LLPS-Mum-3945
Elovl1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Elongation of very long chain fatty acids protein 1; 3-keto acyl-CoA synthase Elovl1; ELOVL fatty acid elongase 1; ELOVL FA elongase 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1 |
| Gene Name: | Elovl1, Ssc1 |
| Ensembl Gene: | ENSMUSG00000006390.15 |
| Ensembl Protein: | ENSMUSP00000099734.4 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000102673.10 | ENSMUSP00000099734.4 |
| Ensembl | ENSMUST00000067896.3 | ENSMUSP00000064816.3 |
| Ensembl | ENSMUST00000167636.7 | ENSMUSP00000126685.1 |
| Ensembl | ENSMUST00000006557.12 | ENSMUSP00000006557.6 |
| UniProt | Q9JLJ5, ELOV1_MOUSE, Q9D1B2 | |
| GeneBank | BC006735, AK003743, AF170907 | AAH06735.1, BAB22975.1, AAF72572.1 |
| RefSeq | NM_001039175.2, NM_001039176.2, NM_019422.3, XM_006503233.2 | NP_001034264.1, NP_001034265.1, NP_062295.1, XP_006503296.1 |
| Entrez | 54325 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEAVVNLYHE LMKHADPRIQ SYPLMGSPLL ITSILLTYVY FILSLGPRIM ANRKPFQLRG 60 61 FMIVYNFSLV ILSLYIVYEF LMSGWLSTYT WRCDPIDFSN SPEALRMVRV AWLFMLSKVI 120 121 ELMDTVIFIL RKKDGQVTFL HVFHHSVLPW SWWWGIKIAP GGMGSFHAMI NSSVHVVMYL 180 181 YYGLSALGPV AQPYLWWKKH MTAIQLIQFV LVSLHISQYY FMPSCNYQYP IIIHLIWMYG 240 241 TIFFILFSNF WYHSYTKGKR LPRAVQQNGA PATTKVKAN 279 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGCTG TTGTGAACTT GTACCACGAG CTGATGAAGC ATGCGGATCC CCGGATCCAA 60 61 AGCTACCCTC TGATGGGGTC CCCCTTGCTA ATAACATCCA TCCTTCTGAC CTATGTGTAC 120 121 TTCATCCTAT CGCTTGGGCC TCGAATCATG GCTAATCGGA AGCCCTTCCA ACTTCGAGGC 180 181 TTCATGATTG TCTACAATTT CTCACTGGTG ATACTCTCCC TCTACATTGT CTATGAGTTT 240 241 CTGATGTCTG GTTGGCTGAG TACCTACACC TGGCGCTGTG ACCCCATAGA CTTTTCCAAT 300 301 AGCCCTGAAG CACTTCGGAT GGTTCGAGTG GCCTGGCTCT TCATGCTTTC CAAGGTCATT 360 361 GAGCTGATGG ACACAGTGAT ATTTATCCTC CGGAAGAAGG ACGGGCAAGT GACCTTCCTC 420 421 CATGTCTTCC ACCACTCGGT GCTTCCCTGG AGTTGGTGGT GGGGGATAAA AATTGCTCCA 480 481 GGAGGAATGG GCTCCTTCCA TGCCATGATA AACTCCTCTG TACATGTCGT CATGTACCTC 540 541 TACTATGGAT TGTCTGCCCT TGGCCCTGTG GCCCAGCCCT ACCTTTGGTG GAAGAAACAT 600 601 ATGACTGCCA TTCAGCTGAT CCAGTTTGTC CTGGTCTCAC TGCACATCAG CCAATACTAC 660 661 TTCATGCCCA GCTGCAACTA CCAGTACCCC ATCATCATCC ACCTCATCTG GATGTATGGC 720 721 ACCATCTTCT TCATACTGTT CTCCAATTTC TGGTATCACT CTTACACCAA GGGGAAGCGG 780 781 CTGCCCCGTG CAGTTCAGCA AAATGGAGCT CCAGCTACCA CCAAGGTCAA GGCCAACTGA 840 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Integral component of endoplasmic reticulum membrane | |
Molecular Function | 3-oxo-arachidoyl-CoA synthase activity | |
Molecular Function | 3-oxo-cerotoyl-CoA synthase activity | |
Molecular Function | 3-oxo-lignoceronyl-CoA synthase activity | |
Molecular Function | Fatty acid elongase activity | |
Molecular Function | Very-long-chain 3-ketoacyl-CoA synthase activity | |
Biological Process | Fatty acid elongation, monounsaturated fatty acid | |
Biological Process | Fatty acid elongation, polyunsaturated fatty acid | |
Biological Process | Fatty acid elongation, saturated fatty acid | |
Biological Process | Long-chain fatty-acyl-CoA biosynthetic process | |
Biological Process | Sphingolipid biosynthetic process | |
Biological Process | Unsaturated fatty acid biosynthetic process | |
Biological Process | Very long-chain fatty acid biosynthetic process |
▼ ANNOTATION
| PTM | ||||
| BioGRID | ||||
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CGDB | CellMarker | RaftProt | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-1974 | Rattus norvegicus | 96.42 | 0.0 | 555 |
| LLPS-Mea-3928 | Mesocricetus auratus | 95.7 | 0.0 | 555 |
| LLPS-Caj-4705 | Callithrix jacchus | 93.19 | 0.0 | 545 |
| LLPS-Fec-4540 | Felis catus | 92.83 | 0.0 | 547 |
| LLPS-Aim-2666 | Ailuropoda melanoleuca | 92.83 | 0.0 | 545 |
| LLPS-Mup-0442 | Mustela putorius furo | 92.78 | 0.0 | 542 |
| LLPS-Caf-2392 | Canis familiaris | 92.47 | 0.0 | 538 |
| LLPS-Hos-1066 | Homo sapiens | 92.47 | 0.0 | 543 |
| LLPS-Orc-4061 | Oryctolagus cuniculus | 92.47 | 0.0 | 545 |
| LLPS-Otg-4046 | Otolemur garnettii | 92.47 | 0.0 | 545 |
| LLPS-Poa-3190 | Pongo abelii | 92.11 | 0.0 | 543 |
| LLPS-Cas-3266 | Carlito syrichta | 92.11 | 0.0 | 541 |
| LLPS-Loa-0499 | Loxodonta africana | 92.11 | 0.0 | 546 |
| LLPS-Dio-3591 | Dipodomys ordii | 92.11 | 0.0 | 540 |
| LLPS-Rhb-4018 | Rhinopithecus bieti | 91.76 | 0.0 | 541 |
| LLPS-Mam-3860 | Macaca mulatta | 91.4 | 0.0 | 539 |
| LLPS-Tut-1384 | Tursiops truncatus | 91.4 | 0.0 | 540 |
| LLPS-Cap-2723 | Cavia porcellus | 91.04 | 0.0 | 534 |
| LLPS-Urm-0291 | Ursus maritimus | 91.04 | 0.0 | 537 |
| LLPS-Ere-0362 | Erinaceus europaeus | 91.04 | 0.0 | 539 |
| LLPS-Eqc-3785 | Equus caballus | 90.87 | 5e-138 | 402 |
| LLPS-Ict-1573 | Ictidomys tridecemlineatus | 90.68 | 0.0 | 535 |
| LLPS-Myl-4228 | Myotis lucifugus | 90.68 | 0.0 | 536 |
| LLPS-Ova-3904 | Ovis aries | 90.32 | 0.0 | 538 |
| LLPS-Bot-0831 | Bos taurus | 89.96 | 0.0 | 546 |
| LLPS-Fud-4155 | Fukomys damarensis | 89.25 | 0.0 | 530 |
| LLPS-Nol-3699 | Nomascus leucogenys | 89.16 | 0.0 | 528 |
| LLPS-Sus-3197 | Sus scrofa | 88.53 | 0.0 | 531 |
| LLPS-Paa-4047 | Papio anubis | 88.46 | 0.0 | 525 |
| LLPS-Mal-4147 | Mandrillus leucophaeus | 88.46 | 0.0 | 526 |
| LLPS-Cea-3674 | Cercocebus atys | 88.46 | 0.0 | 525 |
| LLPS-Man-0644 | Macaca nemestrina | 88.11 | 0.0 | 523 |
| LLPS-Maf-1123 | Macaca fascicularis | 88.11 | 0.0 | 524 |
| LLPS-Pat-4378 | Pan troglodytes | 86.64 | 0.0 | 520 |
| LLPS-Pap-0614 | Pan paniscus | 86.64 | 0.0 | 520 |
| LLPS-Mod-3136 | Monodelphis domestica | 86.38 | 0.0 | 515 |
| LLPS-Gog-2065 | Gorilla gorilla | 86.3 | 0.0 | 518 |
| LLPS-Sah-4051 | Sarcophilus harrisii | 85.3 | 0.0 | 513 |
| LLPS-Anc-3159 | Anolis carolinensis | 74.56 | 6e-160 | 454 |
| LLPS-Tag-1368 | Taeniopygia guttata | 73.68 | 4e-142 | 407 |
| LLPS-Pes-3055 | Pelodiscus sinensis | 73.52 | 1e-155 | 443 |
| LLPS-Meg-0638 | Meleagris gallopavo | 73.1 | 5e-157 | 446 |
| LLPS-Gaga-2764 | Gallus gallus | 72.76 | 1e-156 | 445 |
| LLPS-Xet-2587 | Xenopus tropicalis | 72.76 | 2e-154 | 440 |
| LLPS-Fia-0040 | Ficedula albicollis | 72.76 | 2e-155 | 444 |
| LLPS-Anp-1199 | Anas platyrhynchos | 72.41 | 2e-156 | 445 |
| LLPS-Orl-0337 | Oryzias latipes | 71.91 | 3e-144 | 417 |
| LLPS-Lac-4014 | Latimeria chalumnae | 71.64 | 1e-148 | 426 |
| LLPS-Orn-2539 | Oreochromis niloticus | 70.63 | 2e-143 | 415 |
| LLPS-Pof-4029 | Poecilia formosa | 69.93 | 6e-145 | 417 |
| LLPS-Xim-0120 | Xiphophorus maculatus | 69.31 | 2e-143 | 414 |
| LLPS-Asm-3202 | Astyanax mexicanus | 68.79 | 1e-147 | 424 |
| LLPS-Gaa-0326 | Gasterosteus aculeatus | 68.75 | 2e-141 | 407 |
| LLPS-Leo-1010 | Lepisosteus oculatus | 68.63 | 1e-141 | 408 |
| LLPS-Icp-3938 | Ictalurus punctatus | 66.91 | 1e-141 | 409 |
| LLPS-Tar-0741 | Takifugu rubripes | 66.79 | 3e-141 | 407 |
| LLPS-Ten-1865 | Tetraodon nigroviridis | 66.43 | 8e-139 | 401 |
| LLPS-Scm-3906 | Scophthalmus maximus | 66.43 | 7e-139 | 402 |
| LLPS-Dar-3810 | Danio rerio | 65.47 | 5e-141 | 407 |
| LLPS-Scf-3224 | Scleropages formosus | 63.83 | 4e-137 | 397 |
| LLPS-Ora-1454 | Ornithorhynchus anatinus | 58.66 | 6e-105 | 311 |
| LLPS-Cii-1615 | Ciona intestinalis | 46.13 | 2e-88 | 271 |
| LLPS-Nia-2575 | Nicotiana attenuata | 38.83 | 4e-12 | 68.9 |
| LLPS-Drm-0956 | Drosophila melanogaster | 38.76 | 2e-72 | 234 |
| LLPS-Mae-1673 | Manihot esculenta | 36.63 | 6e-09 | 59.7 |
| LLPS-Aon-2626 | Aotus nancymaae | 36.36 | 2e-44 | 159 |
| LLPS-Chs-1691 | Chlorocebus sabaeus | 36.36 | 1e-44 | 159 |
| LLPS-Phv-1880 | Phaseolus vulgaris | 33.95 | 5e-12 | 68.6 |
| LLPS-Sol-2156 | Solanum lycopersicum | 33.76 | 1e-09 | 61.6 |
| LLPS-Blg-1546 | Blumeria graminis | 33.51 | 7e-12 | 68.6 |
| LLPS-Dos-1426 | Dothistroma septosporum | 32.97 | 2e-13 | 73.2 |
| LLPS-Bro-2458 | Brassica oleracea | 32.69 | 2e-11 | 66.6 |
| LLPS-Brr-0788 | Brassica rapa | 32.34 | 1e-10 | 64.7 |
| LLPS-Abg-1267 | Absidia glauca | 32.08 | 5e-08 | 57.8 |
| LLPS-Zyt-1149 | Zymoseptoria tritici | 31.32 | 4e-10 | 63.5 |
| LLPS-Crn-0928 | Cryptococcus neoformans | 31.15 | 3e-08 | 58.2 |
| LLPS-Tum-0999 | Tuber melanosporum | 30.94 | 1e-08 | 59.3 |
| LLPS-Brn-2958 | Brassica napus | 30.73 | 9e-10 | 62.0 |
| LLPS-Gas-0729 | Galdieria sulphuraria | 30.47 | 1e-14 | 74.7 |
| LLPS-Pot-1549 | Populus trichocarpa | 30.41 | 4e-15 | 77.0 |
| LLPS-Art-2236 | Arabidopsis thaliana | 29.96 | 3e-11 | 66.2 |
| LLPS-Php-0292 | Physcomitrella patens | 29.88 | 2e-22 | 98.6 |
| LLPS-Pug-0786 | Puccinia graminis | 29.38 | 6e-10 | 62.8 |
| LLPS-Asn-1531 | Aspergillus nidulans | 28.85 | 2e-13 | 73.6 |
| LLPS-Met-2317 | Medicago truncatula | 28.7 | 5e-13 | 71.2 |
| LLPS-Arl-2581 | Arabidopsis lyrata | 28.69 | 9e-12 | 67.8 |
| LLPS-Fus-1472 | Fusarium solani | 28.62 | 8e-16 | 79.7 |
| LLPS-Ast-1576 | Aspergillus terreus | 28.35 | 7e-11 | 65.9 |
| LLPS-Aso-0317 | Aspergillus oryzae | 27.48 | 1e-10 | 65.5 |
| LLPS-Asf-0757 | Aspergillus flavus | 27.48 | 1e-10 | 65.5 |
| LLPS-Cogr-0789 | Colletotrichum graminicola | 26.89 | 9e-10 | 62.4 |
| LLPS-Viv-1949 | Vitis vinifera | 26.79 | 4e-08 | 57.8 |