropicalis	73.79	5e-155	443
LLPS-Meg-0638	Meleagris gallopavo	73.45	2e-158	451
LLPS-Orl-0337	Oryzias latipes	73.18	5e-144	418
LLPS-Gaga-2764	Gallus gallus	73.1	7e-158	450
LLPS-Pes-3055	Pelodiscus sinensis	72.82	6e-155	442
LLPS-Anp-1199	Anas platyrhynchos	71.96	2e-159	454
LLPS-Leo-1010	Lepisosteus oculatus	71.32	4e-144	416
LLPS-Orn-2539	Oreochromis niloticus	71.27	2e-143	416
LLPS-Asm-3202	Astyanax mexicanus	70.8	5e-149	429
LLPS-Tar-0741	Takifugu rubripes	70.0	8e-144	416
LLPS-Ten-1865	Tetraodon nigroviridis	69.96	1e-141	410
LLPS-Pof-4029	Poecilia formosa	69.82	1e-144	418
LLPS-Icp-3938	Ictalurus punctatus	69.23	1e-142	413
LLPS-Xim-0120	Xiphophorus maculatus	69.2	1e-142	413
LLPS-Scm-3906	Scophthalmus maximus	68.36	5e-142	411
LLPS-Gaa-0326	Gasterosteus aculeatus	68.36	9e-142	410
LLPS-Fia-0040	Ficedula albicollis	68.31	1e-159	456
LLPS-Dar-3810	Danio rerio	67.63	1e-143	415
LLPS-Scf-3224	Scleropages formosus	64.54	2e-141	409
LLPS-Ora-1454	Ornithorhynchus anatinus	58.36	4e-103	308
LLPS-Cii-1615	Ciona intestinalis	46.57	2e-86	268
LLPS-Drm-0956	Drosophila melanogaster	40.72	3e-74	240
LLPS-Abg-1267	Absidia glauca	38.14	1e-08	60.1
LLPS-Nia-2575	Nicotiana attenuata	37.86	5e-11	66.2
LLPS-Mae-1673	Manihot esculenta	36.54	2e-08	58.2
LLPS-Chs-1691	Chlorocebus sabaeus	36.23	2e-44	159
LLPS-Aon-2626	Aotus nancymaae	36.23	4e-44	159
LLPS-Arl-2581	Arabidopsis lyrata	33.96	3e-11	67.0
LLPS-Sol-2156	Solanum lycopersicum	33.74	3e-09	61.2
LLPS-Brn-2958	Brassica napus	33.33	2e-09	61.6
LLPS-Art-2236	Arabidopsis thaliana	33.14	9e-11	65.5
LLPS-Blg-1546	Blumeria graminis	32.98	5e-13	72.4
LLPS-Fus-1472	Fusarium solani	32.82	8e-16	80.5
LLPS-Phv-1880	Phaseolus vulgaris	32.72	3e-11	67.0
LLPS-Bro-2458	Brassica oleracea	31.9	9e-11	65.5
LLPS-Dos-1426	Dothistroma septosporum	31.87	1e-14	77.0
LLPS-Brr-0788	Brassica rapa	31.67	3e-09	60.8
LLPS-Gas-0729	Galdieria sulphuraria	31.33	6e-16	79.0
LLPS-Asn-1531	Aspergillus nidulans	31.25	2e-13	73.6
LLPS-Crn-0928	Cryptococcus neoformans	31.03	2e-09	62.0
LLPS-Aso-0317	Aspergillus oryzae	31.02	2e-11	68.2
LLPS-Asf-0757	Aspergillus flavus	31.02	2e-11	68.2
LLPS-Ast-1576	Aspergillus terreus	30.48	4e-11	67.0
LLPS-Pot-1549	Populus trichocarpa	30.39	4e-15	77.8
LLPS-Tum-0999	Tuber melanosporum	29.78	7e-08	57.4
LLPS-Zyt-1149	Zymoseptoria tritici	29.67	7e-11	66.2
LLPS-Pug-0786	Puccinia graminis	29.56	1e-10	65.5
LLPS-Php-0292	Physcomitrella patens	29.48	5e-21	95.5
LLPS-Cogr-0789	Colletotrichum graminicola	28.86	7e-10	63.5
LLPS-Met-2317	Medicago truncatula	28.25	5e-13	71.6
LLPS-Viv-1949	Vitis vinifera	27.67	9e-09	60.1

LLPS-Sus-3197ELOVL1

Protein Sequence

Nucleotide Sequence

LLPS-Sus-3197
ELOVL1