LLPS-Sac-0495
ADK1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Adenylate kinase; ATP-AMP transphosphorylase; ATP:AMP phosphotransferase; Adenylate kinase cytosolic and mitochondrial; Adenylate monophosphate kinase |
| Gene Name: | ADK1, AKY, AKY1, AKY2, YDR226W, YD9934.11 |
| Ensembl Gene: | YDR226W |
| Ensembl Protein: | YDR226W_mRNA |
| Organism: | Saccharomyces cerevisiae |
| Taxa ID: | 559292 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Droplet | "...We considered the green fluorescence protein and the enzyme adenylate kinase as model globular proteins. We conjugated these two proteins at both the N- and the C-termini with different LCDs, each with different compositions and physicochemical properties. Indicated as LCD1 and LCD2, these molecular adhesives are derived from the sequences of the DEAD-box proteins Dhh1 and Dpb1, respectively. In their native biological context, Dhh1 and Dpb1 have been shown to undergo liquid-liquid phase separation associated with the formation of processing bodies in yeast.In contrast, the fusion proteins containing the LCD1 and the LCD2 domains exhibited phase separation under varying conditions of pH and salt concentration." | In vitro | 30216718 |
| Nucleolus | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YDR226W_mRNA | YDR226W_mRNA |
| UniProt | P07170, KAD2_YEAST, D6VSK8, Q6Q539 | |
| GeneBank | BK006938, U13239, AY558578, X06304, Y00413, Z48612, M18455 | CAA68471.1, CAA29624.1, DAA12068.1, AAS56904.1, AAC33143.1, CAA88506.1, AAA66319.1 |
| RefSeq | NM_001180534.1 | NP_010512.1 |
| Entrez | 851812 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ LGLEAKKIMD 60 61 QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA EKLDQMLKEQ GTPLEKAIEL 120 121 KVDDELLVAR ITGRLIHPAS GRSYHKIFNP PKEDMKDDVT GEALVQRSDD NADALKKRLA 180 181 AYHAQTEPIV DFYKKTGIWA GVDASQPPAT VWADILNKLG KD 222 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTAGCT CAGAATCCAT TAGAATGGTC CTAATTGGCC CACCTGGTGC CGGTAAAGGT 60 61 ACTCAAGCTC CAAATTTGCA AGAGCGTTTC CATGCCGCTC ACTTGGCCAC TGGTGACATG 120 121 TTGAGATCTC AAATCGCAAA GGGCACTCAA TTAGGTTTGG AAGCAAAGAA AATTATGGAC 180 181 CAAGGTGGTT TAGTCTCTGA TGACATTATG GTTAACATGA TCAAGGATGA ATTGACCAAC 240 241 AATCCAGCTT GTAAGAATGG GTTCATCTTG GACGGTTTCC CAAGAACCAT TCCTCAGGCT 300 301 GAAAAATTGG ACCAAATGTT GAAAGAACAA GGAACTCCTT TGGAAAAAGC CATCGAATTG 360 361 AAGGTTGATG ATGAATTGTT GGTTGCCAGA ATTACCGGTA GATTAATTCA CCCAGCCTCT 420 421 GGCAGATCCT ACCACAAGAT CTTTAACCCA CCAAAGGAAG ACATGAAGGA TGACGTCACC 480 481 GGTGAAGCTT TAGTTCAAAG ATCTGATGAC AATGCAGACG CCTTGAAGAA GAGATTAGCT 540 541 GCTTACCATG CTCAAACCGA ACCAATTGTT GACTTTTACA AAAAGACCGG TATCTGGGCT 600 601 GGTGTTGATG CTTCCCAACC TCCTGCTACT GTTTGGGCTG ACATCTTGAA CAAGCTAGGT 660 661 AAGGATTAA 669 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Mitochondrial intermembrane space | |
Cellular Component | Mitochondrion | |
Molecular Function | Adenylate kinase activity | |
Molecular Function | ATP binding | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | ATP metabolic process | |
Biological Process | DNA replication initiation | |
Biological Process | Nucleotide metabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asg-1224 | Ashbya gossypii | 82.49 | 4e-132 | 380 |
| LLPS-Yal-1440 | Yarrowia lipolytica | 77.46 | 1e-121 | 351 |
| LLPS-Kop-0574 | Komagataella pastoris | 77.1 | 1e-122 | 355 |
| LLPS-Asn-0756 | Aspergillus nidulans | 73.49 | 3e-117 | 342 |
| LLPS-Aso-1040 | Aspergillus oryzae | 72.86 | 1e-115 | 336 |
| LLPS-Asni-0903 | Aspergillus niger | 72.56 | 9e-117 | 340 |
| LLPS-Coo-0474 | Colletotrichum orbiculare | 72.43 | 4e-117 | 342 |
| LLPS-Trv-0307 | Trichoderma virens | 72.35 | 3e-116 | 340 |
| LLPS-Trr-1570 | Trichoderma reesei | 72.35 | 2e-116 | 340 |
| LLPS-Asf-1041 | Aspergillus flavus | 72.09 | 9e-117 | 340 |
| LLPS-Beb-1240 | Beauveria bassiana | 71.89 | 4e-114 | 334 |
| LLPS-Asfu-1253 | Aspergillus fumigatus | 71.82 | 2e-117 | 342 |
| LLPS-Nef-0344 | Neosartorya fischeri | 71.82 | 6e-117 | 341 |
| LLPS-Cog-0477 | Colletotrichum gloeosporioides | 71.5 | 4e-115 | 337 |
| LLPS-Fuo-1051 | Fusarium oxysporum | 71.43 | 4e-116 | 339 |
| LLPS-Fus-0783 | Fusarium solani | 71.43 | 1e-116 | 340 |
| LLPS-Fuv-0733 | Fusarium verticillioides | 70.97 | 3e-115 | 337 |
| LLPS-Mao-0306 | Magnaporthe oryzae | 70.83 | 3e-114 | 335 |
| LLPS-Pyt-0219 | Pyrenophora teres | 70.7 | 6e-111 | 326 |
| LLPS-Cogr-0943 | Colletotrichum graminicola | 70.7 | 4e-115 | 337 |
| LLPS-Ast-0054 | Aspergillus terreus | 70.14 | 1e-116 | 340 |
| LLPS-Asc-1349 | Aspergillus clavatus | 70.0 | 1e-115 | 338 |
| LLPS-Dos-0898 | Dothistroma septosporum | 70.0 | 1e-109 | 323 |
| LLPS-Nec-0794 | Neurospora crassa | 69.91 | 3e-116 | 340 |
| LLPS-Lem-1164 | Leptosphaeria maculans | 69.77 | 2e-111 | 328 |
| LLPS-Scp-0879 | Schizosaccharomyces pombe | 69.77 | 3e-108 | 317 |
| LLPS-Map-0357 | Magnaporthe poae | 69.77 | 7e-114 | 334 |
| LLPS-Ved-0811 | Verticillium dahliae | 69.77 | 6e-114 | 334 |
| LLPS-Usm-0321 | Ustilago maydis | 69.67 | 4e-107 | 317 |
| LLPS-Phn-0119 | Phaeosphaeria nodorum | 69.63 | 1e-109 | 323 |
| LLPS-Gag-1143 | Gaeumannomyces graminis | 69.3 | 4e-112 | 330 |
| LLPS-Blg-0914 | Blumeria graminis | 69.27 | 5e-115 | 337 |
| LLPS-Scc-1065 | Schizosaccharomyces cryophilus | 68.84 | 4e-103 | 305 |
| LLPS-Zyt-0167 | Zymoseptoria tritici | 68.64 | 4e-112 | 329 |
| LLPS-Scs-0397 | Sclerotinia sclerotiorum | 68.18 | 8e-112 | 328 |
| LLPS-Scj-0014 | Schizosaccharomyces japonicus | 67.91 | 3e-104 | 307 |
| LLPS-Abg-0576 | Absidia glauca | 67.77 | 5e-104 | 308 |
| LLPS-Tum-0155 | Tuber melanosporum | 67.58 | 7e-91 | 273 |
| LLPS-Crn-1273 | Cryptococcus neoformans | 67.43 | 6e-106 | 313 |
| LLPS-Spr-0325 | Sporisorium reilianum | 67.13 | 4e-106 | 315 |
| LLPS-Mel-1114 | Melampsora laricipopulina | 66.82 | 7e-106 | 315 |
| LLPS-Pug-0443 | Puccinia graminis | 65.28 | 5e-100 | 301 |
| LLPS-Pytr-1383 | Pyrenophora triticirepentis | 65.12 | 2e-98 | 294 |
| LLPS-Miv-1051 | Microbotryum violaceum | 65.07 | 1e-101 | 303 |
| LLPS-Put-0539 | Puccinia triticina | 64.09 | 2e-99 | 301 |
| LLPS-Gas-0935 | Galdieria sulphuraria | 61.5 | 3e-90 | 273 |
| LLPS-Tut-1792 | Tursiops truncatus | 60.62 | 3e-64 | 204 |
| LLPS-Drm-1487 | Drosophila melanogaster | 60.29 | 3e-87 | 265 |
| LLPS-Fud-1820 | Fukomys damarensis | 60.0 | 2e-90 | 273 |
| LLPS-Cas-0912 | Carlito syrichta | 60.0 | 4e-90 | 272 |
| LLPS-Orc-0029 | Oryctolagus cuniculus | 60.0 | 4e-90 | 272 |
| LLPS-Mod-2951 | Monodelphis domestica | 59.55 | 4e-91 | 275 |
| LLPS-Ere-0880 | Erinaceus europaeus | 59.53 | 4e-89 | 270 |
| LLPS-Cap-3175 | Cavia porcellus | 59.53 | 2e-90 | 273 |
| LLPS-Dio-1985 | Dipodomys ordii | 59.07 | 5e-89 | 269 |
| LLPS-Aim-3342 | Ailuropoda melanoleuca | 59.07 | 2e-88 | 268 |
| LLPS-Mup-0248 | Mustela putorius furo | 59.07 | 2e-88 | 268 |
| LLPS-Ran-2593 | Rattus norvegicus | 59.07 | 6e-90 | 271 |
| LLPS-Sus-4451 | Sus scrofa | 59.07 | 8e-89 | 268 |
| LLPS-Mum-3370 | Mus musculus | 59.07 | 4e-90 | 272 |
| LLPS-Man-0088 | Macaca nemestrina | 59.07 | 5e-89 | 269 |
| LLPS-Loa-1137 | Loxodonta africana | 59.07 | 1e-89 | 271 |
| LLPS-Urm-2137 | Ursus maritimus | 59.07 | 3e-88 | 267 |
| LLPS-Ova-0681 | Ovis aries | 59.02 | 2e-83 | 254 |
| LLPS-Cym-0813 | Cyanidioschyzon merolae | 59.0 | 2e-79 | 245 |
| LLPS-Caf-1162 | Canis familiaris | 58.9 | 2e-89 | 270 |
| LLPS-Eqc-2123 | Equus caballus | 58.9 | 5e-90 | 271 |
| LLPS-Paa-4319 | Papio anubis | 58.6 | 7e-89 | 270 |
| LLPS-Mal-1177 | Mandrillus leucophaeus | 58.6 | 7e-89 | 269 |
| LLPS-Aon-1751 | Aotus nancymaae | 58.6 | 2e-89 | 270 |
| LLPS-Cea-0935 | Cercocebus atys | 58.6 | 7e-89 | 270 |
| LLPS-Maf-2081 | Macaca fascicularis | 58.6 | 5e-89 | 269 |
| LLPS-Chs-1931 | Chlorocebus sabaeus | 58.6 | 7e-89 | 269 |
| LLPS-Caj-3609 | Callithrix jacchus | 58.6 | 5e-89 | 269 |
| LLPS-Gog-1595 | Gorilla gorilla | 58.6 | 7e-89 | 269 |
| LLPS-Mam-0615 | Macaca mulatta | 58.6 | 6e-89 | 270 |
| LLPS-Poa-2939 | Pongo abelii | 58.6 | 7e-89 | 269 |
| LLPS-Pat-2561 | Pan troglodytes | 58.6 | 5e-89 | 269 |
| LLPS-Pap-3346 | Pan paniscus | 58.6 | 6e-89 | 269 |
| LLPS-Hos-0656 | Homo sapiens | 58.6 | 7e-89 | 269 |
| LLPS-Fec-1439 | Felis catus | 58.6 | 6e-88 | 266 |
| LLPS-Scf-1036 | Scleropages formosus | 58.57 | 3e-85 | 259 |
| LLPS-Leo-0075 | Lepisosteus oculatus | 58.57 | 5e-86 | 261 |
| LLPS-Icp-2830 | Ictalurus punctatus | 58.57 | 2e-84 | 258 |
| LLPS-Ict-3594 | Ictidomys tridecemlineatus | 58.14 | 5e-89 | 269 |
| LLPS-Nol-4007 | Nomascus leucogenys | 58.14 | 4e-88 | 267 |
| LLPS-Asm-0168 | Astyanax mexicanus | 58.1 | 1e-84 | 258 |
| LLPS-Orl-3543 | Oryzias latipes | 58.02 | 3e-85 | 260 |
| LLPS-Tag-2993 | Taeniopygia guttata | 58.0 | 2e-80 | 246 |
| LLPS-Fia-0159 | Ficedula albicollis | 58.0 | 3e-80 | 246 |
| LLPS-Myl-1326 | Myotis lucifugus | 57.99 | 7e-89 | 269 |
| LLPS-Xet-2166 | Xenopus tropicalis | 57.73 | 3e-89 | 270 |
| LLPS-Otg-4610 | Otolemur garnettii | 57.67 | 1e-88 | 268 |
| LLPS-Gaga-0344 | Gallus gallus | 57.5 | 2e-76 | 242 |
| LLPS-Lac-3641 | Latimeria chalumnae | 57.44 | 1e-76 | 236 |
| LLPS-Chc-1063 | Chondrus crispus | 57.23 | 8e-68 | 213 |
| LLPS-Sah-1401 | Sarcophilus harrisii | 57.21 | 4e-80 | 246 |
| LLPS-Dar-2427 | Danio rerio | 57.14 | 7e-85 | 259 |
| LLPS-Bot-3815 | Bos taurus | 57.08 | 7e-88 | 266 |
| LLPS-Xim-0690 | Xiphophorus maculatus | 57.08 | 4e-85 | 259 |
| LLPS-Pof-1741 | Poecilia formosa | 57.08 | 4e-85 | 259 |
| LLPS-Ora-3426 | Ornithorhynchus anatinus | 57.0 | 2e-79 | 244 |
| LLPS-Rhb-3620 | Rhinopithecus bieti | 56.68 | 2e-81 | 250 |
| LLPS-Tar-0250 | Takifugu rubripes | 56.6 | 6e-84 | 256 |
| LLPS-Ten-1852 | Tetraodon nigroviridis | 56.6 | 8e-84 | 256 |
| LLPS-Scm-2399 | Scophthalmus maximus | 56.6 | 2e-82 | 253 |
| LLPS-Anc-2421 | Anolis carolinensis | 56.21 | 7e-58 | 187 |
| LLPS-Gaa-0312 | Gasterosteus aculeatus | 56.13 | 3e-82 | 252 |
| LLPS-Meg-1031 | Meleagris gallopavo | 56.04 | 4e-80 | 246 |
| LLPS-Pes-2208 | Pelodiscus sinensis | 55.92 | 3e-78 | 242 |
| LLPS-Coc-2071 | Corchorus capsularis | 55.77 | 2e-82 | 253 |
| LLPS-Cii-0778 | Ciona intestinalis | 55.35 | 5e-84 | 256 |
| LLPS-Sem-1976 | Selaginella moellendorffii | 55.19 | 2e-80 | 247 |
| LLPS-Sot-0077 | Solanum tuberosum | 55.14 | 2e-80 | 247 |
| LLPS-Cae-1365 | Caenorhabditis elegans | 54.72 | 3e-81 | 250 |
| LLPS-Orm-1071 | Oryza meridionalis | 54.67 | 9e-83 | 253 |
| LLPS-Orbr-1883 | Oryza brachyantha | 54.59 | 2e-81 | 250 |
| LLPS-Pot-1410 | Populus trichocarpa | 54.33 | 1e-78 | 243 |
| LLPS-Hea-0536 | Helianthus annuus | 54.21 | 2e-80 | 248 |
| LLPS-Orp-1205 | Oryza punctata | 54.21 | 6e-82 | 251 |
| LLPS-Nia-1810 | Nicotiana attenuata | 54.13 | 2e-82 | 253 |
| LLPS-Cis-0678 | Ciona savignyi | 53.98 | 6e-63 | 202 |
| LLPS-Gor-2434 | Gossypium raimondii | 53.85 | 5e-78 | 241 |
| LLPS-Mae-0067 | Manihot esculenta | 53.85 | 2e-79 | 245 |
| LLPS-Amt-1607 | Amborella trichopoda | 53.81 | 1e-80 | 248 |
| LLPS-Orgl-0879 | Oryza glumaepatula | 53.74 | 4e-81 | 249 |
| LLPS-Orb-0077 | Oryza barthii | 53.74 | 4e-81 | 249 |
| LLPS-Ori-1133 | Oryza indica | 53.74 | 4e-81 | 249 |
| LLPS-Glm-1627 | Glycine max | 53.74 | 1e-80 | 248 |
| LLPS-Orni-1021 | Oryza nivara | 53.74 | 4e-81 | 249 |
| LLPS-Orr-0252 | Oryza rufipogon | 53.74 | 4e-81 | 249 |
| LLPS-Org-0580 | Oryza glaberrima | 53.74 | 4e-81 | 249 |
| LLPS-Ors-0513 | Oryza sativa | 53.74 | 4e-81 | 249 |
| LLPS-Sei-0689 | Setaria italica | 53.67 | 4e-81 | 249 |
| LLPS-Sob-1462 | Sorghum bicolor | 53.67 | 9e-81 | 248 |
| LLPS-Php-2000 | Physcomitrella patens | 53.37 | 1e-78 | 243 |
| LLPS-Tru-0420 | Triticum urartu | 53.37 | 9e-77 | 239 |
| LLPS-Arl-1016 | Arabidopsis lyrata | 53.3 | 6e-82 | 251 |
| LLPS-Brd-1286 | Brachypodium distachyon | 53.3 | 4e-80 | 246 |
| LLPS-Brn-2977 | Brassica napus | 53.3 | 6e-82 | 251 |
| LLPS-Prp-1204 | Prunus persica | 53.3 | 2e-79 | 245 |
| LLPS-Bro-0599 | Brassica oleracea | 53.3 | 1e-82 | 253 |
| LLPS-Art-2486 | Arabidopsis thaliana | 53.3 | 1e-81 | 251 |
| LLPS-Brr-1705 | Brassica rapa | 53.3 | 6e-82 | 251 |
| LLPS-Cus-0610 | Cucumis sativus | 53.27 | 2e-78 | 242 |
| LLPS-Hov-1716 | Hordeum vulgare | 53.21 | 2e-81 | 253 |
| LLPS-Tra-2488 | Triticum aestivum | 53.21 | 3e-81 | 249 |
| LLPS-Thc-2053 | Theobroma cacao | 52.97 | 2e-80 | 248 |
| LLPS-Lep-2363 | Leersia perrieri | 52.8 | 5e-80 | 246 |
| LLPS-Met-1477 | Medicago truncatula | 52.8 | 3e-80 | 247 |
| LLPS-Phv-1102 | Phaseolus vulgaris | 52.8 | 9e-80 | 246 |
| LLPS-Sol-1626 | Solanum lycopersicum | 52.75 | 2e-80 | 248 |
| LLPS-Mua-1517 | Musa acuminata | 52.75 | 1e-79 | 246 |
| LLPS-Zem-1836 | Zea mays | 52.75 | 1e-79 | 245 |
| LLPS-Osl-0221 | Ostreococcus lucimarinus | 52.36 | 2e-75 | 234 |
| LLPS-Viv-1785 | Vitis vinifera | 52.29 | 2e-79 | 244 |
| LLPS-Chr-1589 | Chlamydomonas reinhardtii | 51.89 | 4e-70 | 221 |
| LLPS-Vir-0508 | Vigna radiata | 50.24 | 2e-69 | 218 |
| LLPS-Via-1422 | Vigna angularis | 47.56 | 8e-74 | 231 |
| LLPS-Orn-3711 | Oreochromis niloticus | 42.72 | 7e-45 | 156 |
| LLPS-Mea-3170 | Mesocricetus auratus | 41.63 | 4e-56 | 184 |