• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pap-3345
RRP8

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ribosomal RNA-processing protein 8
Gene Name: RRP8
Ensembl Gene: ENSPPAG00000040792.1
Ensembl Protein: ENSPPAP00000036049.1
Organism: Pan paniscus
Taxa ID: 9597
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MFEEPEWAEA  APVAAGLGPV  ISRPPPAASS  QNKGSKRRQL  LATLRALEAA  SLSQHPPSLC  60
61    ISDSEEEEEE  RKKKCPKKAS  FASASAEVGK  KGKKKCQKQG  PPCSDSEEEV  ERKKKCHKQA  120
121   LVGSDSAEDE  KGKRKCQKHA  PINSAQHLDN  VDQTGPKAWK  GSTTNDPPKQ  SPGSTSPKPP  180
181   HTLSRKQWRN  RQKNKRRCKN  KFQPPQVPDQ  APAEAPTEKT  EVPPVPRTDS  HEARAGALRA  240
241   RMAQRLDGAR  FRYLNEQLYS  GPSSAAQRLF  QEDPEAFLLY  HRGFQSQVKK  WPLQPVDRIA  300
301   RDLRQRPASL  VVADFGCGDC  RLASSIRNPV  HCFDLASLDP  RVTVCDMAQV  PLEDESVDVA  360
361   VFCLSLMGTN  IRDFLEEANR  VLKPGGLLKV  AEVSSRFEDV  RTFLRAVTKL  GFKIVSKDLT  420
421   NSHFFLFDFQ  KTGPPLVGAK  AQLSGLQLQP  CLYKRR  456
Nucleotide CDS Sequence (FASTA)
1     ATGTTCGAAG  AGCCTGAGTG  GGCCGAGGCG  GCCCCAGTAG  CCGCGGGCCT  TGGGCCCGTA  60
61    ATCTCACGAC  CTCCGCCTGC  GGCCTCCTCG  CAAAACAAGG  TTCCTCTGGA  GGATGAGTCT  120
121   GTGGATGTGG  CTGTGTTTTG  CCTTTCGCTG  ATGGGAACCA  ACATCAGGGA  CTTCCTAGAG  180
181   GAGGCAAATA  GAGTACTGAA  GCCAGGGGGT  CTCCTGAAAG  TGGCTGAGGT  CAGCAGCCGC  240
241   TTTGAGGATG  TTCGAACCTT  TCTGCGGGCT  GTGACCAAGC  TAGGCTTCAA  GATTGTCTCC  300
301   AAGGACCTGA  CCAACAGCCA  TTTCTTCTTG  TTTGATTTCC  AAAAGACTGG  GCCCCCTCTG  360
361   GTAGGGGCCA  AGGCTCAGCT  TTCAGGCCTG  CAGCTTCAGC  CATGTCTCTA  CAAGCGCAGG  420
421   TGA  423

▼ KEYWORD

ID
Family
Complete proteome
Methyltransferase
Nucleus
Reference proteome
rRNA processing
S-adenosyl-L-methionine
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromatin silencing complex
Cellular Component
Cytosol
Cellular Component
Nucleolus
Cellular Component
Plasma membrane
Cellular Component
RDNA heterochromatin
Molecular Function
Methylated histone binding
Molecular Function
Methyltransferase activity
Biological Process
Cellular response to glucose starvation
Biological Process
Chromatin silencing at rDNA
Biological Process
Intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process
Positive regulation of cell cycle arrest
Biological Process
Regulation of transcription by glucose
Biological Process
RRNA processing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hos-2271Homo sapiens99.340.0 773
LLPS-Pat-1796Pan troglodytes99.340.0 774
LLPS-Gog-0594Gorilla gorilla99.120.0 775
LLPS-Poa-0581Pongo abelii98.250.0 767
LLPS-Nol-0592Nomascus leucogenys94.30.0 738
LLPS-Man-0641Macaca nemestrina94.040.0 645
LLPS-Maf-2170Macaca fascicularis93.860.0 716
LLPS-Mal-2764Mandrillus leucophaeus93.860.0 717
LLPS-Paa-0380Papio anubis93.640.0 714
LLPS-Mam-0486Macaca mulatta93.640.0 724
LLPS-Cea-3250Cercocebus atys93.20.0 710
LLPS-Rhb-1068Rhinopithecus bieti92.540.0 715
LLPS-Aon-2597Aotus nancymaae91.670.0 699
LLPS-Chs-0104Chlorocebus sabaeus91.450.0 702
LLPS-Caj-1067Callithrix jacchus90.570.0 699
LLPS-Myl-1292Myotis lucifugus83.290.0 592
LLPS-Eqc-0261Equus caballus83.250.0 533
LLPS-Cas-1497Carlito syrichta83.220.0 637
LLPS-Urm-2474Ursus maritimus82.490.0 607
LLPS-Aim-0903Ailuropoda melanoleuca82.350.0 561
LLPS-Orc-1022Oryctolagus cuniculus82.060.0 617
LLPS-Loa-0748Loxodonta africana81.840.0 626
LLPS-Tut-0885Tursiops truncatus81.490.0 607
LLPS-Mup-0233Mustela putorius furo81.180.0 600
LLPS-Caf-1182Canis familiaris80.80.0 563
LLPS-Otg-0658Otolemur garnettii80.480.0 626
LLPS-Fec-1446Felis catus79.780.0 546
LLPS-Dio-1199Dipodomys ordii79.460.0 588
LLPS-Ict-0549Ictidomys tridecemlineatus78.990.0 581
LLPS-Ova-1131Ovis aries78.510.0 577
LLPS-Bot-0446Bos taurus78.280.0 589
LLPS-Mum-1735Mus musculus78.120.0 570
LLPS-Cap-0629Cavia porcellus77.560.0 588
LLPS-Sus-2175Sus scrofa76.80.0 549
LLPS-Fud-0105Fukomys damarensis76.580.0 553
LLPS-Ran-0257Rattus norvegicus74.770.0 565
LLPS-Anp-0249Anas platyrhynchos74.71e-35 132
LLPS-Mea-2335Mesocricetus auratus73.470.0 538
LLPS-Sah-1728Sarcophilus harrisii70.03e-118 362
LLPS-Ten-0439Tetraodon nigroviridis66.969e-48 166
LLPS-Tag-1216Taeniopygia guttata64.161e-95 294
LLPS-Gaga-0848Gallus gallus61.688e-38 140
LLPS-Orl-0588Oryzias latipes61.163e-96 308
LLPS-Scf-0277Scleropages formosus60.278e-90 291
LLPS-Icp-0370Ictalurus punctatus59.646e-92 295
LLPS-Dar-0853Danio rerio59.551e-91 295
LLPS-Lac-2347Latimeria chalumnae59.322e-95 303
LLPS-Tar-0925Takifugu rubripes58.745e-92 296
LLPS-Pof-2875Poecilia formosa57.66e-94 301
LLPS-Gaa-0321Gasterosteus aculeatus57.21e-94 297
LLPS-Asm-0793Astyanax mexicanus57.091e-92 296
LLPS-Xim-0467Xiphophorus maculatus57.036e-93 298
LLPS-Scm-0461Scophthalmus maximus56.579e-96 306
LLPS-Leo-0262Lepisosteus oculatus56.071e-91 295
LLPS-Mae-0694Manihot esculenta51.355e-68 225
LLPS-Sem-0503Selaginella moellendorffii51.134e-66 218
LLPS-Orn-0120Oreochromis niloticus51.086e-46 170
LLPS-Mua-0253Musa acuminata50.894e-67 220
LLPS-Cis-0199Ciona savignyi50.833e-81 263
LLPS-Hov-0085Hordeum vulgare49.736e-54 189
LLPS-Chc-0111Chondrus crispus49.122e-46 167
LLPS-Thc-1210Theobroma cacao48.653e-65 218
LLPS-Pot-0046Populus trichocarpa48.657e-66 218
LLPS-Coc-0689Corchorus capsularis48.651e-65 219
LLPS-Dac-0985Daucus carota48.424e-62 207
LLPS-Orb-0594Oryza barthii48.428e-63 209
LLPS-Via-1693Vigna angularis48.313e-54 187
LLPS-Prp-1205Prunus persica48.264e-65 218
LLPS-Cii-0072Ciona intestinalis48.069e-40 150
LLPS-Tra-1251Triticum aestivum48.026e-63 212
LLPS-Viv-0322Vitis vinifera47.884e-69 227
LLPS-Sob-0743Sorghum bicolor47.793e-63 213
LLPS-Zem-1612Zea mays47.792e-62 211
LLPS-Php-0688Physcomitrella patens47.751e-60 208
LLPS-Hea-0210Helianthus annuus47.754e-65 217
LLPS-Sot-0078Solanum tuberosum47.753e-63 213
LLPS-Orbr-1899Oryza brachyantha47.562e-59 203
LLPS-Phv-1750Phaseolus vulgaris47.53e-69 228
LLPS-Osl-0230Ostreococcus lucimarinus47.355e-54 186
LLPS-Gor-1398Gossypium raimondii47.38e-63 211
LLPS-Amt-1433Amborella trichopoda47.244e-70 231
LLPS-Cus-0300Cucumis sativus46.852e-61 208
LLPS-Brd-1325Brachypodium distachyon46.82e-53 187
LLPS-Arl-1362Arabidopsis lyrata46.723e-62 210
LLPS-Sei-0867Setaria italica46.641e-64 216
LLPS-Lep-0887Leersia perrieri46.461e-62 211
LLPS-Met-1243Medicago truncatula46.329e-65 216
LLPS-Orni-0937Oryza nivara45.997e-63 212
LLPS-Ori-0833Oryza indica45.997e-63 212
LLPS-Orgl-0155Oryza glumaepatula45.997e-63 212
LLPS-Ors-1232Oryza sativa45.997e-63 212
LLPS-Org-1242Oryza glaberrima45.997e-63 212
LLPS-Orr-1760Oryza rufipogon45.997e-63 212
LLPS-Nia-1744Nicotiana attenuata45.923e-62 210
LLPS-Fus-0705Fusarium solani45.899e-45 168
LLPS-Glm-1307Glycine max45.53e-63 212
LLPS-Fuv-0655Fusarium verticillioides45.451e-41 159
LLPS-Trr-0605Trichoderma reesei45.453e-43 164
LLPS-Coo-0242Colletotrichum orbiculare45.281e-43 166
LLPS-Cae-0099Caenorhabditis elegans45.217e-64 216
LLPS-Cogr-0761Colletotrichum graminicola44.955e-40 155
LLPS-Orp-0917Oryza punctata44.739e-58 198
LLPS-Fuo-0734Fusarium oxysporum44.613e-41 158
LLPS-Trv-0233Trichoderma virens44.615e-43 163
LLPS-Mao-0655Magnaporthe oryzae43.782e-37 148
LLPS-Brr-1138Brassica rapa43.757e-63 212
LLPS-Art-2345Arabidopsis thaliana43.443e-59 202
LLPS-Scs-0467Sclerotinia sclerotiorum43.371e-42 162
LLPS-Beb-1065Beauveria bassiana43.261e-40 157
LLPS-Miv-0643Microbotryum violaceum43.221e-50 183
LLPS-Scp-0198Schizosaccharomyces pombe42.915e-63 213
LLPS-Scj-0127Schizosaccharomyces japonicus42.696e-54 189
LLPS-Brn-1071Brassica napus42.652e-65 219
LLPS-Bro-0673Brassica oleracea42.652e-65 219
LLPS-Scc-0448Schizosaccharomyces cryophilus42.343e-53 187
LLPS-Sol-0540Solanum lycopersicum41.93e-56 194
LLPS-Drm-0387Drosophila melanogaster41.489e-59 203
LLPS-Blg-0367Blumeria graminis41.059e-37 145
LLPS-Ast-0662Aspergillus terreus40.619e-31 128
LLPS-Asni-0933Aspergillus niger40.52e-30 126
LLPS-Abg-0144Absidia glauca40.431e-59 209
LLPS-Chr-0347Chlamydomonas reinhardtii40.384e-49 185
LLPS-Gag-0410Gaeumannomyces graminis39.918e-35 140
LLPS-Nec-0045Neurospora crassa39.61e-32 133
LLPS-Asc-0607Aspergillus clavatus39.32e-29 124
LLPS-Asfu-0171Aspergillus fumigatus39.111e-30 127
LLPS-Nef-0307Neosartorya fischeri38.996e-31 128
LLPS-Zyt-0388Zymoseptoria tritici38.762e-36 145
LLPS-Dos-0808Dothistroma septosporum38.662e-35 139
LLPS-Asf-0841Aspergillus flavus38.467e-33 134
LLPS-Aso-0527Aspergillus oryzae38.467e-33 134
LLPS-Gas-0628Galdieria sulphuraria38.431e-44 162
LLPS-Asn-0199Aspergillus nidulans38.03e-37 146
LLPS-Pyt-1380Pyrenophora teres37.447e-31 129
LLPS-Pytr-0209Pyrenophora triticirepentis37.443e-31 129
LLPS-Lem-0063Leptosphaeria maculans36.242e-31 131
LLPS-Asg-0808Ashbya gossypii36.075e-45 167
LLPS-Yal-0333Yarrowia lipolytica35.969e-47 172
LLPS-Ved-0418Verticillium dahliae35.93e-29 122
LLPS-Sac-0411Saccharomyces cerevisiae35.711e-43 163
LLPS-Tum-1298Tuber melanosporum35.692e-37 148
LLPS-Spr-0447Sporisorium reilianum35.454e-37 147
LLPS-Phn-0048Phaeosphaeria nodorum35.291e-31 130
LLPS-Usm-0129Ustilago maydis35.081e-34 139
LLPS-Kop-0331Komagataella pastoris34.553e-46 170
LLPS-Put-1012Puccinia triticina34.426e-1475.5
LLPS-Pug-0901Puccinia graminis33.667e-35 138
LLPS-Cym-0059Cyanidioschyzon merolae31.038e-31 125
LLPS-Mel-0306Melampsora laricipopulina30.911e-34 138
LLPS-Crn-0419Cryptococcus neoformans30.97e-32 130