• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sob-2163
TOP6A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA topoisomerase 6 subunit A
Gene Name: TOP6A, SORBI_3001G410800
Ensembl Gene: SORBI_3001G410800
Ensembl Protein: EER95053
Organism: Sorghum bicolor
Taxa ID: 4558
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEER95053EER95053
UniProtC5WNM1, C5WNM1_SORBI
GeneBankCM000760EER95053.1
RefSeqXM_002468010.1XP_002468055.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSEKKRRAGA  SAVGAASSSK  KPRASAAASY  AESLRSKLRP  DASILATLRS  LASASASKSK  60
61    ATSKSLADLD  LSADPASSYI  VVADQDSASV  TSRINRLVLA  AARSILSGRG  FSFAVPSRAA  120
121   SNQVYLPDLD  RIVLVRRESA  RPFANVATAR  KATITARVLS  LVHAVLGRGI  HVTKRDLFYT  180
181   DVKLFGDQSQ  SDAVLDDVSC  MLGCTRSSLH  VVASEKGVVV  GRLVFADDGD  RIDCTRMGVG  240
241   GKAIPPNVDR  VSGIESDALF  ILLVEKDAAF  MRLAEDRFYN  RFPCIILTAK  GQPDVATRLF  300
301   LRRLKVELKL  PVLALVDSDP  YGLKILSVYM  CGSKNMSYDS  ANLTTPDIKW  LGVRPSDLDK  360
361   YRVPEQCRLP  MTDHDIKVGK  ELLEEDFVKQ  NEGWVKELEM  MLRTKQKAEI  QALSSFGFQY  420
421   LTEVYLPLKL  QEQDWI  436
Nucleotide CDS Sequence (FASTA)
1     ATGTCGGAGA  AAAAGCGCCG  CGCCGGGGCG  AGCGCGGTCG  GCGCCGCATC  CAGCTCCAAG  60
61    AAGCCGCGCG  CTTCCGCGGC  CGCGTCCTAC  GCCGAGTCCC  TCCGCTCGAA  GCTCCGCCCC  120
121   GACGCCTCCA  TCCTCGCCAC  CCTCCGCTCC  CTCGCCTCTG  CCTCGGCTTC  CAAATCCAAG  180
181   GCCACCTCCA  AGTCCCTCGC  GGACCTCGAC  CTGTCCGCGG  ACCCCGCCTC  CTCGTACATC  240
241   GTGGTGGCCG  ACCAGGACTC  CGCCTCCGTC  ACCTCCCGCA  TCAACCGCCT  CGTCCTCGCA  300
301   GCCGCGCGCA  GCATCCTCTC  CGGCCGGGGT  TTCTCCTTCG  CGGTGCCCTC  GCGCGCCGCC  360
361   TCCAACCAGG  TCTACCTCCC  GGACCTCGAC  CGCATCGTGC  TCGTCCGCCG  CGAGTCCGCG  420
421   CGCCCCTTCG  CCAACGTCGC  CACCGCGCGC  AAGGCCACCA  TCACGGCGCG  CGTCCTCTCC  480
481   CTCGTCCACG  CCGTCCTCGG  CAGGGGCATC  CACGTCACCA  AGCGTGACCT  CTTCTACACC  540
541   GACGTCAAGC  TCTTCGGCGA  CCAGTCCCAG  TCTGACGCCG  TCCTCGACGA  CGTCTCCTGC  600
601   ATGCTCGGAT  GCACCCGGTC  GTCGCTCCAC  GTCGTCGCCT  CCGAGAAGGG  CGTCGTCGTG  660
661   GGCCGCCTCG  TCTTCGCCGA  CGATGGGGAC  CGGATCGACT  GCACGCGCAT  GGGCGTCGGC  720
721   GGGAAGGCCA  TACCGCCCAA  CGTCGACAGG  GTCTCGGGCA  TCGAGAGCGA  CGCGCTCTTC  780
781   ATCCTCCTGG  TGGAGAAGGA  CGCTGCATTC  ATGCGACTTG  CCGAGGACAG  GTTCTACAAC  840
841   CGCTTCCCCT  GCATCATTCT  GACGGCCAAG  GGGCAGCCAG  ATGTCGCCAC  CCGGCTGTTC  900
901   CTGCGGCGGC  TCAAGGTGGA  GCTGAAGCTG  CCAGTGCTCG  CGCTGGTGGA  CTCCGATCCA  960
961   TACGGGCTCA  AGATCTTGTC  AGTGTACATG  TGTGGTTCGA  AGAACATGTC  GTATGACAGC  1020
1021  GCCAATCTCA  CGACGCCGGA  CATCAAGTGG  CTCGGTGTCC  GGCCGAGCGA  CCTGGACAAG  1080
1081  TACAGGGTGC  CGGAGCAGTG  CCGTCTCCCC  ATGACCGATC  ACGATATCAA  GGTGGGGAAA  1140
1141  GAGCTGCTCG  AGGAAGACTT  TGTGAAGCAG  AATGAGGGCT  GGGTGAAGGA  GTTGGAGATG  1200
1201  ATGCTGCGCA  CCAAGCAAAA  GGCTGAGATA  CAGGCCCTCA  GTTCCTTCGG  GTTCCAGTAC  1260
1261  CTCACCGAGG  TCTACCTGCC  TCTCAAGTTG  CAGGAGCAGG  ATTGGATTTG  A  1311

▼ KEYWORD

ID
Family
Complete proteome
DNA-binding
Isomerase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
DNA topoisomerase complex (ATP-hydrolyzing)
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
DNA binding
Molecular Function
DNA topoisomerase type II (ATP-hydrolyzing) activity
Molecular Function
Magnesium ion binding
Biological Process
DNA catabolic process, endonucleolytic
Biological Process
DNA topological change

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orgl-0716Oryza glumaepatula97.80.0 732
LLPS-Orni-0620Oryza nivara97.80.0 730
LLPS-Ori-2371Oryza indica97.80.0 731
LLPS-Orb-0726Oryza barthii97.80.0 732
LLPS-Org-1441Oryza glaberrima97.80.0 732
LLPS-Orr-2358Oryza rufipogon97.80.0 732
LLPS-Ors-0521Oryza sativa97.80.0 732
LLPS-Orp-1393Oryza punctata97.80.0 731
LLPS-Zem-1754Zea mays97.750.0 739
LLPS-Orbr-2179Oryza brachyantha97.520.0 730
LLPS-Sei-1780Setaria italica96.480.0 727
LLPS-Lep-2117Leersia perrieri96.40.0 721
LLPS-Brd-2328Brachypodium distachyon93.890.0 707
LLPS-Tra-0974Triticum aestivum93.730.0 712
LLPS-Tru-0238Triticum urartu93.730.0 711
LLPS-Hov-1401Hordeum vulgare93.190.0 710
LLPS-Glm-2940Glycine max78.310.0 597
LLPS-Mae-1282Manihot esculenta78.030.0 600
LLPS-Pot-2659Populus trichocarpa77.750.0 602
LLPS-Vir-1155Vigna radiata77.460.0 593
LLPS-Via-2156Vigna angularis77.460.0 588
LLPS-Sol-2257Solanum lycopersicum77.460.0 589
LLPS-Prp-2098Prunus persica77.460.0 590
LLPS-Phv-2023Phaseolus vulgaris77.460.0 595
LLPS-Met-0689Medicago truncatula77.180.0 593
LLPS-Sot-1372Solanum tuberosum77.180.0 587
LLPS-Dac-2242Daucus carota76.620.0 572
LLPS-Amt-2162Amborella trichopoda76.620.0 590
LLPS-Viv-2449Vitis vinifera76.450.0 596
LLPS-Nia-2522Nicotiana attenuata76.340.0 585
LLPS-Gor-1544Gossypium raimondii76.340.0 591
LLPS-Thc-2327Theobroma cacao76.060.0 587
LLPS-Arl-2192Arabidopsis lyrata75.880.0 599
LLPS-Art-0483Arabidopsis thaliana75.880.0 599
LLPS-Coc-1066Corchorus capsularis75.620.0 590
LLPS-Brn-0024Brassica napus75.610.0 597
LLPS-Bro-1810Brassica oleracea75.610.0 597
LLPS-Brr-2603Brassica rapa75.610.0 597
LLPS-Cus-1929Cucumis sativus75.070.0 587
LLPS-Chr-1557Chlamydomonas reinhardtii74.930.0 555
LLPS-Php-0652Physcomitrella patens73.960.0 585
LLPS-Hea-1990Helianthus annuus73.00.0 595
LLPS-Sem-0908Selaginella moellendorffii72.960.0 566
LLPS-Osl-0217Ostreococcus lucimarinus71.390.0 523
LLPS-Chc-0469Chondrus crispus68.730.0 525
LLPS-Cym-0515Cyanidioschyzon merolae67.210.0 522
LLPS-Nol-0697Nomascus leucogenys42.975e-72 238
LLPS-Asm-3409Astyanax mexicanus42.613e-72 238
LLPS-Tar-0609Takifugu rubripes42.422e-69 232
LLPS-Xet-1022Xenopus tropicalis41.672e-63 211
LLPS-Cis-2025Ciona savignyi41.532e-59 204
LLPS-Pof-1421Poecilia formosa41.132e-74 244
LLPS-Icp-0463Ictalurus punctatus40.971e-72 240
LLPS-Sah-3263Sarcophilus harrisii40.557e-81 258
LLPS-Tag-1353Taeniopygia guttata40.558e-77 249
LLPS-Fia-1337Ficedula albicollis40.213e-75 246
LLPS-Mod-0421Monodelphis domestica40.212e-78 255
LLPS-Lac-1897Latimeria chalumnae40.142e-71 237
LLPS-Anp-3361Anas platyrhynchos39.561e-53 187
LLPS-Sus-4778Sus scrofa39.521e-74 244
LLPS-Gaa-3654Gasterosteus aculeatus37.545e-72 238
LLPS-Leo-2504Lepisosteus oculatus37.432e-76 249
LLPS-Cii-0866Ciona intestinalis37.321e-75 247
LLPS-Cap-3624Cavia porcellus37.292e-80 260
LLPS-Scp-1479Schizosaccharomyces pombe37.121e-31 128
LLPS-Scf-1780Scleropages formosus37.064e-61 209
LLPS-Mum-3319Mus musculus37.014e-81 262
LLPS-Scm-2899Scophthalmus maximus36.974e-73 241
LLPS-Fec-2622Felis catus36.833e-78 255
LLPS-Orl-1727Oryzias latipes36.723e-73 242
LLPS-Cas-0632Carlito syrichta36.725e-80 259
LLPS-Put-1228Puccinia triticina36.76e-29 120
LLPS-Dar-3789Danio rerio36.492e-71 237
LLPS-Ten-1035Tetraodon nigroviridis36.448e-75 245
LLPS-Gog-3341Gorilla gorilla36.161e-79 258
LLPS-Caj-3237Callithrix jacchus36.163e-79 258
LLPS-Mea-4127Mesocricetus auratus36.162e-78 255
LLPS-Pat-2188Pan troglodytes36.168e-80 259
LLPS-Pap-4332Pan paniscus36.168e-80 259
LLPS-Hos-3338Homo sapiens36.166e-80 259
LLPS-Orn-3009Oreochromis niloticus36.034e-77 252
LLPS-Gag-1629Gaeumannomyces graminis36.028e-28 118
LLPS-Mal-1615Mandrillus leucophaeus35.883e-79 257
LLPS-Paa-3019Papio anubis35.881e-79 258
LLPS-Maf-1315Macaca fascicularis35.883e-79 257
LLPS-Cea-3162Cercocebus atys35.883e-79 257
LLPS-Otg-4552Otolemur garnettii35.882e-77 253
LLPS-Man-1991Macaca nemestrina35.883e-79 257
LLPS-Chs-2724Chlorocebus sabaeus35.772e-77 253
LLPS-Ova-3611Ovis aries35.597e-79 256
LLPS-Dio-2760Dipodomys ordii35.593e-79 258
LLPS-Fud-0266Fukomys damarensis35.593e-79 257
LLPS-Meg-2335Meleagris gallopavo35.593e-74 243
LLPS-Pug-0589Puccinia graminis35.583e-32 131
LLPS-Aon-3855Aotus nancymaae35.344e-79 257
LLPS-Gaga-3068Gallus gallus35.311e-72 239
LLPS-Ict-4161Ictidomys tridecemlineatus35.311e-77 253
LLPS-Orc-3402Oryctolagus cuniculus35.297e-75 246
LLPS-Urm-2466Ursus maritimus35.252e-80 260
LLPS-Caf-0043Canis familiaris35.135e-80 259
LLPS-Rhb-1360Rhinopithecus bieti35.074e-76 249
LLPS-Bot-0729Bos taurus34.882e-78 255
LLPS-Mup-2852Mustela putorius furo34.876e-79 256
LLPS-Ora-2213Ornithorhynchus anatinus34.841e-76 251
LLPS-Xim-1400Xiphophorus maculatus34.811e-69 232
LLPS-Loa-3148Loxodonta africana34.641e-73 243
LLPS-Coo-0749Colletotrichum orbiculare34.252e-1168.9
LLPS-Eqc-4517Equus caballus34.186e-72 238
LLPS-Aim-3951Ailuropoda melanoleuca34.164e-76 249
LLPS-Scc-0541Schizosaccharomyces cryophilus34.164e-37 144
LLPS-Crn-0768Cryptococcus neoformans33.573e-26 115
LLPS-Myl-4140Myotis lucifugus33.338e-76 248
LLPS-Nec-1161Neurospora crassa33.181e-29 123
LLPS-Ran-2001Rattus norvegicus33.028e-64 216
LLPS-Abg-1638Absidia glauca32.812e-34 137
LLPS-Fuo-0457Fusarium oxysporum32.581e-32 132
LLPS-Poa-3248Pongo abelii32.013e-58 202
LLPS-Beb-0904Beauveria bassiana31.934e-32 129
LLPS-Fuv-0260Fusarium verticillioides31.748e-32 130
LLPS-Fus-1383Fusarium solani31.642e-23 104
LLPS-Scj-1552Schizosaccharomyces japonicus31.375e-26 112
LLPS-Kop-0718Komagataella pastoris31.192e-1581.6
LLPS-Drm-1738Drosophila melanogaster30.371e-34 137
LLPS-Gas-1038Galdieria sulphuraria29.432e-34 136
LLPS-Asg-0802Ashbya gossypii29.351e-1582.0
LLPS-Spr-1401Sporisorium reilianum28.81e-1375.9
LLPS-Ved-1375Verticillium dahliae28.573e-33 134
LLPS-Cog-0750Colletotrichum gloeosporioides27.553e-1683.6