• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Mae-1826
MANES_08G111500

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Lon protease homolog, mitochondrial
Gene Name: MANES_08G111500
Ensembl Gene: MANES_08G111500
Ensembl Protein: OAY43962
Organism: Manihot esculenta
Taxa ID: 3983
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION


ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblOAY43962OAY43962
UniProtA0A2C9VFD8, A0A2C9VFD8_MANES
GeneBankCM004394OAY43962.1

▼ SEQUENCE


Protein Sequence (FASTA)
1     MLKLLSSSSA  RQIHNHLASP  CLRVTTESST  NPLLKALGSI  TGLTRRTSRN  PTYYQRALFC  60
61    SGSSNDGSGE  VVEVELKSGE  SGADSTDASN  AIVPTNPRPE  DYLTVLALPL  PHRPLFPGFY  120
121   MPIYVKDPKL  LAALQESRKR  QAPYAGAFLL  KDEPGTDPSV  VTGSESEKNI  YDLKGKDLFN  180
181   RLHEVGTLAQ  ISSIQGDQVI  LIGHRRLRIT  EMVSEDPLTV  KVDHLKEKPY  NKDDDVIKAT  240
241   SFEVISTLRD  VLKISSLWRD  HVQTYTQHIG  DFNFPRLADF  GAAISGANKL  QCQEVLEELD  300
301   VYKRLKLTLE  LVKKEVEISK  IQESIAKAIE  EKISGEQRRY  LLNEQLKAIK  KELGLETDDK  360
361   TALSAKFRER  IEPKKEKIPA  NVLQVIEEEL  TKLQLLEASS  SEFNVTRNYL  DWLTALPWGN  420
421   YSDENFDVLR  AQKILDEDHY  GLTDVKERIL  EFIAVGKLRG  VSQGKIICLS  GPPGVGKTSI  480
481   GRSIARALNR  KFFRFSVGGL  SDVAEIKGHR  RTYIGAMPGK  MVQCLKNVGT  ANPLVLIDEI  540
541   DKLGRGHAGD  PASALLELLD  PEQNANFLDH  YLDVPIDLSK  VLFVCTANVV  DMIPNPLLDR  600
601   MEVIAIAGYI  TDEKMHIARD  YLEKSTLEAC  GIKPEQVELT  DAALLALIEN  YCREAGVRNL  660
661   QKHIEKIYRK  IALRLVRQGE  LSEPDVSGES  KKAEAESIQS  SSGSNEASRN  EENDETSVEA  720
721   ETVMTDQPSE  QIQCPVDQPA  NSKEATETEK  IEESEVTKAV  EKVLVDTSNL  ADFVGKPVFH  780
781   AERIYEQTPA  GVVMGLAWTA  MGGSTLYIET  TQVEQGEGKG  ALQLTGQLGD  VMKESAQIAH  840
841   TVARAILVEK  DPDNPFFANT  KLHLHVPAGA  TPKDGPSAGC  TMITSLLSLA  MKKPVRKDLA  900
901   MTGEVTLTGK  ILPIGGVKEK  TIAARRSEVK  TIIFPSANRR  DFDELATNVK  EGLDVHFVDD  960
961   YSQVFNLAFG  YDQNEEK  977
Nucleotide CDS Sequence (FASTA)
1     ATGTTGAAGC  TTCTGTCCTC  CTCTTCGGCG  CGCCAAATCC  ATAACCACCT  AGCCTCTCCG  60
61    TGCCTCCGAG  TTACTACCGA  GTCGTCCACA  AATCCGTTGC  TCAAAGCACT  CGGTTCCATC  120
121   ACTGGATTGA  CTCGTAGGAC  ATCCAGAAAC  CCTACCTATT  ATCAAAGGGC  TCTTTTTTGC  180
181   TCGGGTTCTT  CCAACGATGG  GAGTGGCGAG  GTGGTAGAGG  TGGAGCTAAA  GAGCGGAGAG  240
241   TCGGGTGCTG  ACAGTACTGA  CGCAAGTAAT  GCTATCGTCC  CCACGAATCC  TAGACCCGAG  300
301   GATTATCTCA  CGGTGTTAGC  ATTACCCTTG  CCACATAGAC  CTCTGTTTCC  TGGTTTCTAC  360
361   ATGCCAATTT  ATGTCAAGGA  TCCTAAATTA  TTGGCAGCTT  TACAAGAAAG  TAGAAAAAGG  420
421   CAAGCCCCAT  ATGCTGGTGC  TTTTCTTCTT  AAAGATGAGC  CAGGGACTGA  TCCCAGCGTG  480
481   GTAACTGGTT  CTGAATCAGA  GAAAAACATA  TATGATCTTA  AGGGAAAAGA  TTTGTTTAAT  540
541   CGTCTCCATG  AAGTTGGCAC  ACTTGCCCAG  ATTTCAAGCA  TCCAAGGAGA  CCAGGTCATC  600
601   CTCATTGGTC  ATAGGCGACT  TCGAATAACA  GAGATGGTCA  GTGAGGATCC  GCTTACTGTC  660
661   AAAGTTGATC  ATCTGAAGGA  AAAACCATAT  AACAAAGATG  ATGATGTCAT  AAAGGCAACA  720
721   TCATTTGAGG  TTATTTCAAC  CCTGAGAGAT  GTTCTGAAGA  TAAGTTCCCT  TTGGCGAGAT  780
781   CATGTTCAAA  CATATACTCA  GCATATAGGA  GACTTCAATT  TTCCAAGGTT  AGCTGATTTT  840
841   GGAGCTGCAA  TATCTGGTGC  AAACAAATTG  CAGTGCCAGG  AAGTGCTTGA  AGAGCTGGAT  900
901   GTGTATAAAC  GTTTGAAGCT  CACACTGGAG  TTGGTGAAAA  AAGAAGTAGA  GATCAGCAAG  960
961   ATTCAGGAAT  CAATTGCAAA  AGCAATAGAA  GAGAAGATAA  GTGGTGAGCA  GCGTCGCTAT  1020
1021  TTGTTGAATG  AACAGCTTAA  GGCCATAAAA  AAGGAATTGG  GATTGGAAAC  AGATGACAAA  1080
1081  ACTGCACTCT  CTGCAAAGTT  TAGGGAAAGA  ATTGAACCAA  AGAAGGAAAA  AATTCCAGCT  1140
1141  AACGTTTTGC  AAGTAATAGA  AGAAGAGCTT  ACAAAACTGC  AGCTTTTAGA  AGCCAGTTCA  1200
1201  AGTGAATTTA  ATGTTACTCG  TAATTATCTG  GATTGGTTAA  CTGCTTTGCC  TTGGGGTAAT  1260
1261  TATAGTGATG  AGAATTTTGA  TGTCCTTCGG  GCTCAAAAAA  TTCTTGATGA  AGATCATTAT  1320
1321  GGATTAACTG  ATGTTAAGGA  AAGGATATTG  GAGTTCATTG  CTGTTGGAAA  ACTCAGAGGA  1380
1381  GTGTCTCAAG  GAAAAATCAT  CTGTCTATCT  GGTCCACCAG  GAGTGGGCAA  AACTAGCATT  1440
1441  GGGCGATCAA  TTGCACGTGC  TTTGAACCGG  AAGTTCTTTC  GATTCTCGGT  AGGAGGGTTA  1500
1501  TCTGATGTTG  CTGAAATCAA  GGGGCATCGT  CGAACCTATA  TTGGCGCAAT  GCCAGGAAAA  1560
1561  ATGGTGCAGT  GTCTGAAAAA  TGTAGGAACT  GCTAACCCTC  TTGTTCTCAT  TGACGAGATT  1620
1621  GACAAGTTGG  GAAGAGGACA  CGCTGGTGAT  CCAGCAAGTG  CTTTGTTGGA  GCTTCTTGAT  1680
1681  CCAGAGCAAA  ATGCTAATTT  TCTGGACCAC  TACCTTGATG  TTCCAATTGA  CCTATCAAAG  1740
1741  GTTCTATTTG  TATGCACAGC  AAATGTTGTG  GACATGATAC  CTAATCCTCT  CTTGGATAGA  1800
1801  ATGGAGGTAA  TTGCTATTGC  TGGGTATATT  ACTGATGAGA  AAATGCACAT  TGCCAGAGAT  1860
1861  TATTTGGAGA  AGTCTACACT  TGAAGCATGC  GGCATCAAGC  CTGAACAGGT  TGAGTTGACA  1920
1921  GATGCCGCTC  TTCTTGCACT  TATAGAGAAT  TACTGCCGAG  AAGCAGGGGT  TCGGAATCTA  1980
1981  CAAAAGCACA  TAGAAAAGAT  TTATCGCAAG  ATTGCACTGA  GACTTGTACG  TCAAGGAGAA  2040
2041  TTAAGTGAAC  CTGATGTTTC  TGGAGAATCA  AAAAAAGCAG  AAGCAGAATC  CATCCAAAGC  2100
2101  TCTTCAGGAT  CAAATGAGGC  TAGCAGAAAT  GAAGAAAATG  ATGAAACCTC  TGTAGAAGCT  2160
2161  GAGACTGTGA  TGACAGATCA  GCCATCTGAG  CAAATTCAGT  GTCCTGTAGA  TCAACCTGCC  2220
2221  AATTCAAAGG  AAGCAACTGA  AACTGAAAAA  ATTGAGGAAA  GTGAAGTAAC  TAAGGCAGTT  2280
2281  GAGAAGGTGT  TGGTGGACAC  ATCTAACCTA  GCTGATTTTG  TTGGCAAACC  TGTTTTCCAT  2340
2341  GCTGAGCGCA  TCTATGAACA  GACTCCAGCT  GGAGTTGTTA  TGGGTCTTGC  ATGGACTGCA  2400
2401  ATGGGTGGTT  CCACATTGTA  TATAGAGACC  ACTCAGGTTG  AGCAAGGAGA  GGGGAAAGGA  2460
2461  GCTCTTCAAC  TTACTGGTCA  ACTTGGAGAT  GTTATGAAAG  AAAGTGCCCA  AATTGCTCAC  2520
2521  ACAGTTGCAA  GAGCAATACT  GGTTGAGAAA  GATCCAGATA  ACCCCTTCTT  TGCTAATACC  2580
2581  AAGCTGCATC  TCCATGTTCC  TGCAGGGGCC  ACCCCTAAGG  ATGGGCCCAG  TGCTGGTTGC  2640
2641  ACCATGATCA  CATCCTTGCT  TTCCCTTGCC  ATGAAGAAGC  CTGTCAGGAA  AGATCTAGCA  2700
2701  ATGACTGGGG  AAGTTACACT  AACAGGGAAA  ATTCTTCCCA  TTGGTGGGGT  TAAGGAGAAA  2760
2761  ACAATAGCAG  CAAGGAGAAG  TGAAGTGAAG  ACTATCATAT  TCCCATCAGC  TAACAGAAGG  2820
2821  GATTTTGATG  AGCTTGCAAC  CAATGTGAAA  GAAGGCCTCG  ACGTTCACTT  TGTAGATGAC  2880
2881  TACAGCCAGG  TATTCAATTT  GGCGTTTGGA  TATGACCAGA  ATGAGGAAAA  ATAA  2934

▼ KEYWORD


ID
Family
ATP-binding
Coiled coil
Complete proteome
DNA-binding
Hydrolase
Mitochondrion
Nucleotide-binding
Protease
Reference proteome
Serine protease

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Mitochondrial matrix
Molecular Function
ATP binding
Molecular Function
ATP-dependent peptidase activity
Molecular Function
Sequence-specific DNA binding
Molecular Function
Serine-type endopeptidase activity
Biological Process
Cellular response to oxidative stress
Biological Process
Chaperone-mediated protein complex assembly
Biological Process
Oxidation-dependent protein catabolic process
Biological Process
Protein quality control for misfolded or incompletely synthesized proteins

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hov-0112Hordeum vulgare90.871e-167 498
LLPS-Pot-1106Populus trichocarpa85.090.01640
LLPS-Coc-0944Corchorus capsularis82.819e-62 230
LLPS-Gor-1358Gossypium raimondii82.580.01549
LLPS-Dac-0965Daucus carota82.130.01391
LLPS-Thc-1184Theobroma cacao81.740.01511
LLPS-Prp-0034Prunus persica81.090.01575
LLPS-Cus-0258Cucumis sativus80.690.01549
LLPS-Viv-0326Vitis vinifera80.040.01513
LLPS-Orbr-0067Oryza brachyantha80.040.01418
LLPS-Glm-0063Glycine max79.940.01541
LLPS-Lep-1057Leersia perrieri79.50.01375
LLPS-Phv-1491Phaseolus vulgaris79.160.0 828
LLPS-Met-0609Medicago truncatula78.930.01512
LLPS-Sol-0941Solanum lycopersicum78.840.01503
LLPS-Tru-0118Triticum urartu78.620.01395
LLPS-Vir-0652Vigna radiata78.550.01531
LLPS-Amt-0437Amborella trichopoda78.470.01516
LLPS-Via-0937Vigna angularis78.350.01527
LLPS-Org-0582Oryza glaberrima77.360.01427
LLPS-Hea-0153Helianthus annuus77.220.01462
LLPS-Sei-0251Setaria italica76.540.01449
LLPS-Zem-1085Zea mays76.380.01439
LLPS-Art-0482Arabidopsis thaliana76.380.01457
LLPS-Brr-1221Brassica rapa76.330.01467
LLPS-Tra-0239Triticum aestivum76.040.01420
LLPS-Arl-0412Arabidopsis lyrata75.990.01457
LLPS-Orgl-1498Oryza glumaepatula75.950.01428
LLPS-Ori-0861Oryza indica75.950.01428
LLPS-Orb-1363Oryza barthii75.950.01427
LLPS-Orni-0177Oryza nivara75.950.01428
LLPS-Brn-0535Brassica napus75.890.01454
LLPS-Orr-0361Oryza rufipogon75.850.01427
LLPS-Bro-1686Brassica oleracea75.840.01447
LLPS-Orm-0036Oryza meridionalis75.750.01436
LLPS-Sob-1196Sorghum bicolor75.720.01431
LLPS-Brd-0204Brachypodium distachyon75.570.01432
LLPS-Orp-1262Oryza punctata72.620.01342
LLPS-Ors-1574Oryza sativa70.630.0 646
LLPS-Mua-0366Musa acuminata69.330.01397
LLPS-Osl-0886Ostreococcus lucimarinus67.172e-80 287
LLPS-Rhb-1053Rhinopithecus bieti64.51e-60 228
LLPS-Sem-0447Selaginella moellendorffii64.060.01155
LLPS-Gaga-0664Gallus gallus63.684e-81 288
LLPS-Meg-1488Meleagris gallopavo63.683e-82 289
LLPS-Php-0041Physcomitrella patens63.370.01144
LLPS-Cap-1913Cavia porcellus63.139e-79 283
LLPS-Fia-2223Ficedula albicollis62.793e-81 288
LLPS-Pes-1577Pelodiscus sinensis62.743e-81 287
LLPS-Tag-0751Taeniopygia guttata62.732e-33 142
LLPS-Ict-1476Ictidomys tridecemlineatus62.337e-80 285
LLPS-Mea-1010Mesocricetus auratus61.973e-80 285
LLPS-Xet-1499Xenopus tropicalis61.92e-79 283
LLPS-Scf-0175Scleropages formosus61.687e-80 283
LLPS-Caf-1846Canis familiaris61.59e-81 284
LLPS-Cii-0013Ciona intestinalis61.44e-80 284
LLPS-Mod-0464Monodelphis domestica61.291e-79 285
LLPS-Aim-0102Ailuropoda melanoleuca61.193e-81 288
LLPS-Ten-2300Tetraodon nigroviridis61.038e-74 266
LLPS-Scm-0969Scophthalmus maximus60.952e-76 276
LLPS-Eqc-1869Equus caballus60.938e-79 282
LLPS-Orl-0362Oryzias latipes60.933e-77 278
LLPS-Anp-0324Anas platyrhynchos60.914e-33 141
LLPS-Gaa-2638Gasterosteus aculeatus60.832e-79 283
LLPS-Myl-0891Myotis lucifugus60.781e-26 121
LLPS-Urm-0981Ursus maritimus60.731e-80 287
LLPS-Aon-1514Aotus nancymaae60.636e-81 288
LLPS-Orn-0453Oreochromis niloticus60.563e-78 281
LLPS-Otg-1777Otolemur garnettii60.473e-79 283
LLPS-Ran-1106Rattus norvegicus60.365e-79 283
LLPS-Mum-3232Mus musculus60.362e-78 281
LLPS-Tut-1277Tursiops truncatus60.276e-80 286
LLPS-Pof-0615Poecilia formosa60.194e-78 281
LLPS-Xim-1063Xiphophorus maculatus60.191e-78 282
LLPS-Fec-2515Felis catus60.184e-77 277
LLPS-Pap-1310Pan paniscus60.182e-79 284
LLPS-Pat-0382Pan troglodytes60.182e-79 284
LLPS-Mal-1463Mandrillus leucophaeus60.183e-81 287
LLPS-Cea-2070Cercocebus atys60.188e-80 285
LLPS-Leo-0375Lepisosteus oculatus60.02e-74 270
LLPS-Caj-1912Callithrix jacchus59.912e-79 285
LLPS-Nol-0234Nomascus leucogenys59.732e-80 283
LLPS-Hos-1585Homo sapiens59.737e-79 282
LLPS-Man-2100Macaca nemestrina59.731e-78 282
LLPS-Mup-1825Mustela putorius furo59.733e-77 278
LLPS-Paa-0308Papio anubis59.739e-79 282
LLPS-Chs-1626Chlorocebus sabaeus59.731e-78 282
LLPS-Maf-2670Macaca fascicularis59.731e-78 282
LLPS-Gog-3671Gorilla gorilla59.731e-78 282
LLPS-Poa-1651Pongo abelii59.495e-1996.7
LLPS-Sus-0855Sus scrofa59.462e-79 284
LLPS-Lac-1271Latimeria chalumnae59.432e-74 270
LLPS-Dar-1230Danio rerio58.965e-76 274
LLPS-Ora-0250Ornithorhynchus anatinus58.881e-62 232
LLPS-Loa-1856Loxodonta africana58.828e-78 279
LLPS-Cis-0328Ciona savignyi58.741e-162 510
LLPS-Bot-0345Bos taurus58.561e-77 280
LLPS-Icp-3695Ictalurus punctatus58.413e-74 270
LLPS-Asm-1733Astyanax mexicanus58.412e-75 273
LLPS-Drm-0058Drosophila melanogaster58.064e-71 260
LLPS-Ova-1721Ovis aries58.044e-75 271
LLPS-Tar-2132Takifugu rubripes55.971e-163 511
LLPS-Sah-1707Sarcophilus harrisii55.618e-76 272
LLPS-Pug-0273Puccinia graminis54.985e-169 533
LLPS-Cog-0928Colletotrichum gloeosporioides54.635e-66 244
LLPS-Abg-1175Absidia glauca52.620.0 771
LLPS-Scj-0497Schizosaccharomyces japonicus51.720.0 755
LLPS-Put-0741Puccinia triticina51.578e-62 231
LLPS-Fuo-0479Fusarium oxysporum51.520.0 753
LLPS-Beb-0376Beauveria bassiana51.520.0 762
LLPS-Fus-0860Fusarium solani51.390.0 746
LLPS-Phn-0724Phaeosphaeria nodorum51.380.0 723
LLPS-Fuv-0351Fusarium verticillioides51.380.0 752
LLPS-Gas-0318Galdieria sulphuraria51.241e-57 220
LLPS-Ved-0308Verticillium dahliae51.190.0 749
LLPS-Cogr-0694Colletotrichum graminicola51.120.0 740
LLPS-Coo-0557Colletotrichum orbiculare51.120.0 752
LLPS-Blg-0331Blumeria graminis51.110.0 744
LLPS-Nec-1110Neurospora crassa51.050.0 747
LLPS-Trv-0697Trichoderma virens50.920.0 745
LLPS-Cym-0188Cyanidioschyzon merolae50.71e-61 230
LLPS-Mao-0325Magnaporthe oryzae50.460.0 749
LLPS-Kop-0068Komagataella pastoris50.390.0 721
LLPS-Cas-1244Carlito syrichta49.912e-166 513
LLPS-Sac-0081Saccharomyces cerevisiae49.80.0 729
LLPS-Fud-2993Fukomys damarensis49.746e-164 508
LLPS-Dos-0115Dothistroma septosporum49.420.0 729
LLPS-Cae-1005Caenorhabditis elegans49.280.0 694
LLPS-Dio-0270Dipodomys ordii48.560.0 553
LLPS-Tum-0681Tuber melanosporum48.550.0 801
LLPS-Trr-0882Trichoderma reesei48.480.0 691
LLPS-Chr-0163Chlamydomonas reinhardtii48.30.0 847
LLPS-Usm-0554Ustilago maydis48.280.0 682
LLPS-Miv-0928Microbotryum violaceum47.760.0 684
LLPS-Crn-0164Cryptococcus neoformans47.580.0 654
LLPS-Spr-0489Sporisorium reilianum47.550.0 680
LLPS-Chc-0641Chondrus crispus47.090.0 777
LLPS-Asni-0905Aspergillus niger46.780.0 807
LLPS-Asn-0753Aspergillus nidulans46.620.0 808
LLPS-Asc-0862Aspergillus clavatus46.580.0 799
LLPS-Zyt-0848Zymoseptoria tritici46.450.0 785
LLPS-Aso-0694Aspergillus oryzae46.170.0 778
LLPS-Asf-0722Aspergillus flavus46.170.0 793
LLPS-Pyt-1033Pyrenophora teres46.150.0 749
LLPS-Nef-0013Neosartorya fischeri46.020.0 791
LLPS-Asfu-0658Aspergillus fumigatus45.970.0 791
LLPS-Ast-0265Aspergillus terreus45.940.0 800
LLPS-Pytr-0090Pyrenophora triticirepentis45.890.0 740
LLPS-Gag-0567Gaeumannomyces graminis45.640.0 774
LLPS-Map-0298Magnaporthe poae45.610.0 778
LLPS-Scs-0246Sclerotinia sclerotiorum45.457e-1062.4
LLPS-Lem-0989Leptosphaeria maculans45.290.0 754
LLPS-Asg-0589Ashbya gossypii44.80.0 739
LLPS-Yal-0265Yarrowia lipolytica44.690.0 647
LLPS-Scp-0611Schizosaccharomyces pombe44.420.0 739
LLPS-Scc-1200Schizosaccharomyces cryophilus44.410.0 754
LLPS-Mel-0443Melampsora laricipopulina42.440.0 708
LLPS-Mam-2898Macaca mulatta40.622e-143 455
LLPS-Orc-0541Oryctolagus cuniculus40.63e-147 466
LLPS-Anc-3130Anolis carolinensis40.22e-148 469
LLPS-Sot-1668Solanum tuberosum40.137e-146 463
LLPS-Nia-0152Nicotiana attenuata40.05e-151 477