LLPS-Rhb-4252
PAN3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; Poly(A)-nuclease deadenylation complex subunit 3; PAN deadenylation complex subunit 3 |
| Gene Name: | PAN3 |
| Ensembl Gene: | ENSRBIG00000036981.1 |
| Ensembl Protein: | ENSRBIP00000026227.1 |
| Organism: | Rhinopithecus bieti |
| Taxa ID: | 61621 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRBIT00000050141.1 | ENSRBIP00000026227.1 |
| Ensembl | ENSRBIT00000050136.1 | ENSRBIP00000026222.1 |
| UniProt | A0A2K6LRS3, A0A2K6LRS3_RHIBE | |
| RefSeq | XM_017848497.1 | XP_017703986.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDGGALTDTS LTDSYFSTSF IGVNGFGSPV ETKYPLMQRM TNSSSSPSLL NDSAKPYSGH 60 61 DPLTSPASSL FNDFGALNIS QRRKPRKYRL GMLEERLVPM GSKARKAKNP IGCLADRCKS 120 121 GVPINMVWWN RVTENNLQTP NPTASEFIPK GGSSSRLSNV SQSNMSAFSQ VFSHPSMGSP 180 181 ATAGLAPGMS LSAGSSPLHS PKITPHTSPA PRRRSHTPNP ASYMVPSSAS TSVNNPVSQT 240 241 PSSGQVIQKE TVGGTTYFYT DTTPAPLTGM VFPNYHIYPP TAPHVAYMQP KANAPSFFMA 300 301 DELRQELINR HLITMAQIDQ ADMPAVPTEV DSYHSLFPLE PLPPPNRIQK SSNFGYITSC 360 361 YKAVNSKDDL PYCLRRIHGF RLVNTKCMVL VDMWKKIQHS NIVTLREVFT TKAFAEPSLV 420 421 FAYDFHAGGE TMMSRHFNDP NADAYFTKRK WGQHDGPLPR QHAGLLPESL IWAYIVQLSS 480 481 ALRTIHTAGL ACRVMDPTKI LITGKTRLRV NCVGVFDVLT FDNSQNNNPL ALMAQYQQAD 540 541 LISLGKVVLA LACNSLAGIQ RENLQKAMEL VTINYSSDLK NLILYLLTDQ NRMRSVNDIM 600 601 PMIGARFYTQ LDAAQMRNDV IEEDLAKEVQ NGRLFRLLAK LGTINERPEF QKDPTWSETG 660 661 DRYLLKLFRD HLFHQVTEAG APWIDLSHII SCLNKLDAGV PEKISLISRD EKSVLVVTYS 720 721 DLKRCFENTF QELIAAANGQ L 741 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGATGGAG GTGCTTTAAC TGATACAAGT CTCACAGATT CCTATTTTAG CACCAGCTTT 60 61 ATTGGAGTCA ATGGATTTGG AAGCCCTGTA GAAACAAAAT ATCCCCTGAT GCAGAGAATG 120 121 ACTAATAGTA GCAGCTCCCC AAGCCTTCTA AACGACAGTG CCAAGCCATA TTCAGGCCAT 180 181 GATCCTCTAA CTTCACCTGC TTCATCCTTG TTTAATGACT TTGGTGCCCT CAACATCTCT 240 241 CAGAGACGAA AGCCAAGGAA GTATCGCCTG GGGATGCTGG AGGAGAGGCT AGTTCCGATG 300 301 GGATCAAAGG CACGAAAAGC AAAGAACCCT ATTGGCTGCC TTGCTGACAG GTGTAAATCA 360 361 GGAGTACCCA TCAATATGGT TTGGTGGAAC AGAGTCACAG AAAACAATTT ACAGACACCA 420 421 AATCCTACTG CAAGCGAGTT TATTCCTAAA GGAGGATCAT CCTCCAGGCT GAGTAACGTG 480 481 TCCCAGTCAA ATATGTCTGC CTTCTCTCAA GTTTTCTCTC ACCCATCCAT GGGAAGCCCT 540 541 GCTACTGCTG GATTAGCACC AGGAATGTCG TTGTCTGCTG GGTCTTCCCC TCTTCATTCC 600 601 CCCAAGATTA CTCCACATAC TTCTCCTGCT CCCAGAAGAA GAAGTCACAC TCCAAATCCA 660 661 GCAAGTTACA TGGTGCCTTC TAGTGCCTCT ACATCTGTTA ATAATCCTGT TTCTCAGACT 720 721 CCATCTTCTG GTCAGGTGAT CCAAAAGGAA ACTGTTGGTG GAACGACTTA CTTCTATACA 780 781 GACACAACTC CAGCACCTTT GACTGGAATG GTGTTTCCAA ACTATCATAT TTATCCTCCG 840 841 ACTGCACCTC ATGTTGCTTA TATGCAACCG AAAGCAAATG CACCTTCCTT CTTCATGGCC 900 901 GATGAACTCC GACAGGAGCT GATCAACAGA CATTTAATAA CAATGGCTCA AATTGATCAA 960 961 GCAGATATGC CAGCAGTTCC TACAGAGGTT GACAGCTACC ATAGCCTATT TCCTCTAGAA 1020 1021 CCACTGCCAC CTCCCAACCG GATACAGAAA TCAAGTAATT TTGGGTATAT TACATCTTGC 1080 1081 TACAAAGCTG TAAATAGCAA AGATGATCTG CCATATTGCC TTCGGAGGAT ACATGGTTTT 1140 1141 CGTCTTGTTA ACACAAAGTG CATGGTGTTG GTCGACATGT GGAAGAAAAT TCAACACTCA 1200 1201 AATATCGTAA CTTTGCGCGA AGTATTCACC ACTAAAGCAT TTGCCGAGCC CTCTCTTGTG 1260 1261 TTTGCATATG ATTTCCATGC TGGAGGAGAA ACTATGATGA GCAGACACTT TAATGACCCT 1320 1321 AATGCTGATG CCTATTTCAC CAAGAGAAAG TGGGGTCAAC ATGATGGACC GTTGCCCAGG 1380 1381 CAACATGCTG GATTATTGCC AGAATCTCTT ATTTGGGCAT ATATTGTCCA ACTAAGTTCT 1440 1441 GCATTGCGTA CCATTCATAC AGCAGGTTTG GCATGTCGAG TTATGGATCC AACAAAGATT 1500 1501 CTGATAACTG GCAAAACAAG GTTGCGAGTA AATTGTGTTG GAGTTTTTGA TGTTTTAACA 1560 1561 TTTGATAACA GTCAAAATAA TAATCCATTG GCATTAATGG CCCAGTACCA GCAAGCAGAT 1620 1621 CTGATATCAT TAGGAAAAGT TGTGTTGGCT TTGGCTTGCA ACTCTTTGGC AGGAATTCAG 1680 1681 CGAGAGAATT TACAGAAAGC CATGGAACTG GTGACAATCA ACTATTCCTC TGACCTGAAG 1740 1741 AATCTGATTT TGTATTTGTT GACTGACCAA AACAGGATGC GAAGTGTAAA TGACATCATG 1800 1801 CCCATGATTG GTGCTCGATT TTATACTCAA TTGGATGCTG CTCAAATGAG AAATGATGTC 1860 1861 ATAGAGGAAG ACCTTGCAAA GGAGGTTCAA AATGGAAGAC TGTTTAGGCT CCTAGCAAAA 1920 1921 TTGGGAACAA TCAATGAGAG GCCGGAGTTT CAGAAGGATC CAACTTGGTC AGAGACCGGA 1980 1981 GACCGTTATC TGTTGAAACT CTTTAGGGAT CATCTTTTTC ATCAGGTGAC AGAAGCGGGT 2040 2041 GCTCCCTGGA TTGACCTCAG TCATATCATT TCTTGTCTTA ACAAGCTAGA TGCTGGTGTG 2100 2101 CCAGAAAAAA TAAGCCTGAT TTCCAGAGAT GAGAAGAGTG TACTCGTGGT GACCTACAGT 2160 2161 GACTTAAAGC GCTGCTTTGA AAATACTTTT CAAGAACTGA TTGCAGCTGC GAATGGTCAG 2220 2221 TTGTAG 2226 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | P-body | |
Cellular Component | PAN complex | |
Molecular Function | ATP binding | |
Molecular Function | Poly(A)-specific ribonuclease activity | |
Molecular Function | Protein kinase activity | |
Molecular Function | RNA binding | |
Biological Process | Deadenylation-dependent decapping of nuclear-transcribed mRNA | |
Biological Process | MRNA processing | |
Biological Process | Nuclear-transcribed mRNA poly(A) tail shortening | |
Biological Process | Positive regulation of cytoplasmic mRNA processing body assembly | |
Biological Process | Protein targeting |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-2684 | Pongo abelii | 99.87 | 0.0 | 1463 |
| LLPS-Maf-1273 | Macaca fascicularis | 99.87 | 0.0 | 1460 |
| LLPS-Chs-3946 | Chlorocebus sabaeus | 99.87 | 0.0 | 1460 |
| LLPS-Paa-3785 | Papio anubis | 99.87 | 0.0 | 1460 |
| LLPS-Pat-1798 | Pan troglodytes | 99.73 | 0.0 | 1457 |
| LLPS-Pap-4272 | Pan paniscus | 99.73 | 0.0 | 1460 |
| LLPS-Hos-0412 | Homo sapiens | 99.6 | 0.0 | 1457 |
| LLPS-Gog-1950 | Gorilla gorilla | 99.6 | 0.0 | 1457 |
| LLPS-Man-3677 | Macaca nemestrina | 99.59 | 0.0 | 1456 |
| LLPS-Cea-1957 | Cercocebus atys | 99.59 | 0.0 | 1456 |
| LLPS-Nol-2792 | Nomascus leucogenys | 99.46 | 0.0 | 1452 |
| LLPS-Aon-4613 | Aotus nancymaae | 99.46 | 0.0 | 1454 |
| LLPS-Caj-0722 | Callithrix jacchus | 99.46 | 0.0 | 1457 |
| LLPS-Fud-4135 | Fukomys damarensis | 99.33 | 0.0 | 1455 |
| LLPS-Aim-4100 | Ailuropoda melanoleuca | 99.19 | 0.0 | 1454 |
| LLPS-Ict-2153 | Ictidomys tridecemlineatus | 98.65 | 0.0 | 1445 |
| LLPS-Orc-3431 | Oryctolagus cuniculus | 98.38 | 0.0 | 1439 |
| LLPS-Cap-1940 | Cavia porcellus | 98.38 | 0.0 | 1443 |
| LLPS-Cas-2266 | Carlito syrichta | 98.38 | 0.0 | 1443 |
| LLPS-Mea-2561 | Mesocricetus auratus | 98.25 | 0.0 | 1437 |
| LLPS-Myl-1125 | Myotis lucifugus | 98.25 | 0.0 | 1442 |
| LLPS-Loa-3843 | Loxodonta africana | 98.11 | 0.0 | 1435 |
| LLPS-Ran-0981 | Rattus norvegicus | 97.97 | 0.0 | 1436 |
| LLPS-Mum-3428 | Mus musculus | 96.9 | 0.0 | 1409 |
| LLPS-Caf-3304 | Canis familiaris | 96.71 | 0.0 | 1439 |
| LLPS-Fec-4287 | Felis catus | 96.45 | 0.0 | 1435 |
| LLPS-Mal-0307 | Mandrillus leucophaeus | 96.14 | 0.0 | 1431 |
| LLPS-Eqc-4082 | Equus caballus | 95.92 | 0.0 | 1426 |
| LLPS-Ova-3831 | Ovis aries | 95.79 | 0.0 | 1437 |
| LLPS-Mod-3916 | Monodelphis domestica | 94.88 | 0.0 | 1393 |
| LLPS-Sus-1633 | Sus scrofa | 94.87 | 0.0 | 1417 |
| LLPS-Pes-0147 | Pelodiscus sinensis | 94.63 | 0.0 | 1319 |
| LLPS-Anp-1503 | Anas platyrhynchos | 93.94 | 0.0 | 1381 |
| LLPS-Fia-1298 | Ficedula albicollis | 93.8 | 0.0 | 1383 |
| LLPS-Tag-2931 | Taeniopygia guttata | 93.4 | 0.0 | 1378 |
| LLPS-Meg-3210 | Meleagris gallopavo | 93.13 | 0.0 | 1376 |
| LLPS-Mam-2382 | Macaca mulatta | 91.86 | 0.0 | 1296 |
| LLPS-Dio-0156 | Dipodomys ordii | 91.84 | 0.0 | 902 |
| LLPS-Anc-0763 | Anolis carolinensis | 91.59 | 0.0 | 1367 |
| LLPS-Ora-1076 | Ornithorhynchus anatinus | 89.65 | 0.0 | 1223 |
| LLPS-Urm-1812 | Ursus maritimus | 88.78 | 0.0 | 1215 |
| LLPS-Sah-3529 | Sarcophilus harrisii | 88.49 | 0.0 | 1111 |
| LLPS-Bot-3852 | Bos taurus | 88.03 | 0.0 | 1281 |
| LLPS-Gaga-2676 | Gallus gallus | 86.79 | 0.0 | 1239 |
| LLPS-Xet-0966 | Xenopus tropicalis | 84.66 | 0.0 | 1197 |
| LLPS-Lac-0833 | Latimeria chalumnae | 82.33 | 0.0 | 1166 |
| LLPS-Leo-0135 | Lepisosteus oculatus | 80.83 | 0.0 | 1139 |
| LLPS-Scm-3232 | Scophthalmus maximus | 77.42 | 0.0 | 1107 |
| LLPS-Asm-0390 | Astyanax mexicanus | 77.05 | 0.0 | 1102 |
| LLPS-Xim-0507 | Xiphophorus maculatus | 76.99 | 0.0 | 1096 |
| LLPS-Icp-0010 | Ictalurus punctatus | 76.91 | 0.0 | 1109 |
| LLPS-Orn-3032 | Oreochromis niloticus | 76.87 | 0.0 | 1096 |
| LLPS-Gaa-3216 | Gasterosteus aculeatus | 76.61 | 0.0 | 1125 |
| LLPS-Tar-2603 | Takifugu rubripes | 76.48 | 0.0 | 1088 |
| LLPS-Dar-4194 | Danio rerio | 76.17 | 0.0 | 1093 |
| LLPS-Orl-1064 | Oryzias latipes | 75.81 | 0.0 | 1083 |
| LLPS-Pof-2509 | Poecilia formosa | 75.77 | 0.0 | 1074 |
| LLPS-Scf-1080 | Scleropages formosus | 74.33 | 0.0 | 1037 |
| LLPS-Ten-1281 | Tetraodon nigroviridis | 74.06 | 0.0 | 1025 |
| LLPS-Cii-1991 | Ciona intestinalis | 71.03 | 4e-124 | 383 |
| LLPS-Cis-1858 | Ciona savignyi | 65.31 | 0.0 | 708 |
| LLPS-Drm-0579 | Drosophila melanogaster | 48.96 | 1e-166 | 507 |
| LLPS-Abg-1962 | Absidia glauca | 48.11 | 5e-52 | 193 |
| LLPS-Tum-0671 | Tuber melanosporum | 42.48 | 8e-113 | 358 |
| LLPS-Crn-1514 | Cryptococcus neoformans | 41.23 | 3e-121 | 385 |
| LLPS-Asfu-1158 | Aspergillus fumigatus | 40.11 | 2e-84 | 282 |
| LLPS-Map-0775 | Magnaporthe poae | 40.0 | 2e-102 | 340 |
| LLPS-Spr-0202 | Sporisorium reilianum | 39.52 | 2e-110 | 362 |
| LLPS-Gag-1067 | Gaeumannomyces graminis | 39.28 | 9e-103 | 336 |
| LLPS-Usm-0598 | Ustilago maydis | 39.24 | 9e-111 | 363 |
| LLPS-Cae-1572 | Caenorhabditis elegans | 38.87 | 7e-109 | 352 |
| LLPS-Mao-1360 | Magnaporthe oryzae | 38.36 | 2e-107 | 349 |
| LLPS-Asn-0168 | Aspergillus nidulans | 38.12 | 1e-108 | 345 |
| LLPS-Cog-1171 | Colletotrichum gloeosporioides | 38.07 | 2e-91 | 300 |
| LLPS-Cogr-1281 | Colletotrichum graminicola | 37.9 | 2e-102 | 330 |
| LLPS-Miv-1579 | Microbotryum violaceum | 37.8 | 8e-105 | 343 |
| LLPS-Nef-0170 | Neosartorya fischeri | 37.77 | 2e-106 | 343 |
| LLPS-Trr-1613 | Trichoderma reesei | 37.73 | 2e-100 | 330 |
| LLPS-Ved-0528 | Verticillium dahliae | 37.71 | 2e-76 | 265 |
| LLPS-Mel-0432 | Melampsora laricipopulina | 37.63 | 2e-99 | 322 |
| LLPS-Asf-1241 | Aspergillus flavus | 37.02 | 2e-107 | 347 |
| LLPS-Trv-1436 | Trichoderma virens | 36.99 | 1e-102 | 334 |
| LLPS-Php-1101 | Physcomitrella patens | 36.95 | 5e-98 | 335 |
| LLPS-Zyt-1295 | Zymoseptoria tritici | 36.95 | 3e-101 | 327 |
| LLPS-Ast-0954 | Aspergillus terreus | 36.81 | 1e-105 | 341 |
| LLPS-Blg-1214 | Blumeria graminis | 36.56 | 1e-100 | 330 |
| LLPS-Asc-1299 | Aspergillus clavatus | 36.46 | 6e-103 | 339 |
| LLPS-Lem-0915 | Leptosphaeria maculans | 36.27 | 2e-98 | 330 |
| LLPS-Asni-1498 | Aspergillus niger | 36.26 | 2e-107 | 347 |
| LLPS-Pytr-0684 | Pyrenophora triticirepentis | 36.16 | 5e-96 | 323 |
| LLPS-Beb-1117 | Beauveria bassiana | 35.96 | 7e-99 | 325 |
| LLPS-Pyt-0223 | Pyrenophora teres | 35.96 | 9e-96 | 323 |
| LLPS-Dos-1239 | Dothistroma septosporum | 35.77 | 4e-96 | 319 |
| LLPS-Pug-1091 | Puccinia graminis | 35.47 | 1e-91 | 308 |
| LLPS-Coo-0984 | Colletotrichum orbiculare | 35.01 | 1e-96 | 319 |
| LLPS-Chr-1734 | Chlamydomonas reinhardtii | 34.88 | 2e-69 | 247 |
| LLPS-Aso-0840 | Aspergillus oryzae | 34.77 | 3e-109 | 351 |
| LLPS-Nec-1047 | Neurospora crassa | 34.18 | 4e-78 | 270 |
| LLPS-Fuv-1558 | Fusarium verticillioides | 34.03 | 4e-85 | 290 |
| LLPS-Yal-1561 | Yarrowia lipolytica | 33.85 | 6e-86 | 291 |
| LLPS-Fus-0824 | Fusarium solani | 33.28 | 2e-89 | 299 |
| LLPS-Put-0603 | Puccinia triticina | 32.49 | 3e-57 | 211 |
| LLPS-Kop-1436 | Komagataella pastoris | 32.36 | 3e-87 | 294 |
| LLPS-Fuo-1066 | Fusarium oxysporum | 31.16 | 6e-39 | 153 |
| LLPS-Phn-0674 | Phaeosphaeria nodorum | 31.11 | 1e-71 | 247 |
| LLPS-Asg-0691 | Ashbya gossypii | 30.79 | 4e-63 | 228 |
| LLPS-Cym-1083 | Cyanidioschyzon merolae | 29.04 | 3e-35 | 145 |
| LLPS-Scp-0950 | Schizosaccharomyces pombe | 29.02 | 6e-48 | 184 |
| LLPS-Gas-0639 | Galdieria sulphuraria | 28.9 | 1e-40 | 161 |
| LLPS-Scc-0847 | Schizosaccharomyces cryophilus | 28.21 | 1e-52 | 199 |
| LLPS-Sac-1012 | Saccharomyces cerevisiae | 26.62 | 6e-49 | 187 |
| LLPS-Scj-1598 | Schizosaccharomyces japonicus | 26.52 | 5e-55 | 204 |
| LLPS-Otg-3133 | Otolemur garnettii | 24.28 | 2e-09 | 63.5 |
| LLPS-Tut-0778 | Tursiops truncatus | 24.28 | 3e-09 | 63.2 |
| LLPS-Mup-1192 | Mustela putorius furo | 24.28 | 3e-09 | 63.2 |