LLPS-Spr-0489
PIM1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Lon protease homolog, mitochondrial |
| Gene Name: | PIM1, sr12363 |
| Ensembl Gene: | sr12363 |
| Ensembl Protein: | CBQ70467 |
| Organism: | Sporisorium reilianum |
| Taxa ID: | 999809 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CBQ70467 | CBQ70467 |
| UniProt | E6ZTB0, E6ZTB0_SPORE | |
| GeneBank | FQ311441 | CBQ70467.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MIPSQRYAAG NAARWRTSAS NAATMSSRRL ASFSSTAAAA AATARKPTAS RFAQARIPLS 60 61 VDANTAATSF ASVPTRSLFT SSPQYLPRVK KLERFLKEGE EREGEEHHEV ENEHEHRKQT 120 121 DESEAKAESS SSSSSSSGAR SATGGAPASG SGASGSGSSS GSGSGSGSNS IARSTVPSVY 180 181 PQVLALPITR RPLFPGFYKA VVIKNQAVCA AIKESLKRGQ PYIGAFLLKD EEEDADVITD 240 241 LSKVHKVGVF AQVTSLFPVQ GGGQTGGSKK GKDGDDKSDD EEGITAVLYP HRRIRIDELI 300 301 TPTGQTIPSP PPGTEGAGPA NPVSDEAANE AVKAASFAKV HEIQQEARDD GILPEVNDAS 360 361 SAHLQQNAPP SPPAAVDGQP EPDSDAASTD GQDMPSHSAP FQTSFLQDYA VSLVNVTNLA 420 421 AAPYDKRNDQ YIRAVMSELI SVFKDIAQLN PLFRDQIANF SISQGAGNVF EEPEKLADFA 480 481 AAVSTGEVGE LQAVLEALDI RERLQKALVV LKKELMNAQL QSKISKDVES KIQKRQREYY 540 541 LMEQLKGIKK ELGIESDGKD KMVEKFREKA GELNMPEAVR KVFDEELNKL QTLEPAASEF 600 601 NVTRGYLDWL TSIPWGVHSP ENYSISNATG VLDEDHYGLS DVKDRILEFL AVGKLKGTVE 660 661 GKIVCLVGPP GVGKTSIGKS IARAVERQFF RFSVGGLSDV AEIKGHRRTY VGAMPGKAIQ 720 721 ALKKVGTENP LILIDEVDKI GRGHNGDPSS ALLEMLDPEQ NGSFLDHYMD VPVDLSRVLF 780 781 VCTANTLETI PQPLLDRMEV MEVSSYTADE KRHIARGYLA PQAKEASGLQ DANIELPDET 840 841 IDFLIKHHAR ESGVRGLRKL LEKVYRKIAF QIVKDHGESV FPEPKEGELA SAKTEAASAV 900 901 PAGAADSTTQ SVTPPDVDGQ QPAESKETPS PFTEPSASTS EAETSPDSKP KQDGKVPGKD 960 961 AAPEAPAKVT TEKHQPMAVP KDVKVVITID SLRKYLGPPV YHKDRLYTSA MPAGVSTGLG 1020 1021 YLGNGSGSLM PIETTIMPGK GGLQLTGKLG DVIKESASIA LSWMKTNAHE LGIVKDAKDQ 1080 1081 LLENRDVHLH MPEGAIGKEG PSAGVAFTVS LTSLLTNRSV APTLAMTGEV SLRGMVLPVG 1140 1141 GLKEKLLAAH RAGITKVILP AQNQPNVEAD VPKAVLDDLE VHYVNNVWSA LNHAFGEGPW 1200 1201 TAKATEMEEL ERQESIVPPA PAKETIKQDD GANQDQPVN 1239 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | Sequence-specific DNA binding | |
Molecular Function | Serine-type endopeptidase activity | |
Biological Process | Cellular response to oxidative stress | |
Biological Process | Chaperone-mediated protein complex assembly | |
Biological Process | Oxidation-dependent protein catabolic process | |
Biological Process | Protein quality control for misfolded or incompletely synthesized proteins |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Usm-0554 | Ustilago maydis | 92.16 | 0.0 | 1875 |
| LLPS-Mel-0443 | Melampsora laricipopulina | 71.55 | 0.0 | 716 |
| LLPS-Aso-0694 | Aspergillus oryzae | 70.23 | 0.0 | 741 |
| LLPS-Asf-0722 | Aspergillus flavus | 70.23 | 0.0 | 742 |
| LLPS-Hov-0112 | Hordeum vulgare | 68.32 | 2e-121 | 383 |
| LLPS-Tum-0681 | Tuber melanosporum | 65.17 | 2e-29 | 131 |
| LLPS-Pug-0273 | Puccinia graminis | 62.33 | 0.0 | 890 |
| LLPS-Abg-1363 | Absidia glauca | 61.56 | 0.0 | 859 |
| LLPS-Ast-0265 | Aspergillus terreus | 61.26 | 0.0 | 846 |
| LLPS-Fus-0860 | Fusarium solani | 60.66 | 0.0 | 850 |
| LLPS-Asn-0753 | Aspergillus nidulans | 60.63 | 0.0 | 843 |
| LLPS-Trv-0697 | Trichoderma virens | 60.59 | 0.0 | 856 |
| LLPS-Scj-0497 | Schizosaccharomyces japonicus | 60.48 | 0.0 | 853 |
| LLPS-Map-0298 | Magnaporthe poae | 60.34 | 0.0 | 851 |
| LLPS-Miv-0928 | Microbotryum violaceum | 60.04 | 0.0 | 1125 |
| LLPS-Cis-0328 | Ciona savignyi | 59.76 | 4e-156 | 500 |
| LLPS-Cas-1244 | Carlito syrichta | 58.77 | 1e-151 | 482 |
| LLPS-Cii-0013 | Ciona intestinalis | 58.39 | 5e-168 | 528 |
| LLPS-Osl-0886 | Ostreococcus lucimarinus | 57.97 | 5e-174 | 546 |
| LLPS-Scf-0175 | Scleropages formosus | 57.92 | 6e-170 | 532 |
| LLPS-Icp-3695 | Ictalurus punctatus | 57.47 | 4e-169 | 536 |
| LLPS-Bot-0345 | Bos taurus | 57.29 | 7e-172 | 544 |
| LLPS-Fec-2515 | Felis catus | 57.23 | 5e-172 | 542 |
| LLPS-Php-0041 | Physcomitrella patens | 57.14 | 4e-177 | 558 |
| LLPS-Ova-1721 | Ovis aries | 57.08 | 3e-172 | 542 |
| LLPS-Pof-0615 | Poecilia formosa | 57.02 | 2e-169 | 536 |
| LLPS-Rhb-1053 | Rhinopithecus bieti | 57.02 | 4e-170 | 539 |
| LLPS-Otg-1777 | Otolemur garnettii | 57.02 | 9e-172 | 540 |
| LLPS-Cap-1913 | Cavia porcellus | 57.02 | 1e-171 | 543 |
| LLPS-Leo-0375 | Lepisosteus oculatus | 57.02 | 1e-167 | 532 |
| LLPS-Xim-1063 | Xiphophorus maculatus | 57.02 | 2e-169 | 536 |
| LLPS-Eqc-1869 | Equus caballus | 56.87 | 2e-170 | 538 |
| LLPS-Sus-0855 | Sus scrofa | 56.87 | 4e-171 | 540 |
| LLPS-Sob-0124 | Sorghum bicolor | 56.86 | 1e-08 | 63.9 |
| LLPS-Caj-1912 | Callithrix jacchus | 56.84 | 1e-171 | 543 |
| LLPS-Scm-0969 | Scophthalmus maximus | 56.79 | 5e-167 | 530 |
| LLPS-Scp-0611 | Schizosaccharomyces pombe | 56.68 | 0.0 | 768 |
| LLPS-Tut-1277 | Tursiops truncatus | 56.66 | 1e-170 | 538 |
| LLPS-Man-2100 | Macaca nemestrina | 56.63 | 3e-171 | 540 |
| LLPS-Aon-1514 | Aotus nancymaae | 56.63 | 8e-173 | 542 |
| LLPS-Maf-2670 | Macaca fascicularis | 56.63 | 3e-171 | 540 |
| LLPS-Chs-1626 | Chlorocebus sabaeus | 56.63 | 3e-171 | 540 |
| LLPS-Gog-3671 | Gorilla gorilla | 56.63 | 9e-172 | 541 |
| LLPS-Mod-0464 | Monodelphis domestica | 56.6 | 3e-170 | 538 |
| LLPS-Aim-0102 | Ailuropoda melanoleuca | 56.6 | 1e-170 | 537 |
| LLPS-Caf-1846 | Canis familiaris | 56.42 | 7e-174 | 540 |
| LLPS-Myl-0891 | Myotis lucifugus | 56.42 | 7e-173 | 540 |
| LLPS-Orn-0453 | Oreochromis niloticus | 56.39 | 1e-169 | 537 |
| LLPS-Xet-1499 | Xenopus tropicalis | 56.33 | 3e-171 | 538 |
| LLPS-Fia-2223 | Ficedula albicollis | 56.21 | 2e-172 | 541 |
| LLPS-Mup-1825 | Mustela putorius furo | 56.21 | 1e-170 | 538 |
| LLPS-Crn-0164 | Cryptococcus neoformans | 56.2 | 0.0 | 1050 |
| LLPS-Pes-1577 | Pelodiscus sinensis | 56.17 | 3e-173 | 541 |
| LLPS-Orl-0362 | Oryzias latipes | 56.07 | 8e-168 | 531 |
| LLPS-Sah-1707 | Sarcophilus harrisii | 56.03 | 8e-171 | 535 |
| LLPS-Mea-1010 | Mesocricetus auratus | 55.79 | 1e-171 | 540 |
| LLPS-Asm-1733 | Astyanax mexicanus | 55.72 | 1e-168 | 534 |
| LLPS-Dar-1230 | Danio rerio | 55.6 | 1e-169 | 536 |
| LLPS-Ora-0250 | Ornithorhynchus anatinus | 55.58 | 1e-172 | 538 |
| LLPS-Brr-2301 | Brassica rapa | 55.17 | 1e-168 | 532 |
| LLPS-Coc-0944 | Corchorus capsularis | 54.95 | 3e-109 | 370 |
| LLPS-Loa-1856 | Loxodonta africana | 54.74 | 7e-160 | 509 |
| LLPS-Gaa-2638 | Gasterosteus aculeatus | 54.64 | 1e-169 | 534 |
| LLPS-Ict-1476 | Ictidomys tridecemlineatus | 54.15 | 2e-171 | 541 |
| LLPS-Art-0482 | Arabidopsis thaliana | 54.13 | 8e-170 | 537 |
| LLPS-Brn-2682 | Brassica napus | 54.12 | 1e-165 | 524 |
| LLPS-Zyt-0848 | Zymoseptoria tritici | 53.87 | 0.0 | 804 |
| LLPS-Cym-0188 | Cyanidioschyzon merolae | 53.44 | 1e-150 | 484 |
| LLPS-Chr-0163 | Chlamydomonas reinhardtii | 53.14 | 1e-158 | 509 |
| LLPS-Scc-1200 | Schizosaccharomyces cryophilus | 53.09 | 0.0 | 741 |
| LLPS-Kop-0068 | Komagataella pastoris | 52.97 | 0.0 | 732 |
| LLPS-Ved-0308 | Verticillium dahliae | 52.9 | 0.0 | 955 |
| LLPS-Mao-0325 | Magnaporthe oryzae | 52.79 | 0.0 | 932 |
| LLPS-Asni-0905 | Aspergillus niger | 52.5 | 0.0 | 944 |
| LLPS-Nec-1110 | Neurospora crassa | 52.43 | 0.0 | 946 |
| LLPS-Coo-0557 | Colletotrichum orbiculare | 52.4 | 0.0 | 946 |
| LLPS-Tar-2132 | Takifugu rubripes | 52.39 | 5e-157 | 501 |
| LLPS-Cogr-0694 | Colletotrichum graminicola | 52.3 | 0.0 | 947 |
| LLPS-Fuo-0479 | Fusarium oxysporum | 51.96 | 0.0 | 951 |
| LLPS-Fuv-0351 | Fusarium verticillioides | 51.96 | 0.0 | 950 |
| LLPS-Trr-0882 | Trichoderma reesei | 51.9 | 0.0 | 913 |
| LLPS-Asc-0862 | Aspergillus clavatus | 51.76 | 0.0 | 942 |
| LLPS-Beb-0376 | Beauveria bassiana | 51.67 | 0.0 | 964 |
| LLPS-Cog-0928 | Colletotrichum gloeosporioides | 51.6 | 1e-62 | 236 |
| LLPS-Nef-0013 | Neosartorya fischeri | 51.54 | 0.0 | 931 |
| LLPS-Asfu-0658 | Aspergillus fumigatus | 51.35 | 0.0 | 929 |
| LLPS-Put-0741 | Puccinia triticina | 51.16 | 6e-60 | 228 |
| LLPS-Chc-0641 | Chondrus crispus | 51.11 | 1e-143 | 465 |
| LLPS-Mal-1463 | Mandrillus leucophaeus | 51.09 | 4e-154 | 491 |
| LLPS-Gag-0567 | Gaeumannomyces graminis | 51.02 | 0.0 | 934 |
| LLPS-Paa-0308 | Papio anubis | 50.89 | 2e-173 | 546 |
| LLPS-Dio-0270 | Dipodomys ordii | 50.74 | 3e-170 | 530 |
| LLPS-Cea-2070 | Cercocebus atys | 50.44 | 4e-172 | 542 |
| LLPS-Nol-0234 | Nomascus leucogenys | 50.42 | 1e-139 | 449 |
| LLPS-Hos-1585 | Homo sapiens | 50.26 | 4e-172 | 542 |
| LLPS-Pap-1310 | Pan paniscus | 50.26 | 4e-172 | 542 |
| LLPS-Pat-0382 | Pan troglodytes | 50.26 | 8e-172 | 541 |
| LLPS-Gaga-0664 | Gallus gallus | 50.18 | 4e-173 | 544 |
| LLPS-Fud-2993 | Fukomys damarensis | 50.0 | 2e-153 | 488 |
| LLPS-Meg-1488 | Meleagris gallopavo | 49.82 | 8e-175 | 544 |
| LLPS-Anp-0324 | Anas platyrhynchos | 49.65 | 1e-174 | 540 |
| LLPS-Tag-0751 | Taeniopygia guttata | 49.48 | 4e-173 | 538 |
| LLPS-Mum-3232 | Mus musculus | 49.39 | 3e-171 | 540 |
| LLPS-Dos-0115 | Dothistroma septosporum | 49.38 | 0.0 | 895 |
| LLPS-Scs-0246 | Sclerotinia sclerotiorum | 49.33 | 2e-15 | 79.3 |
| LLPS-Ran-1106 | Rattus norvegicus | 49.3 | 4e-171 | 540 |
| LLPS-Sot-1668 | Solanum tuberosum | 49.04 | 1e-36 | 154 |
| LLPS-Blg-0331 | Blumeria graminis | 48.51 | 0.0 | 904 |
| LLPS-Gor-0573 | Gossypium raimondii | 48.08 | 0.0 | 645 |
| LLPS-Lem-0989 | Leptosphaeria maculans | 48.06 | 0.0 | 857 |
| LLPS-Phn-0724 | Phaeosphaeria nodorum | 47.9 | 0.0 | 833 |
| LLPS-Viv-0326 | Vitis vinifera | 47.76 | 0.0 | 654 |
| LLPS-Pyt-1033 | Pyrenophora teres | 47.71 | 0.0 | 827 |
| LLPS-Orp-0330 | Oryza punctata | 47.49 | 0.0 | 613 |
| LLPS-Thc-1184 | Theobroma cacao | 47.45 | 0.0 | 636 |
| LLPS-Pot-1106 | Populus trichocarpa | 47.35 | 0.0 | 652 |
| LLPS-Mae-1826 | Manihot esculenta | 47.29 | 0.0 | 657 |
| LLPS-Sei-0251 | Setaria italica | 47.22 | 0.0 | 641 |
| LLPS-Pytr-0090 | Pyrenophora triticirepentis | 47.17 | 0.0 | 820 |
| LLPS-Tra-1456 | Triticum aestivum | 47.16 | 0.0 | 635 |
| LLPS-Cus-0258 | Cucumis sativus | 47.08 | 0.0 | 647 |
| LLPS-Tru-0118 | Triticum urartu | 47.03 | 0.0 | 632 |
| LLPS-Asg-0589 | Ashbya gossypii | 46.82 | 0.0 | 665 |
| LLPS-Orbr-0067 | Oryza brachyantha | 46.78 | 0.0 | 641 |
| LLPS-Prp-0034 | Prunus persica | 46.64 | 0.0 | 642 |
| LLPS-Org-0582 | Oryza glaberrima | 46.64 | 0.0 | 635 |
| LLPS-Hea-0153 | Helianthus annuus | 46.63 | 0.0 | 640 |
| LLPS-Brd-0204 | Brachypodium distachyon | 46.63 | 0.0 | 639 |
| LLPS-Sem-0447 | Selaginella moellendorffii | 46.62 | 0.0 | 637 |
| LLPS-Orb-1363 | Oryza barthii | 46.48 | 0.0 | 635 |
| LLPS-Ori-0861 | Oryza indica | 46.48 | 0.0 | 636 |
| LLPS-Orni-0177 | Oryza nivara | 46.48 | 0.0 | 636 |
| LLPS-Orgl-1498 | Oryza glumaepatula | 46.48 | 0.0 | 636 |
| LLPS-Drm-0058 | Drosophila melanogaster | 46.46 | 0.0 | 597 |
| LLPS-Gas-0318 | Galdieria sulphuraria | 46.43 | 6e-122 | 414 |
| LLPS-Orm-0036 | Oryza meridionalis | 46.36 | 0.0 | 633 |
| LLPS-Orr-0361 | Oryza rufipogon | 46.36 | 0.0 | 636 |
| LLPS-Lep-1057 | Leersia perrieri | 46.18 | 0.0 | 635 |
| LLPS-Sac-0081 | Saccharomyces cerevisiae | 46.14 | 0.0 | 853 |
| LLPS-Glm-1496 | Glycine max | 46.13 | 0.0 | 635 |
| LLPS-Dac-0965 | Daucus carota | 46.01 | 0.0 | 636 |
| LLPS-Bro-1686 | Brassica oleracea | 46.0 | 0.0 | 634 |
| LLPS-Met-0609 | Medicago truncatula | 45.97 | 0.0 | 643 |
| LLPS-Urm-0981 | Ursus maritimus | 45.95 | 2e-139 | 454 |
| LLPS-Phv-0445 | Phaseolus vulgaris | 45.91 | 7e-21 | 103 |
| LLPS-Sol-0941 | Solanum lycopersicum | 45.62 | 0.0 | 649 |
| LLPS-Arl-0412 | Arabidopsis lyrata | 45.6 | 0.0 | 631 |
| LLPS-Amt-0437 | Amborella trichopoda | 45.48 | 0.0 | 635 |
| LLPS-Zem-1085 | Zea mays | 45.44 | 0.0 | 635 |
| LLPS-Anc-3130 | Anolis carolinensis | 45.37 | 7e-87 | 306 |
| LLPS-Lac-1271 | Latimeria chalumnae | 45.26 | 7e-116 | 392 |
| LLPS-Via-0937 | Vigna angularis | 44.91 | 0.0 | 638 |
| LLPS-Vir-0652 | Vigna radiata | 44.91 | 0.0 | 638 |
| LLPS-Mua-0366 | Musa acuminata | 43.41 | 0.0 | 617 |
| LLPS-Ten-2300 | Tetraodon nigroviridis | 43.33 | 3e-27 | 124 |
| LLPS-Cae-1005 | Caenorhabditis elegans | 43.24 | 1e-172 | 544 |
| LLPS-Yal-0265 | Yarrowia lipolytica | 40.96 | 0.0 | 701 |
| LLPS-Nia-0152 | Nicotiana attenuata | 40.93 | 2e-145 | 469 |
| LLPS-Mam-2898 | Macaca mulatta | 40.93 | 7e-33 | 142 |
| LLPS-Ors-1574 | Oryza sativa | 40.04 | 8e-84 | 287 |
| LLPS-Poa-1200 | Pongo abelii | 39.6 | 2e-35 | 150 |
| LLPS-Orc-0541 | Oryctolagus cuniculus | 39.34 | 2e-35 | 150 |