LLPS-Ran-2316
Eif6

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 6
Gene Name: Eif6, Itgb4bp
Ensembl Gene: ENSRNOG00000049497.2
Ensembl Protein: ENSRNOP00000071658.1
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAVRASFENN  CEVGCFAKLT  NTYCLVAIGG  SENFYSVFEG  ELSDTIPVVH  ASIAGCRIIG  60
61    RMCVGNRHGL  LVPNNTTDQE  LQHIRNSLPD  SVQIRRVEER  LSALGNVTTC  NDYVALVHPD  120
121   LDRETEEILA  DVLKVEVFRQ  TVADQVLVGS  YCVFSNQGGL  VHPKTSIEDQ  DELSSLLQVP  180
181   LVAGTVNRGS  EVIAAGMVVN  DWCAFCGLDT  TSTELSVVES  VFKLNEAKPS  TIATSMRDSL  240
241   IDRSLT  246
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGTCA  GAGCGTCGTT  CGAGAACAAC  TGTGAGGTCG  GTTGTTTTGC  CAAACTCACT  60
61    AACACCTACT  GCCTGGTGGC  CATCGGAGGG  TCAGAGAACT  TCTACAGTGT  GTTCGAGGGC  120
121   GAGCTCTCCG  ATACCATTCC  TGTAGTGCAC  GCATCCATCG  CCGGCTGCCG  AATCATCGGG  180
181   CGCATGTGTG  TGGGGAACAG  GCATGGGCTG  CTGGTACCCA  ACAACACCAC  CGACCAGGAG  240
241   CTGCAGCATA  TCCGCAACAG  CCTTCCGGAT  TCAGTGCAGA  TACGGCGGGT  AGAGGAGCGG  300
301   CTCTCAGCCC  TTGGCAATGT  CACCACCTGC  AATGACTATG  TGGCCTTGGT  CCACCCAGAC  360
361   TTGGATAGGG  AGACAGAAGA  AATCCTGGCT  GATGTGCTCA  AGGTGGAAGT  CTTCAGGCAG  420
421   ACGGTTGCTG  ACCAGGTGTT  AGTTGGAAGC  TACTGTGTCT  TCAGTAATCA  AGGAGGTCTG  480
481   GTGCACCCTA  AAACTTCGAT  CGAGGATCAG  GATGAGCTGT  CCTCCCTTCT  TCAGGTTCCC  540
541   CTTGTGGCAG  GCACTGTGAA  CCGAGGGAGC  GAGGTGATTG  CTGCCGGGAT  GGTAGTGAAT  600
601   GATTGGTGTG  CTTTCTGTGG  CCTGGACACG  ACCAGCACAG  AGCTGTCAGT  GGTGGAGAGT  660
661   GTCTTCAAGC  TGAATGAAGC  CAAACCTAGC  ACCATTGCCA  CCAGCATGCG  GGACTCCCTC  720
721   ATTGACAGAT  CACTGACC  738

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Nucleus
Phosphoprotein
Protein biosynthesis
Reference proteome
Ribosome biogenesis

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleolus
Cellular Component
Preribosome, large subunit precursor
Molecular Function
Ribosomal large subunit binding
Molecular Function
Ribosome binding
Molecular Function
Translation initiation factor activity
Biological Process
Assembly of large subunit precursor of preribosome
Biological Process
Gene silencing by miRNA
Biological Process
Mature ribosome assembly
Biological Process
MiRNA mediated inhibition of translation
Biological Process
Positive regulation of translation
Biological Process
Regulation of fatty acid biosynthetic process
Biological Process
Regulation of glycolytic process
Biological Process
Regulation of megakaryocyte differentiation
Biological Process
Regulation of reactive oxygen species metabolic process
Biological Process
Response to insulin
Biological Process
Ribosomal large subunit biogenesis
Biological Process
Ribosomal subunit export from nucleus

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-0724Mus musculus98.781e-176 493
LLPS-Gog-0605Gorilla gorilla98.722e-170 478
LLPS-Mal-0272Mandrillus leucophaeus98.375e-177 494
LLPS-Paa-2362Papio anubis98.374e-177 495
LLPS-Aon-1324Aotus nancymaae98.373e-178 498
LLPS-Cea-0461Cercocebus atys98.374e-177 495
LLPS-Chs-0426Chlorocebus sabaeus98.375e-177 494
LLPS-Mea-1234Mesocricetus auratus98.374e-176 492
LLPS-Maf-0199Macaca fascicularis98.375e-177 494
LLPS-Caj-0749Callithrix jacchus98.377e-178 498
LLPS-Nol-0777Nomascus leucogenys98.375e-177 494
LLPS-Man-0762Macaca nemestrina98.375e-177 494
LLPS-Pap-1605Pan paniscus98.375e-177 494
LLPS-Pat-0111Pan troglodytes98.375e-177 494
LLPS-Hos-1849Homo sapiens98.375e-177 494
LLPS-Rhb-0534Rhinopithecus bieti98.375e-177 494
LLPS-Eqc-0180Equus caballus98.356e-176 491
LLPS-Cas-1872Carlito syrichta98.354e-175 490
LLPS-Sah-0864Sarcophilus harrisii98.112e-148 420
LLPS-Mod-1029Monodelphis domestica97.974e-176 491
LLPS-Fec-0390Felis catus97.976e-176 491
LLPS-Aim-1446Ailuropoda melanoleuca97.942e-175 490
LLPS-Otg-0086Otolemur garnettii97.947e-176 492
LLPS-Caf-0140Canis familiaris97.931e-174 488
LLPS-Dio-0383Dipodomys ordii97.561e-175 490
LLPS-Mup-0576Mustela putorius furo97.561e-174 488
LLPS-Sus-0781Sus scrofa97.562e-175 490
LLPS-Poa-0115Pongo abelii97.566e-176 491
LLPS-Urm-2394Ursus maritimus97.561e-174 488
LLPS-Myl-0520Myotis lucifugus97.552e-176 493
LLPS-Fud-2304Fukomys damarensis97.533e-175 489
LLPS-Orc-0484Oryctolagus cuniculus97.522e-174 488
LLPS-Ict-0683Ictidomys tridecemlineatus97.463e-170 477
LLPS-Bot-0634Bos taurus97.452e-168 472
LLPS-Ova-0658Ovis aries97.142e-175 490
LLPS-Cap-0898Cavia porcellus97.121e-174 488
LLPS-Tut-1153Tursiops truncatus96.345e-174 486
LLPS-Loa-0986Loxodonta africana95.512e-174 488
LLPS-Pes-0118Pelodiscus sinensis95.221e-144 410
LLPS-Xet-2828Xenopus tropicalis93.981e-87 263
LLPS-Ora-0627Ornithorhynchus anatinus93.964e-120 348
LLPS-Gaga-1911Gallus gallus93.81e-167 470
LLPS-Meg-0111Meleagris gallopavo93.51e-167 470
LLPS-Tag-0027Taeniopygia guttata93.394e-167 469
LLPS-Anc-1012Anolis carolinensis93.097e-169 473
LLPS-Anp-1184Anas platyrhynchos92.98e-121 349
LLPS-Leo-2208Lepisosteus oculatus92.282e-165 464
LLPS-Xim-1374Xiphophorus maculatus92.181e-164 462
LLPS-Pof-0157Poecilia formosa92.181e-164 462
LLPS-Lac-0271Latimeria chalumnae91.871e-77 237
LLPS-Orl-2433Oryzias latipes91.779e-164 460
LLPS-Icp-0248Ictalurus punctatus91.468e-165 463
LLPS-Asm-0744Astyanax mexicanus91.466e-165 463
LLPS-Orn-1352Oreochromis niloticus91.091e-163 460
LLPS-Fia-0063Ficedula albicollis91.062e-163 460
LLPS-Scf-0269Scleropages formosus90.657e-163 458
LLPS-Dar-0303Danio rerio90.651e-163 460
LLPS-Tar-1861Takifugu rubripes90.162e-158 453
LLPS-Scm-1936Scophthalmus maximus90.126e-162 456
LLPS-Gaa-1213Gasterosteus aculeatus89.713e-161 454
LLPS-Ten-1449Tetraodon nigroviridis89.68e-161 453
LLPS-Cii-0521Ciona intestinalis85.121e-150 427
LLPS-Cis-0060Ciona savignyi84.362e-149 424
LLPS-Drm-0881Drosophila melanogaster77.691e-143 409
LLPS-Abg-0326Absidia glauca76.865e-143 408
LLPS-Glm-0451Glycine max76.454e-136 390
LLPS-Gor-2521Gossypium raimondii76.452e-135 392
LLPS-Sem-0867Selaginella moellendorffii76.031e-133 384
LLPS-Mua-0595Musa acuminata76.032e-136 391
LLPS-Php-0070Physcomitrella patens76.036e-134 385
LLPS-Coc-1381Corchorus capsularis76.031e-135 389
LLPS-Asfu-0241Aspergillus fumigatus75.983e-127 368
LLPS-Nef-0072Neosartorya fischeri75.983e-127 368
LLPS-Via-0566Vigna angularis75.623e-135 388
LLPS-Pot-0485Populus trichocarpa75.622e-134 386
LLPS-Viv-0361Vitis vinifera75.621e-134 386
LLPS-Thc-1176Theobroma cacao75.214e-134 385
LLPS-Mae-0335Manihot esculenta75.218e-134 384
LLPS-Phv-0709Phaseolus vulgaris75.213e-135 388
LLPS-Brd-0063Brachypodium distachyon74.795e-134 385
LLPS-Sei-0047Setaria italica74.791e-133 384
LLPS-Sob-0327Sorghum bicolor74.792e-134 386
LLPS-Fuv-0047Fusarium verticillioides74.492e-132 381
LLPS-Fuo-0638Fusarium oxysporum74.492e-132 381
LLPS-Tra-0068Triticum aestivum74.381e-133 384
LLPS-Scc-0030Schizosaccharomyces cryophilus74.384e-132 380
LLPS-Hea-0497Helianthus annuus74.382e-134 386
LLPS-Prp-0384Prunus persica74.385e-134 385
LLPS-Zem-0444Zea mays74.383e-134 385
LLPS-Orbr-0578Oryza brachyantha74.382e-133 384
LLPS-Spr-0089Sporisorium reilianum74.072e-131 378
LLPS-Usm-0777Ustilago maydis74.074e-131 377
LLPS-Orgl-0599Oryza glumaepatula73.972e-132 381
LLPS-Ori-0424Oryza indica73.972e-132 381
LLPS-Orb-0241Oryza barthii73.972e-132 381
LLPS-Orni-0294Oryza nivara73.972e-132 381
LLPS-Orm-0202Oryza meridionalis73.972e-132 381
LLPS-Orr-1507Oryza rufipogon73.972e-132 381
LLPS-Org-0365Oryza glaberrima73.972e-132 381
LLPS-Orp-0105Oryza punctata73.972e-132 381
LLPS-Ors-0656Oryza sativa73.972e-132 381
LLPS-Asni-0753Aspergillus niger73.826e-127 367
LLPS-Dac-1449Daucus carota73.799e-109 320
LLPS-Amt-0304Amborella trichopoda73.731e-127 370
LLPS-Scs-0132Sclerotinia sclerotiorum73.662e-131 379
LLPS-Trv-0090Trichoderma virens73.661e-132 381
LLPS-Trr-0760Trichoderma reesei73.661e-132 381
LLPS-Hov-0643Hordeum vulgare73.554e-131 378
LLPS-Brn-0114Brassica napus73.552e-133 384
LLPS-Bro-1910Brassica oleracea73.553e-133 383
LLPS-Art-0635Arabidopsis thaliana73.556e-134 385
LLPS-Brr-0575Brassica rapa73.552e-133 384
LLPS-Nia-0795Nicotiana attenuata73.556e-132 380
LLPS-Pug-0185Puccinia graminis73.368e-129 372
LLPS-Gag-0108Gaeumannomyces graminis73.255e-130 375
LLPS-Mao-0265Magnaporthe oryzae73.252e-129 374
LLPS-Ved-1191Verticillium dahliae73.254e-131 377
LLPS-Arl-0556Arabidopsis lyrata73.143e-133 383
LLPS-Cus-0722Cucumis sativus73.141e-130 377
LLPS-Vir-0813Vigna radiata72.984e-132 380
LLPS-Put-0362Puccinia triticina72.954e-128 370
LLPS-Fus-0429Fusarium solani72.844e-131 377
LLPS-Scp-0453Schizosaccharomyces pombe72.732e-130 375
LLPS-Kop-0526Komagataella pastoris72.732e-132 381
LLPS-Sac-0417Saccharomyces cerevisiae72.732e-133 384
LLPS-Met-1424Medicago truncatula72.737e-131 377
LLPS-Chr-0685Chlamydomonas reinhardtii72.731e-130 376
LLPS-Sot-0968Solanum tuberosum72.314e-129 372
LLPS-Sol-0424Solanum lycopersicum72.313e-129 373
LLPS-Asg-0086Ashbya gossypii72.311e-131 379
LLPS-Lem-0256Leptosphaeria maculans72.024e-129 372
LLPS-Tum-0158Tuber melanosporum72.023e-128 370
LLPS-Crn-0755Cryptococcus neoformans72.023e-131 378
LLPS-Map-0024Magnaporthe poae72.025e-129 372
LLPS-Beb-0927Beauveria bassiana72.021e-129 374
LLPS-Yal-0649Yarrowia lipolytica72.03e-119 347
LLPS-Ast-0261Aspergillus terreus71.99e-130 374
LLPS-Asn-0338Aspergillus nidulans71.721e-127 369
LLPS-Zyt-0121Zymoseptoria tritici71.69e-128 369
LLPS-Nec-0697Neurospora crassa71.61e-127 369
LLPS-Cogr-0832Colletotrichum graminicola71.62e-128 370
LLPS-Phn-0338Phaeosphaeria nodorum71.61e-128 371
LLPS-Miv-0408Microbotryum violaceum71.69e-127 367
LLPS-Cog-0127Colletotrichum gloeosporioides71.63e-129 373
LLPS-Chc-0415Chondrus crispus71.491e-127 369
LLPS-Scj-0528Schizosaccharomyces japonicus71.499e-129 372
LLPS-Asf-0994Aspergillus flavus71.313e-128 370
LLPS-Asc-0258Aspergillus clavatus71.313e-127 368
LLPS-Pyt-0792Pyrenophora teres71.196e-128 370
LLPS-Coo-1347Colletotrichum orbiculare71.191e-128 371
LLPS-Pytr-0123Pyrenophora triticirepentis71.196e-128 370
LLPS-Dos-0400Dothistroma septosporum71.193e-129 373
LLPS-Lep-0036Leersia perrieri70.591e-129 374
LLPS-Blg-1094Blumeria graminis69.559e-125 362
LLPS-Gas-0577Galdieria sulphuraria69.552e-122 355
LLPS-Tru-0785Triticum urartu69.017e-123 357
LLPS-Cym-0025Cyanidioschyzon merolae68.837e-123 357
LLPS-Osl-0024Ostreococcus lucimarinus67.974e-117 342
LLPS-Mel-0000Melampsora laricipopulina66.541e-121 355
LLPS-Mam-1133Macaca mulatta66.143e-97 291
LLPS-Cae-0001Caenorhabditis elegans64.635e-114 334
LLPS-Aso-0233Aspergillus oryzae64.314e-121 353