• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Rhb-1529
EIF3H

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit H
Gene Name: EIF3H, EIF3S3
Ensembl Gene: ENSRBIG00000041058.1
Ensembl Protein: ENSRBIP00000034759.1
Organism: Rhinopithecus bieti
Taxa ID: 61621
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSRBIT00000058749.1ENSRBIP00000034759.1
UniProtA0A2K6MG51, A0A2K6MG51_RHIBE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MYSRHAQRIT  PGNKMASRKE  GTGSTATSSS  STTGAAGKGK  GKGGSGDSAV  KQVQIDGLVV  60
61    LKIIKHYQEE  GQGTEVVQGV  LLGLVVEDRL  EITNCFPFPQ  HTEDDADFDE  VQYQMEMMRS  120
121   LRHVNIDHLH  VGWYQSTYYG  SFVTRALLDS  QFSYQHAIEE  SVVLIYDPIK  TAQGSLSLKA  180
181   YRLTPKLMEV  CKEKDFPEAL  KKANITFEYM  FEEVPIVIKN  SHLINVLMWE  LEKKSAVADK  240
241   HELLSLASSN  HLGKNLQLLM  DRVDEMSQDI  VKYNTYMRNT  SKQQQQKHQY  QQRRQQENMQ  300
301   RQSRGEPPLP  EEDLSKLFKP  PQPPARMDSL  LIAGQINTYC  QNIKEFTAQN  LGKLFMAQAL  360
361   QEYNN  365
Nucleotide CDS Sequence (FASTA)
1     ATGTACAGTA  GGCATGCACA  AAGGATAACG  CCTGGAAATA  AGATGGCGTC  CCGCAAGGAA  60
61    GGCACCGGCT  CTACTGCCAC  CTCTTCCAGC  TCCACCACCG  GCGCAGCAGG  GAAAGGCAAA  120
121   GGCAAAGGCG  GCTCCGGAGA  TTCAGCCGTG  AAGCAAGTGC  AGATAGATGG  CCTCGTGGTA  180
181   TTAAAGATAA  TCAAACATTA  TCAAGAAGAA  GGACAAGGAA  CTGAAGTTGT  TCAAGGAGTG  240
241   CTTTTGGGCC  TGGTTGTAGA  AGATCGGCTT  GAAATTACCA  ACTGCTTTCC  TTTCCCTCAG  300
301   CACACAGAGG  ATGATGCTGA  CTTTGATGAA  GTCCAATATC  AGATGGAAAT  GATGCGGAGC  360
361   CTTCGCCATG  TAAACATTGA  TCATCTTCAT  GTGGGCTGGT  ACCAGTCCAC  ATACTATGGC  420
421   TCATTCGTTA  CCCGGGCACT  TCTGGACTCT  CAGTTCAGTT  ACCAGCATGC  CATTGAAGAA  480
481   TCTGTCGTTC  TCATTTATGA  TCCCATAAAA  ACTGCCCAAG  GGTCTCTCTC  ACTAAAGGCT  540
541   TACAGACTGA  CTCCTAAACT  GATGGAAGTT  TGTAAAGAAA  AGGATTTTCC  TGAAGCTTTG  600
601   AAAAAAGCAA  ATATCACCTT  TGAGTACATG  TTTGAAGAAG  TGCCGATTGT  AATTAAAAAT  660
661   TCACATCTGA  TCAATGTCCT  AATGTGGGAA  CTTGAAAAGA  AGTCAGCTGT  TGCAGATAAA  720
721   CATGAGTTGC  TCAGCCTTGC  CAGCAGCAAT  CATTTGGGGA  AAAATCTACA  GTTGCTGATG  780
781   GACAGAGTGG  ATGAAATGAG  CCAAGATATA  GTTAAATACA  ACACATACAT  GAGGAATACT  840
841   AGTAAACAAC  AGCAGCAGAA  ACATCAGTAT  CAGCAGCGTC  GCCAGCAGGA  GAATATGCAG  900
901   CGCCAGAGCC  GAGGAGAACC  CCCGCTCCCT  GAGGAGGACC  TGTCCAAACT  CTTCAAACCG  960
961   CCACAGCCCC  CTGCCAGGAT  GGACTCGCTG  CTCATTGCAG  GCCAGATAAA  CACTTACTGC  1020
1021  CAGAACATCA  AGGAGTTCAC  TGCCCAAAAC  TTAGGCAAGC  TCTTCATGGC  CCAGGCTCTT  1080
1081  CAAGAATACA  ACAACTAA  1098

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cea-3037Cercocebus atys99.680.0 535
LLPS-Man-2381Macaca nemestrina99.450.0 590
LLPS-Mam-3699Macaca mulatta99.450.0 590
LLPS-Maf-3484Macaca fascicularis99.450.0 590
LLPS-Mal-2885Mandrillus leucophaeus99.450.0 590
LLPS-Paa-1872Papio anubis99.450.0 590
LLPS-Poa-2668Pongo abelii99.430.0 560
LLPS-Hos-1034Homo sapiens98.910.0 586
LLPS-Pat-2550Pan troglodytes98.910.0 586
LLPS-Pap-1910Pan paniscus98.910.0 586
LLPS-Gog-2355Gorilla gorilla98.630.0 585
LLPS-Otg-1329Otolemur garnettii98.580.0 553
LLPS-Urm-1447Ursus maritimus98.580.0 556
LLPS-Loa-1043Loxodonta africana98.580.0 557
LLPS-Mup-3661Mustela putorius furo98.580.0 556
LLPS-Sus-1310Sus scrofa98.30.0 551
LLPS-Aim-4386Ailuropoda melanoleuca98.030.0 558
LLPS-Caf-3633Canis familiaris98.020.0 558
LLPS-Orc-1296Oryctolagus cuniculus98.010.0 558
LLPS-Ova-3322Ovis aries98.010.0 551
LLPS-Bot-1271Bos taurus98.010.0 549
LLPS-Nol-1009Nomascus leucogenys97.810.0 580
LLPS-Dio-3279Dipodomys ordii97.730.0 550
LLPS-Mod-2881Monodelphis domestica97.50.0 551
LLPS-Fec-2921Felis catus97.460.0 551
LLPS-Ict-4675Ictidomys tridecemlineatus97.440.0 550
LLPS-Ran-4749Rattus norvegicus97.440.0 548
LLPS-Tut-1668Tursiops truncatus97.440.0 527
LLPS-Mea-4274Mesocricetus auratus97.274e-161 459
LLPS-Caj-1907Callithrix jacchus97.210.0 553
LLPS-Sah-2814Sarcophilus harrisii97.190.0 550
LLPS-Cap-2223Cavia porcellus97.170.0 517
LLPS-Mum-4898Mus musculus96.880.0 551
LLPS-Myl-4429Myotis lucifugus96.880.0 554
LLPS-Aon-3242Aotus nancymaae96.720.0 580
LLPS-Cas-0925Carlito syrichta95.630.0 572
LLPS-Eqc-2193Equus caballus95.330.0 559
LLPS-Pes-1411Pelodiscus sinensis95.00.0 541
LLPS-Anp-2072Anas platyrhynchos93.835e-179 507
LLPS-Meg-1231Meleagris gallopavo93.750.0 531
LLPS-Gaga-2482Gallus gallus93.750.0 531
LLPS-Tag-2590Taeniopygia guttata93.440.0 528
LLPS-Fia-1794Ficedula albicollis92.942e-154 442
LLPS-Anc-1354Anolis carolinensis91.886e-175 496
LLPS-Scf-2325Scleropages formosus89.641e-172 492
LLPS-Leo-0668Lepisosteus oculatus89.593e-178 506
LLPS-Fud-4025Fukomys damarensis88.992e-176 501
LLPS-Scm-3419Scophthalmus maximus88.711e-178 507
LLPS-Lac-1666Latimeria chalumnae88.122e-170 486
LLPS-Xim-2857Xiphophorus maculatus88.093e-176 501
LLPS-Pof-1904Poecilia formosa87.463e-174 496
LLPS-Tar-1567Takifugu rubripes87.461e-175 499
LLPS-Gaa-0038Gasterosteus aculeatus86.833e-174 496
LLPS-Dar-2698Danio rerio86.712e-170 486
LLPS-Ten-2576Tetraodon nigroviridis86.252e-169 484
LLPS-Icp-1190Ictalurus punctatus85.06e-158 454
LLPS-Ora-3498Ornithorhynchus anatinus84.984e-130 380
LLPS-Xet-1958Xenopus tropicalis84.797e-155 446
LLPS-Asm-3745Astyanax mexicanus84.121e-148 432
LLPS-Cii-1833Ciona intestinalis62.03e-69 223
LLPS-Cis-1333Ciona savignyi55.12e-104 317
LLPS-Drm-2067Drosophila melanogaster46.522e-80 256
LLPS-Sem-1571Selaginella moellendorffii43.616e-69 226
LLPS-Prp-2080Prunus persica42.956e-68 224
LLPS-Mua-0467Musa acuminata42.95e-68 224
LLPS-Sol-1951Solanum lycopersicum42.591e-59 209
LLPS-Mae-0659Manihot esculenta42.276e-67 221
LLPS-Amt-1222Amborella trichopoda42.249e-63 211
LLPS-Viv-1330Vitis vinifera42.011e-66 220
LLPS-Nia-1628Nicotiana attenuata41.648e-64 213
LLPS-Sot-0228Solanum tuberosum41.642e-64 214
LLPS-Phv-2021Phaseolus vulgaris41.322e-64 214
LLPS-Glm-2866Glycine max41.322e-64 214
LLPS-Orbr-1816Oryza brachyantha41.076e-64 214
LLPS-Ors-1615Oryza sativa41.076e-64 214
LLPS-Orp-1701Oryza punctata41.075e-64 214
LLPS-Org-0818Oryza glaberrima41.076e-64 214
LLPS-Orr-1446Oryza rufipogon41.076e-64 214
LLPS-Orm-0853Oryza meridionalis41.076e-64 214
LLPS-Php-1264Physcomitrella patens41.072e-59 202
LLPS-Orni-1937Oryza nivara41.076e-64 214
LLPS-Ori-1822Oryza indica41.076e-64 214
LLPS-Orb-0046Oryza barthii41.076e-64 214
LLPS-Hea-1124Helianthus annuus41.012e-61 209
LLPS-Brn-2935Brassica napus41.014e-61 206
LLPS-Brd-2164Brachypodium distachyon41.011e-63 213
LLPS-Dac-2460Daucus carota40.943e-60 204
LLPS-Via-1428Vigna angularis40.888e-64 213
LLPS-Lep-2338Leersia perrieri40.794e-57 197
LLPS-Zem-1755Zea mays40.752e-63 212
LLPS-Coc-0703Corchorus capsularis40.751e-64 215
LLPS-Cus-2204Cucumis sativus40.755e-63 211
LLPS-Brr-1212Brassica rapa40.694e-61 206
LLPS-Pot-1943Populus trichocarpa40.694e-62 209
LLPS-Gor-2132Gossypium raimondii40.441e-62 210
LLPS-Thc-1949Theobroma cacao40.445e-63 211
LLPS-Sei-0531Setaria italica40.136e-59 200
LLPS-Art-2271Arabidopsis thaliana40.064e-59 201
LLPS-Bro-1197Brassica oleracea40.062e-60 204
LLPS-Hov-2010Hordeum vulgare40.069e-61 206
LLPS-Arl-1105Arabidopsis lyrata40.064e-59 201
LLPS-Tra-1818Triticum aestivum39.751e-60 205
LLPS-Tru-1852Triticum urartu39.622e-55 191
LLPS-Met-1453Medicago truncatula39.56e-62 208
LLPS-Abg-0233Absidia glauca37.762e-56 194
LLPS-Chr-0937Chlamydomonas reinhardtii37.743e-53 185
LLPS-Cae-2012Caenorhabditis elegans37.281e-50 179
LLPS-Sob-2369Sorghum bicolor36.692e-50 179
LLPS-Gas-1042Galdieria sulphuraria35.559e-41 151
LLPS-Orgl-1700Oryza glumaepatula35.229e-52 180
LLPS-Tum-0968Tuber melanosporum34.812e-47 171
LLPS-Vir-1544Vigna radiata34.51e-31 126
LLPS-Asf-0591Aspergillus flavus34.25e-47 169
LLPS-Aso-1555Aspergillus oryzae34.25e-47 169
LLPS-Nef-1518Neosartorya fischeri34.081e-43 160
LLPS-Yal-0481Yarrowia lipolytica33.923e-35 137
LLPS-Asn-1478Aspergillus nidulans33.621e-49 176
LLPS-Osl-0851Ostreococcus lucimarinus33.542e-43 159
LLPS-Trv-0976Trichoderma virens33.533e-45 165
LLPS-Fus-1054Fusarium solani33.522e-45 165
LLPS-Trr-1179Trichoderma reesei33.431e-45 166
LLPS-Chc-0615Chondrus crispus33.431e-45 165
LLPS-Ast-1465Aspergillus terreus33.334e-48 172
LLPS-Asfu-1167Aspergillus fumigatus33.336e-46 167
LLPS-Zyt-1423Zymoseptoria tritici33.246e-43 159
LLPS-Beb-0502Beauveria bassiana33.058e-42 155
LLPS-Asni-0561Aspergillus niger33.053e-46 167
LLPS-Asc-0521Aspergillus clavatus33.052e-46 168
LLPS-Fuo-1372Fusarium oxysporum32.559e-46 166
LLPS-Scc-1330Schizosaccharomyces cryophilus32.521e-24 107
LLPS-Lem-1342Leptosphaeria maculans32.481e-39 150
LLPS-Cogr-1420Colletotrichum graminicola32.392e-41 154
LLPS-Fuv-0264Fusarium verticillioides32.192e-45 165
LLPS-Dos-1359Dothistroma septosporum32.115e-43 159
LLPS-Coo-0703Colletotrichum orbiculare32.083e-40 151
LLPS-Pyt-1367Pyrenophora teres31.939e-40 150
LLPS-Pytr-1502Pyrenophora triticirepentis31.481e-38 147
LLPS-Scs-0708Sclerotinia sclerotiorum30.773e-40 151
LLPS-Ved-0530Verticillium dahliae30.482e-40 152
LLPS-Phn-1487Phaeosphaeria nodorum29.946e-36 144
LLPS-Gag-1620Gaeumannomyces graminis29.782e-37 144
LLPS-Scp-1395Schizosaccharomyces pombe29.641e-23 103
LLPS-Mao-0848Magnaporthe oryzae29.492e-38 146
LLPS-Blg-0771Blumeria graminis29.491e-37 144
LLPS-Cog-0791Colletotrichum gloeosporioides29.481e-39 149
LLPS-Nec-1013Neurospora crassa29.433e-42 157
LLPS-Map-0520Magnaporthe poae29.212e-38 146
LLPS-Scj-0792Schizosaccharomyces japonicus28.922e-33 132
LLPS-Kop-0686Komagataella pastoris26.574e-1888.2
LLPS-Usm-1549Ustilago maydis25.862e-29 122
LLPS-Spr-1336Sporisorium reilianum25.578e-29 119