• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sus-2175
RRP8

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ribosomal RNA-processing protein 8
Gene Name: RRP8
Ensembl Gene: ENSSSCG00000023880.2
Ensembl Protein: ENSSSCP00000038984.1
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     EILTEHSSFS  SNNSFLSGDP  PCPDRLCLAL  IRPRGKSTAS  PGPEHRTSGE  DQGSKRRRLL  60
61    ATLRVLEAAA  LPRQPPSLPG  SDSEEEEVVE  RKRKHPKKAL  CASASPEGEK  KRKKKCQNRG  120
121   PPGSDSEVEE  AARNRCHEGA  LRGRDSANKE  TGKRKHQKRA  PADPAQHLGS  VAQTGPKAWN  180
181   SSAANDPTKP  SPETPSSEPP  RTLSRKQWRN  RQKNKRRQKN  KFRPPQPPDQ  PPEPAPAPTQ  240
241   ETEVPPAAGP  DGPGARAEAL  RARMAQRLDG  ARFRYLNEQL  YSQPSHAAQR  LFQEDPEAFL  300
301   LYHRGFQSQV  RKWPLQPVDR  IARDLRQRPA  SLVVADFGCG  DCRLASSIRN  PVHCFDLASL  360
361   DPRVTVCDMA  QVPLEDASVD  VAVFCLSLMG  TNIRDFLEEA  NRVLKPGGLL  KVAEVSSRFE  420
421   DVRTFLGAVA  KLGFKVISKD  LTNSHFFLFD  FQKTGPPRVG  PKAQLAGLKL  QPCLYKRR  478
Nucleotide CDS Sequence (FASTA)
1     ATGTTTGAGG  AGCCCGCGTG  GGCCGAGGAG  GCCCCGGCCG  TCCCGGACCC  CCGGCCGGTG  60
61    CCCTTACGGC  CGCGGCCCCC  GGCAGCCTCG  CACACCAAGG  GATCCAAGCG  CCGCCGGCTC  120
121   TTGGCGACAT  TAAGGGTCCT  GGAGGCAGCA  GCTCTGCCCC  GGCAGCCCCC  CAGCCTGCCC  180
181   GGTAGTGACT  CTGAGGAGGA  GGAAGTGGTG  GAGAGGAAGA  GGAAACACCC  GAAAAAGGCC  240
241   TTATGTGCCA  GTGCTTCTCC  CGAAGGAGAG  AAGAAAAGAA  AGAAGAAATG  TCAAAATCGG  300
301   GGCCCGCCTG  GCAGTGACTC  TGAGGTAGAG  GAAGCGGCAA  GGAACAGGTG  CCACGAAGGG  360
361   GCTCTTCGTG  GCAGAGACTC  TGCTAACAAA  GAGACAGGAA  AGAGGAAACA  CCAGAAACGG  420
421   GCCCCTGCAG  ATCCTGCCCA  GCACTTGGGC  AGTGTTGCCC  AAACAGGTCC  TAAAGCTTGG  480
481   AATTCTAGTG  CTGCAAATGA  CCCCACCAAG  CCAAGCCCTG  AGACCCCTTC  CTCTGAACCC  540
541   CCCCGCACCT  TGAGTCGCAA  GCAGTGGCGG  AACCGGCAGA  AGAATAAGCG  AAGACAGAAG  600
601   AACAAGTTTC  GCCCCCCTCA  GCCCCCGGAC  CAGCCTCCGG  AGCCGGCCCC  TGCCCCCACC  660
661   CAGGAGACAG  AGGTGCCTCC  TGCCGCCGGG  CCAGATGGCC  CCGGGGCCCG  GGCCGAGGCC  720
721   CTAAGGGCCC  GCATGGCCCA  GCGGCTGGAC  GGCGCCCGCT  TCCGCTACCT  CAACGAACAG  780
781   CTGTACTCGC  AGCCCAGCCA  TGCCGCGCAG  CGCCTCTTCC  AGGAAGACCC  CGAGGCCTTC  840
841   CTCCTGTACC  ACCGTGGGTT  CCAGAGCCAG  GTCAGGAAGT  GGCCGCTGCA  GCCCGTGGAC  900
901   CGCATCGCCA  GGGATCTTCG  CCAGCGGCCT  GCGTCTCTGG  TGGTGGCCGA  CTTTGGCTGT  960
961   GGGGATTGCC  GCCTGGCCTC  GAGCATCCGG  AATCCTGTGC  ACTGCTTTGA  CTTGGCCTCC  1020
1021  CTGGACCCCA  GGGTCACCGT  GTGTGACATG  GCCCAGGTGC  CTCTGGAGGA  TGCGTCTGTG  1080
1081  GACGTGGCCG  TGTTCTGCCT  TTCACTGATG  GGAACCAACA  TCCGAGACTT  CCTAGAGGAG  1140
1141  GCCAATCGCG  TACTGAAGCC  AGGGGGTCTC  CTGAAAGTGG  CTGAGGTCAG  CAGCCGCTTC  1200
1201  GAAGATGTTC  GGACCTTCCT  GGGGGCTGTC  GCCAAACTGG  GCTTCAAGGT  CATCTCCAAG  1260
1261  GACCTGACCA  ACAGCCATTT  CTTCCTGTTC  GACTTTCAAA  AGACTGGGCC  CCCTCGGGTA  1320
1321  GGGCCCAAGG  CTCAACTCGC  AGGCCTGAAG  CTTCAGCCCT  GTCTCTACAA  GCGCAGGTGA  1380

▼ KEYWORD

ID
Family
Complete proteome
Methyltransferase
Nucleus
Reference proteome
rRNA processing
S-adenosyl-L-methionine
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromatin silencing complex
Cellular Component
Cytosol
Cellular Component
Nucleolus
Cellular Component
Plasma membrane
Cellular Component
RDNA heterochromatin
Molecular Function
Methylated histone binding
Molecular Function
Methyltransferase activity
Biological Process
Cellular response to glucose starvation
Biological Process
Chromatin silencing at rDNA
Biological Process
Intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process
Positive regulation of cell cycle arrest
Biological Process
Regulation of transcription by glucose
Biological Process
RRNA processing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tut-0885Tursiops truncatus96.836e-151 446
LLPS-Cap-0629Cavia porcellus96.385e-152 448
LLPS-Eqc-0261Equus caballus96.139e-118 362
LLPS-Cas-1497Carlito syrichta95.911e-148 439
LLPS-Caf-1182Canis familiaris95.911e-145 439
LLPS-Mup-0233Mustela putorius furo95.912e-149 441
LLPS-Myl-1292Myotis lucifugus95.914e-149 442
LLPS-Orc-1022Oryctolagus cuniculus95.484e-150 443
LLPS-Urm-2474Ursus maritimus95.454e-148 439
LLPS-Ict-0549Ictidomys tridecemlineatus95.458e-148 437
LLPS-Nol-0592Nomascus leucogenys95.452e-147 436
LLPS-Aon-2597Aotus nancymaae95.452e-148 439
LLPS-Aim-0903Ailuropoda melanoleuca95.457e-148 439
LLPS-Hos-2271Homo sapiens95.01e-147 437
LLPS-Poa-0581Pongo abelii95.09e-148 437
LLPS-Gog-0594Gorilla gorilla95.01e-147 437
LLPS-Ova-1131Ovis aries94.575e-145 437
LLPS-Pap-3345Pan paniscus94.552e-146 434
LLPS-Caj-1067Callithrix jacchus94.555e-148 438
LLPS-Bot-0446Bos taurus94.122e-147 437
LLPS-Pat-1796Pan troglodytes94.091e-145 432
LLPS-Otg-0658Otolemur garnettii93.679e-149 440
LLPS-Loa-0748Loxodonta africana93.644e-146 433
LLPS-Fud-0105Fukomys damarensis92.566e-141 420
LLPS-Fec-1446Felis catus92.384e-141 421
LLPS-Dio-1199Dipodomys ordii91.864e-145 430
LLPS-Mum-1735Mus musculus91.823e-144 430
LLPS-Mea-2335Mesocricetus auratus90.454e-139 416
LLPS-Maf-2170Macaca fascicularis75.993e-177 513
LLPS-Mam-0486Macaca mulatta75.760.0 527
LLPS-Mal-2764Mandrillus leucophaeus75.762e-176 511
LLPS-Chs-0104Chlorocebus sabaeus75.529e-176 509
LLPS-Paa-0380Papio anubis75.521e-175 508
LLPS-Cea-3250Cercocebus atys75.067e-174 504
LLPS-Sah-1728Sarcophilus harrisii75.04e-115 355
LLPS-Man-0641Macaca nemestrina74.762e-161 474
LLPS-Rhb-1068Rhinopithecus bieti74.084e-177 512
LLPS-Anp-0249Anas platyrhynchos73.492e-34 129
LLPS-Ran-0257Rattus norvegicus71.731e-168 490
LLPS-Ten-0439Tetraodon nigroviridis68.754e-48 168
LLPS-Tag-1216Taeniopygia guttata63.729e-95 293
LLPS-Gaga-0848Gallus gallus63.557e-39 143
LLPS-Lac-2347Latimeria chalumnae62.734e-95 302
LLPS-Pof-2875Poecilia formosa61.547e-91 294
LLPS-Scf-0277Scleropages formosus61.362e-90 293
LLPS-Orl-0588Oryzias latipes61.261e-94 304
LLPS-Asm-0793Astyanax mexicanus61.094e-91 293
LLPS-Xim-0467Xiphophorus maculatus61.093e-90 291
LLPS-Icp-0370Ictalurus punctatus59.553e-91 294
LLPS-Scm-0461Scophthalmus maximus59.465e-89 289
LLPS-Gaa-0321Gasterosteus aculeatus59.018e-88 280
LLPS-Leo-0262Lepisosteus oculatus58.181e-89 290
LLPS-Tar-0925Takifugu rubripes58.186e-90 291
LLPS-Dar-0853Danio rerio57.924e-89 289
LLPS-Orn-0120Oreochromis niloticus56.92e-42 160
LLPS-Cis-0199Ciona savignyi52.476e-79 258
LLPS-Amt-1433Amborella trichopoda51.83e-67 223
LLPS-Mae-0694Manihot esculenta50.92e-66 221
LLPS-Mua-0253Musa acuminata50.451e-65 217
LLPS-Sem-0503Selaginella moellendorffii50.233e-65 216
LLPS-Viv-0322Vitis vinifera50.01e-66 221
LLPS-Hov-0085Hordeum vulgare49.731e-53 188
LLPS-Thc-1210Theobroma cacao49.17e-65 218
LLPS-Fus-0705Fusarium solani48.892e-44 168
LLPS-Cii-0072Ciona intestinalis48.857e-42 157
LLPS-Prp-1205Prunus persica48.677e-64 215
LLPS-Brd-1325Brachypodium distachyon48.662e-52 185
LLPS-Pot-0046Populus trichocarpa48.655e-65 217
LLPS-Coc-0689Corchorus capsularis48.651e-64 217
LLPS-Chc-0111Chondrus crispus48.544e-45 164
LLPS-Brr-1138Brassica rapa48.421e-59 204
LLPS-Bro-0673Brassica oleracea48.421e-63 214
LLPS-Dac-0985Daucus carota48.421e-61 207
LLPS-Brn-1071Brassica napus48.421e-63 214
LLPS-Via-1693Vigna angularis48.315e-54 187
LLPS-Tra-1054Triticum aestivum48.236e-63 213
LLPS-Phv-1750Phaseolus vulgaris48.21e-67 224
LLPS-Sei-0867Setaria italica48.23e-63 214
LLPS-Orb-0594Oryza barthii47.967e-62 207
LLPS-Osl-0230Ostreococcus lucimarinus47.795e-55 189
LLPS-Nia-1744Nicotiana attenuata47.758e-61 206
LLPS-Php-0688Physcomitrella patens47.759e-60 206
LLPS-Met-1243Medicago truncatula47.756e-65 217
LLPS-Sot-0078Solanum tuberosum47.756e-62 209
LLPS-Sob-0743Sorghum bicolor47.352e-62 211
LLPS-Ors-1232Oryza sativa47.357e-62 210
LLPS-Org-1242Oryza glaberrima47.357e-62 210
LLPS-Zem-1612Zea mays47.352e-61 209
LLPS-Orr-1760Oryza rufipogon47.357e-62 210
LLPS-Orni-0937Oryza nivara47.357e-62 210
LLPS-Ori-0833Oryza indica47.357e-62 210
LLPS-Orgl-0155Oryza glumaepatula47.357e-62 210
LLPS-Gor-1398Gossypium raimondii47.32e-61 208
LLPS-Hea-0210Helianthus annuus47.33e-64 215
LLPS-Orbr-1207Oryza brachyantha47.062e-60 204
LLPS-Orp-0917Oryza punctata46.461e-57 199
LLPS-Lep-0887Leersia perrieri46.463e-62 211
LLPS-Cus-0300Cucumis sativus46.43e-60 205
LLPS-Arl-1362Arabidopsis lyrata46.388e-62 210
LLPS-Coo-0242Colletotrichum orbiculare45.816e-43 164
LLPS-Scc-0448Schizosaccharomyces cryophilus45.493e-53 188
LLPS-Cae-0099Caenorhabditis elegans45.218e-62 211
LLPS-Glm-1307Glycine max45.052e-63 213
LLPS-Cogr-0761Colletotrichum graminicola44.952e-39 154
LLPS-Fuv-0655Fusarium verticillioides44.956e-42 161
LLPS-Scp-0198Schizosaccharomyces pombe44.871e-59 205
LLPS-Trr-0605Trichoderma reesei44.611e-43 166
LLPS-Beb-1065Beauveria bassiana44.442e-40 156
LLPS-Trv-0233Trichoderma virens44.442e-43 164
LLPS-Fuo-0734Fusarium oxysporum44.441e-41 160
LLPS-Mao-0655Magnaporthe oryzae43.785e-38 149
LLPS-Scj-0127Schizosaccharomyces japonicus43.722e-52 185
LLPS-Miv-0643Microbotryum violaceum43.643e-50 183
LLPS-Art-2345Arabidopsis thaliana43.62e-58 201
LLPS-Scs-0467Sclerotinia sclerotiorum43.469e-42 160
LLPS-Drm-0387Drosophila melanogaster42.081e-55 196
LLPS-Abg-0144Absidia glauca42.063e-56 200
LLPS-Sol-0540Solanum lycopersicum41.96e-55 191
LLPS-Chr-0347Chlamydomonas reinhardtii41.135e-50 188
LLPS-Blg-0367Blumeria graminis41.052e-36 145
LLPS-Asf-0841Aspergillus flavus40.23e-31 129
LLPS-Aso-0527Aspergillus oryzae40.23e-31 129
LLPS-Ast-0662Aspergillus terreus40.19e-31 128
LLPS-Put-1012Puccinia triticina40.03e-1373.6
LLPS-Asni-0933Aspergillus niger40.05e-30 125
LLPS-Gag-0410Gaeumannomyces graminis39.915e-35 141
LLPS-Nec-0045Neurospora crassa39.64e-33 135
LLPS-Nef-0307Neosartorya fischeri39.114e-30 126
LLPS-Asfu-0171Aspergillus fumigatus39.112e-30 127
LLPS-Sac-0411Saccharomyces cerevisiae39.063e-42 160
LLPS-Zyt-0388Zymoseptoria tritici38.763e-37 148
LLPS-Dos-0808Dothistroma septosporum38.666e-36 141
LLPS-Asc-0607Aspergillus clavatus38.317e-29 122
LLPS-Gas-0628Galdieria sulphuraria37.993e-43 159
LLPS-Asn-0199Aspergillus nidulans37.973e-36 143
LLPS-Pytr-0209Pyrenophora triticirepentis37.122e-31 130
LLPS-Pyt-1380Pyrenophora teres37.126e-31 129
LLPS-Yal-0333Yarrowia lipolytica36.932e-46 172
LLPS-Ved-0418Verticillium dahliae36.413e-30 125
LLPS-Lem-0063Leptosphaeria maculans36.242e-31 131
LLPS-Spr-0447Sporisorium reilianum35.793e-36 145
LLPS-Phn-0048Phaeosphaeria nodorum35.063e-32 133
LLPS-Asg-0808Ashbya gossypii35.05e-44 165
LLPS-Kop-0331Komagataella pastoris34.911e-45 169
LLPS-Usm-0129Ustilago maydis33.991e-33 137
LLPS-Tum-1298Tuber melanosporum33.897e-37 146
LLPS-Mel-0306Melampsora laricipopulina32.194e-35 139
LLPS-Cym-0059Cyanidioschyzon merolae31.943e-31 126
LLPS-Pug-0901Puccinia graminis31.868e-34 135
LLPS-Crn-0419Cryptococcus neoformans31.561e-31 130