• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Phv-2023
TOP6A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA topoisomerase 6 subunit A
Gene Name: TOP6A, PHAVU_007G162700g
Ensembl Gene: PHAVU_007G162700g
Ensembl Protein: ESW16513
Organism: Phaseolus vulgaris
Taxa ID: 3885
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblESW16513ESW16513
UniProtV7BI00, V7BI00_PHAVU
GeneBankCM002294ESW16513.1
RefSeqXM_007144457.1XP_007144519.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADNNKRRRK  DPIGDELPFK  NKLKSDALIL  ETLKNFSTAS  SSSSVSQTLT  LQDLTLPFRC  60
61    REVADLSLSS  VQSNIESLIL  KIAHSIISGQ  GFSFDVPSRS  ATNQLYVAEL  DRIVLKEKSS  120
121   QRPFANISTV  RKSAITARII  QLIHQLCLKG  IHVTKRDLFY  TDVKLFQDQI  QSDAVLDDVS  180
181   CMLGCTRSSL  NVVAAEKGVV  VGRLIFSDNG  DMIDCTKMGM  GGKAIPPNID  RVGDMQSDAL  240
241   FILLVEKDAA  YMRLAEDRFY  NRFPCIIVTA  KGQPDVATRL  FLRKMKTELK  LPVLALVDSD  300
301   PYGLKILSVY  GCGSKNMSYD  SANLTTPDIK  WLGVRPSDLD  KYKIPEQCRL  PMTEQDIKTG  360
361   KDMLEEDFVK  KNPGWVEELT  LMVKTKQKAE  IQALSTFGFQ  YLSEVYLPLK  LQQKDWL  417
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGACA  ACAACAAACG  CCGGCGAAAG  GATCCAATCG  GCGACGAGCT  GCCCTTCAAG  60
61    AACAAGCTGA  AATCCGACGC  ATTGATTCTC  GAAACCCTAA  AAAACTTCTC  CACCGCATCC  120
121   TCGTCCTCCT  CAGTCTCCCA  AACCCTAACA  CTCCAGGACC  TGACACTCCC  GTTCCGGTGC  180
181   CGCGAGGTGG  CGGACCTGTC  CCTCTCCTCG  GTGCAGTCCA  ACATTGAGTC  CCTCATCCTG  240
241   AAGATCGCGC  ACTCCATCAT  CTCGGGCCAG  GGCTTCTCCT  TTGACGTGCC  GTCGCGCTCC  300
301   GCCACCAACC  AGCTCTACGT  GGCGGAGCTG  GACCGCATCG  TGCTGAAGGA  AAAGTCCTCC  360
361   CAACGCCCCT  TCGCCAACAT  ATCTACCGTG  CGCAAGTCCG  CCATCACCGC  CCGCATCATT  420
421   CAGCTCATTC  ACCAGCTCTG  CCTCAAAGGC  ATCCACGTCA  CCAAGCGTGA  CCTCTTCTAC  480
481   ACCGACGTCA  AACTCTTTCA  AGACCAGATC  CAATCCGATG  CTGTTCTGGA  TGATGTTTCG  540
541   TGCATGCTGG  GATGCACTAG  GTCCAGCCTC  AACGTTGTAG  CTGCAGAGAA  AGGGGTGGTG  600
601   GTTGGGAGGT  TGATTTTCAG  TGACAATGGG  GATATGATTG  ATTGCACTAA  AATGGGGATG  660
661   GGAGGGAAGG  CAATTCCACC  GAATATTGAT  CGAGTTGGGG  ATATGCAGAG  CGATGCTTTG  720
721   TTCATTCTGT  TGGTGGAGAA  GGATGCTGCT  TATATGAGGT  TGGCTGAGGA  TAGGTTCTAC  780
781   AACCGCTTTC  CTTGTATAAT  TGTAACTGCA  AAGGGCCAGC  CAGATGTTGC  CACTAGGCTG  840
841   TTCTTGAGGA  AGATGAAGAC  AGAGTTGAAG  CTTCCGGTGC  TGGCTCTGGT  TGACAGTGAT  900
901   CCTTACGGGT  TGAAGATTCT  GTCGGTTTAT  GGGTGTGGGT  CAAAGAACAT  GTCCTATGAC  960
961   AGTGCCAACT  TGACCACCCC  TGATATCAAG  TGGCTTGGGG  TTAGGCCTAG  TGATTTGGAC  1020
1021  AAGTACAAGA  TACCTGAGCA  ATGTAGGTTG  CCAATGACGG  AGCAGGATAT  TAAGACTGGG  1080
1081  AAGGACATGC  TGGAGGAGGA  TTTTGTCAAG  AAGAATCCAG  GTTGGGTTGA  GGAATTGACT  1140
1141  TTGATGGTCA  AAACTAAGCA  GAAGGCTGAA  ATACAGGCTT  TAAGTACCTT  CGGTTTTCAA  1200
1201  TATCTTTCAG  AAGTTTATTT  GCCCTTGAAG  TTGCAGCAGA  AGGACTGGCT  GTAA  1254

▼ KEYWORD

ID
Family
Complete proteome
DNA-binding
Isomerase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
DNA topoisomerase complex (ATP-hydrolyzing)
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
DNA binding
Molecular Function
DNA topoisomerase type II (ATP-hydrolyzing) activity
Molecular Function
Identical protein binding
Molecular Function
Magnesium ion binding
Biological Process
DNA catabolic process, endonucleolytic
Biological Process
DNA topological change

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Via-2156Vigna angularis96.640.0 783
LLPS-Vir-1155Vigna radiata96.410.0 780
LLPS-Glm-2940Glycine max92.840.0 772
LLPS-Met-0689Medicago truncatula90.170.0 756
LLPS-Viv-2449Vitis vinifera85.950.0 725
LLPS-Hea-1990Helianthus annuus85.540.0 689
LLPS-Cus-1929Cucumis sativus85.00.0 708
LLPS-Mae-1282Manihot esculenta84.930.0 711
LLPS-Coc-1066Corchorus capsularis84.890.0 706
LLPS-Pot-2659Populus trichocarpa84.630.0 711
LLPS-Gor-1544Gossypium raimondii83.050.0 700
LLPS-Thc-2327Theobroma cacao82.820.0 694
LLPS-Dac-2242Daucus carota82.350.0 673
LLPS-Arl-2192Arabidopsis lyrata81.60.0 695
LLPS-Art-0483Arabidopsis thaliana81.60.0 695
LLPS-Bro-1810Brassica oleracea81.550.0 691
LLPS-Prp-2098Prunus persica81.00.0 682
LLPS-Sot-1372Solanum tuberosum80.520.0 686
LLPS-Nia-2522Nicotiana attenuata80.520.0 687
LLPS-Sol-2257Solanum lycopersicum80.290.0 685
LLPS-Brn-0024Brassica napus80.090.0 696
LLPS-Brr-2603Brassica rapa79.950.0 694
LLPS-Brd-2328Brachypodium distachyon77.750.0 600
LLPS-Orgl-0716Oryza glumaepatula77.750.0 596
LLPS-Orni-0620Oryza nivara77.750.0 596
LLPS-Orb-0726Oryza barthii77.750.0 596
LLPS-Org-1441Oryza glaberrima77.750.0 596
LLPS-Orr-2358Oryza rufipogon77.750.0 596
LLPS-Ors-0521Oryza sativa77.750.0 596
LLPS-Orp-1393Oryza punctata77.750.0 596
LLPS-Tra-0974Triticum aestivum77.460.0 598
LLPS-Sei-1780Setaria italica77.460.0 594
LLPS-Lep-2117Leersia perrieri77.460.0 597
LLPS-Zem-1754Zea mays77.460.0 593
LLPS-Orbr-2179Oryza brachyantha77.460.0 595
LLPS-Sob-2163Sorghum bicolor77.460.0 595
LLPS-Tru-0238Triticum urartu77.180.0 596
LLPS-Hov-1401Hordeum vulgare76.90.0 596
LLPS-Php-0652Physcomitrella patens74.810.0 612
LLPS-Amt-2162Amborella trichopoda73.890.0 637
LLPS-Chr-1557Chlamydomonas reinhardtii72.30.0 563
LLPS-Sem-0908Selaginella moellendorffii72.210.0 606
LLPS-Ori-2371Oryza indica70.590.0 597
LLPS-Osl-0217Ostreococcus lucimarinus70.50.0 518
LLPS-Chc-0469Chondrus crispus69.190.0 538
LLPS-Cym-0515Cyanidioschyzon merolae68.540.0 533
LLPS-Sus-4778Sus scrofa39.863e-73 240
LLPS-Sah-3263Sarcophilus harrisii39.526e-77 248
LLPS-Tag-1353Taeniopygia guttata39.183e-73 240
LLPS-Mod-0421Monodelphis domestica39.186e-75 245
LLPS-Fia-1337Ficedula albicollis38.831e-71 236
LLPS-Xet-1022Xenopus tropicalis38.641e-59 201
LLPS-Lac-1897Latimeria chalumnae38.495e-70 233
LLPS-Cis-2025Ciona savignyi38.021e-61 209
LLPS-Mup-2852Mustela putorius furo37.758e-80 258
LLPS-Cap-3624Cavia porcellus37.759e-79 255
LLPS-Anp-3361Anas platyrhynchos37.393e-48 172
LLPS-Mum-3319Mus musculus37.182e-77 252
LLPS-Caf-0043Canis familiaris37.189e-79 255
LLPS-Fec-2622Felis catus37.187e-78 253
LLPS-Urm-2466Ursus maritimus36.833e-78 254
LLPS-Cas-0632Carlito syrichta36.755e-78 254
LLPS-Ten-1035Tetraodon nigroviridis36.722e-73 241
LLPS-Icp-0463Ictalurus punctatus36.649e-66 221
LLPS-Ova-3611Ovis aries36.622e-77 252
LLPS-Bot-0729Bos taurus36.622e-77 252
LLPS-Caj-3237Callithrix jacchus36.621e-78 255
LLPS-Fud-0266Fukomys damarensis36.621e-78 255
LLPS-Scm-2899Scophthalmus maximus36.575e-71 235
LLPS-Otg-4552Otolemur garnettii36.443e-78 254
LLPS-Aim-3951Ailuropoda melanoleuca36.346e-75 246
LLPS-Paa-3019Papio anubis36.341e-78 255
LLPS-Mal-1615Mandrillus leucophaeus36.349e-78 253
LLPS-Maf-1315Macaca fascicularis36.346e-78 253
LLPS-Cea-3162Cercocebus atys36.349e-78 253
LLPS-Aon-3855Aotus nancymaae36.344e-78 254
LLPS-Man-1991Macaca nemestrina36.346e-78 253
LLPS-Chs-2724Chlorocebus sabaeus36.243e-76 249
LLPS-Mea-4127Mesocricetus auratus36.211e-75 247
LLPS-Dio-2760Dipodomys ordii36.115e-77 251
LLPS-Gog-3341Gorilla gorilla36.061e-77 253
LLPS-Pat-2188Pan troglodytes36.068e-78 253
LLPS-Pap-4332Pan paniscus36.068e-78 253
LLPS-Hos-3338Homo sapiens35.774e-77 251
LLPS-Xim-1400Xiphophorus maculatus35.712e-68 228
LLPS-Meg-2335Meleagris gallopavo35.574e-71 234
LLPS-Rhb-1360Rhinopithecus bieti35.527e-75 246
LLPS-Pof-1421Poecilia formosa35.449e-75 245
LLPS-Asm-3409Astyanax mexicanus35.398e-71 234
LLPS-Cii-0866Ciona intestinalis35.285e-75 245
LLPS-Gaa-3654Gasterosteus aculeatus35.263e-69 230
LLPS-Dar-3789Danio rerio35.263e-71 235
LLPS-Ran-2001Rattus norvegicus35.131e-67 226
LLPS-Nol-0697Nomascus leucogenys35.113e-70 233
LLPS-Gag-1629Gaeumannomyces graminis35.072e-29 122
LLPS-Ict-4161Ictidomys tridecemlineatus34.937e-76 248
LLPS-Eqc-4517Equus caballus34.938e-71 234
LLPS-Orn-3009Oreochromis niloticus34.894e-74 243
LLPS-Leo-2504Lepisosteus oculatus34.737e-70 232
LLPS-Orl-1727Oryzias latipes34.728e-70 232
LLPS-Gaga-3068Gallus gallus34.289e-68 226
LLPS-Loa-3148Loxodonta africana34.271e-70 234
LLPS-Myl-4140Myotis lucifugus34.084e-74 243
LLPS-Orc-3402Oryctolagus cuniculus34.085e-73 240
LLPS-Abg-1638Absidia glauca34.022e-35 140
LLPS-Scp-1479Schizosaccharomyces pombe33.972e-33 133
LLPS-Fuv-0260Fusarium verticillioides33.573e-36 142
LLPS-Nec-1161Neurospora crassa33.338e-33 133
LLPS-Ora-2213Ornithorhynchus anatinus33.241e-70 234
LLPS-Scc-0541Schizosaccharomyces cryophilus33.224e-36 140
LLPS-Coo-0749Colletotrichum orbiculare33.112e-1168.9
LLPS-Tar-0609Takifugu rubripes32.748e-65 219
LLPS-Put-1228Puccinia triticina32.727e-27 114
LLPS-Fus-1383Fusarium solani32.53e-25 110
LLPS-Scf-1780Scleropages formosus32.222e-56 196
LLPS-Fuo-0457Fusarium oxysporum32.142e-37 145
LLPS-Beb-0904Beauveria bassiana31.937e-32 127
LLPS-Poa-3248Pongo abelii31.928e-56 194
LLPS-Pug-0589Puccinia graminis31.482e-29 123
LLPS-Crn-0768Cryptococcus neoformans31.082e-24 109
LLPS-Scj-1552Schizosaccharomyces japonicus30.68e-25 108
LLPS-Asg-0802Ashbya gossypii30.052e-1169.3
LLPS-Kop-0718Komagataella pastoris29.82e-1581.6
LLPS-Drm-1738Drosophila melanogaster28.822e-39 150
LLPS-Spr-1401Sporisorium reilianum28.742e-1477.8
LLPS-Gas-1038Galdieria sulphuraria28.085e-33 132
LLPS-Ved-1375Verticillium dahliae27.961e-32 132
LLPS-Cog-0750Colletotrichum gloeosporioides27.081e-1684.3