LLPS-Ran-4642
Itgb1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Integrin beta-1; Beta oligodendroglia; Beta OL; Fibronectin receptor subunit beta; VLA-4 subunit beta
Gene Name: Itgb1
Ensembl Gene: ENSRNOG00000010966.6
Ensembl Protein: ENSRNOP00000014785.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNLQLVFWIG  LISLICSVFG  QTDKNRCLKA  NAKSCGECIQ  AGPNCGWCTN  TTFLQEGMPT  60
61    SARCDDLEAL  KKKGCQPSDI  ENPRGSQTIK  KNKNVTNRSK  GMAEKLRPED  ITQIQPQQLL  120
121   LKLRSGEPQK  FTLKFKRAED  YPIDLYYLMD  LSYSMKDDLE  NVKSLGTDLM  NEMRRITSDF  180
181   RIGFGSFVEK  TVMPYISTTP  AKLRNPCTSE  QNCTSPFSYK  NVLSLTDRGE  FFNELVGQQR  240
241   ISGNLDSPEG  GFDAIMQVAV  CGSLIGWRNV  TRLLVFSTDA  GFHFAGDGKL  GGIVLPNDGQ  300
301   CHLENNVYTM  SHYYDYPSIA  HLVQKLSENN  IQTIFAVTEE  FQPVYKELKN  LIPKSAVGTL  360
361   SGNSSNVIQL  IIDAYNSLSS  EVILENSKLP  DGVTINYKSY  CKNGVNGTGE  NGRKCSNISI  420
421   GDEVQFEISI  TANKCPNKES  ETIKIKPLGF  TEEVEVVLQF  ICKCNCQSHG  IPASPKCHEG  480
481   NGTFECGACR  CNEGRVGRHC  ECSTDEVNSE  DMDAYCRKEN  SSEICSNNGE  CVCGQCVCRK  540
541   RENTNEIYSG  KFCECDNFNC  DRSNGLICGG  NGVCRCRVCE  CYPNYTGSAC  DCSLDTVPCV  600
601   ATNGQICNGR  GICECGACKC  TDPKFQGPTC  ETCQTCLGVC  AEHKECVQCR  AFNKGEKKDT  660
661   CAQECSHFNL  TKVESREKLP  QPVQVDPVTH  CKEKDIDDCW  FYFTYSVNSN  GEAHVHVVET  720
721   PDCPTGPDII  PIVAGVVAGI  VLIGLALLLI  WKLLMIIHDR  REFAKFEKEK  MNAKWDTGEN  780
781   PIYKSAVTTV  VNPKYEGK  798
Nucleotide CDS Sequence (FASTA)
1     ATGAATTTGC  AACTGGTTTT  CTGGATTGGA  TTGATCAGCT  TGATTTGTTC  TGTATTTGGC  60
61    CAAACAGATA  AAAATAGATG  TTTAAAAGCA  AATGCCAAAT  CTTGTGGAGA  ATGTATACAA  120
121   GCAGGGCCAA  ATTGTGGGTG  GTGTACAAAT  ACGACATTTT  TACAAGAAGG  AATGCCTACT  180
181   TCTGCACGAT  GTGATGATTT  AGAAGCTTTG  AAAAAGAAGG  GTTGCCAACC  AAGTGACATA  240
241   GAGAATCCCA  GAGGCTCCCA  AACTATAAAG  AAGAATAAAA  ACGTCACCAA  TCGCAGCAAA  300
301   GGGATGGCAG  AGAAGCTCCG  GCCAGAAGAC  ATTACTCAGA  TCCAACCACA  ACAGCTGCTT  360
361   CTAAAGTTGC  GATCAGGAGA  ACCACAGAAG  TTTACATTAA  AATTCAAGAG  GGCTGAAGAC  420
421   TACCCTATTG  ATCTGTACTA  CCTTATGGAT  CTCTCCTACT  CTATGAAAGA  TGATCTGGAG  480
481   AATGTGAAGA  GTCTTGGGAC  GGATCTGATG  AATGAAATGA  GGAGGATTAC  TTCAGACTTC  540
541   CGCATTGGCT  TTGGCTCATT  TGTGGAGAAA  ACTGTGATGC  CATACATTAG  TACAACACCA  600
601   GCAAAGCTAA  GAAATCCTTG  TACGAGTGAA  CAAAACTGTA  CCAGCCCATT  TAGCTACAAA  660
661   AACGTGCTTA  GTCTTACTGA  CAGAGGAGAG  TTTTTCAATG  AACTTGTTGG  TCAGCAGCGC  720
721   ATATCTGGAA  ACTTGGACTC  TCCAGAAGGT  GGCTTTGATG  CAATCATGCA  GGTTGCAGTT  780
781   TGTGGGTCGC  TGATTGGCTG  GAGGAATGTA  ACACGACTGC  TGGTGTTTTC  CACGGATGCT  840
841   GGGTTTCACT  TTGCTGGAGA  TGGGAAACTT  GGTGGTATTG  TTTTACCCAA  TGATGGCCAG  900
901   TGTCACCTGG  AAAATAATGT  GTATACAATG  AGCCATTACT  ATGATTATCC  TTCAATTGCT  960
961   CACCTTGTTC  AGAAACTAAG  TGAAAATAAT  ATTCAGACGA  TTTTTGCAGT  CACTGAAGAG  1020
1021  TTCCAGCCTG  TTTACAAGGA  ATTGAAGAAT  TTGATTCCTA  AGTCAGCAGT  GGGCACACTG  1080
1081  TCTGGAAACT  CTAGTAATGT  GATACAGCTG  ATTATCGATG  CCTACAATTC  CCTTTCTTCA  1140
1141  GAAGTCATTC  TGGAAAACAG  CAAATTGCCA  GATGGAGTAA  CAATAAATTA  CAAGTCCTAC  1200
1201  TGCAAGAATG  GAGTGAATGG  GACAGGAGAA  AATGGACGAA  AGTGCTCTAA  CATTTCCATT  1260
1261  GGAGATGAGG  TTCAATTTGA  AATTAGCATA  ACTGCTAATA  AATGTCCAAA  CAAGGAGTCT  1320
1321  GAAACAATTA  AAATTAAACC  TCTGGGCTTC  ACAGAAGAAG  TAGAGGTGGT  CCTTCAGTTC  1380
1381  ATCTGTAAGT  GTAATTGTCA  AAGCCATGGC  ATCCCAGCAA  GTCCCAAGTG  CCATGAGGGA  1440
1441  AATGGGACAT  TTGAGTGTGG  AGCCTGCAGG  TGCAATGAGG  GTCGTGTTGG  GAGACACTGT  1500
1501  GAATGTAGCA  CAGATGAAGT  GAACAGTGAA  GACATGGATG  CTTACTGCAG  AAAAGAGAAC  1560
1561  AGCTCAGAGA  TCTGCAGTAA  CAATGGAGAG  TGTGTCTGTG  GACAGTGTGT  GTGCAGGAAG  1620
1621  AGAGAGAATA  CAAATGAAAT  TTACTCCGGC  AAATTCTGCG  AGTGTGATAA  CTTCAACTGC  1680
1681  GATAGGTCCA  ACGGCTTAAT  CTGTGGAGGA  AATGGTGTGT  GCAGGTGTCG  TGTCTGTGAA  1740
1741  TGCTATCCCA  ACTACACTGG  CAGTGCATGT  GACTGTTCCT  TGGACACTGT  TCCATGCGTA  1800
1801  GCGACAAATG  GTCAGATCTG  CAATGGCCGG  GGCATCTGTG  AATGTGGTGC  TTGTAAGTGC  1860
1861  ACAGATCCCA  AGTTCCAAGG  GCCAACCTGT  GAGACCTGTC  AGACCTGCCT  TGGTGTCTGT  1920
1921  GCAGAGCATA  AAGAATGTGT  TCAGTGCAGA  GCCTTCAATA  AAGGAGAAAA  AAAAGACACG  1980
1981  TGTGCACAGG  AGTGCTCCCA  TTTCAACCTC  ACTAAAGTGG  AAAGCAGGGA  GAAGTTGCCC  2040
2041  CAGCCTGTGC  AGGTGGACCC  TGTGACCCAC  TGCAAGGAGA  AGGACATTGA  TGACTGCTGG  2100
2101  TTCTATTTCA  CCTACTCAGT  GAACAGCAAC  GGTGAAGCTC  ACGTGCATGT  TGTGGAGACT  2160
2161  CCAGACTGTC  CTACTGGTCC  CGACATCATC  CCAATTGTAG  CAGGCGTGGT  TGCCGGAATT  2220
2221  GTTCTTATTG  GCCTTGCCTT  GCTGCTGATT  TGGAAACTTT  TAATGATAAT  TCATGACAGA  2280
2281  AGGGAATTTG  CTAAATTTGA  AAAGGAGAAA  ATGAATGCCA  AGTGGGACAC  GGGTGAAAAT  2340
2341  CCTATTTACA  AGAGTGCCGT  GACAACTGTG  GTCAATCCGA  AGTATGAGGG  AAAATGA  2397

▼ KEYWORD

ID
Family
Acetylation
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Disulfide bond
Endosome
Glycoprotein
Integrin
Isopeptide bond
Magnesium
Membrane
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Acrosomal vesicle
Cellular Component
Adherens junction
Cellular Component
Basement membrane
Cellular Component
Cell surface
Cellular Component
Cell-cell junction
Cellular Component
Dendritic spine
Cellular Component
Focal adhesion
Cellular Component
Glial cell projection
Cellular Component
Glutamatergic synapse
Cellular Component
Hemidesmosome
Cellular Component
Integral component of postsynaptic membrane
Cellular Component
Integrin alpha3-beta1 complex
Cellular Component
Integrin alpha9-beta1 complex
Cellular Component
Integrin complex
Cellular Component
Invadopodium membrane
Cellular Component
Lamellipodium
Cellular Component
Melanosome
Cellular Component
Membrane
Cellular Component
Membrane raft
Cellular Component
Plasma membrane
Cellular Component
Postsynaptic membrane
Cellular Component
Recycling endosome
Cellular Component
Ruffle membrane
Molecular Function
Actin binding
Molecular Function
Alpha-actinin binding
Molecular Function
Collagen binding
Molecular Function
Collagen binding involved in cell-matrix adhesion
Molecular Function
Fibronectin binding
Molecular Function
Integrin binding
Molecular Function
Kinase binding
Molecular Function
Laminin binding
Molecular Function
Metal ion binding
Molecular Function
Protease binding
Molecular Function
Protein domain specific binding
Molecular Function
Protein heterodimerization activity
Molecular Function
Protein kinase binding
Molecular Function
Protein-containing complex binding
Molecular Function
Signaling receptor activity
Molecular Function
Signaling receptor binding
Biological Process
Bicellular tight junction assembly
Biological Process
Cell adhesion mediated by integrin
Biological Process
Cell migration
Biological Process
Cell projection organization
Biological Process
Cell-matrix adhesion
Biological Process
Cellular response to ionizing radiation
Biological Process
Cellular response to low-density lipoprotein particle stimulus
Biological Process
Cellular response to mechanical stimulus
Biological Process
Cellular response to vitamin D
Biological Process
Establishment of Sertoli cell barrier
Biological Process
Integrin-mediated signaling pathway
Biological Process
Lamellipodium assembly
Biological Process
Maternal process involved in female pregnancy
Biological Process
Negative regulation of apoptotic process
Biological Process
Negative regulation of cell population proliferation
Biological Process
Negative regulation of cell projection organization
Biological Process
Negative regulation of neuron differentiation
Biological Process
Phagocytosis
Biological Process
Positive regulation of cell migration
Biological Process
Positive regulation of cell-substrate adhesion
Biological Process
Positive regulation of endocytosis
Biological Process
Positive regulation of neuron differentiation
Biological Process
Positive regulation of neuron projection development
Biological Process
Positive regulation of peptidyl-tyrosine phosphorylation
Biological Process
Positive regulation of protein localization to plasma membrane
Biological Process
Protein transport within lipid bilayer
Biological Process
Receptor internalization
Biological Process
Regulation of collagen catabolic process
Biological Process
Regulation of G protein-coupled receptor signaling pathway
Biological Process
Response to activity
Biological Process
Response to drug
Biological Process
Response to gonadotropin
Biological Process
Response to nutrient levels
Biological Process
Response to transforming growth factor beta
Biological Process
Tissue homeostasis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4498Mus musculus99.00.01523
LLPS-Ict-2309Ictidomys tridecemlineatus94.860.01469
LLPS-Caf-3944Canis familiaris93.980.01459
LLPS-Urm-3846Ursus maritimus93.980.01459
LLPS-Dio-1851Dipodomys ordii93.980.01450
LLPS-Aim-3330Ailuropoda melanoleuca93.980.01459
LLPS-Mup-1276Mustela putorius furo93.480.01453
LLPS-Sus-4568Sus scrofa93.480.01454
LLPS-Fud-4125Fukomys damarensis93.450.01442
LLPS-Ova-4318Ovis aries93.360.01453
LLPS-Myl-3058Myotis lucifugus93.230.01453
LLPS-Tut-0291Tursiops truncatus93.180.01414
LLPS-Otg-3059Otolemur garnettii92.980.01413
LLPS-Cas-1845Carlito syrichta92.960.01429
LLPS-Eqc-1247Equus caballus92.860.01438
LLPS-Orc-1714Oryctolagus cuniculus92.860.01436
LLPS-Rhb-1906Rhinopithecus bieti92.610.01439
LLPS-Chs-2653Chlorocebus sabaeus92.610.01434
LLPS-Loa-3509Loxodonta africana92.480.01434
LLPS-Fec-4276Felis catus92.360.01431
LLPS-Cap-1600Cavia porcellus92.330.01423
LLPS-Poa-4109Pongo abelii92.30.01414
LLPS-Bot-3526Bos taurus92.230.01433
LLPS-Caj-0193Callithrix jacchus91.820.01426
LLPS-Aon-4010Aotus nancymaae91.60.01418
LLPS-Man-0394Macaca nemestrina91.570.01412
LLPS-Paa-4591Papio anubis91.570.01412
LLPS-Maf-2664Macaca fascicularis91.570.01412
LLPS-Mam-1671Macaca mulatta91.450.01411
LLPS-Nol-4242Nomascus leucogenys91.070.01408
LLPS-Hos-2275Homo sapiens90.850.01405
LLPS-Gog-2765Gorilla gorilla90.850.01405
LLPS-Pap-0262Pan paniscus90.730.01404
LLPS-Pat-2744Pan troglodytes90.60.01401
LLPS-Ora-1844Ornithorhynchus anatinus90.240.01389
LLPS-Sah-3798Sarcophilus harrisii89.740.01368
LLPS-Cea-4515Cercocebus atys89.560.01374
LLPS-Fia-1331Ficedula albicollis88.330.01100
LLPS-Mod-4118Monodelphis domestica87.940.01338
LLPS-Meg-3107Meleagris gallopavo84.860.01310
LLPS-Tag-2959Taeniopygia guttata84.80.01303
LLPS-Anp-2821Anas platyrhynchos84.540.01309
LLPS-Gaga-1372Gallus gallus83.670.01283
LLPS-Mal-2254Mandrillus leucophaeus83.270.01284
LLPS-Anc-3926Anolis carolinensis80.580.01226
LLPS-Xet-1524Xenopus tropicalis80.50.01241
LLPS-Lac-3553Latimeria chalumnae80.150.01209
LLPS-Pes-1674Pelodiscus sinensis79.80.01212
LLPS-Leo-2024Lepisosteus oculatus78.00.01200
LLPS-Scm-3707Scophthalmus maximus77.620.01159
LLPS-Dar-4162Danio rerio77.510.01182
LLPS-Asm-2261Astyanax mexicanus76.970.01172
LLPS-Gaa-3273Gasterosteus aculeatus76.750.01170
LLPS-Scf-3688Scleropages formosus75.910.01142
LLPS-Orn-2216Oreochromis niloticus75.580.01125
LLPS-Icp-3840Ictalurus punctatus75.220.01143
LLPS-Ten-2729Tetraodon nigroviridis75.190.01123
LLPS-Orl-1840Oryzias latipes74.380.01136
LLPS-Tar-1760Takifugu rubripes74.120.01124
LLPS-Xim-1230Xiphophorus maculatus73.00.01103
LLPS-Pof-2525Poecilia formosa71.890.01095
LLPS-Cii-0447Ciona intestinalis42.589e-156 478
LLPS-Drm-2251Drosophila melanogaster41.572e-178 541
LLPS-Cae-1521Caenorhabditis elegans41.185e-178 539
LLPS-Cis-1494Ciona savignyi38.464e-138 435