LLPS-Loa-0986
EIF6
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Eukaryotic translation initiation factor 6 |
| Gene Name: | EIF6, ITGB4BP |
| Ensembl Gene: | ENSLAFG00000012356.2 |
| Ensembl Protein: | ENSLAFP00000010332.2 |
| Organism: | Loxodonta africana |
| Taxa ID: | 9785 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSLAFT00000012356.2 | ENSLAFP00000010332.2 |
| UniProt | G3T994, G3T994_LOXAF |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELADTIPVIH ASIAGCRIIG 60 61 RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD SVQIRRVEER FSALGNVTTC NDYVALVHPD 120 121 LDRDTEEILA DVLKVEVFRQ TVADQVLVGS YSIFSNQGGL VHPKTSIEDQ DELSSLLQVP 180 181 LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS AIATSMRDSL 240 241 VDRYL 245 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGTCC GAGCGTCTTT CGAGAACAAC TGTGAGATCG GCTGCTTTGC TAAGCTCACC 60 61 AACACCTACT GCCTGGTGGC CATCGGGGGA TCAGAGAACT TCTACAGTGT GTTCGAGGGT 120 121 GAGCTCGCTG ATACCATTCC CGTGATACAC GCGTCCATCG CCGGCTGCCG GATCATCGGG 180 181 CGCATGTGTG TGGGGAACAG GCATGGTCTC TTGGTGCCCA ACAACACCAC CGACCAGGAG 240 241 CTACAACACA TTCGCAACTC CCTCCCAGAC TCGGTGCAGA TCCGTCGGGT AGAGGAACGG 300 301 TTCTCGGCCC TAGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 360 361 CTGGACAGGG ACACAGAAGA AATCCTTGCT GATGTGCTCA AGGTGGAAGT CTTCAGACAG 420 421 ACAGTGGCTG ACCAGGTGCT AGTAGGAAGC TACTCTATCT TCAGCAATCA GGGAGGGCTA 480 481 GTGCATCCCA AGACTTCAAT TGAAGACCAG GACGAGCTGT CCTCTCTCCT TCAGGTGCCC 540 541 CTTGTGGCGG GCACTGTGAA TCGAGGCAGC GAGGTGATTG CTGCTGGGAT GGTGGTAAAT 600 601 GACTGGTGTG CCTTCTGCGG CCTGGATACA ACCAGCACGG AACTATCAGT GGTGGAGAGT 660 661 GTCTTCAAGC TGAATGAAGC TCAGCCTAGC GCCATTGCCA CCAGCATGCG GGATTCCCTC 720 721 GTTGACAGGT ACCTG 735 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Lamin filament | |
Cellular Component | Nucleolus | |
Molecular Function | Ribosomal large subunit binding | |
Molecular Function | Ribosome binding | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Mature ribosome assembly | |
Biological Process | Positive regulation of translation | |
Biological Process | Regulation of fatty acid biosynthetic process | |
Biological Process | Regulation of glycolytic process | |
Biological Process | Regulation of megakaryocyte differentiation | |
Biological Process | Regulation of reactive oxygen species metabolic process | |
Biological Process | Response to insulin | |
Biological Process | Ribosomal large subunit biogenesis | |
Biological Process | Ribosomal subunit export from nucleus |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mup-0576 | Mustela putorius furo | 97.11 | 2e-174 | 487 |
| LLPS-Urm-2394 | Ursus maritimus | 97.11 | 2e-174 | 487 |
| LLPS-Caf-0140 | Canis familiaris | 97.11 | 2e-174 | 487 |
| LLPS-Aim-1446 | Ailuropoda melanoleuca | 96.73 | 3e-176 | 492 |
| LLPS-Fec-0390 | Felis catus | 96.69 | 2e-173 | 485 |
| LLPS-Mod-1029 | Monodelphis domestica | 96.69 | 4e-174 | 486 |
| LLPS-Eqc-0180 | Equus caballus | 96.69 | 2e-173 | 485 |
| LLPS-Cas-1872 | Carlito syrichta | 96.69 | 1e-172 | 484 |
| LLPS-Gog-0605 | Gorilla gorilla | 96.58 | 2e-167 | 470 |
| LLPS-Aon-1324 | Aotus nancymaae | 96.33 | 7e-176 | 493 |
| LLPS-Cea-0461 | Cercocebus atys | 96.33 | 4e-175 | 490 |
| LLPS-Caj-0749 | Callithrix jacchus | 96.33 | 1e-175 | 492 |
| LLPS-Paa-2362 | Papio anubis | 96.33 | 4e-175 | 490 |
| LLPS-Myl-0520 | Myotis lucifugus | 96.33 | 3e-175 | 489 |
| LLPS-Otg-0086 | Otolemur garnettii | 96.31 | 2e-174 | 488 |
| LLPS-Maf-0199 | Macaca fascicularis | 96.28 | 1e-173 | 485 |
| LLPS-Chs-0426 | Chlorocebus sabaeus | 96.28 | 1e-173 | 485 |
| LLPS-Sus-0781 | Sus scrofa | 96.28 | 7e-173 | 483 |
| LLPS-Mal-0272 | Mandrillus leucophaeus | 96.28 | 1e-173 | 485 |
| LLPS-Pat-0111 | Pan troglodytes | 96.28 | 1e-173 | 485 |
| LLPS-Pap-1605 | Pan paniscus | 96.28 | 1e-173 | 485 |
| LLPS-Hos-1849 | Homo sapiens | 96.28 | 1e-173 | 485 |
| LLPS-Man-0762 | Macaca nemestrina | 96.28 | 1e-173 | 485 |
| LLPS-Rhb-0534 | Rhinopithecus bieti | 96.28 | 1e-173 | 485 |
| LLPS-Poa-0115 | Pongo abelii | 96.28 | 4e-173 | 484 |
| LLPS-Nol-0777 | Nomascus leucogenys | 96.28 | 1e-173 | 485 |
| LLPS-Ict-0683 | Ictidomys tridecemlineatus | 96.19 | 5e-168 | 471 |
| LLPS-Bot-0634 | Bos taurus | 96.17 | 2e-166 | 467 |
| LLPS-Ova-0658 | Ovis aries | 95.92 | 3e-174 | 487 |
| LLPS-Fud-2304 | Fukomys damarensis | 95.9 | 5e-174 | 486 |
| LLPS-Orc-0484 | Oryctolagus cuniculus | 95.87 | 3e-171 | 479 |
| LLPS-Ran-2316 | Rattus norvegicus | 95.51 | 2e-174 | 488 |
| LLPS-Dio-0383 | Dipodomys ordii | 95.45 | 3e-172 | 482 |
| LLPS-Sah-0864 | Sarcophilus harrisii | 95.19 | 1e-144 | 411 |
| LLPS-Cap-0898 | Cavia porcellus | 95.1 | 2e-173 | 485 |
| LLPS-Mum-0724 | Mus musculus | 95.04 | 8e-172 | 481 |
| LLPS-Tut-1153 | Tursiops truncatus | 95.04 | 1e-171 | 480 |
| LLPS-Mea-1234 | Mesocricetus auratus | 94.63 | 4e-171 | 479 |
| LLPS-Ora-0627 | Ornithorhynchus anatinus | 92.7 | 4e-118 | 342 |
| LLPS-Pes-0118 | Pelodiscus sinensis | 91.87 | 4e-141 | 402 |
| LLPS-Xet-2828 | Xenopus tropicalis | 91.73 | 3e-86 | 259 |
| LLPS-Leo-2208 | Lepisosteus oculatus | 91.32 | 3e-163 | 459 |
| LLPS-Meg-0111 | Meleagris gallopavo | 91.32 | 2e-164 | 462 |
| LLPS-Gaga-1911 | Gallus gallus | 91.32 | 2e-164 | 462 |
| LLPS-Anc-1012 | Anolis carolinensis | 91.32 | 2e-165 | 464 |
| LLPS-Xim-1374 | Xiphophorus maculatus | 90.95 | 4e-162 | 456 |
| LLPS-Pof-0157 | Poecilia formosa | 90.95 | 4e-162 | 456 |
| LLPS-Tag-0027 | Taeniopygia guttata | 90.91 | 9e-164 | 460 |
| LLPS-Asm-0744 | Astyanax mexicanus | 90.5 | 6e-163 | 458 |
| LLPS-Dar-0303 | Danio rerio | 90.5 | 5e-162 | 456 |
| LLPS-Anp-1184 | Anas platyrhynchos | 90.5 | 2e-117 | 340 |
| LLPS-Lac-0271 | Latimeria chalumnae | 90.24 | 1e-76 | 235 |
| LLPS-Orl-2433 | Oryzias latipes | 89.71 | 5e-161 | 453 |
| LLPS-Icp-0248 | Ictalurus punctatus | 89.67 | 3e-161 | 454 |
| LLPS-Scf-0269 | Scleropages formosus | 89.67 | 7e-161 | 453 |
| LLPS-Tar-1861 | Takifugu rubripes | 89.43 | 2e-158 | 453 |
| LLPS-Orn-1352 | Oreochromis niloticus | 89.3 | 7e-160 | 451 |
| LLPS-Scm-1936 | Scophthalmus maximus | 88.89 | 8e-160 | 450 |
| LLPS-Fia-0063 | Ficedula albicollis | 88.84 | 4e-160 | 451 |
| LLPS-Ten-1449 | Tetraodon nigroviridis | 88.35 | 5e-158 | 446 |
| LLPS-Gaa-1213 | Gasterosteus aculeatus | 88.16 | 2e-160 | 452 |
| LLPS-Cii-0521 | Ciona intestinalis | 83.47 | 6e-149 | 423 |
| LLPS-Cis-0060 | Ciona savignyi | 82.72 | 2e-147 | 419 |
| LLPS-Abg-0326 | Absidia glauca | 76.64 | 1e-142 | 406 |
| LLPS-Drm-0881 | Drosophila melanogaster | 76.03 | 7e-142 | 405 |
| LLPS-Sem-0867 | Selaginella moellendorffii | 75.62 | 3e-134 | 385 |
| LLPS-Phv-0709 | Phaseolus vulgaris | 75.1 | 2e-135 | 388 |
| LLPS-Php-0070 | Physcomitrella patens | 74.79 | 1e-131 | 379 |
| LLPS-Via-0566 | Vigna angularis | 74.69 | 4e-135 | 387 |
| LLPS-Gor-2521 | Gossypium raimondii | 74.69 | 1e-134 | 390 |
| LLPS-Spr-0089 | Sporisorium reilianum | 74.69 | 3e-133 | 383 |
| LLPS-Glm-0451 | Glycine max | 74.29 | 2e-135 | 389 |
| LLPS-Coc-1381 | Corchorus capsularis | 74.29 | 4e-135 | 388 |
| LLPS-Usm-0777 | Ustilago maydis | 74.29 | 3e-132 | 380 |
| LLPS-Scc-0030 | Schizosaccharomyces cryophilus | 74.18 | 1e-131 | 379 |
| LLPS-Viv-0361 | Vitis vinifera | 73.88 | 3e-134 | 385 |
| LLPS-Hea-0497 | Helianthus annuus | 73.47 | 3e-134 | 385 |
| LLPS-Thc-1176 | Theobroma cacao | 73.47 | 2e-133 | 384 |
| LLPS-Mua-0595 | Musa acuminata | 73.47 | 2e-134 | 386 |
| LLPS-Brd-0063 | Brachypodium distachyon | 73.47 | 3e-134 | 385 |
| LLPS-Pot-0485 | Populus trichocarpa | 73.47 | 6e-133 | 382 |
| LLPS-Mae-0335 | Manihot esculenta | 73.47 | 2e-133 | 384 |
| LLPS-Nia-0795 | Nicotiana attenuata | 73.47 | 2e-132 | 381 |
| LLPS-Zem-0444 | Zea mays | 73.47 | 3e-134 | 385 |
| LLPS-Fuv-0047 | Fusarium verticillioides | 73.06 | 2e-131 | 378 |
| LLPS-Sei-0047 | Setaria italica | 73.06 | 3e-133 | 383 |
| LLPS-Tra-0068 | Triticum aestivum | 73.06 | 1e-133 | 384 |
| LLPS-Orbr-0578 | Oryza brachyantha | 73.06 | 1e-133 | 384 |
| LLPS-Sob-0327 | Sorghum bicolor | 73.06 | 4e-134 | 385 |
| LLPS-Fuo-0638 | Fusarium oxysporum | 73.06 | 2e-131 | 378 |
| LLPS-Vir-0813 | Vigna radiata | 72.91 | 1e-132 | 381 |
| LLPS-Cym-0025 | Cyanidioschyzon merolae | 72.77 | 8e-121 | 352 |
| LLPS-Orb-0241 | Oryza barthii | 72.65 | 1e-132 | 381 |
| LLPS-Scs-0132 | Sclerotinia sclerotiorum | 72.65 | 9e-131 | 377 |
| LLPS-Ori-0424 | Oryza indica | 72.65 | 1e-132 | 381 |
| LLPS-Orni-0294 | Oryza nivara | 72.65 | 1e-132 | 381 |
| LLPS-Orgl-0599 | Oryza glumaepatula | 72.65 | 1e-132 | 381 |
| LLPS-Ors-0656 | Oryza sativa | 72.65 | 1e-132 | 381 |
| LLPS-Orp-0105 | Oryza punctata | 72.65 | 1e-132 | 381 |
| LLPS-Orr-1507 | Oryza rufipogon | 72.65 | 1e-132 | 381 |
| LLPS-Orm-0202 | Oryza meridionalis | 72.65 | 1e-132 | 381 |
| LLPS-Prp-0384 | Prunus persica | 72.65 | 2e-133 | 384 |
| LLPS-Org-0365 | Oryza glaberrima | 72.65 | 1e-132 | 381 |
| LLPS-Scp-0453 | Schizosaccharomyces pombe | 72.54 | 8e-130 | 374 |
| LLPS-Hov-0643 | Hordeum vulgare | 72.24 | 3e-131 | 378 |
| LLPS-Trr-0760 | Trichoderma reesei | 72.24 | 1e-131 | 379 |
| LLPS-Trv-0090 | Trichoderma virens | 72.24 | 1e-131 | 379 |
| LLPS-Amt-0304 | Amborella trichopoda | 71.97 | 5e-127 | 368 |
| LLPS-Gag-0108 | Gaeumannomyces graminis | 71.84 | 3e-128 | 370 |
| LLPS-Mao-0265 | Magnaporthe oryzae | 71.84 | 8e-128 | 369 |
| LLPS-Cus-0722 | Cucumis sativus | 71.84 | 5e-131 | 377 |
| LLPS-Ved-1191 | Verticillium dahliae | 71.84 | 2e-129 | 373 |
| LLPS-Dac-1449 | Daucus carota | 71.77 | 7e-108 | 317 |
| LLPS-Chr-0685 | Chlamydomonas reinhardtii | 71.49 | 3e-129 | 373 |
| LLPS-Sol-0424 | Solanum lycopersicum | 71.43 | 1e-128 | 371 |
| LLPS-Brn-0114 | Brassica napus | 71.43 | 4e-132 | 380 |
| LLPS-Sot-0968 | Solanum tuberosum | 71.43 | 1e-128 | 371 |
| LLPS-Art-0635 | Arabidopsis thaliana | 71.43 | 2e-132 | 381 |
| LLPS-Pug-0185 | Puccinia graminis | 71.43 | 2e-126 | 366 |
| LLPS-Brr-0575 | Brassica rapa | 71.43 | 4e-132 | 380 |
| LLPS-Miv-0408 | Microbotryum violaceum | 71.43 | 3e-125 | 363 |
| LLPS-Fus-0429 | Fusarium solani | 71.43 | 9e-130 | 374 |
| LLPS-Bro-1910 | Brassica oleracea | 71.43 | 7e-132 | 379 |
| LLPS-Crn-0755 | Cryptococcus neoformans | 71.31 | 1e-130 | 376 |
| LLPS-Scj-0528 | Schizosaccharomyces japonicus | 71.31 | 2e-128 | 370 |
| LLPS-Sac-0417 | Saccharomyces cerevisiae | 71.31 | 6e-132 | 380 |
| LLPS-Met-1424 | Medicago truncatula | 71.02 | 6e-130 | 374 |
| LLPS-Arl-0556 | Arabidopsis lyrata | 71.02 | 8e-132 | 379 |
| LLPS-Put-0362 | Puccinia triticina | 71.02 | 6e-126 | 364 |
| LLPS-Cogr-0832 | Colletotrichum graminicola | 71.02 | 3e-127 | 368 |
| LLPS-Kop-0526 | Komagataella pastoris | 70.9 | 4e-131 | 377 |
| LLPS-Chc-0415 | Chondrus crispus | 70.66 | 8e-126 | 364 |
| LLPS-Map-0024 | Magnaporthe poae | 70.61 | 2e-127 | 369 |
| LLPS-Lem-0256 | Leptosphaeria maculans | 70.61 | 9e-128 | 369 |
| LLPS-Tum-0158 | Tuber melanosporum | 70.61 | 4e-126 | 365 |
| LLPS-Ast-0261 | Aspergillus terreus | 70.49 | 8e-129 | 372 |
| LLPS-Asn-0338 | Aspergillus nidulans | 70.33 | 2e-126 | 366 |
| LLPS-Nef-0072 | Neosartorya fischeri | 70.33 | 3e-126 | 365 |
| LLPS-Asfu-0241 | Aspergillus fumigatus | 70.33 | 3e-126 | 365 |
| LLPS-Nec-0697 | Neurospora crassa | 70.2 | 2e-126 | 365 |
| LLPS-Zyt-0121 | Zymoseptoria tritici | 70.2 | 8e-127 | 367 |
| LLPS-Beb-0927 | Beauveria bassiana | 70.2 | 1e-127 | 369 |
| LLPS-Cog-0127 | Colletotrichum gloeosporioides | 70.2 | 2e-127 | 369 |
| LLPS-Dos-0400 | Dothistroma septosporum | 70.2 | 1e-128 | 371 |
| LLPS-Phn-0338 | Phaeosphaeria nodorum | 70.2 | 4e-127 | 367 |
| LLPS-Yal-0649 | Yarrowia lipolytica | 70.18 | 2e-116 | 340 |
| LLPS-Asg-0086 | Ashbya gossypii | 70.08 | 7e-130 | 374 |
| LLPS-Asc-0258 | Aspergillus clavatus | 69.92 | 3e-126 | 365 |
| LLPS-Asf-0994 | Aspergillus flavus | 69.92 | 6e-127 | 367 |
| LLPS-Coo-1347 | Colletotrichum orbiculare | 69.8 | 5e-127 | 367 |
| LLPS-Pyt-0792 | Pyrenophora teres | 69.8 | 2e-126 | 366 |
| LLPS-Pytr-0123 | Pyrenophora triticirepentis | 69.8 | 2e-126 | 366 |
| LLPS-Asni-0753 | Aspergillus niger | 69.51 | 1e-125 | 364 |
| LLPS-Blg-1094 | Blumeria graminis | 69.39 | 3e-124 | 360 |
| LLPS-Lep-0036 | Leersia perrieri | 69.38 | 7e-130 | 375 |
| LLPS-Gas-0577 | Galdieria sulphuraria | 68.31 | 2e-120 | 350 |
| LLPS-Tru-0785 | Triticum urartu | 68.18 | 5e-121 | 352 |
| LLPS-Osl-0024 | Ostreococcus lucimarinus | 67.1 | 2e-114 | 335 |
| LLPS-Mel-0000 | Melampsora laricipopulina | 65.54 | 7e-120 | 350 |
| LLPS-Mam-1133 | Macaca mulatta | 65.2 | 2e-95 | 286 |
| LLPS-Aso-0233 | Aspergillus oryzae | 63.1 | 3e-120 | 351 |
| LLPS-Cae-0001 | Caenorhabditis elegans | 62.2 | 9e-111 | 326 |