• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Aim-4386
EIF3H

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit H
Gene Name: EIF3H, EIF3S3
Ensembl Gene: ENSAMEG00000010322.1
Ensembl Protein: ENSAMEP00000010864.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

▼ SEQUENCE


Protein Sequence (FASTA)
1     AKKMASRKEG  TGSAATSSSS  TTGPAGKGKG  KGGSGDSAVK  QVQIDGLVVL  KIIKHYQEEG  60
61    QGTEVVQGVL  LGLVVEDRLE  ITNCFPFPQH  TEDDADFDEV  QYQMEMMRSL  RHVNIDHLHV  120
121   GWYQSTYYGS  FVTRALLDSQ  FSYQHAIEES  VVLIYDPIKT  AQGSLSLKAY  RLTPKLMEVC  180
181   KEKDFSPEAL  KKGNITFEHM  FEEVPIVIKN  SHLINVLMWE  LEKKSAVADK  HELLSLASSN  240
241   HLGKNLQLLM  DRVDEMSQDI  VKYNTYMRNT  SKQQQQKHQY  QQRRQQENMQ  RQSRGEPPLP  300
301   EEDLSKLFKP  PQPPARMDSL  LIAGQINTYC  QNIKEFTAQN  LGKLFMAQAL  QEYNN  355
Nucleotide CDS Sequence (FASTA)
1     GCTAAAAAGA  TGGCGTCTCG  CAAGGAAGGT  ACCGGCTCTG  CTGCCACTTC  TTCCAGCTCC  60
61    ACCACCGGCC  CGGCGGGGAA  AGGCAAAGGC  AAAGGCGGGT  CCGGAGATTC  GGCTGTGAAG  120
121   CAAGTGCAGA  TAGATGGCTT  GGTGGTATTA  AAAATAATCA  AACATTATCA  AGAAGAAGGA  180
181   CAAGGAACTG  AAGTGGTTCA  AGGAGTGCTA  TTGGGCTTGG  TTGTAGAAGA  TCGTCTTGAA  240
241   ATTACCAACT  GCTTTCCTTT  CCCGCAGCAC  ACGGAAGATG  ATGCTGACTT  TGATGAAGTC  300
301   CAATATCAGA  TGGAAATGAT  GCGCAGCCTC  CGCCATGTCA  ACATTGATCA  CCTCCATGTG  360
361   GGCTGGTACC  AGTCCACGTA  CTATGGCTCG  TTCGTCACCC  GAGCGCTCCT  GGATTCTCAG  420
421   TTCAGTTACC  AGCATGCCAT  TGAAGAATCT  GTCGTTCTCA  TTTACGATCC  CATAAAAACT  480
481   GCCCAAGGGT  CTCTCTCGCT  GAAAGCATAC  AGACTCACTC  CTAAACTGAT  GGAAGTTTGT  540
541   AAAGAGAAGG  ATTTTTCTCC  TGAAGCATTG  AAAAAGGGAA  ATATCACCTT  TGAGCACATG  600
601   TTTGAAGAAG  TGCCGATTGT  AATTAAAAAT  TCACATCTGA  TCAACGTCCT  AATGTGGGAG  660
661   CTTGAGAAGA  AGTCAGCTGT  AGCAGATAAA  CATGAATTGC  TTAGTCTTGC  TAGCAGCAAC  720
721   CATTTGGGGA  AGAATCTACA  GTTGCTGATG  GACAGAGTGG  ATGAAATGAG  CCAGGATATA  780
781   GTTAAATATA  ACACATACAT  GAGGAACACG  AGTAAACAGC  AGCAGCAGAA  ACATCAGTAT  840
841   CAGCAGCGTC  GCCAACAGGA  GAATATGCAG  CGCCAGAGTC  GAGGAGAACC  CCCACTGCCT  900
901   GAGGAGGATC  TGTCCAAGCT  TTTCAAGCCC  CCTCAGCCTC  CTGCCAGGAT  GGACTCGCTG  960
961   CTCATTGCAG  GCCAGATTAA  CACTTACTGC  CAGAACATCA  AGGAGTTCAC  TGCCCAAAAC  1020
1021  TTGGGCAAAC  TCTTCATGGC  CCAGGCTCTT  CAGGAATACA  ACAAC  1065

▼ KEYWORD


ID
Family
Complete proteome
Cytoplasm
Initiation factor
Phosphoprotein
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mup-3661Mustela putorius furo100.00.0 560
LLPS-Eqc-2193Equus caballus100.00.0 561
LLPS-Caf-3633Canis familiaris100.00.0 563
LLPS-Fec-2921Felis catus100.00.0 558
LLPS-Urm-1447Ursus maritimus100.00.0 560
LLPS-Cas-0925Carlito syrichta99.680.0 558
LLPS-Orc-1296Oryctolagus cuniculus99.680.0 558
LLPS-Ova-3322Ovis aries99.370.0 555
LLPS-Mal-2885Mandrillus leucophaeus99.370.0 556
LLPS-Paa-1872Papio anubis99.370.0 556
LLPS-Gog-2355Gorilla gorilla99.370.0 556
LLPS-Aon-3242Aotus nancymaae99.370.0 556
LLPS-Sus-1310Sus scrofa99.370.0 556
LLPS-Maf-3484Macaca fascicularis99.370.0 556
LLPS-Mam-3699Macaca mulatta99.370.0 556
LLPS-Poa-2668Pongo abelii99.370.0 556
LLPS-Loa-1043Loxodonta africana99.370.0 558
LLPS-Man-2381Macaca nemestrina99.370.0 556
LLPS-Pat-2550Pan troglodytes99.370.0 556
LLPS-Pap-1910Pan paniscus99.370.0 556
LLPS-Hos-1034Homo sapiens99.370.0 556
LLPS-Cea-3037Cercocebus atys99.350.0 537
LLPS-Myl-4429Myotis lucifugus99.050.0 556
LLPS-Bot-1271Bos taurus99.050.0 553
LLPS-Nol-1009Nomascus leucogenys99.050.0 554
LLPS-Rhb-1529Rhinopithecus bieti99.050.0 549
LLPS-Otg-1329Otolemur garnettii99.050.0 553
LLPS-Dio-3279Dipodomys ordii98.740.0 550
LLPS-Tut-1668Tursiops truncatus98.740.0 531
LLPS-Ict-4675Ictidomys tridecemlineatus98.740.0 550
LLPS-Ran-4749Rattus norvegicus98.110.0 548
LLPS-Mum-4898Mus musculus98.110.0 550
LLPS-Mod-2881Monodelphis domestica97.790.0 551
LLPS-Mea-4274Mesocricetus auratus97.665e-164 466
LLPS-Sah-2814Sarcophilus harrisii97.480.0 550
LLPS-Cap-2223Cavia porcellus97.480.0 523
LLPS-Caj-1907Callithrix jacchus97.220.0 549
LLPS-Pes-1411Pelodiscus sinensis95.270.0 543
LLPS-Anp-2072Anas platyrhynchos93.830.0 512
LLPS-Tag-2590Taeniopygia guttata93.690.0 531
LLPS-Gaga-2482Gallus gallus93.690.0 531
LLPS-Meg-1231Meleagris gallopavo93.690.0 530
LLPS-Fia-1794Ficedula albicollis92.945e-157 448
LLPS-Anc-1354Anolis carolinensis91.887e-177 501
LLPS-Leo-0668Lepisosteus oculatus89.812e-178 506
LLPS-Scf-2325Scleropages formosus89.641e-174 496
LLPS-Fud-4025Fukomys damarensis89.271e-178 506
LLPS-Scm-3419Scophthalmus maximus88.925e-179 508
LLPS-Lac-1666Latimeria chalumnae88.334e-171 487
LLPS-Xim-2857Xiphophorus maculatus87.978e-177 502
LLPS-Tar-1567Takifugu rubripes87.345e-176 500
LLPS-Pof-1904Poecilia formosa87.341e-174 496
LLPS-Dar-2698Danio rerio87.222e-172 490
LLPS-Gaa-0038Gasterosteus aculeatus87.034e-175 498
LLPS-Ten-2576Tetraodon nigroviridis86.126e-170 484
LLPS-Ora-3498Ornithorhynchus anatinus85.386e-133 387
LLPS-Icp-1190Ictalurus punctatus85.171e-158 456
LLPS-Xet-1958Xenopus tropicalis84.795e-157 451
LLPS-Asm-3745Astyanax mexicanus83.964e-148 431
LLPS-Cii-1833Ciona intestinalis62.124e-70 224
LLPS-Cis-1333Ciona savignyi55.459e-106 320
LLPS-Drm-2067Drosophila melanogaster46.651e-81 259
LLPS-Sem-1571Selaginella moellendorffii43.571e-70 230
LLPS-Mua-0467Musa acuminata42.92e-70 230
LLPS-Prp-2080Prunus persica42.97e-70 228
LLPS-Sol-1951Solanum lycopersicum42.593e-62 216
LLPS-Amt-1222Amborella trichopoda42.524e-65 217
LLPS-Mae-0659Manihot esculenta42.273e-69 227
LLPS-Viv-1330Vitis vinifera41.961e-68 225
LLPS-Php-1264Physcomitrella patens41.699e-63 210
LLPS-Sot-0228Solanum tuberosum41.641e-66 220
LLPS-Nia-1628Nicotiana attenuata41.643e-66 219
LLPS-Glm-2866Glycine max41.321e-66 220
LLPS-Phv-2021Phaseolus vulgaris41.329e-67 220
LLPS-Brd-2164Brachypodium distachyon41.014e-66 219
LLPS-Via-1428Vigna angularis41.016e-66 219
LLPS-Orni-1937Oryza nivara41.017e-66 218
LLPS-Hea-1124Helianthus annuus41.018e-64 215
LLPS-Ori-1822Oryza indica41.017e-66 218
LLPS-Orb-0046Oryza barthii41.017e-66 218
LLPS-Brn-2935Brassica napus41.012e-63 212
LLPS-Org-0818Oryza glaberrima41.017e-66 218
LLPS-Zem-1755Zea mays41.011e-65 218
LLPS-Orm-0853Oryza meridionalis41.019e-66 218
LLPS-Orr-1446Oryza rufipogon41.017e-66 218
LLPS-Orbr-1816Oryza brachyantha41.018e-66 218
LLPS-Orp-1701Oryza punctata41.018e-66 218
LLPS-Ors-1615Oryza sativa41.017e-66 218
LLPS-Dac-2460Daucus carota40.884e-62 208
LLPS-Lep-2338Leersia perrieri40.736e-59 202
LLPS-Cus-2204Cucumis sativus40.696e-65 216
LLPS-Coc-0703Corchorus capsularis40.691e-66 220
LLPS-Pot-1943Populus trichocarpa40.692e-64 214
LLPS-Brr-1212Brassica rapa40.692e-63 211
LLPS-Sei-0531Setaria italica40.384e-61 206
LLPS-Thc-1949Theobroma cacao40.386e-65 216
LLPS-Gor-2132Gossypium raimondii40.382e-64 214
LLPS-Tru-1852Triticum urartu40.131e-57 197
LLPS-Arl-1105Arabidopsis lyrata40.062e-61 206
LLPS-Hov-2010Hordeum vulgare40.065e-63 211
LLPS-Bro-1197Brassica oleracea40.068e-63 210
LLPS-Art-2271Arabidopsis thaliana40.062e-61 206
LLPS-Tra-1818Triticum aestivum39.757e-63 210
LLPS-Met-1453Medicago truncatula39.754e-64 213
LLPS-Abg-0233Absidia glauca37.462e-58 199
LLPS-Chr-0937Chlamydomonas reinhardtii37.425e-55 189
LLPS-Cae-2012Caenorhabditis elegans37.097e-52 182
LLPS-Sob-2369Sorghum bicolor36.91e-52 184
LLPS-Gas-1042Galdieria sulphuraria35.886e-43 157
LLPS-Orgl-1700Oryza glumaepatula35.131e-53 184
LLPS-Tum-0968Tuber melanosporum34.818e-50 177
LLPS-Vir-1544Vigna radiata34.56e-34 132
LLPS-Asf-0591Aspergillus flavus34.23e-49 175
LLPS-Aso-1555Aspergillus oryzae34.23e-49 175
LLPS-Nef-1518Neosartorya fischeri34.089e-46 166
LLPS-Asfu-1167Aspergillus fumigatus33.916e-48 172
LLPS-Trv-0976Trichoderma virens33.829e-47 168
LLPS-Fus-1054Fusarium solani33.821e-46 168
LLPS-Chc-0615Chondrus crispus33.734e-47 169
LLPS-Trr-1179Trichoderma reesei33.725e-47 169
LLPS-Yal-0481Yarrowia lipolytica33.635e-37 142
LLPS-Asn-1478Aspergillus nidulans33.627e-52 182
LLPS-Asc-0521Aspergillus clavatus33.622e-48 173
LLPS-Osl-0851Ostreococcus lucimarinus33.543e-44 161
LLPS-Ast-1465Aspergillus terreus33.332e-50 178
LLPS-Zyt-1423Zymoseptoria tritici33.242e-44 162
LLPS-Asni-0561Aspergillus niger33.052e-48 173
LLPS-Beb-0502Beauveria bassiana33.045e-43 159
LLPS-Fuo-1372Fusarium oxysporum32.551e-47 171
LLPS-Scc-1330Schizosaccharomyces cryophilus32.522e-26 112
LLPS-Lem-1342Leptosphaeria maculans32.488e-42 155
LLPS-Cogr-1420Colletotrichum graminicola32.392e-43 159
LLPS-Fuv-0264Fusarium verticillioides32.263e-47 170
LLPS-Dos-1359Dothistroma septosporum32.13e-44 162
LLPS-Coo-0703Colletotrichum orbiculare32.083e-42 156
LLPS-Pyt-1367Pyrenophora teres32.013e-41 154
LLPS-Pytr-1502Pyrenophora triticirepentis31.832e-39 149
LLPS-Scs-0708Sclerotinia sclerotiorum30.772e-42 157
LLPS-Ved-0530Verticillium dahliae30.727e-42 155
LLPS-Blg-0771Blumeria graminis30.031e-38 147
LLPS-Phn-1487Phaeosphaeria nodorum30.01e-37 149
LLPS-Nec-1013Neurospora crassa29.971e-43 160
LLPS-Gag-1620Gaeumannomyces graminis29.831e-38 146
LLPS-Scp-1395Schizosaccharomyces pombe29.641e-25 110
LLPS-Map-0520Magnaporthe poae29.553e-39 148
LLPS-Cog-0791Colletotrichum gloeosporioides29.481e-41 154
LLPS-Mao-0848Magnaporthe oryzae29.464e-40 150
LLPS-Scj-0792Schizosaccharomyces japonicus29.228e-36 139
LLPS-Kop-0686Komagataella pastoris25.879e-1886.7
LLPS-Usm-1549Ustilago maydis25.865e-31 126
LLPS-Spr-1336Sporisorium reilianum25.574e-30 123
LLPS-Pug-0923Puccinia graminis24.192e-0962.8
LLPS-Mel-0677Melampsora laricipopulina23.811e-0963.5
LLPS-Crn-1202Cryptococcus neoformans23.494e-0961.6
LLPS-Put-1053Puccinia triticina20.81e-0963.2