• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-4061
ELOVL1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Elongation of very long chain fatty acids protein 1; 3-keto acyl-CoA synthase ELOVL1; ELOVL fatty acid elongase 1; ELOVL FA elongase 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1
Gene Name: ELOVL1
Ensembl Gene: ENSOCUG00000011349.2
Ensembl Protein: ENSOCUP00000009764.2
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEAVVNLYHE  MMKHADPRMQ  GYPLMGSPLL  MTSILLTYVY  FVLSLGPRIM  ANRKPFQLRG  60
61    FMIVYNFSLV  ALSLYIVYEF  LMSGWLSTYT  WRCDPVDYSN  SPEALRMVRV  AWLFLFSKFI  120
121   ELIDTVIFIL  RKKDGQVTFL  HVFHHSVLPW  SWWWGVKVAP  GGMGSFHAMI  NSSVHVVMYL  180
181   YYGLSALGPV  AQPYLWWKKH  MTAIQLIQFV  LVSLHISQYY  FMPSCNYQYP  VIIHLIWMYG  240
241   TIFFVLFSNF  WYQSYTKGKR  LPRALQQNGA  PGIAKVKAN  279
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCTG  TTGTGAACTT  GTACCATGAG  ATGATGAAGC  ATGCAGATCC  CCGGATGCAG  60
61    GGCTACCCTC  TGATGGGGTC  CCCCCTGCTG  ATGACTTCCA  TTCTCCTGAC  CTATGTGTAC  120
121   TTTGTCCTCT  CACTGGGGCC  TCGCATCATG  GCCAATCGGA  AGCCCTTCCA  GCTACGTGGC  180
181   TTCATGATTG  TCTACAACTT  CTCCCTGGTG  GCACTCTCTC  TATACATCGT  CTATGAGTTC  240
241   CTGATGTCTG  GCTGGCTGAG  CACTTATACC  TGGCGTTGTG  ACCCCGTGGA  CTACTCCAAC  300
301   AGCCCTGAGG  CTCTCAGGAT  GGTTCGAGTG  GCCTGGCTCT  TCCTCTTCTC  TAAGTTCATT  360
361   GAGCTGATAG  ACACGGTGAT  CTTTATCCTC  CGGAAGAAAG  ACGGGCAGGT  GACCTTCCTC  420
421   CATGTCTTCC  ATCACTCAGT  GCTCCCCTGG  AGCTGGTGGT  GGGGGGTAAA  GGTGGCCCCA  480
481   GGAGGGATGG  GCTCTTTCCA  CGCCATGATC  AACTCCTCCG  TGCATGTGGT  CATGTACCTG  540
541   TACTATGGGT  TGTCTGCCCT  CGGCCCTGTG  GCGCAGCCCT  ACCTCTGGTG  GAAAAAGCAT  600
601   ATGACGGCCA  TTCAGCTGAT  CCAGTTTGTC  CTGGTCTCGC  TGCACATCTC  CCAGTACTAC  660
661   TTCATGCCCA  GCTGCAACTA  CCAGTACCCA  GTCATCATCC  ACCTCATCTG  GATGTATGGC  720
721   ACCATCTTCT  TTGTGCTCTT  CTCCAATTTT  TGGTATCAGT  CTTACACCAA  GGGCAAGCGG  780
781   CTGCCCCGTG  CACTACAGCA  AAATGGAGCT  CCAGGTATCG  CCAAGGTCAA  GGCCAACTGA  840

▼ KEYWORD

ID
Family
Complete proteome
Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
Reference proteome
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Molecular Function
3-oxo-arachidoyl-CoA synthase activity
Molecular Function
3-oxo-cerotoyl-CoA synthase activity
Molecular Function
3-oxo-lignoceronyl-CoA synthase activity
Molecular Function
Fatty acid elongase activity
Molecular Function
Very-long-chain 3-ketoacyl-CoA synthase activity
Biological Process
Fatty acid elongation, monounsaturated fatty acid
Biological Process
Fatty acid elongation, saturated fatty acid
Biological Process
Long-chain fatty-acyl-CoA biosynthetic process
Biological Process
Sphingolipid biosynthetic process
Biological Process
Unsaturated fatty acid biosynthetic process
Biological Process
Very long-chain fatty acid biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fec-4540Felis catus97.130.0 559
LLPS-Loa-0499Loxodonta africana97.130.0 562
LLPS-Otg-4046Otolemur garnettii97.130.0 561
LLPS-Poa-3190Pongo abelii96.770.0 559
LLPS-Caf-2392Canis familiaris96.420.0 551
LLPS-Hos-1066Homo sapiens96.420.0 557
LLPS-Caj-4705Callithrix jacchus96.420.0 558
LLPS-Rhb-4018Rhinopithecus bieti96.060.0 557
LLPS-Aim-2666Ailuropoda melanoleuca96.060.0 554
LLPS-Mam-3860Macaca mulatta95.70.0 555
LLPS-Cas-3266Carlito syrichta95.70.0 553
LLPS-Mup-0442Mustela putorius furo95.670.0 550
LLPS-Ere-0362Erinaceus europaeus95.340.0 551
LLPS-Ict-1573Ictidomys tridecemlineatus94.980.0 550
LLPS-Eqc-3785Equus caballus94.718e-143 414
LLPS-Cap-2723Cavia porcellus94.620.0 546
LLPS-Tut-1384Tursiops truncatus94.620.0 553
LLPS-Dio-3591Dipodomys ordii94.620.0 546
LLPS-Ova-3904Ovis aries94.620.0 552
LLPS-Urm-0291Ursus maritimus93.910.0 546
LLPS-Bot-0831Bos taurus93.910.0 559
LLPS-Fud-4155Fukomys damarensis93.910.0 547
LLPS-Nol-3699Nomascus leucogenys93.710.0 545
LLPS-Myl-4228Myotis lucifugus93.190.0 543
LLPS-Paa-4047Papio anubis92.660.0 541
LLPS-Mal-4147Mandrillus leucophaeus92.660.0 542
LLPS-Cea-3674Cercocebus atys92.660.0 541
LLPS-Mum-3945Mus musculus92.470.0 545
LLPS-Mea-3928Mesocricetus auratus92.470.0 541
LLPS-Man-0644Macaca nemestrina92.310.0 539
LLPS-Maf-1123Macaca fascicularis92.310.0 539
LLPS-Ran-1974Rattus norvegicus91.760.0 536
LLPS-Sus-3197Sus scrofa91.760.0 541
LLPS-Gog-2065Gorilla gorilla91.10.0 536
LLPS-Pat-4378Pan troglodytes90.750.0 535
LLPS-Pap-0614Pan paniscus90.750.0 535
LLPS-Mod-3136Monodelphis domestica90.320.0 524
LLPS-Sah-4051Sarcophilus harrisii89.960.0 527
LLPS-Anc-3159Anolis carolinensis74.915e-161 456
LLPS-Xet-2587Xenopus tropicalis74.833e-157 447
LLPS-Tag-1368Taeniopygia guttata74.442e-143 411
LLPS-Pes-3055Pelodiscus sinensis73.523e-156 444
LLPS-Meg-0638Meleagris gallopavo73.458e-158 449
LLPS-Orl-0337Oryzias latipes73.411e-145 421
LLPS-Gaga-2764Gallus gallus73.13e-157 447
LLPS-Fia-0040Ficedula albicollis73.18e-156 445
LLPS-Orn-2539Oreochromis niloticus72.832e-144 417
LLPS-Anp-1199Anas platyrhynchos72.763e-157 447
LLPS-Lac-4014Latimeria chalumnae72.693e-150 430
LLPS-Ten-1865Tetraodon nigroviridis72.242e-142 411
LLPS-Asm-3202Astyanax mexicanus71.173e-150 431
LLPS-Tar-0741Takifugu rubripes70.111e-144 416
LLPS-Leo-1010Lepisosteus oculatus69.892e-145 418
LLPS-Xim-0120Xiphophorus maculatus69.684e-144 416
LLPS-Icp-3938Ictalurus punctatus69.61e-145 419
LLPS-Pof-4029Poecilia formosa69.574e-145 418
LLPS-Gaa-0326Gasterosteus aculeatus69.571e-143 414
LLPS-Scm-3906Scophthalmus maximus69.264e-140 405
LLPS-Dar-3810Danio rerio66.671e-144 416
LLPS-Scf-3224Scleropages formosus66.313e-141 407
LLPS-Ora-1454Ornithorhynchus anatinus59.791e-105 313
LLPS-Cii-1615Ciona intestinalis48.125e-89 273
LLPS-Drm-0956Drosophila melanogaster40.727e-75 240
LLPS-Mae-1673Manihot esculenta35.645e-0857.0
LLPS-Aon-2626Aotus nancymaae35.615e-45 160
LLPS-Chs-1691Chlorocebus sabaeus35.258e-45 159
LLPS-Sol-2156Solanum lycopersicum34.622e-0961.2
LLPS-Phv-1880Phaseolus vulgaris33.332e-1166.6
LLPS-Abg-1267Absidia glauca32.721e-0859.3
LLPS-Brr-0788Brassica rapa32.541e-0962.0
LLPS-Bro-2458Brassica oleracea32.281e-1064.3
LLPS-Zyt-1149Zymoseptoria tritici31.913e-1166.6
LLPS-Dos-1426Dothistroma septosporum31.874e-1475.1
LLPS-Brn-2958Brassica napus31.856e-0959.7
LLPS-Arl-2581Arabidopsis lyrata31.651e-1064.7
LLPS-Crn-0928Cryptococcus neoformans31.034e-0960.1
LLPS-Nia-2575Nicotiana attenuata30.649e-1267.8
LLPS-Met-2317Medicago truncatula30.599e-1370.5
LLPS-Art-2236Arabidopsis thaliana30.49e-1164.7
LLPS-Gas-0729Galdieria sulphuraria30.043e-1576.3
LLPS-Pot-1549Populus trichocarpa29.93e-1577.4
LLPS-Tum-0999Tuber melanosporum29.783e-0857.8
LLPS-Php-0292Physcomitrella patens29.392e-2299.0
LLPS-Fus-1472Fusarium solani29.061e-1682.4
LLPS-Pug-0786Puccinia graminis28.872e-1064.7
LLPS-Asn-1531Aspergillus nidulans28.622e-1476.3
LLPS-Blg-1546Blumeria graminis28.423e-1372.4
LLPS-Ast-1576Aspergillus terreus27.928e-1268.6
LLPS-Cogr-0789Colletotrichum graminicola27.887e-1062.8
LLPS-Aso-0317Aspergillus oryzae27.559e-1268.6
LLPS-Asf-0757Aspergillus flavus27.559e-1268.6
LLPS-Orp-2129Oryza punctata26.922e-0652.4
LLPS-Viv-1949Vitis vinifera26.797e-0959.7