• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Sus-0855
LONP1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Lon protease homolog, mitochondrial; Lon protease-like protein; LONP; Mitochondrial ATP-dependent protease Lon; Serine protease 15
Gene Name: LONP1
Ensembl Gene: ENSSSCG00000027128.2
Ensembl Protein: ENSSSCP00000014373.3
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION


ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MAAGAGCVRL  WGAARWWALR  RPLLAAAAGR  VPTAVRAWLP  RGRRACDASP  PWAQWGQGPA  60
61    AAGHWRGLWE  ANNRSSGGAF  SGGEDAPEGG  AEDGASGVGG  NAGGGEGPVI  TALTPMTIPD  120
121   VFPHLPLIAV  TRNPVFPRFI  KIVEVKNKKL  VELLRRKVRL  AQPYAGVFLK  RDDNNESDVV  180
181   ESLDEIYHTG  TFVQIHEMQD  LGDKLRMIVM  GHRRVHINRQ  LEVEPEEPEG  EKQKPRRKPK  240
241   RSKKEVEEDG  GAKQQVEVVV  EPGLSPTGEV  LMVEVENVVH  EDFQVTEEVK  ALTAEIVKTI  300
301   RDIIALNPLY  RESVLQMMQA  GHRVVDNPIY  LSDMGAALTG  AESHELQDVL  EETNIPKRLY  360
361   KALSLLKKEF  ELSKLQQRLG  REVEEKIKQT  HRKYLLQEQL  KIIKKELGLE  KDDKDAIEEK  420
421   FRERLKELVV  PKHVMDVVDE  ELSKLGLLDN  HSSEFNVTRN  YLDWLTSIPW  GKYSDENLDL  480
481   ARAQAVLEED  HYGMEDVKKR  ILEFIAVSQL  RGSTQGKILC  FYGPPGVGKT  SIARSIARAL  540
541   NREYFRFSVG  GMTDVAEIKG  HRRTYVGAMP  GKIIQCLKKT  KTENPLVLID  EVDKIGRGYQ  600
601   GDPSSALLEL  LDPEQNANFL  DHYLDVPVDL  SKVLFICTAN  ITETIPEPLR  DRMEMINVSG  660
661   YVAQEKLAIA  ERYLVPQARA  QCGLDESKAK  LSSDVLTLLI  KQYCRESGVR  NLQKQVEKVL  720
721   RKSAYKIVSG  EAEFVEVTPE  NLQDFVGKPV  FTVERMYDVT  PPGVVMGLAW  TAMGGSTLFV  780
781   ETSLRRPRDR  DSTKGDKDGS  LEVTGQLGEV  MKESARIAYT  FARAFLMQHD  PTNEYLVTSH  840
841   IHLHVPEGAT  PKDGPSAGCT  IVTALLSLAM  DRPVRQNLAM  TGEVSLTGKV  LPVGGIKEKT  900
901   IAAKRAGVTC  IVLPAENKKD  FYDLAAFITE  GLEVHFVEHY  REIFDIAFPE  EQAEALAVER  960
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGG  GTGCAGGCTG  TGTCCGGCTG  TGGGGAGCTG  CGAGGTGGTG  GGCGCTTCGG  60
61    CGGCCGCTGC  TGGCCGCCGC  CGCGGGGCGG  GTTCCGACTG  CAGTCAGAGC  GTGGTTGCCC  120
121   AGAGGCCGGC  GGGCCTGCGA  CGCCTCGCCT  CCCTGGGCGC  AGTGGGGCCA  AGGCCCCGCT  180
181   GCCGCGGGCC  ACTGGCGGGG  ACTTTGGGAG  GCGAACAACC  GCAGCAGCGG  AGGCGCATTC  240
241   TCGGGTGGCG  AGGATGCCCC  CGAGGGCGGC  GCGGAGGATG  GGGCCTCGGG  AGTGGGAGGC  300
301   AACGCCGGCG  GCGGTGAAGG  CCCAGTCATA  ACGGCGCTAA  CGCCCATGAC  GATACCGGAC  360
361   GTATTCCCGC  ACCTGCCGCT  CATCGCCGTT  ACGCGCAACC  CAGTGTTCCC  GCGCTTTATC  420
421   AAGATTGTCG  AGGTTAAAAA  TAAAAAGTTG  GTTGAGCTGC  TAAGAAGGAA  AGTCCGCCTC  480
481   GCCCAGCCAT  ATGCCGGCGT  CTTTCTAAAG  AGAGATGACA  ACAATGAGTC  TGACGTGGTT  540
541   GAGAGCCTGG  ACGAGATCTA  TCACACGGGG  ACATTTGTCC  AGATCCACGA  GATGCAGGAC  600
601   CTTGGGGACA  AGCTGCGCAT  GATCGTCATG  GGACACAGGA  GGGTTCACAT  CAACAGACAG  660
661   CTGGAGGTGG  AGCCAGAAGA  GCCGGAGGGT  GAAAAGCAGA  AGCCTCGCAG  GAAGCCAAAG  720
721   CGGAGCAAGA  AGGAGGTGGA  GGAGGATGGG  GGCGCCAAGC  AGCAGGTGGA  GGTGGTGGTG  780
781   GAGCCAGGCC  TCAGCCCCAC  TGGCGAGGTG  CTGATGGTGG  AGGTGGAGAA  TGTCGTCCAT  840
841   GAGGACTTCC  AGGTCACAGA  GGAGGTGAAG  GCCCTGACTG  CAGAGATTGT  GAAGACCATC  900
901   CGGGATATCA  TCGCCTTGAA  CCCGCTGTAC  AGAGAGTCTG  TGCTGCAGAT  GATGCAGGCC  960
961   GGCCACAGGG  TGGTGGACAA  CCCCATCTAC  CTGAGTGACA  TGGGCGCCGC  CCTCACTGGA  1020
1021  GCCGAGTCCC  ACGAGCTGCA  GGATGTGCTG  GAGGAGACCA  ATGTGGAGGA  GAAGATCAAG  1080
1081  CAGACACATC  GCAAATATCT  GCTGCAGGAG  CAGCTGAAGA  TCATCAAGAA  GGAGCTGGGC  1140
1141  CTGGAGAAGG  ACGACAAGGA  TGCCATCGAG  GAGAAGTTCC  GAGAGCGGCT  GAAGGAGCTG  1200
1201  GTGGTTCCCA  AGCACGTCAT  GGATGTGGTG  GATGAGGAGC  TGAGCAAGCT  GGGCCTGCTG  1260
1261  GACAACCACT  CCTCTGAGTT  CAACGTCACC  CGGAACTACC  TGGACTGGCT  GACATCCATT  1320
1321  CCGTGGGGCA  AGTACAGTGA  CGAGAACCTG  GACCTGGCCC  GCGCCCAGGC  AGTGCTGGAG  1380
1381  GAGGACCACT  ATGGGATGGA  GGACGTCAAG  AAGCGTATCC  TGGAGTTCAT  CGCCGTCAGC  1440
1441  CAGCTCCGGG  GCTCCACCCA  GGGCAAGATC  CTCTGCTTCT  ACGGCCCCCC  GGGCGTGGGC  1500
1501  AAGACCAGCA  TCGCCCGCTC  CATCGCCCGT  GCCCTGAACC  GGGAGTACTT  CCGCTTCAGT  1560
1561  GTCGGGGGCA  TGACGGACGT  GGCTGAGATC  AAGGGGCACA  GGCGGACGTA  TGTGGGCGCC  1620
1621  ATGCCTGGGA  AGATCATCCA  GTGCCTGAAG  AAGACCAAGA  CGGAGAACCC  CCTGGTCCTC  1680
1681  ATAGATGAGG  TGGACAAGAT  CGGCCGGGGT  TACCAGGGGG  ACCCCTCCTC  AGCGCTGCTC  1740
1741  GAGCTGCTGG  ACCCTGAGCA  GAACGCCAAC  TTCCTGGACC  ACTATCTGGA  TGTGCCTGTG  1800
1801  GACTTGTCCA  AGGTGCTGTT  CATCTGCACG  GCCAACATCA  CCGAGACCAT  CCCCGAGCCG  1860
1861  CTGCGGGACC  GGATGGAGAT  GATCAATGTG  TCGGGCTACG  TGGCCCAGGA  GAAGCTGGCC  1920
1921  ATTGCAGAGC  GGTACCTGGT  GCCTCAGGCC  CGTGCCCAGT  GTGGCCTGGA  CGAGAGCAAG  1980
1981  GCCAAGCTGT  CGTCAGACGT  GCTGACCCTC  CTCATCAAGC  AGTACTGCCG  AGAGAGCGGC  2040
2041  GTCCGCAACC  TGCAAAAGCA  GGTGGAGAAG  GTGTTACGGA  AGTCCGCCTA  CAAGATTGTC  2100
2101  AGCGGTGAGG  CCGAGTTTGT  GGAGGTGACA  CCTGAGAACC  TGCAGGACTT  TGTGGGGAAG  2160
2161  CCGGTGTTCA  CAGTGGAGCG  CATGTACGAC  GTGACGCCCC  CCGGTGTGGT  CATGGGCCTG  2220
2221  GCCTGGACCG  CCATGGGAGG  CTCTACACTG  TTTGTTGAGA  CGTCTCTGAG  GCGGCCACGG  2280
2281  GACAGAGACA  GCACCAAGGG  GGACAAGGAT  GGGAGCCTGG  AGGTGACAGG  CCAGTTGGGG  2340
2341  GAGGTGATGA  AGGAGAGTGC  CCGCATCGCC  TACACCTTCG  CCAGGGCCTT  CCTGATGCAG  2400
2401  CATGACCCCA  CCAACGAGTA  CCTGGTGACC  TCGCACATCC  ACCTGCACGT  ACCTGAGGGT  2460
2461  GCCACCCCGA  AGGATGGCCC  CAGTGCGGGC  TGCACTATCG  TCACGGCCCT  GCTCTCCTTG  2520
2521  GCTATGGATC  GGCCGGTGCG  GCAGAACTTG  GCCATGACAG  GCGAGGTCTC  CCTCACAGGG  2580
2581  AAGGTCCTGC  CTGTGGGTGG  CATCAAAGAG  AAGACCATTG  CGGCCAAGCG  AGCTGGGGTG  2640
2641  ACATGCATTG  TCTTGCCGGC  TGAGAACAAG  AAAGACTTCT  ATGACCTGGC  CGCCTTCATC  2700
2701  ACCGAGGGCC  TGGAGGTGCA  CTTTGTGGAG  CACTACCGTG  AGATCTTTGA  TATCGCCTTC  2760
2761  CCTGAGGAAC  AGGCTGAAGC  CCTGGCCGTG  GAGCGGTGA  2799

▼ KEYWORD


ID
Family
ATP-binding
Complete proteome
DNA-binding
Hydrolase
Mitochondrion
Nucleotide-binding
Protease
Proteomics identification
Reference proteome
Serine protease
Signal
Transit peptide

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Mitochondrial matrix
Cellular Component
Mitochondrial nucleoid
Cellular Component
Nucleoplasm
Molecular Function
ADP binding
Molecular Function
ATP binding
Molecular Function
ATP-dependent peptidase activity
Molecular Function
DNA polymerase binding
Molecular Function
G-quadruplex DNA binding
Molecular Function
Mitochondrial promoter sequence-specific DNA binding
Molecular Function
Sequence-specific DNA binding
Molecular Function
Serine-type endopeptidase activity
Molecular Function
Single-stranded DNA binding
Molecular Function
Single-stranded RNA binding
Biological Process
Cellular response to oxidative stress
Biological Process
Chaperone-mediated protein complex assembly
Biological Process
Mitochondrion organization
Biological Process
Oxidation-dependent protein catabolic process
Biological Process
Protein homooligomerization
Biological Process
Protein quality control for misfolded or incompletely synthesized proteins
Biological Process
Response to hypoxia

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-0345Bos taurus95.630.01583
LLPS-Caf-1846Canis familiaris94.760.01354
LLPS-Tut-1277Tursiops truncatus94.690.01556
LLPS-Ova-1721Ovis aries94.420.01541
LLPS-Aim-0102Ailuropoda melanoleuca93.560.01495
LLPS-Aon-1514Aotus nancymaae93.440.01487
LLPS-Myl-0891Myotis lucifugus92.580.01274
LLPS-Eqc-1869Equus caballus92.390.01538
LLPS-Gog-3671Gorilla gorilla92.160.01522
LLPS-Fec-2515Felis catus91.990.01508
LLPS-Pat-0382Pan troglodytes91.940.01519
LLPS-Hos-1585Homo sapiens91.940.01519
LLPS-Fud-2993Fukomys damarensis91.670.0 907
LLPS-Maf-2670Macaca fascicularis91.640.01516
LLPS-Chs-1626Chlorocebus sabaeus91.640.01514
LLPS-Rhb-1053Rhinopithecus bieti91.640.01402
LLPS-Man-2100Macaca nemestrina91.640.01516
LLPS-Cea-2070Cercocebus atys91.530.01515
LLPS-Paa-0308Papio anubis91.530.01512
LLPS-Caj-1912Callithrix jacchus91.270.01515
LLPS-Mup-1825Mustela putorius furo90.990.01494
LLPS-Cas-1244Carlito syrichta90.330.0 977
LLPS-Ict-1476Ictidomys tridecemlineatus90.020.01491
LLPS-Pap-1310Pan paniscus89.80.01512
LLPS-Otg-1777Otolemur garnettii88.980.01494
LLPS-Mea-1010Mesocricetus auratus88.930.01343
LLPS-Sah-1707Sarcophilus harrisii88.710.01427
LLPS-Loa-1856Loxodonta africana88.580.01429
LLPS-Mal-1463Mandrillus leucophaeus88.440.01363
LLPS-Dio-0270Dipodomys ordii88.370.01038
LLPS-Urm-0981Ursus maritimus88.280.01381
LLPS-Fia-2223Ficedula albicollis87.860.01355
LLPS-Pes-1577Pelodiscus sinensis87.760.01352
LLPS-Meg-1488Meleagris gallopavo87.740.01348
LLPS-Anp-0324Anas platyrhynchos87.630.01156
LLPS-Gaga-0664Gallus gallus87.620.01402
LLPS-Tag-0751Taeniopygia guttata87.30.01209
LLPS-Cap-1913Cavia porcellus87.240.01438
LLPS-Mod-0464Monodelphis domestica86.330.01436
LLPS-Nol-0234Nomascus leucogenys85.750.01130
LLPS-Poa-1651Pongo abelii85.711e-27 124
LLPS-Ran-1106Rattus norvegicus85.120.01436
LLPS-Xet-1499Xenopus tropicalis84.90.01361
LLPS-Mum-3232Mus musculus84.450.01431
LLPS-Ora-0250Ornithorhynchus anatinus84.210.01263
LLPS-Leo-0375Lepisosteus oculatus82.770.01331
LLPS-Dar-1230Danio rerio82.450.01313
LLPS-Asm-1733Astyanax mexicanus82.430.01320
LLPS-Scf-0175Scleropages formosus81.240.01300
LLPS-Icp-3695Ictalurus punctatus80.650.01313
LLPS-Orn-0453Oreochromis niloticus80.440.01292
LLPS-Scm-0969Scophthalmus maximus80.420.01286
LLPS-Gaa-2638Gasterosteus aculeatus80.090.01289
LLPS-Ten-2300Tetraodon nigroviridis79.810.01254
LLPS-Orl-0362Oryzias latipes79.70.01283
LLPS-Xim-1063Xiphophorus maculatus79.510.01278
LLPS-Pof-0615Poecilia formosa79.510.01276
LLPS-Lac-1271Latimeria chalumnae78.450.01214
LLPS-Tar-2132Takifugu rubripes73.830.01143
LLPS-Hov-0112Hordeum vulgare71.435e-118 369
LLPS-Drm-0058Drosophila melanogaster69.810.0 952
LLPS-Cii-0013Ciona intestinalis68.850.01098
LLPS-Cis-0328Ciona savignyi67.311e-28 128
LLPS-Phv-1491Phaseolus vulgaris64.863e-96 320
LLPS-Ors-1574Oryza sativa62.943e-54 201
LLPS-Orp-0330Oryza punctata62.842e-156 493
LLPS-Gor-0573Gossypium raimondii62.041e-79 285
LLPS-Coc-1471Corchorus capsularis60.954e-75 275
LLPS-Viv-0326Vitis vinifera60.631e-78 281
LLPS-Sei-0251Setaria italica60.194e-78 280
LLPS-Amt-0437Amborella trichopoda59.434e-77 278
LLPS-Brd-0204Brachypodium distachyon59.363e-78 281
LLPS-Sob-1196Sorghum bicolor59.263e-77 278
LLPS-Zem-1085Zea mays59.262e-77 278
LLPS-Abg-1175Absidia glauca59.152e-167 527
LLPS-Tra-1456Triticum aestivum58.995e-77 277
LLPS-Tru-0118Triticum urartu58.997e-77 276
LLPS-Glm-0063Glycine max58.933e-78 281
LLPS-Thc-1184Theobroma cacao58.822e-68 251
LLPS-Met-0609Medicago truncatula58.677e-79 283
LLPS-Pot-0290Populus trichocarpa58.647e-76 274
LLPS-Mae-1826Manihot esculenta58.597e-80 285
LLPS-Dac-0965Daucus carota58.565e-79 281
LLPS-Orm-0036Oryza meridionalis58.163e-79 284
LLPS-Miv-0928Microbotryum violaceum57.981e-158 520
LLPS-Osl-0886Ostreococcus lucimarinus57.60.0 743
LLPS-Sem-0447Selaginella moellendorffii57.488e-75 270
LLPS-Cae-1005Caenorhabditis elegans57.440.0 781
LLPS-Orbr-0067Oryza brachyantha57.326e-79 281
LLPS-Cus-0258Cucumis sativus57.271e-77 279
LLPS-Prp-0530Prunus persica57.022e-78 281
LLPS-Spr-0489Sporisorium reilianum56.876e-154 494
LLPS-Usm-0554Ustilago maydis56.661e-153 493
LLPS-Pug-0747Puccinia graminis55.382e-163 518
LLPS-Mua-0366Musa acuminata55.074e-75 272
LLPS-Vir-0652Vigna radiata55.023e-79 284
LLPS-Via-0937Vigna angularis55.023e-79 285
LLPS-Orb-1363Oryza barthii54.721e-80 288
LLPS-Org-0582Oryza glaberrima54.557e-80 285
LLPS-Chc-0641Chondrus crispus54.440.0 737
LLPS-Orni-0177Oryza nivara54.331e-79 285
LLPS-Ori-0861Oryza indica54.331e-79 285
LLPS-Orgl-1498Oryza glumaepatula54.331e-79 285
LLPS-Orr-0361Oryza rufipogon54.331e-79 285
LLPS-Fuv-0351Fusarium verticillioides53.510.0 734
LLPS-Lep-1057Leersia perrieri53.332e-79 283
LLPS-Cym-0188Cyanidioschyzon merolae53.260.0 711
LLPS-Tum-0681Tuber melanosporum53.040.0 732
LLPS-Kop-0068Komagataella pastoris53.022e-71 261
LLPS-Beb-0376Beauveria bassiana52.890.0 736
LLPS-Brn-2682Brassica napus52.540.0 728
LLPS-Bro-2866Brassica oleracea52.540.0 731
LLPS-Sol-0941Solanum lycopersicum51.892e-78 281
LLPS-Yal-0265Yarrowia lipolytica51.634e-135 442
LLPS-Blg-0331Blumeria graminis51.380.0 709
LLPS-Scj-0497Schizosaccharomyces japonicus50.830.0 711
LLPS-Scs-0246Sclerotinia sclerotiorum50.71e-1373.6
LLPS-Hea-0153Helianthus annuus49.940.0 787
LLPS-Sac-0081Saccharomyces cerevisiae49.530.0 685
LLPS-Brr-2301Brassica rapa49.380.0 773
LLPS-Php-0041Physcomitrella patens48.610.0 762
LLPS-Art-0482Arabidopsis thaliana48.610.0 771
LLPS-Asc-0862Aspergillus clavatus48.550.0 793
LLPS-Nef-0013Neosartorya fischeri48.110.0 781
LLPS-Asfu-0658Aspergillus fumigatus48.070.0 781
LLPS-Asni-0905Aspergillus niger48.060.0 785
LLPS-Chr-0163Chlamydomonas reinhardtii48.035e-160 505
LLPS-Asn-0753Aspergillus nidulans48.010.0 795
LLPS-Arl-0412Arabidopsis lyrata47.980.0 775
LLPS-Asf-0722Aspergillus flavus47.840.0 784
LLPS-Aso-0694Aspergillus oryzae47.840.0 768
LLPS-Zyt-0848Zymoseptoria tritici47.820.0 771
LLPS-Ast-0265Aspergillus terreus47.660.0 780
LLPS-Fuo-0479Fusarium oxysporum47.610.0 769
LLPS-Pyt-1033Pyrenophora teres47.590.0 756
LLPS-Pytr-0090Pyrenophora triticirepentis47.420.0 749
LLPS-Trv-0697Trichoderma virens47.40.0 783
LLPS-Cogr-0694Colletotrichum graminicola47.220.0 774
LLPS-Gas-0318Galdieria sulphuraria46.910.0 602
LLPS-Ved-0308Verticillium dahliae46.890.0 763
LLPS-Crn-0164Cryptococcus neoformans46.530.0 614
LLPS-Dos-0115Dothistroma septosporum46.080.0 744
LLPS-Coo-0557Colletotrichum orbiculare46.060.0 756
LLPS-Lem-0989Leptosphaeria maculans46.010.0 769
LLPS-Trr-0882Trichoderma reesei45.950.0 724
LLPS-Scp-0611Schizosaccharomyces pombe45.870.0 746
LLPS-Phn-0724Phaeosphaeria nodorum45.70.0 728
LLPS-Cog-0928Colletotrichum gloeosporioides45.543e-114 380
LLPS-Map-0298Magnaporthe poae45.440.0 738
LLPS-Fus-0860Fusarium solani45.150.0 732
LLPS-Nec-1110Neurospora crassa44.750.0 742
LLPS-Mao-0325Magnaporthe oryzae44.580.0 726
LLPS-Gag-0567Gaeumannomyces graminis44.560.0 734
LLPS-Asg-0589Ashbya gossypii44.460.0 703
LLPS-Scc-1200Schizosaccharomyces cryophilus43.520.0 700
LLPS-Mam-2898Macaca mulatta43.043e-145 459
LLPS-Mel-0443Melampsora laricipopulina43.020.0 655
LLPS-Put-0741Puccinia triticina42.452e-101 346
LLPS-Orc-0541Oryctolagus cuniculus42.411e-149 472
LLPS-Anc-3130Anolis carolinensis42.413e-149 471
LLPS-Sot-1668Solanum tuberosum39.919e-135 433
LLPS-Nia-0152Nicotiana attenuata38.595e-137 440