• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pof-1904
EIF3H

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit H
Gene Name: EIF3H, EIF3S3
Ensembl Gene: ENSPFOG00000018331.2
Ensembl Protein: ENSPFOP00000018445.2
Organism: Poecilia formosa
Taxa ID: 48698
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASRKESSSA  SSTPMASTGG  TLDSPVKQIQ  IEGLVVLKII  KHYQEEGQGS  EVVQGVLLGL  60
61    VVDDRLEITN  CFPFPQHTED  DADFDEVQYQ  MEMMRSLRHV  NIDHLHVGWY  QSTYYGSFVS  120
121   RALLDSQFSY  QHAIEESVVL  IYDPIKTAQG  SLSLKAYRLT  PKLMEICKEK  DFTTEGLKKA  180
181   SVGFENMFEE  VPIVIKNSHL  INVLLWELED  KSTVSDKHEL  LNLSSSNHLE  KSLQLLMDRV  240
241   DDLNQDIVKY  NTYSRNLSKQ  QQQKHQYLQR  RQQENTQRQS  RGEPPLPEED  ISKLFKPPQA  300
301   PPRMDTLLIA  GIINNYCQNV  KEFTSQNLGK  LFMAEALQGH  N  341
Nucleotide CDS Sequence (FASTA)
1     ATGGCTTCCC  GTAAGGAGTC  CAGTTCAGCA  TCCAGCACAC  CAATGGCTTC  TACAGGCGGT  60
61    ACCCTGGACT  CTCCGGTCAA  ACAGATCCAA  ATTGAGGGAC  TGGTGGTGCT  GAAGATTATT  120
121   AAGCACTATC  AGGAAGAGGG  CCAGGGCAGC  GAGGTGGTTC  AGGGCGTCCT  GCTGGGCCTG  180
181   GTGGTCGACG  ACCGGCTGGA  GATCACTAAC  TGCTTCCCGT  TCCCGCAGCA  CACCGAGGAC  240
241   GACGCCGACT  TTGATGAAGT  CCAGTACCAG  ATGGAGATGA  TGCGTTCCCT  GCGTCACGTC  300
301   AACATTGACC  ATCTGCATGT  GGGCTGGTAC  CAGTCCACCT  ACTATGGCTC  CTTTGTCAGC  360
361   CGAGCTCTGC  TAGACTCCCA  GTTCAGCTAC  CAACACGCCA  TTGAGGAGTC  TGTTGTTCTG  420
421   ATCTATGATC  CTATAAAAAC  AGCCCAAGGC  TCCCTATCCC  TGAAAGCCTA  CAGACTCACC  480
481   CCGAAGCTCA  TGGAGATCTG  CAAGGAGAAG  GACTTCACCA  CTGAAGGCTT  GAAGAAGGCC  540
541   AGCGTCGGCT  TTGAAAATAT  GTTCGAGGAG  GTGCCCATAG  TCATCAAAAA  CTCCCACCTC  600
601   ATCAACGTGT  TGCTGTGGGA  GCTGGAGGAC  AAGTCCACCG  TCTCCGACAA  GCACGAACTG  660
661   CTCAACCTCT  CCAGCAGCAA  CCACTTGGAG  AAGAGTCTTC  AGCTTCTGAT  GGACAGGGTG  720
721   GACGACCTGA  ACCAAGACAT  TGTCAAATAT  AACACCTACA  GCCGGAACCT  GAGCAAGCAG  780
781   CAGCAGCAGA  AGCACCAGTA  CCTCCAGAGG  CGGCAGCAGG  AGAACACCCA  GCGACAGAGC  840
841   AGAGGTGAGC  CCCCGCTACC  GGAGGAGGAC  ATCAGCAAGT  TGTTCAAGCC  CCCCCAGGCG  900
901   CCACCGCGCA  TGGATACACT  GCTCATCGCA  GGGCAAATTA  ACAACTACTG  CCAGAACGTG  960
961   AAGGAATTCA  CCTCGCAGAA  CCTCGGGAAG  CTGTTCATGG  CCGAGGCGCT  CCAAGGCCAC  1020
1021  AACTAG  1026

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Brain development
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Lateral line development
Biological Process
Regulation of translation
Biological Process
Vasculature development

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-2857Xiphophorus maculatus98.830.0 545
LLPS-Tar-1567Takifugu rubripes94.130.0 532
LLPS-Leo-0668Lepisosteus oculatus93.694e-177 502
LLPS-Ten-2576Tetraodon nigroviridis92.980.0 515
LLPS-Scf-2325Scleropages formosus92.869e-171 486
LLPS-Scm-3419Scophthalmus maximus92.670.0 529
LLPS-Icp-1190Ictalurus punctatus90.02e-173 493
LLPS-Gaa-0038Gasterosteus aculeatus89.744e-180 510
LLPS-Pes-1411Pelodiscus sinensis88.612e-169 483
LLPS-Cea-3037Cercocebus atys87.952e-161 463
LLPS-Cap-2223Cavia porcellus87.866e-167 477
LLPS-Mum-4898Mus musculus87.771e-170 486
LLPS-Dio-3279Dipodomys ordii87.773e-170 485
LLPS-Ran-4749Rattus norvegicus87.663e-168 480
LLPS-Otg-1329Otolemur garnettii87.461e-168 481
LLPS-Orc-1296Oryctolagus cuniculus87.462e-169 483
LLPS-Rhb-1529Rhinopithecus bieti87.467e-167 477
LLPS-Pat-2550Pan troglodytes87.468e-169 482
LLPS-Pap-1910Pan paniscus87.468e-169 482
LLPS-Hos-1034Homo sapiens87.468e-169 482
LLPS-Man-2381Macaca nemestrina87.467e-169 482
LLPS-Cas-0925Carlito syrichta87.464e-169 483
LLPS-Nol-1009Nomascus leucogenys87.467e-169 482
LLPS-Poa-2668Pongo abelii87.464e-169 482
LLPS-Mam-3699Macaca mulatta87.467e-169 482
LLPS-Gog-2355Gorilla gorilla87.461e-168 482
LLPS-Maf-3484Macaca fascicularis87.467e-169 482
LLPS-Aon-3242Aotus nancymaae87.466e-169 482
LLPS-Paa-1872Papio anubis87.467e-169 482
LLPS-Mal-2885Mandrillus leucophaeus87.467e-169 482
LLPS-Myl-4429Myotis lucifugus87.463e-170 485
LLPS-Fec-2921Felis catus87.341e-166 477
LLPS-Eqc-2193Equus caballus87.343e-167 478
LLPS-Urm-1447Ursus maritimus87.151e-168 481
LLPS-Mod-2881Monodelphis domestica87.153e-161 462
LLPS-Loa-1043Loxodonta africana87.153e-169 483
LLPS-Ict-4675Ictidomys tridecemlineatus87.157e-169 481
LLPS-Caf-3633Canis familiaris87.153e-169 483
LLPS-Aim-4386Ailuropoda melanoleuca87.155e-169 482
LLPS-Mup-3661Mustela putorius furo87.151e-168 481
LLPS-Anp-2072Anas platyrhynchos86.972e-160 458
LLPS-Tag-2590Taeniopygia guttata86.836e-169 481
LLPS-Sah-2814Sarcophilus harrisii86.832e-167 478
LLPS-Sus-1310Sus scrofa86.833e-167 478
LLPS-Ova-3322Ovis aries86.831e-167 478
LLPS-Bot-1271Bos taurus86.838e-168 479
LLPS-Dar-2698Danio rerio86.84e-174 494
LLPS-Meg-1231Meleagris gallopavo86.522e-167 478
LLPS-Gaga-2482Gallus gallus86.522e-167 478
LLPS-Tut-1668Tursiops truncatus86.523e-167 478
LLPS-Anc-1354Anolis carolinensis86.324e-158 452
LLPS-Mea-4274Mesocricetus auratus86.273e-139 402
LLPS-Asm-3745Astyanax mexicanus85.494e-156 451
LLPS-Fia-1794Ficedula albicollis85.431e-137 398
LLPS-Xet-1958Xenopus tropicalis84.743e-152 438
LLPS-Lac-1666Latimeria chalumnae84.718e-168 478
LLPS-Caj-1907Callithrix jacchus84.661e-166 476
LLPS-Fud-4025Fukomys damarensis78.83e-151 436
LLPS-Ora-3498Ornithorhynchus anatinus75.02e-108 324
LLPS-Cii-1833Ciona intestinalis64.322e-68 219
LLPS-Cis-1333Ciona savignyi56.733e-100 305
LLPS-Drm-2067Drosophila melanogaster47.474e-81 257
LLPS-Prp-2080Prunus persica44.482e-66 219
LLPS-Mua-0467Musa acuminata43.223e-66 219
LLPS-Sem-1571Selaginella moellendorffii42.955e-65 215
LLPS-Amt-1222Amborella trichopoda42.92e-60 205
LLPS-Viv-1330Vitis vinifera42.91e-64 214
LLPS-Phv-2021Phaseolus vulgaris42.723e-63 211
LLPS-Nia-1628Nicotiana attenuata42.727e-62 207
LLPS-Glm-2866Glycine max42.723e-63 211
LLPS-Brn-2935Brassica napus42.723e-62 208
LLPS-Brd-2164Brachypodium distachyon42.593e-62 208
LLPS-Sot-0228Solanum tuberosum42.591e-61 206
LLPS-Via-1428Vigna angularis42.542e-61 206
LLPS-Mae-0659Manihot esculenta42.273e-64 213
LLPS-Coc-0703Corchorus capsularis42.276e-64 213
LLPS-Sol-1951Solanum lycopersicum42.278e-58 203
LLPS-Orbr-1816Oryza brachyantha42.142e-62 209
LLPS-Ors-1615Oryza sativa42.142e-62 209
LLPS-Orp-1701Oryza punctata42.142e-62 209
LLPS-Org-0818Oryza glaberrima42.142e-62 209
LLPS-Orr-1446Oryza rufipogon42.142e-62 209
LLPS-Orm-0853Oryza meridionalis42.142e-62 209
LLPS-Orni-1937Oryza nivara42.142e-62 209
LLPS-Orb-0046Oryza barthii42.142e-62 209
LLPS-Ori-1822Oryza indica42.142e-62 209
LLPS-Lep-2338Leersia perrieri42.113e-56 194
LLPS-Brr-1212Brassica rapa42.091e-61 206
LLPS-Zem-1755Zea mays41.963e-63 211
LLPS-Cus-2204Cucumis sativus41.968e-63 209
LLPS-Php-1264Physcomitrella patens41.825e-58 197
LLPS-Art-2271Arabidopsis thaliana41.774e-60 202
LLPS-Bro-1197Brassica oleracea41.775e-61 205
LLPS-Gor-2132Gossypium raimondii41.643e-62 208
LLPS-Dac-2460Daucus carota41.644e-61 205
LLPS-Sei-0531Setaria italica41.641e-57 196
LLPS-Hov-2010Hordeum vulgare41.642e-59 202
LLPS-Hea-1124Helianthus annuus41.461e-59 203
LLPS-Arl-1105Arabidopsis lyrata41.461e-59 201
LLPS-Thc-1949Theobroma cacao41.324e-62 207
LLPS-Met-1453Medicago truncatula41.012e-60 203
LLPS-Pot-1943Populus trichocarpa40.829e-61 204
LLPS-Tra-1818Triticum aestivum40.513e-58 197
LLPS-Tru-1852Triticum urartu40.447e-53 184
LLPS-Cae-2012Caenorhabditis elegans39.44e-50 177
LLPS-Sob-2369Sorghum bicolor38.693e-50 177
LLPS-Chr-0937Chlamydomonas reinhardtii37.856e-54 186
LLPS-Orgl-1700Oryza glumaepatula37.547e-55 187
LLPS-Abg-0233Absidia glauca36.923e-57 195
LLPS-Gas-1042Galdieria sulphuraria36.671e-42 155
LLPS-Chc-0615Chondrus crispus35.88e-50 176
LLPS-Tum-0968Tuber melanosporum35.08e-48 171
LLPS-Vir-1544Vigna radiata34.383e-30 121
LLPS-Beb-0502Beauveria bassiana33.912e-45 165
LLPS-Fus-1054Fusarium solani33.813e-49 174
LLPS-Osl-0851Ostreococcus lucimarinus33.642e-41 153
LLPS-Trv-0976Trichoderma virens33.536e-47 168
LLPS-Asc-0521Aspergillus clavatus33.524e-47 169
LLPS-Nef-1518Neosartorya fischeri33.444e-42 155
LLPS-Asf-0591Aspergillus flavus33.433e-49 174
LLPS-Aso-1555Aspergillus oryzae33.433e-49 174
LLPS-Asfu-1167Aspergillus fumigatus33.242e-46 167
LLPS-Zyt-1423Zymoseptoria tritici33.242e-45 165
LLPS-Ast-1465Aspergillus terreus33.157e-49 174
LLPS-Dos-1359Dothistroma septosporum32.961e-45 165
LLPS-Asni-0561Aspergillus niger32.879e-48 171
LLPS-Cogr-1420Colletotrichum graminicola32.683e-42 156
LLPS-Fuo-1372Fusarium oxysporum32.665e-49 174
LLPS-Coo-0703Colletotrichum orbiculare32.568e-41 152
LLPS-Fuv-0264Fusarium verticillioides32.371e-48 173
LLPS-Trr-1179Trichoderma reesei32.282e-46 167
LLPS-Gag-1620Gaeumannomyces graminis32.12e-38 145
LLPS-Asn-1478Aspergillus nidulans31.936e-52 182
LLPS-Lem-1342Leptosphaeria maculans31.831e-41 155
LLPS-Ved-0530Verticillium dahliae31.323e-44 161
LLPS-Yal-0481Yarrowia lipolytica31.293e-33 131
LLPS-Map-0520Magnaporthe poae31.256e-39 147
LLPS-Phn-1487Phaeosphaeria nodorum31.072e-39 154
LLPS-Pyt-1367Pyrenophora teres31.076e-42 155
LLPS-Pytr-1502Pyrenophora triticirepentis30.95e-40 150
LLPS-Nec-1013Neurospora crassa30.233e-44 161
LLPS-Scs-0708Sclerotinia sclerotiorum30.145e-43 158
LLPS-Cog-0791Colletotrichum gloeosporioides29.974e-43 158
LLPS-Blg-0771Blumeria graminis29.784e-40 150
LLPS-Mao-0848Magnaporthe oryzae29.553e-38 145
LLPS-Scj-0792Schizosaccharomyces japonicus29.462e-36 140
LLPS-Kop-0686Komagataella pastoris28.223e-1888.2
LLPS-Mel-0466Melampsora laricipopulina28.172e-0652.8
LLPS-Scp-1395Schizosaccharomyces pombe28.064e-27 114
LLPS-Orn-3150Oreochromis niloticus27.785e-0651.6
LLPS-Scc-1330Schizosaccharomyces cryophilus27.763e-28 117
LLPS-Spr-1336Sporisorium reilianum26.637e-29 119
LLPS-Usm-1549Ustilago maydis26.351e-28 119
LLPS-Pug-0364Puccinia graminis25.871e-0653.5
LLPS-Put-0073Puccinia triticina25.878e-0754.3