LLPS-Spr-0202
PAN3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; Poly(A)-nuclease deadenylation complex subunit 3; PAN deadenylation complex subunit 3 |
| Gene Name: | PAN3, sr13608 |
| Ensembl Gene: | sr13608 |
| Ensembl Protein: | CBQ71245 |
| Organism: | Sporisorium reilianum |
| Taxa ID: | 999809 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CBQ71245 | CBQ71245 |
| UniProt | E6ZVI8, E6ZVI8_SPORE | |
| GeneBank | FQ311442 | CBQ71245.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MYHYSPSQQP PYHHQQHKQQ PQPPPHFNHA HPPPGPPPPP PHQPYQQQQP QQQQRPPPHN 60 61 QPGMQQHHHT HQQQQIPPAF NGALPARPTR SSAIPIVAPA STPPPGAATK PALSYGATTA 120 121 AGTGAAAAQP EASKSPVGAN ASASARKPCR NVAIYGHCKY QNDGCPFDHA SASTSNASGA 180 181 SAQTPKSPAA QFASGFSAAS SSPATSPNKV RGANNAPTSP LKGALSARNV AAAVFVPKIG 240 241 GSSSPSLSAA SPAITARSAL EGVTTDVNDM RIDSASSKEF TPSAYTQNGP GTPNMYTASY 300 301 DVDPINSSFD PSHNGESQVG ASASSAVQGQ ASRPYNPYEH MNEFGDPTPP QGPPGLALGG 360 361 GMDYYSAAAN GAAKIRQPLH YHLYAPPLPH VSNLHPHHLS ANAFFLNPNQ REELQRKQEA 420 421 MLASVPPPEL GGPHLPEELH VYHSLVPLEH PGPGAPSSMS MPPGLIDPRM GAPGANGVTG 480 481 ASGDHSKVFG YRSHSYKATC TLDGKRYVLR RLEGFRLQHE AAIALVERWR RIRHPSIVSV 540 541 REAFTTRAFG DQSIVFVYDY HPLATTLYAE HMTIKAAQPD RRTGRMQPVS MQVPERTLWS 600 601 YLCQLTSALR SIHSSNLAAR CIETSKVLRT GKNRVRINCC SVFDVIAYNP DENGTDALKA 660 661 QQLEDLVNLG ALIVSVGLNN FSAPKDMASS LAVFAGRYSA ELKNVVAWLV GQTAAPHEAT 720 721 AEDAAEVTRN VGELVKVLGS HCADEMDSAL NYTDLMENSL MKELENGRLV RLLCKFGFIN 780 781 ERPEFDHDLR WAETGDRYVI KLFRDHVFHS VDEAGRPVVD LSHILTNLNK LDAGTDEKIM 840 841 LTSRDEHSCL VVSYREIKNC IENAFQDLSR TR 872 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | PAN complex | |
Molecular Function | ATP binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein kinase activity | |
Molecular Function | RNA binding | |
Biological Process | MRNA processing | |
Biological Process | Nuclear-transcribed mRNA poly(A) tail shortening |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Usm-0598 | Ustilago maydis | 81.7 | 0.0 | 1100 |
| LLPS-Miv-1579 | Microbotryum violaceum | 47.88 | 2e-126 | 404 |
| LLPS-Tum-0671 | Tuber melanosporum | 46.14 | 8e-126 | 396 |
| LLPS-Lem-0915 | Leptosphaeria maculans | 45.32 | 3e-103 | 346 |
| LLPS-Pyt-0223 | Pyrenophora teres | 44.81 | 2e-100 | 339 |
| LLPS-Asfu-1158 | Aspergillus fumigatus | 44.7 | 2e-96 | 317 |
| LLPS-Crn-1514 | Cryptococcus neoformans | 44.65 | 2e-126 | 403 |
| LLPS-Ved-0528 | Verticillium dahliae | 44.32 | 2e-90 | 305 |
| LLPS-Mel-0432 | Melampsora laricipopulina | 44.31 | 9e-120 | 379 |
| LLPS-Pytr-0684 | Pyrenophora triticirepentis | 44.3 | 2e-100 | 338 |
| LLPS-Pug-1091 | Puccinia graminis | 43.55 | 8e-120 | 387 |
| LLPS-Cog-1171 | Colletotrichum gloeosporioides | 43.08 | 3e-100 | 326 |
| LLPS-Pes-0147 | Pelodiscus sinensis | 42.97 | 4e-102 | 339 |
| LLPS-Cas-2266 | Carlito syrichta | 42.78 | 1e-98 | 331 |
| LLPS-Myl-1125 | Myotis lucifugus | 42.78 | 9e-99 | 331 |
| LLPS-Fia-1298 | Ficedula albicollis | 42.71 | 1e-101 | 339 |
| LLPS-Anp-1503 | Anas platyrhynchos | 42.71 | 2e-101 | 338 |
| LLPS-Meg-3210 | Meleagris gallopavo | 42.71 | 2e-101 | 338 |
| LLPS-Tag-2931 | Taeniopygia guttata | 42.71 | 2e-101 | 338 |
| LLPS-Gaga-2676 | Gallus gallus | 42.71 | 2e-102 | 340 |
| LLPS-Rhb-4252 | Rhinopithecus bieti | 42.53 | 1e-98 | 331 |
| LLPS-Loa-3843 | Loxodonta africana | 42.53 | 3e-98 | 330 |
| LLPS-Pat-1798 | Pan troglodytes | 42.53 | 4e-97 | 330 |
| LLPS-Urm-1812 | Ursus maritimus | 42.53 | 6e-99 | 331 |
| LLPS-Pap-4272 | Pan paniscus | 42.53 | 1e-98 | 331 |
| LLPS-Hos-0412 | Homo sapiens | 42.53 | 2e-97 | 331 |
| LLPS-Fec-4287 | Felis catus | 42.53 | 1e-95 | 330 |
| LLPS-Ict-2153 | Ictidomys tridecemlineatus | 42.53 | 4e-97 | 330 |
| LLPS-Nol-2792 | Nomascus leucogenys | 42.53 | 3e-97 | 330 |
| LLPS-Mam-2382 | Macaca mulatta | 42.53 | 6e-98 | 331 |
| LLPS-Poa-2684 | Pongo abelii | 42.53 | 1e-98 | 331 |
| LLPS-Caf-3304 | Canis familiaris | 42.53 | 7e-97 | 330 |
| LLPS-Eqc-4082 | Equus caballus | 42.53 | 3e-96 | 329 |
| LLPS-Fud-4135 | Fukomys damarensis | 42.53 | 1e-98 | 331 |
| LLPS-Caj-0722 | Callithrix jacchus | 42.53 | 5e-97 | 330 |
| LLPS-Gog-1950 | Gorilla gorilla | 42.53 | 3e-98 | 331 |
| LLPS-Cea-1957 | Cercocebus atys | 42.53 | 1e-96 | 330 |
| LLPS-Aon-4613 | Aotus nancymaae | 42.53 | 1e-97 | 331 |
| LLPS-Sus-1633 | Sus scrofa | 42.53 | 8e-97 | 330 |
| LLPS-Mea-2561 | Mesocricetus auratus | 42.53 | 5e-97 | 330 |
| LLPS-Maf-1273 | Macaca fascicularis | 42.53 | 3e-97 | 330 |
| LLPS-Chs-3946 | Chlorocebus sabaeus | 42.53 | 3e-97 | 330 |
| LLPS-Paa-3785 | Papio anubis | 42.53 | 3e-97 | 330 |
| LLPS-Mal-0307 | Mandrillus leucophaeus | 42.53 | 3e-98 | 330 |
| LLPS-Aim-4100 | Ailuropoda melanoleuca | 42.53 | 1e-98 | 331 |
| LLPS-Ova-3831 | Ovis aries | 42.53 | 3e-98 | 330 |
| LLPS-Ran-0981 | Rattus norvegicus | 42.53 | 5e-98 | 329 |
| LLPS-Bot-3852 | Bos taurus | 42.53 | 2e-97 | 330 |
| LLPS-Xet-0966 | Xenopus tropicalis | 42.46 | 4e-101 | 338 |
| LLPS-Tar-2603 | Takifugu rubripes | 42.46 | 2e-100 | 337 |
| LLPS-Mod-3916 | Monodelphis domestica | 42.39 | 9e-99 | 335 |
| LLPS-Orc-3431 | Oryctolagus cuniculus | 42.28 | 7e-97 | 328 |
| LLPS-Man-3677 | Macaca nemestrina | 42.28 | 2e-96 | 330 |
| LLPS-Mum-3428 | Mus musculus | 42.28 | 7e-96 | 327 |
| LLPS-Lac-0833 | Latimeria chalumnae | 42.2 | 2e-99 | 335 |
| LLPS-Asn-0168 | Aspergillus nidulans | 42.12 | 5e-114 | 363 |
| LLPS-Orn-3032 | Oreochromis niloticus | 42.03 | 1e-96 | 327 |
| LLPS-Cap-1940 | Cavia porcellus | 42.03 | 5e-98 | 329 |
| LLPS-Scm-3232 | Scophthalmus maximus | 41.94 | 4e-99 | 334 |
| LLPS-Icp-0010 | Ictalurus punctatus | 41.94 | 1e-98 | 333 |
| LLPS-Xim-0507 | Xiphophorus maculatus | 41.94 | 2e-99 | 334 |
| LLPS-Dar-4194 | Danio rerio | 41.88 | 2e-98 | 332 |
| LLPS-Aso-0840 | Aspergillus oryzae | 41.72 | 1e-111 | 360 |
| LLPS-Asf-1241 | Aspergillus flavus | 41.7 | 7e-111 | 360 |
| LLPS-Asm-0390 | Astyanax mexicanus | 41.69 | 1e-98 | 333 |
| LLPS-Asni-1498 | Aspergillus niger | 41.67 | 1e-111 | 362 |
| LLPS-Abg-1962 | Absidia glauca | 41.54 | 8e-41 | 162 |
| LLPS-Orl-1064 | Oryzias latipes | 41.43 | 8e-99 | 333 |
| LLPS-Leo-0135 | Lepisosteus oculatus | 41.33 | 4e-96 | 328 |
| LLPS-Nef-0170 | Neosartorya fischeri | 41.11 | 1e-112 | 363 |
| LLPS-Ast-0954 | Aspergillus terreus | 41.08 | 2e-108 | 352 |
| LLPS-Put-0603 | Puccinia triticina | 40.91 | 1e-79 | 277 |
| LLPS-Scf-1080 | Scleropages formosus | 40.82 | 2e-98 | 328 |
| LLPS-Asc-1299 | Aspergillus clavatus | 40.65 | 2e-107 | 355 |
| LLPS-Pof-2509 | Poecilia formosa | 40.61 | 2e-94 | 321 |
| LLPS-Cii-1991 | Ciona intestinalis | 40.5 | 1e-54 | 199 |
| LLPS-Anc-0763 | Anolis carolinensis | 40.24 | 8e-97 | 327 |
| LLPS-Cogr-1281 | Colletotrichum graminicola | 40.08 | 8e-105 | 340 |
| LLPS-Cis-1858 | Ciona savignyi | 39.9 | 6e-93 | 310 |
| LLPS-Dos-1239 | Dothistroma septosporum | 39.55 | 2e-96 | 323 |
| LLPS-Zyt-1295 | Zymoseptoria tritici | 39.02 | 7e-99 | 324 |
| LLPS-Trv-1436 | Trichoderma virens | 38.96 | 2e-105 | 345 |
| LLPS-Yal-1561 | Yarrowia lipolytica | 38.78 | 7e-89 | 302 |
| LLPS-Ten-1281 | Tetraodon nigroviridis | 38.36 | 2e-80 | 280 |
| LLPS-Gaa-3216 | Gasterosteus aculeatus | 38.0 | 1e-101 | 337 |
| LLPS-Coo-0984 | Colletotrichum orbiculare | 37.81 | 8e-99 | 328 |
| LLPS-Dio-0156 | Dipodomys ordii | 37.72 | 6e-77 | 264 |
| LLPS-Ora-1076 | Ornithorhynchus anatinus | 37.31 | 5e-78 | 273 |
| LLPS-Fuo-1066 | Fusarium oxysporum | 37.01 | 3e-46 | 175 |
| LLPS-Gag-1067 | Gaeumannomyces graminis | 37.01 | 7e-94 | 316 |
| LLPS-Php-1101 | Physcomitrella patens | 36.99 | 4e-70 | 256 |
| LLPS-Drm-0579 | Drosophila melanogaster | 36.77 | 5e-92 | 314 |
| LLPS-Fuv-1558 | Fusarium verticillioides | 36.7 | 1e-90 | 308 |
| LLPS-Map-0775 | Magnaporthe poae | 36.59 | 1e-91 | 314 |
| LLPS-Phn-0674 | Phaeosphaeria nodorum | 36.2 | 6e-67 | 236 |
| LLPS-Fus-0824 | Fusarium solani | 36.08 | 1e-94 | 316 |
| LLPS-Nec-1047 | Neurospora crassa | 35.89 | 1e-83 | 288 |
| LLPS-Cae-1572 | Caenorhabditis elegans | 35.55 | 3e-70 | 250 |
| LLPS-Mao-1360 | Magnaporthe oryzae | 35.5 | 4e-89 | 303 |
| LLPS-Beb-1117 | Beauveria bassiana | 34.56 | 5e-118 | 380 |
| LLPS-Trr-1613 | Trichoderma reesei | 34.25 | 2e-106 | 349 |
| LLPS-Asg-0691 | Ashbya gossypii | 33.68 | 1e-66 | 239 |
| LLPS-Kop-1436 | Komagataella pastoris | 33.26 | 2e-75 | 264 |
| LLPS-Sah-3529 | Sarcophilus harrisii | 33.22 | 2e-47 | 183 |
| LLPS-Blg-1214 | Blumeria graminis | 33.11 | 8e-111 | 360 |
| LLPS-Chr-1734 | Chlamydomonas reinhardtii | 32.43 | 4e-52 | 198 |
| LLPS-Sac-1012 | Saccharomyces cerevisiae | 32.16 | 2e-53 | 202 |
| LLPS-Scp-0950 | Schizosaccharomyces pombe | 31.19 | 4e-44 | 174 |
| LLPS-Scc-0847 | Schizosaccharomyces cryophilus | 30.45 | 2e-44 | 175 |
| LLPS-Scj-1598 | Schizosaccharomyces japonicus | 27.64 | 1e-53 | 201 |
| LLPS-Cym-1083 | Cyanidioschyzon merolae | 25.12 | 3e-25 | 115 |
| LLPS-Gas-0639 | Galdieria sulphuraria | 24.88 | 1e-35 | 147 |