LLPS-Aim-4386
EIF3H
Integrated Annotations
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Eukaryotic translation initiation factor 3 subunit H |
Gene Name: | EIF3H, EIF3S3 |
Ensembl Gene: | ENSAMEG00000010322.1 |
Ensembl Protein: | ENSAMEP00000010864.1 |
Organism: | Ailuropoda melanoleuca |
Taxa ID: | 9646 |
LLPS Type: | Others |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENSAMET00000011329.1 | ENSAMEP00000010864.1 |
Ensembl | ENSAMET00000011321.1 | ENSAMEP00000010856.1 |
UniProt | G1LUV7, G1LUV7_AILME | |
GeneBank | ACTA01098808, ACTA01090808, ACTA01114808, ACTA01106808, ACTA01122808 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 AKKMASRKEG TGSAATSSSS TTGPAGKGKG KGGSGDSAVK QVQIDGLVVL KIIKHYQEEG 60 61 QGTEVVQGVL LGLVVEDRLE ITNCFPFPQH TEDDADFDEV QYQMEMMRSL RHVNIDHLHV 120 121 GWYQSTYYGS FVTRALLDSQ FSYQHAIEES VVLIYDPIKT AQGSLSLKAY RLTPKLMEVC 180 181 KEKDFSPEAL KKGNITFEHM FEEVPIVIKN SHLINVLMWE LEKKSAVADK HELLSLASSN 240 241 HLGKNLQLLM DRVDEMSQDI VKYNTYMRNT SKQQQQKHQY QQRRQQENMQ RQSRGEPPLP 300 301 EEDLSKLFKP PQPPARMDSL LIAGQINTYC QNIKEFTAQN LGKLFMAQAL QEYNN 355 |
Nucleotide CDS Sequence (FASTA) |
1 GCTAAAAAGA TGGCGTCTCG CAAGGAAGGT ACCGGCTCTG CTGCCACTTC TTCCAGCTCC 60 61 ACCACCGGCC CGGCGGGGAA AGGCAAAGGC AAAGGCGGGT CCGGAGATTC GGCTGTGAAG 120 121 CAAGTGCAGA TAGATGGCTT GGTGGTATTA AAAATAATCA AACATTATCA AGAAGAAGGA 180 181 CAAGGAACTG AAGTGGTTCA AGGAGTGCTA TTGGGCTTGG TTGTAGAAGA TCGTCTTGAA 240 241 ATTACCAACT GCTTTCCTTT CCCGCAGCAC ACGGAAGATG ATGCTGACTT TGATGAAGTC 300 301 CAATATCAGA TGGAAATGAT GCGCAGCCTC CGCCATGTCA ACATTGATCA CCTCCATGTG 360 361 GGCTGGTACC AGTCCACGTA CTATGGCTCG TTCGTCACCC GAGCGCTCCT GGATTCTCAG 420 421 TTCAGTTACC AGCATGCCAT TGAAGAATCT GTCGTTCTCA TTTACGATCC CATAAAAACT 480 481 GCCCAAGGGT CTCTCTCGCT GAAAGCATAC AGACTCACTC CTAAACTGAT GGAAGTTTGT 540 541 AAAGAGAAGG ATTTTTCTCC TGAAGCATTG AAAAAGGGAA ATATCACCTT TGAGCACATG 600 601 TTTGAAGAAG TGCCGATTGT AATTAAAAAT TCACATCTGA TCAACGTCCT AATGTGGGAG 660 661 CTTGAGAAGA AGTCAGCTGT AGCAGATAAA CATGAATTGC TTAGTCTTGC TAGCAGCAAC 720 721 CATTTGGGGA AGAATCTACA GTTGCTGATG GACAGAGTGG ATGAAATGAG CCAGGATATA 780 781 GTTAAATATA ACACATACAT GAGGAACACG AGTAAACAGC AGCAGCAGAA ACATCAGTAT 840 841 CAGCAGCGTC GCCAACAGGA GAATATGCAG CGCCAGAGTC GAGGAGAACC CCCACTGCCT 900 901 GAGGAGGATC TGTCCAAGCT TTTCAAGCCC CCTCAGCCTC CTGCCAGGAT GGACTCGCTG 960 961 CTCATTGCAG GCCAGATTAA CACTTACTGC CAGAACATCA AGGAGTTCAC TGCCCAAAAC 1020 1021 TTGGGCAAAC TCTTCATGGC CCAGGCTCTT CAGGAATACA ACAAC 1065 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Eukaryotic 43S preinitiation complex | |
Cellular Component | Eukaryotic 48S preinitiation complex | |
Cellular Component | Eukaryotic translation initiation factor 3 complex | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Formation of cytoplasmic translation initiation complex |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Mup-3661 | Mustela putorius furo | 100.0 | 0.0 | 560 |
LLPS-Eqc-2193 | Equus caballus | 100.0 | 0.0 | 561 |
LLPS-Caf-3633 | Canis familiaris | 100.0 | 0.0 | 563 |
LLPS-Fec-2921 | Felis catus | 100.0 | 0.0 | 558 |
LLPS-Urm-1447 | Ursus maritimus | 100.0 | 0.0 | 560 |
LLPS-Cas-0925 | Carlito syrichta | 99.68 | 0.0 | 558 |
LLPS-Orc-1296 | Oryctolagus cuniculus | 99.68 | 0.0 | 558 |
LLPS-Ova-3322 | Ovis aries | 99.37 | 0.0 | 555 |
LLPS-Mal-2885 | Mandrillus leucophaeus | 99.37 | 0.0 | 556 |
LLPS-Paa-1872 | Papio anubis | 99.37 | 0.0 | 556 |
LLPS-Gog-2355 | Gorilla gorilla | 99.37 | 0.0 | 556 |
LLPS-Aon-3242 | Aotus nancymaae | 99.37 | 0.0 | 556 |
LLPS-Sus-1310 | Sus scrofa | 99.37 | 0.0 | 556 |
LLPS-Maf-3484 | Macaca fascicularis | 99.37 | 0.0 | 556 |
LLPS-Mam-3699 | Macaca mulatta | 99.37 | 0.0 | 556 |
LLPS-Poa-2668 | Pongo abelii | 99.37 | 0.0 | 556 |
LLPS-Loa-1043 | Loxodonta africana | 99.37 | 0.0 | 558 |
LLPS-Man-2381 | Macaca nemestrina | 99.37 | 0.0 | 556 |
LLPS-Pat-2550 | Pan troglodytes | 99.37 | 0.0 | 556 |
LLPS-Pap-1910 | Pan paniscus | 99.37 | 0.0 | 556 |
LLPS-Hos-1034 | Homo sapiens | 99.37 | 0.0 | 556 |
LLPS-Cea-3037 | Cercocebus atys | 99.35 | 0.0 | 537 |
LLPS-Myl-4429 | Myotis lucifugus | 99.05 | 0.0 | 556 |
LLPS-Bot-1271 | Bos taurus | 99.05 | 0.0 | 553 |
LLPS-Nol-1009 | Nomascus leucogenys | 99.05 | 0.0 | 554 |
LLPS-Rhb-1529 | Rhinopithecus bieti | 99.05 | 0.0 | 549 |
LLPS-Otg-1329 | Otolemur garnettii | 99.05 | 0.0 | 553 |
LLPS-Dio-3279 | Dipodomys ordii | 98.74 | 0.0 | 550 |
LLPS-Tut-1668 | Tursiops truncatus | 98.74 | 0.0 | 531 |
LLPS-Ict-4675 | Ictidomys tridecemlineatus | 98.74 | 0.0 | 550 |
LLPS-Ran-4749 | Rattus norvegicus | 98.11 | 0.0 | 548 |
LLPS-Mum-4898 | Mus musculus | 98.11 | 0.0 | 550 |
LLPS-Mod-2881 | Monodelphis domestica | 97.79 | 0.0 | 551 |
LLPS-Mea-4274 | Mesocricetus auratus | 97.66 | 5e-164 | 466 |
LLPS-Sah-2814 | Sarcophilus harrisii | 97.48 | 0.0 | 550 |
LLPS-Cap-2223 | Cavia porcellus | 97.48 | 0.0 | 523 |
LLPS-Caj-1907 | Callithrix jacchus | 97.22 | 0.0 | 549 |
LLPS-Pes-1411 | Pelodiscus sinensis | 95.27 | 0.0 | 543 |
LLPS-Anp-2072 | Anas platyrhynchos | 93.83 | 0.0 | 512 |
LLPS-Tag-2590 | Taeniopygia guttata | 93.69 | 0.0 | 531 |
LLPS-Gaga-2482 | Gallus gallus | 93.69 | 0.0 | 531 |
LLPS-Meg-1231 | Meleagris gallopavo | 93.69 | 0.0 | 530 |
LLPS-Fia-1794 | Ficedula albicollis | 92.94 | 5e-157 | 448 |
LLPS-Anc-1354 | Anolis carolinensis | 91.88 | 7e-177 | 501 |
LLPS-Leo-0668 | Lepisosteus oculatus | 89.81 | 2e-178 | 506 |
LLPS-Scf-2325 | Scleropages formosus | 89.64 | 1e-174 | 496 |
LLPS-Fud-4025 | Fukomys damarensis | 89.27 | 1e-178 | 506 |
LLPS-Scm-3419 | Scophthalmus maximus | 88.92 | 5e-179 | 508 |
LLPS-Lac-1666 | Latimeria chalumnae | 88.33 | 4e-171 | 487 |
LLPS-Xim-2857 | Xiphophorus maculatus | 87.97 | 8e-177 | 502 |
LLPS-Tar-1567 | Takifugu rubripes | 87.34 | 5e-176 | 500 |
LLPS-Pof-1904 | Poecilia formosa | 87.34 | 1e-174 | 496 |
LLPS-Dar-2698 | Danio rerio | 87.22 | 2e-172 | 490 |
LLPS-Gaa-0038 | Gasterosteus aculeatus | 87.03 | 4e-175 | 498 |
LLPS-Ten-2576 | Tetraodon nigroviridis | 86.12 | 6e-170 | 484 |
LLPS-Ora-3498 | Ornithorhynchus anatinus | 85.38 | 6e-133 | 387 |
LLPS-Icp-1190 | Ictalurus punctatus | 85.17 | 1e-158 | 456 |
LLPS-Xet-1958 | Xenopus tropicalis | 84.79 | 5e-157 | 451 |
LLPS-Asm-3745 | Astyanax mexicanus | 83.96 | 4e-148 | 431 |
LLPS-Cii-1833 | Ciona intestinalis | 62.12 | 4e-70 | 224 |
LLPS-Cis-1333 | Ciona savignyi | 55.45 | 9e-106 | 320 |
LLPS-Drm-2067 | Drosophila melanogaster | 46.65 | 1e-81 | 259 |
LLPS-Sem-1571 | Selaginella moellendorffii | 43.57 | 1e-70 | 230 |
LLPS-Mua-0467 | Musa acuminata | 42.9 | 2e-70 | 230 |
LLPS-Prp-2080 | Prunus persica | 42.9 | 7e-70 | 228 |
LLPS-Sol-1951 | Solanum lycopersicum | 42.59 | 3e-62 | 216 |
LLPS-Amt-1222 | Amborella trichopoda | 42.52 | 4e-65 | 217 |
LLPS-Mae-0659 | Manihot esculenta | 42.27 | 3e-69 | 227 |
LLPS-Viv-1330 | Vitis vinifera | 41.96 | 1e-68 | 225 |
LLPS-Php-1264 | Physcomitrella patens | 41.69 | 9e-63 | 210 |
LLPS-Sot-0228 | Solanum tuberosum | 41.64 | 1e-66 | 220 |
LLPS-Nia-1628 | Nicotiana attenuata | 41.64 | 3e-66 | 219 |
LLPS-Glm-2866 | Glycine max | 41.32 | 1e-66 | 220 |
LLPS-Phv-2021 | Phaseolus vulgaris | 41.32 | 9e-67 | 220 |
LLPS-Brd-2164 | Brachypodium distachyon | 41.01 | 4e-66 | 219 |
LLPS-Via-1428 | Vigna angularis | 41.01 | 6e-66 | 219 |
LLPS-Orni-1937 | Oryza nivara | 41.01 | 7e-66 | 218 |
LLPS-Hea-1124 | Helianthus annuus | 41.01 | 8e-64 | 215 |
LLPS-Ori-1822 | Oryza indica | 41.01 | 7e-66 | 218 |
LLPS-Orb-0046 | Oryza barthii | 41.01 | 7e-66 | 218 |
LLPS-Brn-2935 | Brassica napus | 41.01 | 2e-63 | 212 |
LLPS-Org-0818 | Oryza glaberrima | 41.01 | 7e-66 | 218 |
LLPS-Zem-1755 | Zea mays | 41.01 | 1e-65 | 218 |
LLPS-Orm-0853 | Oryza meridionalis | 41.01 | 9e-66 | 218 |
LLPS-Orr-1446 | Oryza rufipogon | 41.01 | 7e-66 | 218 |
LLPS-Orbr-1816 | Oryza brachyantha | 41.01 | 8e-66 | 218 |
LLPS-Orp-1701 | Oryza punctata | 41.01 | 8e-66 | 218 |
LLPS-Ors-1615 | Oryza sativa | 41.01 | 7e-66 | 218 |
LLPS-Dac-2460 | Daucus carota | 40.88 | 4e-62 | 208 |
LLPS-Lep-2338 | Leersia perrieri | 40.73 | 6e-59 | 202 |
LLPS-Cus-2204 | Cucumis sativus | 40.69 | 6e-65 | 216 |
LLPS-Coc-0703 | Corchorus capsularis | 40.69 | 1e-66 | 220 |
LLPS-Pot-1943 | Populus trichocarpa | 40.69 | 2e-64 | 214 |
LLPS-Brr-1212 | Brassica rapa | 40.69 | 2e-63 | 211 |
LLPS-Sei-0531 | Setaria italica | 40.38 | 4e-61 | 206 |
LLPS-Thc-1949 | Theobroma cacao | 40.38 | 6e-65 | 216 |
LLPS-Gor-2132 | Gossypium raimondii | 40.38 | 2e-64 | 214 |
LLPS-Tru-1852 | Triticum urartu | 40.13 | 1e-57 | 197 |
LLPS-Arl-1105 | Arabidopsis lyrata | 40.06 | 2e-61 | 206 |
LLPS-Hov-2010 | Hordeum vulgare | 40.06 | 5e-63 | 211 |
LLPS-Bro-1197 | Brassica oleracea | 40.06 | 8e-63 | 210 |
LLPS-Art-2271 | Arabidopsis thaliana | 40.06 | 2e-61 | 206 |
LLPS-Tra-1818 | Triticum aestivum | 39.75 | 7e-63 | 210 |
LLPS-Met-1453 | Medicago truncatula | 39.75 | 4e-64 | 213 |
LLPS-Abg-0233 | Absidia glauca | 37.46 | 2e-58 | 199 |
LLPS-Chr-0937 | Chlamydomonas reinhardtii | 37.42 | 5e-55 | 189 |
LLPS-Cae-2012 | Caenorhabditis elegans | 37.09 | 7e-52 | 182 |
LLPS-Sob-2369 | Sorghum bicolor | 36.9 | 1e-52 | 184 |
LLPS-Gas-1042 | Galdieria sulphuraria | 35.88 | 6e-43 | 157 |
LLPS-Orgl-1700 | Oryza glumaepatula | 35.13 | 1e-53 | 184 |
LLPS-Tum-0968 | Tuber melanosporum | 34.81 | 8e-50 | 177 |
LLPS-Vir-1544 | Vigna radiata | 34.5 | 6e-34 | 132 |
LLPS-Asf-0591 | Aspergillus flavus | 34.2 | 3e-49 | 175 |
LLPS-Aso-1555 | Aspergillus oryzae | 34.2 | 3e-49 | 175 |
LLPS-Nef-1518 | Neosartorya fischeri | 34.08 | 9e-46 | 166 |
LLPS-Asfu-1167 | Aspergillus fumigatus | 33.91 | 6e-48 | 172 |
LLPS-Trv-0976 | Trichoderma virens | 33.82 | 9e-47 | 168 |
LLPS-Fus-1054 | Fusarium solani | 33.82 | 1e-46 | 168 |
LLPS-Chc-0615 | Chondrus crispus | 33.73 | 4e-47 | 169 |
LLPS-Trr-1179 | Trichoderma reesei | 33.72 | 5e-47 | 169 |
LLPS-Yal-0481 | Yarrowia lipolytica | 33.63 | 5e-37 | 142 |
LLPS-Asn-1478 | Aspergillus nidulans | 33.62 | 7e-52 | 182 |
LLPS-Asc-0521 | Aspergillus clavatus | 33.62 | 2e-48 | 173 |
LLPS-Osl-0851 | Ostreococcus lucimarinus | 33.54 | 3e-44 | 161 |
LLPS-Ast-1465 | Aspergillus terreus | 33.33 | 2e-50 | 178 |
LLPS-Zyt-1423 | Zymoseptoria tritici | 33.24 | 2e-44 | 162 |
LLPS-Asni-0561 | Aspergillus niger | 33.05 | 2e-48 | 173 |
LLPS-Beb-0502 | Beauveria bassiana | 33.04 | 5e-43 | 159 |
LLPS-Fuo-1372 | Fusarium oxysporum | 32.55 | 1e-47 | 171 |
LLPS-Scc-1330 | Schizosaccharomyces cryophilus | 32.52 | 2e-26 | 112 |
LLPS-Lem-1342 | Leptosphaeria maculans | 32.48 | 8e-42 | 155 |
LLPS-Cogr-1420 | Colletotrichum graminicola | 32.39 | 2e-43 | 159 |
LLPS-Fuv-0264 | Fusarium verticillioides | 32.26 | 3e-47 | 170 |
LLPS-Dos-1359 | Dothistroma septosporum | 32.1 | 3e-44 | 162 |
LLPS-Coo-0703 | Colletotrichum orbiculare | 32.08 | 3e-42 | 156 |
LLPS-Pyt-1367 | Pyrenophora teres | 32.01 | 3e-41 | 154 |
LLPS-Pytr-1502 | Pyrenophora triticirepentis | 31.83 | 2e-39 | 149 |
LLPS-Scs-0708 | Sclerotinia sclerotiorum | 30.77 | 2e-42 | 157 |
LLPS-Ved-0530 | Verticillium dahliae | 30.72 | 7e-42 | 155 |
LLPS-Blg-0771 | Blumeria graminis | 30.03 | 1e-38 | 147 |
LLPS-Phn-1487 | Phaeosphaeria nodorum | 30.0 | 1e-37 | 149 |
LLPS-Nec-1013 | Neurospora crassa | 29.97 | 1e-43 | 160 |
LLPS-Gag-1620 | Gaeumannomyces graminis | 29.83 | 1e-38 | 146 |
LLPS-Scp-1395 | Schizosaccharomyces pombe | 29.64 | 1e-25 | 110 |
LLPS-Map-0520 | Magnaporthe poae | 29.55 | 3e-39 | 148 |
LLPS-Cog-0791 | Colletotrichum gloeosporioides | 29.48 | 1e-41 | 154 |
LLPS-Mao-0848 | Magnaporthe oryzae | 29.46 | 4e-40 | 150 |
LLPS-Scj-0792 | Schizosaccharomyces japonicus | 29.22 | 8e-36 | 139 |
LLPS-Kop-0686 | Komagataella pastoris | 25.87 | 9e-18 | 86.7 |
LLPS-Usm-1549 | Ustilago maydis | 25.86 | 5e-31 | 126 |
LLPS-Spr-1336 | Sporisorium reilianum | 25.57 | 4e-30 | 123 |
LLPS-Pug-0923 | Puccinia graminis | 24.19 | 2e-09 | 62.8 |
LLPS-Mel-0677 | Melampsora laricipopulina | 23.81 | 1e-09 | 63.5 |
LLPS-Crn-1202 | Cryptococcus neoformans | 23.49 | 4e-09 | 61.6 |
LLPS-Put-1053 | Puccinia triticina | 20.8 | 1e-09 | 63.2 |