LLPS-Pytr-0684
PAN3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; Poly(A)-nuclease deadenylation complex subunit 3; PAN deadenylation complex subunit 3 |
| Gene Name: | PAN3, PTRG_10345 |
| Ensembl Gene: | PTRG_10345 |
| Ensembl Protein: | EDU43396 |
| Organism: | Pyrenophora triticirepentis |
| Taxa ID: | 426418 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EDU43396 | EDU43396 |
| UniProt | B2WJJ9, B2WJJ9_PYRTR | |
| GeneBank | DS231627 | EDU43396.1 |
| RefSeq | XM_001940642.1 | XP_001940677.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSGGSAHVHV HAEHEAAARS KALPLSLPLM TSLSNVAAGS SHHKGSRLPT IQPASPNKGA 60 61 PHASPTSNRP AYFAIPKGHP HATAIVSSAS STTESLSELT PSSSRDSLPH PQGRNGPTTP 120 121 QKQSRNNRRK TPTKSGGRWS RGGASSDDTA TDRKPPTSQP AEHAQSTTRS PHTSSKTRHQ 180 181 PSIATNTPSN HQPRFMATAF GGPSGDSRRG VVSPRPKGRE AKNTLCRNVT IYGHCRYENT 240 241 CPYIHDSLKL NQNENTKKRF NVDSPSFTPL QASTNGSVTP SSRSAAISPK AANAAVFTPK 300 301 SQRSTVTTPH MHAKEPAIDW HTQDFQEFVP QNFESQQMVD PNVGYDPFST PTNISSMAGP 360 361 SHQPPTINPY AQDASATYFQ NANAFQNPAY HLYWPVGPQP SGLLAYQRTA HDFFIPDALR 420 421 EELQKKAEIA RQVAPNSTLP AIEQFHSLFC LDISPQKNTA PFGYASWIYK AVSSKDGKTY 480 481 ALRRLENFRL TSETAIRSAQ PWKRVLNGNV VTIHEAFTTR AFGDSSLILV TDYHPNSKSL 540 541 ADEHFKPAQR FHGRQPTSSH VPEQVLWGYT VQIASALKAI HGSGLAARLI TPSKILLTSK 600 601 NRIRLNACSI MDIVQFDNAR PVSELQADDF IQLGRLILCI ANNNPTAHLQ MQKSIDYITR 660 661 SYTARLKECV QWLLNPQPSS GSPSSPTSPV PMQKDIDTFL AGIADQFASV FDSELHAQDT 720 721 LIVNLGRELE SSRLVRLLIK LSMINERPEL DASQNMPGNA GASSSTVWAE TGERYYLKLF 780 781 RDYVFHQVDQ NGHPVTDLAH VLDCLNKLDA GTDEKIPLIS RDEQNVLIVS YREVKRALES 840 841 AFQDLVRAGR ASGK 854 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCGGCG GCTCAGCACA TGTGCATGTG CATGCTGAAC ATGAGGCGGC CGCACGCAGC 60 61 AAAGCGTTAC CGCTGTCGTT GCCGTTGATG ACCTCCCTCT CTAATGTGGC AGCAGGAAGC 120 121 TCTCACCACA AAGGCAGCCG GTTGCCCACC ATTCAGCCTG CGTCGCCGAA CAAGGGCGCG 180 181 CCGCACGCTT CACCAACCTC CAACCGCCCT GCATACTTTG CGATCCCAAA GGGCCACCCA 240 241 CATGCGACTG CCATTGTCAG TTCTGCGTCG TCGACTACTG AATCACTATC CGAGTTGACA 300 301 CCGTCATCGT CGCGGGATTC GCTACCGCAC CCCCAAGGGC GCAACGGCCC TACCACGCCC 360 361 CAGAAGCAGT CGCGTAACAA CCGGCGGAAG ACTCCAACAA AGTCGGGTGG CAGATGGAGT 420 421 AGAGGAGGCG CTTCTTCAGA TGACACGGCC ACCGACCGCA AACCGCCCAC CTCCCAGCCA 480 481 GCTGAGCACG CGCAGAGCAC CACCCGCTCC CCCCACACTT CGTCCAAGAC ACGCCACCAA 540 541 CCCTCTATTG CTACCAACAC CCCATCGAAC CACCAGCCGC GATTCATGGC AACAGCCTTT 600 601 GGAGGTCCTT CGGGTGACTC GCGACGGGGA GTAGTATCTC CTCGCCCCAA GGGTCGCGAA 660 661 GCCAAAAACA CACTCTGCCG CAATGTCACC ATCTACGGAC ACTGTCGGTA CGAGAATACC 720 721 TGTCCCTATA TCCACGACAG CCTCAAGTTA AACCAGAATG AGAATACCAA GAAAAGGTTC 780 781 AATGTAGACT CCCCGTCATT CACGCCGCTG CAGGCAAGCA CCAATGGATC CGTCACACCT 840 841 TCGTCTCGCA GCGCTGCCAT TTCGCCCAAG GCGGCGAACG CGGCTGTCTT TACGCCCAAA 900 901 TCGCAACGCT CCACCGTTAC TACACCGCAC ATGCACGCGA AAGAGCCTGC CATCGATTGG 960 961 CATACGCAAG ATTTCCAAGA ATTCGTTCCC CAGAACTTTG AGAGCCAGCA GATGGTCGAT 1020 1021 CCCAATGTTG GCTACGATCC CTTCAGTACT CCCACCAATA TCTCTTCAAT GGCCGGCCCA 1080 1081 AGCCACCAAC CGCCTACCAT CAATCCCTAT GCTCAAGATG CCTCGGCGAC GTACTTTCAA 1140 1141 AACGCCAATG CTTTCCAAAA CCCAGCGTAC CACTTGTACT GGCCGGTAGG ACCGCAACCA 1200 1201 AGCGGGCTTT TAGCTTATCA GCGAACGGCG CATGACTTTT TTATTCCGGA TGCCTTACGA 1260 1261 GAAGAATTAC AGAAAAAGGC GGAAATTGCG CGACAAGTTG CTCCTAATAG CACTTTGCCA 1320 1321 GCTATCGAGC AGTTTCATTC TTTGTTTTGC TTGGATATTT CGCCACAAAA GAACACAGCA 1380 1381 CCGTTCGGCT ATGCCAGCTG GATCTACAAA GCCGTGTCTA GCAAAGATGG CAAGACGTAT 1440 1441 GCGCTACGCC GTCTGGAAAA CTTTCGTCTC ACGAGCGAGA CTGCCATTAG GTCTGCTCAA 1500 1501 CCCTGGAAAC GCGTCTTGAA CGGCAATGTG GTAACCATCC ATGAAGCATT TACCACTCGC 1560 1561 GCTTTCGGCG ACAGTTCCTT GATCCTGGTC ACAGACTACC ACCCAAACTC CAAGTCGCTT 1620 1621 GCTGACGAAC ACTTCAAACC AGCGCAACGG TTCCATGGTA GGCAGCCAAC GTCATCCCAT 1680 1681 GTACCAGAGC AAGTGTTATG GGGTTACACT GTCCAGATTG CATCTGCTTT AAAAGCCATA 1740 1741 CACGGGTCCG GCTTGGCTGC AAGGCTGATA ACGCCTTCGA AAATACTCCT TACGTCCAAG 1800 1801 AACAGGATAC GATTGAACGC ATGCAGTATC ATGGATATCG TTCAGTTCGA CAATGCTCGT 1860 1861 CCTGTTTCCG AACTCCAAGC CGACGACTTT ATCCAGCTCG GACGATTGAT ACTTTGCATC 1920 1921 GCAAATAACA ATCCCACGGC TCACTTGCAG ATGCAAAAGT CAATAGACTA CATCACTCGG 1980 1981 AGTTATACAG CCCGCCTCAA GGAATGCGTT CAGTGGCTTC TCAACCCTCA ACCGTCATCC 2040 2041 GGATCGCCAT CGTCTCCTAC TTCACCTGTG CCGATGCAGA AAGACATTGA TACCTTCCTT 2100 2101 GCGGGCATCG CTGATCAGTT CGCTTCCGTT TTCGACAGTG AGCTACATGC TCAGGATACA 2160 2161 CTGATCGTCA ACCTTGGGAG AGAGTTAGAA TCATCAAGGC TAGTCCGCCT GCTTATCAAA 2220 2221 CTCAGCATGA TCAATGAGCG ACCCGAGCTA GACGCCTCCC AAAACATGCC AGGAAATGCT 2280 2281 GGTGCAAGTT CATCCACGGT ATGGGCGGAG ACAGGAGAAC GCTACTACCT TAAACTTTTT 2340 2341 CGCGACTACG TTTTCCACCA AGTGGATCAG AACGGTCATC CAGTTACCGA TCTGGCGCAC 2400 2401 GTGTTGGACT GCTTGAACAA ATTGGACGCG GGTACCGACG AGAAGATACC GCTCATAAGC 2460 2461 AGAGACGAGC AGAATGTTTT GATCGTCAGT TACCGCGAGG TGAAGCGGGC GCTGGAGTCG 2520 2521 GCCTTCCAAG ACTTGGTACG AGCGGGACGG GCGTCTGGGA AATAG 2565 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | PAN complex | |
Molecular Function | ATP binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein kinase activity | |
Molecular Function | RNA binding | |
Biological Process | MRNA processing | |
Biological Process | Nuclear-transcribed mRNA poly(A) tail shortening |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pyt-0223 | Pyrenophora teres | 97.31 | 0.0 | 1514 |
| LLPS-Phn-0674 | Phaeosphaeria nodorum | 81.51 | 4e-146 | 446 |
| LLPS-Lem-0915 | Leptosphaeria maculans | 74.82 | 0.0 | 1093 |
| LLPS-Asfu-1158 | Aspergillus fumigatus | 55.68 | 6e-119 | 375 |
| LLPS-Asn-0168 | Aspergillus nidulans | 55.67 | 8e-164 | 491 |
| LLPS-Nef-0170 | Neosartorya fischeri | 54.01 | 5e-170 | 512 |
| LLPS-Asc-1299 | Aspergillus clavatus | 53.33 | 2e-173 | 527 |
| LLPS-Ast-0954 | Aspergillus terreus | 53.0 | 4e-173 | 520 |
| LLPS-Zyt-1295 | Zymoseptoria tritici | 51.53 | 2e-160 | 484 |
| LLPS-Tum-0671 | Tuber melanosporum | 51.35 | 9e-146 | 447 |
| LLPS-Cogr-1281 | Colletotrichum graminicola | 50.4 | 2e-155 | 471 |
| LLPS-Asni-1498 | Aspergillus niger | 50.16 | 0.0 | 560 |
| LLPS-Cog-1171 | Colletotrichum gloeosporioides | 49.89 | 4e-127 | 396 |
| LLPS-Beb-1117 | Beauveria bassiana | 48.75 | 0.0 | 553 |
| LLPS-Asf-1241 | Aspergillus flavus | 48.67 | 0.0 | 550 |
| LLPS-Trr-1613 | Trichoderma reesei | 48.02 | 0.0 | 543 |
| LLPS-Coo-0984 | Colletotrichum orbiculare | 47.85 | 4e-166 | 503 |
| LLPS-Aso-0840 | Aspergillus oryzae | 46.42 | 1e-177 | 532 |
| LLPS-Trv-1436 | Trichoderma virens | 45.89 | 3e-162 | 493 |
| LLPS-Blg-1214 | Blumeria graminis | 45.52 | 3e-172 | 520 |
| LLPS-Fus-0824 | Fusarium solani | 44.68 | 4e-156 | 476 |
| LLPS-Fuv-1558 | Fusarium verticillioides | 44.23 | 1e-146 | 456 |
| LLPS-Fuo-1066 | Fusarium oxysporum | 43.75 | 2e-92 | 303 |
| LLPS-Dos-1239 | Dothistroma septosporum | 42.9 | 1e-163 | 500 |
| LLPS-Gag-1067 | Gaeumannomyces graminis | 42.54 | 2e-162 | 496 |
| LLPS-Nec-1047 | Neurospora crassa | 41.47 | 2e-142 | 444 |
| LLPS-Ved-0528 | Verticillium dahliae | 41.18 | 2e-136 | 427 |
| LLPS-Usm-0598 | Ustilago maydis | 40.76 | 2e-99 | 336 |
| LLPS-Mao-1360 | Magnaporthe oryzae | 40.32 | 2e-145 | 452 |
| LLPS-Map-0775 | Magnaporthe poae | 40.12 | 3e-138 | 439 |
| LLPS-Spr-0202 | Sporisorium reilianum | 39.96 | 6e-98 | 332 |
| LLPS-Miv-1579 | Microbotryum violaceum | 38.8 | 3e-92 | 312 |
| LLPS-Mel-0432 | Melampsora laricipopulina | 38.72 | 7e-93 | 308 |
| LLPS-Gas-0639 | Galdieria sulphuraria | 38.55 | 3e-13 | 77.4 |
| LLPS-Yal-1561 | Yarrowia lipolytica | 38.01 | 9e-91 | 307 |
| LLPS-Pug-1091 | Puccinia graminis | 36.56 | 3e-87 | 300 |
| LLPS-Php-1101 | Physcomitrella patens | 36.54 | 1e-68 | 252 |
| LLPS-Xet-0966 | Xenopus tropicalis | 36.31 | 7e-87 | 300 |
| LLPS-Orn-3032 | Oreochromis niloticus | 36.29 | 4e-81 | 284 |
| LLPS-Aon-4613 | Aotus nancymaae | 36.23 | 2e-84 | 295 |
| LLPS-Nol-2792 | Nomascus leucogenys | 36.23 | 6e-84 | 293 |
| LLPS-Cea-1957 | Cercocebus atys | 36.22 | 1e-83 | 294 |
| LLPS-Bot-3852 | Bos taurus | 36.22 | 1e-84 | 295 |
| LLPS-Leo-0135 | Lepisosteus oculatus | 36.2 | 3e-82 | 289 |
| LLPS-Maf-1273 | Macaca fascicularis | 36.16 | 6e-84 | 293 |
| LLPS-Mum-3428 | Mus musculus | 36.16 | 9e-84 | 293 |
| LLPS-Chs-3946 | Chlorocebus sabaeus | 36.16 | 8e-84 | 293 |
| LLPS-Gog-1950 | Gorilla gorilla | 36.16 | 2e-84 | 293 |
| LLPS-Caj-0722 | Callithrix jacchus | 36.16 | 6e-84 | 293 |
| LLPS-Paa-3785 | Papio anubis | 36.16 | 6e-84 | 293 |
| LLPS-Mal-0307 | Mandrillus leucophaeus | 36.16 | 1e-84 | 293 |
| LLPS-Aim-4100 | Ailuropoda melanoleuca | 36.16 | 7e-85 | 293 |
| LLPS-Ova-3831 | Ovis aries | 36.16 | 8e-85 | 293 |
| LLPS-Hos-0412 | Homo sapiens | 36.16 | 6e-84 | 293 |
| LLPS-Pat-1798 | Pan troglodytes | 36.16 | 6e-84 | 293 |
| LLPS-Pap-4272 | Pan paniscus | 36.16 | 7e-85 | 293 |
| LLPS-Rhb-4252 | Rhinopithecus bieti | 36.16 | 6e-85 | 293 |
| LLPS-Poa-2684 | Pongo abelii | 36.16 | 7e-85 | 293 |
| LLPS-Mam-2382 | Macaca mulatta | 36.16 | 2e-84 | 294 |
| LLPS-Ict-2153 | Ictidomys tridecemlineatus | 36.16 | 8e-84 | 293 |
| LLPS-Lac-0833 | Latimeria chalumnae | 36.07 | 8e-79 | 278 |
| LLPS-Man-3677 | Macaca nemestrina | 36.02 | 2e-83 | 293 |
| LLPS-Loa-3843 | Loxodonta africana | 36.02 | 2e-84 | 292 |
| LLPS-Fec-4287 | Felis catus | 35.94 | 5e-83 | 294 |
| LLPS-Urm-1812 | Ursus maritimus | 35.92 | 8e-86 | 295 |
| LLPS-Eqc-4082 | Equus caballus | 35.92 | 8e-84 | 294 |
| LLPS-Caf-3304 | Canis familiaris | 35.87 | 1e-83 | 293 |
| LLPS-Scf-1080 | Scleropages formosus | 35.85 | 5e-83 | 286 |
| LLPS-Gaa-3216 | Gasterosteus aculeatus | 35.8 | 3e-87 | 298 |
| LLPS-Scm-3232 | Scophthalmus maximus | 35.8 | 2e-83 | 290 |
| LLPS-Tar-2603 | Takifugu rubripes | 35.7 | 5e-82 | 286 |
| LLPS-Asm-0390 | Astyanax mexicanus | 35.66 | 2e-85 | 296 |
| LLPS-Xim-0507 | Xiphophorus maculatus | 35.6 | 4e-83 | 290 |
| LLPS-Anc-0763 | Anolis carolinensis | 35.48 | 2e-82 | 287 |
| LLPS-Dar-4194 | Danio rerio | 35.44 | 4e-84 | 292 |
| LLPS-Icp-0010 | Ictalurus punctatus | 35.41 | 3e-85 | 296 |
| LLPS-Cap-1940 | Cavia porcellus | 35.39 | 8e-86 | 296 |
| LLPS-Meg-3210 | Meleagris gallopavo | 35.36 | 6e-88 | 301 |
| LLPS-Anp-1503 | Anas platyrhynchos | 35.36 | 8e-88 | 301 |
| LLPS-Gaga-2676 | Gallus gallus | 35.36 | 1e-88 | 302 |
| LLPS-Kop-1436 | Komagataella pastoris | 35.26 | 9e-90 | 303 |
| LLPS-Cas-2266 | Carlito syrichta | 35.25 | 6e-86 | 296 |
| LLPS-Orl-1064 | Oryzias latipes | 35.21 | 9e-83 | 288 |
| LLPS-Pof-2509 | Poecilia formosa | 35.19 | 1e-79 | 280 |
| LLPS-Fia-1298 | Ficedula albicollis | 35.17 | 2e-87 | 300 |
| LLPS-Tag-2931 | Taeniopygia guttata | 35.17 | 3e-87 | 300 |
| LLPS-Sus-1633 | Sus scrofa | 35.06 | 8e-84 | 293 |
| LLPS-Mea-2561 | Mesocricetus auratus | 35.03 | 6e-85 | 296 |
| LLPS-Ran-0981 | Rattus norvegicus | 35.03 | 2e-85 | 295 |
| LLPS-Myl-1125 | Myotis lucifugus | 35.03 | 4e-85 | 294 |
| LLPS-Fud-4135 | Fukomys damarensis | 34.85 | 6e-85 | 293 |
| LLPS-Crn-1514 | Cryptococcus neoformans | 34.81 | 2e-102 | 339 |
| LLPS-Pes-0147 | Pelodiscus sinensis | 34.81 | 3e-87 | 298 |
| LLPS-Mod-3916 | Monodelphis domestica | 34.8 | 1e-84 | 296 |
| LLPS-Orc-3431 | Oryctolagus cuniculus | 34.72 | 2e-84 | 293 |
| LLPS-Drm-0579 | Drosophila melanogaster | 34.62 | 1e-80 | 283 |
| LLPS-Ora-1076 | Ornithorhynchus anatinus | 34.16 | 3e-66 | 239 |
| LLPS-Cis-1858 | Ciona savignyi | 34.08 | 4e-89 | 299 |
| LLPS-Dio-0156 | Dipodomys ordii | 33.54 | 8e-67 | 236 |
| LLPS-Cii-1991 | Ciona intestinalis | 33.33 | 7e-38 | 151 |
| LLPS-Put-0603 | Puccinia triticina | 33.11 | 7e-51 | 194 |
| LLPS-Sac-1012 | Saccharomyces cerevisiae | 32.24 | 9e-49 | 187 |
| LLPS-Cae-1572 | Caenorhabditis elegans | 32.1 | 2e-55 | 207 |
| LLPS-Ten-1281 | Tetraodon nigroviridis | 32.08 | 2e-65 | 237 |
| LLPS-Sah-3529 | Sarcophilus harrisii | 31.99 | 4e-49 | 188 |
| LLPS-Abg-1962 | Absidia glauca | 31.37 | 3e-50 | 189 |
| LLPS-Scp-0950 | Schizosaccharomyces pombe | 31.22 | 3e-43 | 171 |
| LLPS-Scj-1598 | Schizosaccharomyces japonicus | 30.92 | 2e-75 | 263 |
| LLPS-Chr-1734 | Chlamydomonas reinhardtii | 30.42 | 2e-45 | 177 |
| LLPS-Asg-0691 | Ashbya gossypii | 30.28 | 4e-62 | 226 |
| LLPS-Scc-0847 | Schizosaccharomyces cryophilus | 27.96 | 2e-35 | 147 |
| LLPS-Cym-1083 | Cyanidioschyzon merolae | 27.31 | 1e-22 | 107 |