DrLLPS - Data resource of LLPS

LLPS-Scp-1479
rec12

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Meiotic recombination protein rec12; SPO11 protein homolog
Gene Name:	rec12, SPAC17A5.11
Ensembl Gene:	SPAC17A5.11
Ensembl Protein:	SPAC17A5.11.1
Organism:	Schizosaccharomyces pombe
Taxa ID:	284812
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Arabidopsis thaliana	LLPS-Art-0483	Q9LZ03	Client	Nucleolus	34.81	2e-34	136

▼ FUNCTION

Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination (PubMed:10882124). Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II (PubMed:12437782, PubMed:16303567).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	SPAC17A5.11.1	SPAC17A5.11.1
UniProt		P40384, SPO11_SCHPO
GeneBank	AF195027, CU329670, L14774	CAB11511.1, AAF06017.1, AAA35332.1
RefSeq	NM_001018912.1	NP_593479.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MNSNDKKKVV RSWIEQFVHD FVEQLSKPTK DSVNVALKRR KHNSWNGSLD SKANERQKVK 60 61 VFSFPRNETT IAQLFRVLDC VHEAVISDTV ITKRDIYYRD VDLFKRQTVV DELLGDISNT 120 121 IGCSRSDLNV EASAKGLVFG SIHIALENGT VITATKPLLI SHHRISSITS TAKWVLVIEK 180 181 EAVFQTLTEE ALADTIIVTA KGFPDLMTRK FLVKLAKALP DAKFFGIFDW DPHGLCIYSC 240 241 FKYGSNAYSH EPHSQLRNLQ LLGPLYEDIF NKNQEFSLKL NKRDIKMITT LLQFEGFQKE 300 301 PVVREQLQRM LFIQKKAEIQ AILEFPSWIK GKLADADKSG KHSVR 345
Nucleotide CDS Sequence (FASTA)
1 ATGAATTCGA ATGATAAAAA AAAAGTTGTT AGATCATGGA TTGAGCAATT TGTTCATGAT 60 61 TTTGTTGAGC AATTAAGTAA GCCTACCAAA GATTCAGTAA ATGTTGCTTT GAAAAGACGA 120 121 AAGCACAATT CTTGGAATGG CAGCTTAGAT TCAAAGGCCA ATGAAAGACA AAAAGTTAAG 180 181 GTTTTTTCAT TCCCCAGGAA TGAAACAACA ATTGCTCAAC TATTCAGGGT TTTAGATTGT 240 241 GTTCATGAAG CTGTTATTTC GGATACAGTA ATCACTAAGC GAGATATTTA TTACAGAGAT 300 301 GTAGATTTAT TCAAGCGACA AACCGTAGTC GATGAGCTGC TTGGAGATAT TTCAAACACC 360 361 ATTGGTTGCT CCAGGTCCGA CCTTAACGTT GAAGCATCTG CTAAAGGATT GGTATTTGGG 420 421 TCCATTCATA TTGCTCTTGA AAACGGGACA GTAATTACTG CTACTAAACC ATTATTAATC 480 481 TCTCACCATC GAATTTCATC AATCACTTCC ACAGCAAAAT GGGTCTTGGT CATCGAAAAG 540 541 GAAGCGGTAT TCCAAACGCT AACCGAAGAG GCTTTAGCGG ATACAATAAT TGTTACAGCT 600 601 AAAGGATTTC CAGATTTGAT GACGAGAAAA TTTTTAGTTA AATTAGCCAA AGCCCTCCCG 660 661 GATGCTAAAT TTTTTGGTAT TTTTGATTGG GACCCCCATG GCTTATGCAT TTATTCCTGT 720 721 TTCAAGTACG GTTCTAATGC CTACAGTCAT GAACCGCACA GTCAATTACG AAATTTACAG 780 781 CTTTTAGGCC CTCTGTATGA GGACATTTTT AATAAAAACC AAGAATTCTC TTTAAAATTG 840 841 AATAAAAGGG ATATTAAAAT GATTACAACA TTATTACAAT TTGAAGGCTT CCAAAAGGAG 900 901 CCCGTTGTTC GTGAACAGCT ACAGCGAATG CTGTTTATCC AGAAAAAAGC GGAAATACAA 960 961 GCAATTCTAG AATTTCCTTC ATGGATCAAA GGAAAATTAG CTGATGCCGA CAAAAGTGGA 1020 1021 AAGCACTCAG TACGTTAA 1038

▼ KEYWORD

ID	Family
KW-0159	Chromosome partition
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0460	Magnesium
KW-0469	Meiosis
KW-0479	Metal-binding
KW-0539	Nucleus
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0000228	Cellular Component	Nuclear chromosome
GO:0005634	Cellular Component	Nucleus
GO:0035861	Cellular Component	Site of double-strand break
GO:0005524	Molecular Function	ATP binding
GO:0003677	Molecular Function	DNA binding
GO:0045027	Molecular Function	DNA end binding
GO:0016889	Molecular Function	Endodeoxyribonuclease activity, producing 3'-phosphomonoesters
GO:0046872	Molecular Function	Metal ion binding
GO:0000737	Biological Process	DNA catabolic process, endonucleolytic
GO:0031619	Biological Process	Homologous chromosome orientation involved in meiotic metaphase I plate congression
GO:0042138	Biological Process	Meiotic DNA double-strand break formation
GO:0000706	Biological Process	Meiotic DNA double-strand break processing
GO:0007131	Biological Process	Reciprocal meiotic recombination

▼ KEGG

spo:SPAC17A5.11

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Scc-0541	Schizosaccharomyces cryophilus	52.91	3e-113	340
LLPS-Scj-1552	Schizosaccharomyces japonicus	40.49	2e-68	224
LLPS-Zem-1754	Zea mays	37.5	7e-29	119
LLPS-Orbr-2179	Oryza brachyantha	37.12	2e-28	118
LLPS-Sob-2163	Sorghum bicolor	37.12	2e-28	118
LLPS-Ors-0521	Oryza sativa	37.12	2e-28	118
LLPS-Orp-1393	Oryza punctata	37.12	3e-28	118
LLPS-Org-1441	Oryza glaberrima	37.12	2e-28	118
LLPS-Tru-0238	Triticum urartu	37.12	2e-29	121
LLPS-Orr-2358	Oryza rufipogon	37.12	2e-28	118
LLPS-Orni-0620	Oryza nivara	37.12	3e-27	117
LLPS-Orb-0726	Oryza barthii	37.12	2e-28	118
LLPS-Ori-2371	Oryza indica	37.12	3e-27	117
LLPS-Sei-1780	Setaria italica	37.12	2e-28	118
LLPS-Hov-1401	Hordeum vulgare	37.12	2e-29	122
LLPS-Tra-0974	Triticum aestivum	37.12	3e-29	120
LLPS-Orgl-0716	Oryza glumaepatula	37.12	2e-28	118
LLPS-Lep-2117	Leersia perrieri	37.12	2e-28	119
LLPS-Cym-0515	Cyanidioschyzon merolae	36.67	2e-34	135
LLPS-Kop-0718	Komagataella pastoris	36.52	7e-24	104
LLPS-Brd-2328	Brachypodium distachyon	36.36	7e-28	117
LLPS-Chr-1557	Chlamydomonas reinhardtii	36.26	3e-32	129
LLPS-Sol-2257	Solanum lycopersicum	36.12	6e-35	137
LLPS-Sot-1372	Solanum tuberosum	36.12	5e-35	137
LLPS-Thc-2327	Theobroma cacao	35.93	7e-33	131
LLPS-Cus-1929	Cucumis sativus	35.88	2e-32	130
LLPS-Prp-2098	Prunus persica	35.61	1e-31	128
LLPS-Viv-2449	Vitis vinifera	35.5	2e-32	130
LLPS-Beb-0904	Beauveria bassiana	35.29	1e-44	161
LLPS-Pot-2659	Populus trichocarpa	35.11	3e-32	129
LLPS-Sem-0908	Selaginella moellendorffii	35.11	4e-32	129
LLPS-Fus-1383	Fusarium solani	35.0	7e-32	128
LLPS-Amt-2162	Amborella trichopoda	34.95	6e-33	131
LLPS-Glm-2940	Glycine max	34.85	6e-31	125
LLPS-Nia-2522	Nicotiana attenuata	34.81	1e-32	130
LLPS-Art-0483	Arabidopsis thaliana	34.81	7e-32	128
LLPS-Brr-2603	Brassica rapa	34.81	1e-31	128
LLPS-Bro-1810	Brassica oleracea	34.81	2e-31	127
LLPS-Hea-1990	Helianthus annuus	34.81	6e-32	129
LLPS-Brn-0024	Brassica napus	34.81	1e-31	128
LLPS-Arl-2192	Arabidopsis lyrata	34.81	7e-32	128
LLPS-Ten-1035	Tetraodon nigroviridis	34.72	9e-33	130
LLPS-Dac-2242	Daucus carota	34.6	1e-31	127
LLPS-Scm-2899	Scophthalmus maximus	34.44	2e-33	132
LLPS-Fec-2622	Felis catus	34.41	6e-35	137
LLPS-Chc-0469	Chondrus crispus	34.4	7e-32	128
LLPS-Met-0689	Medicago truncatula	34.35	2e-31	127
LLPS-Vir-1155	Vigna radiata	34.35	5e-31	126
LLPS-Via-2156	Vigna angularis	34.35	4e-30	126
LLPS-Phv-2023	Phaseolus vulgaris	33.97	1e-30	125
LLPS-Sah-3263	Sarcophilus harrisii	33.96	7e-35	135
LLPS-Lac-1897	Latimeria chalumnae	33.94	3e-30	124
LLPS-Caf-0043	Canis familiaris	33.84	6e-33	131
LLPS-Mup-2852	Mustela putorius furo	33.84	2e-32	130
LLPS-Fud-0266	Fukomys damarensis	33.82	4e-35	137
LLPS-Anp-3361	Anas platyrhynchos	33.78	4e-27	113
LLPS-Nol-0697	Nomascus leucogenys	33.75	1e-28	119
LLPS-Pap-4332	Pan paniscus	33.7	8e-35	136
LLPS-Urm-2466	Ursus maritimus	33.7	3e-34	135
LLPS-Pat-2188	Pan troglodytes	33.7	8e-35	136
LLPS-Gog-3341	Gorilla gorilla	33.7	5e-35	137
LLPS-Caj-3237	Callithrix jacchus	33.7	2e-34	135
LLPS-Gag-1629	Gaeumannomyces graminis	33.66	3e-28	117
LLPS-Mod-0421	Monodelphis domestica	33.58	1e-33	133
LLPS-Leo-2504	Lepisosteus oculatus	33.46	2e-33	132
LLPS-Hos-3338	Homo sapiens	33.33	2e-34	135
LLPS-Man-1991	Macaca nemestrina	33.33	4e-34	134
LLPS-Maf-1315	Macaca fascicularis	33.33	4e-34	134
LLPS-Cea-3162	Cercocebus atys	33.33	4e-34	134
LLPS-Paa-3019	Papio anubis	33.33	9e-35	136
LLPS-Mal-1615	Mandrillus leucophaeus	33.33	4e-34	134
LLPS-Eqc-4517	Equus caballus	33.21	2e-34	135
LLPS-Chs-2724	Chlorocebus sabaeus	33.21	2e-32	130
LLPS-Ved-1375	Verticillium dahliae	33.12	4e-39	149
LLPS-Otg-4552	Otolemur garnettii	33.09	2e-33	132
LLPS-Put-1228	Puccinia triticina	32.99	3e-29	120
LLPS-Cap-3624	Cavia porcellus	32.96	2e-32	129
LLPS-Aon-3855	Aotus nancymaae	32.96	3e-34	135
LLPS-Osl-0217	Ostreococcus lucimarinus	32.95	4e-28	117
LLPS-Php-0652	Physcomitrella patens	32.87	4e-31	126
LLPS-Myl-4140	Myotis lucifugus	32.82	4e-32	129
LLPS-Aim-3951	Ailuropoda melanoleuca	32.74	3e-31	126
LLPS-Sus-4778	Sus scrofa	32.71	2e-33	132
LLPS-Ict-4161	Ictidomys tridecemlineatus	32.64	2e-33	132
LLPS-Orn-3009	Oreochromis niloticus	32.62	1e-34	136
LLPS-Cas-0632	Carlito syrichta	32.59	1e-33	133
LLPS-Dio-2760	Dipodomys ordii	32.59	2e-33	132
LLPS-Meg-2335	Meleagris gallopavo	32.36	6e-33	130
LLPS-Gor-1544	Gossypium raimondii	32.33	6e-32	129
LLPS-Gaa-3654	Gasterosteus aculeatus	32.32	7e-31	125
LLPS-Crn-0768	Cryptococcus neoformans	32.28	3e-38	148
LLPS-Mae-1282	Manihot esculenta	32.23	1e-31	127
LLPS-Coo-0749	Colletotrichum orbiculare	32.17	1e-12	72.0
LLPS-Rhb-1360	Rhinopithecus bieti	32.03	3e-31	126
LLPS-Asm-3409	Astyanax mexicanus	31.97	7e-27	113
LLPS-Ran-2001	Rattus norvegicus	31.95	9e-27	113
LLPS-Ora-2213	Ornithorhynchus anatinus	31.94	2e-31	127
LLPS-Ova-3611	Ovis aries	31.91	7e-35	136
LLPS-Pof-1421	Poecilia formosa	31.85	4e-31	126
LLPS-Dar-3789	Danio rerio	31.85	6e-31	125
LLPS-Orl-1727	Oryzias latipes	31.83	6e-32	128
LLPS-Loa-3148	Loxodonta africana	31.82	1e-34	136
LLPS-Coc-1066	Corchorus capsularis	31.72	2e-31	127
LLPS-Gaga-3068	Gallus gallus	31.64	1e-31	127
LLPS-Mea-4127	Mesocricetus auratus	31.63	2e-33	133
LLPS-Abg-1638	Absidia glauca	31.56	2e-28	118
LLPS-Icp-0463	Ictalurus punctatus	31.42	1e-30	124
LLPS-Fuo-0457	Fusarium oxysporum	31.39	4e-36	140
LLPS-Cis-2025	Ciona savignyi	31.35	4e-28	116
LLPS-Bot-0729	Bos taurus	31.31	4e-34	134
LLPS-Fia-1337	Ficedula albicollis	31.27	3e-31	126
LLPS-Cii-0866	Ciona intestinalis	31.16	2e-33	132
LLPS-Tag-1353	Taeniopygia guttata	30.91	1e-31	127
LLPS-Tar-0609	Takifugu rubripes	30.9	3e-29	120
LLPS-Orc-3402	Oryctolagus cuniculus	30.63	8e-33	130
LLPS-Xet-1022	Xenopus tropicalis	30.38	6e-25	106
LLPS-Nec-1161	Neurospora crassa	30.3	1e-41	156
LLPS-Xim-1400	Xiphophorus maculatus	30.08	3e-24	105
LLPS-Fuv-0260	Fusarium verticillioides	29.87	2e-35	138
LLPS-Mum-3319	Mus musculus	29.73	2e-32	129
LLPS-Asg-0802	Ashbya gossypii	29.6	3e-17	85.5
LLPS-Poa-3248	Pongo abelii	29.1	1e-21	97.8
LLPS-Drm-1738	Drosophila melanogaster	28.52	4e-18	87.4
LLPS-Scf-1780	Scleropages formosus	27.84	6e-22	98.6
LLPS-Spr-1401	Sporisorium reilianum	27.24	5e-11	67.4
LLPS-Cog-0750	Colletotrichum gloeosporioides	26.65	1e-24	106
LLPS-Pug-0589	Puccinia graminis	26.55	2e-25	110

LLPS-Scp-1479rec12

Protein Sequence

Nucleotide Sequence

LLPS-Scp-1479
rec12