• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Php-0070
EIF6

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 6
Gene Name: EIF6, PHYPA_028217, PHYPADRAFT_194687
Ensembl Gene: Pp3c23_17430
Ensembl Protein: Pp3c23_17430V3.3
Organism: Physcomitrella patens
Taxa ID: 3218
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATRVQFENS  NEIGVFSKLT  NAYCLVAIGG  SENFYSTFEA  ELGDVIPVVK  ASIAGTRVIG  60
61    RMCVGNKNGL  LLPQATTDQE  LLHIRNCLPD  SVVVQRVDER  LSALGNCIAC  NDYVSLIHTD  120
121   LDRETEELVA  DVLGVEVFRQ  TIAGNILVGS  YCQFTNRGGL  VHPHTSIEDL  DELSSLLQVP  180
181   LVAGTVNRGS  EVIGAGLVVN  DWTAFCGLDT  TATELSVIES  VFKLRDAQPS  NIVNEMRASL  240
241   IDTMS  245
Nucleotide CDS Sequence (FASTA)
1     ATGTGTGTTG  GTAATAAGAA  TGGTCTCCTC  CTTCCACAAG  CAACCACTGA  TCAAGAGCTA  60
61    CTGCATATAA  GGAATTGCTT  ACCAGACAGC  GTGGTCGTTC  AAAGAGTGGA  TGAACGTCTC  120
121   TCAGCGCTTG  GAAATTGTAT  CGCTTGTAAT  GACTATGTGT  CGCTTATTCA  CACTGATCTG  180
181   GATAGGGAAA  CGGAAGAACT  TGTAGCAGAT  GTCCTGGGAG  TTGAAGTATT  CAGGCAAACC  240
241   ATTGCTGGCA  ATATTCTTGT  TGGGAGCTAT  TGTCAATTCA  CTAATCGTGG  TGGATTGGTA  300
301   CACCCACACA  CATCGATAGA  GGATTTGGAT  GAGTTGTCAT  CGTTATTACA  AGTGCCACTC  360
361   GTGGCTGGTA  CTGTAAACAG  AGGAAGTGAA  GTCATTGGTG  CTGGTTTGGT  GGTTAATGAC  420
421   TGGACTGCTT  TCTGTGGATT  GGACACAACA  GCTACAGAAC  TCTCTGTTAT  AGAGAGTGTG  480
481   TTCAAACTCC  GTGACGCTCA  ACCCAGTAAT  ATTGTCAATG  AAATGAGGGC  TTCCCTTATC  540
541   GACACCATGT  CATAG  555

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Nucleus
Protein biosynthesis
Reference proteome
Ribosome biogenesis

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleolus
Cellular Component
Preribosome, large subunit precursor
Molecular Function
Ribosomal large subunit binding
Molecular Function
Ribosome binding
Molecular Function
Translation initiation factor activity
Biological Process
Assembly of large subunit precursor of preribosome
Biological Process
Mature ribosome assembly
Biological Process
Ribosomal large subunit biogenesis
Biological Process
Ribosomal subunit export from nucleus

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sem-0639Selaginella moellendorffii88.982e-151 429
LLPS-Hea-0497Helianthus annuus86.831e-148 422
LLPS-Thc-1176Theobroma cacao86.011e-146 417
LLPS-Dac-1449Daucus carota85.442e-119 347
LLPS-Nia-0795Nicotiana attenuata85.191e-145 414
LLPS-Prp-0384Prunus persica85.192e-146 416
LLPS-Glm-2615Glycine max85.197e-145 412
LLPS-Via-0566Vigna angularis85.191e-145 414
LLPS-Pot-0485Populus trichocarpa84.772e-145 414
LLPS-Gor-2521Gossypium raimondii84.771e-144 415
LLPS-Mae-0335Manihot esculenta84.772e-144 412
LLPS-Coc-1381Corchorus capsularis84.776e-146 415
LLPS-Mua-0595Musa acuminata84.771e-144 412
LLPS-Viv-0361Vitis vinifera84.363e-144 410
LLPS-Orbr-0578Oryza brachyantha84.361e-144 412
LLPS-Amt-0304Amborella trichopoda84.174e-139 399
LLPS-Phv-0709Phaseolus vulgaris83.955e-145 413
LLPS-Zem-0444Zea mays83.955e-144 410
LLPS-Sol-0424Solanum lycopersicum83.951e-142 407
LLPS-Brd-0063Brachypodium distachyon83.952e-144 411
LLPS-Orp-0105Oryza punctata83.543e-143 408
LLPS-Ors-0656Oryza sativa83.543e-143 408
LLPS-Sob-0327Sorghum bicolor83.548e-144 410
LLPS-Orm-0202Oryza meridionalis83.543e-143 408
LLPS-Orr-1507Oryza rufipogon83.543e-143 408
LLPS-Org-0365Oryza glaberrima83.543e-143 408
LLPS-Ori-0424Oryza indica83.543e-143 408
LLPS-Orb-0241Oryza barthii83.543e-143 408
LLPS-Orni-0294Oryza nivara83.543e-143 408
LLPS-Sot-0968Solanum tuberosum83.549e-142 404
LLPS-Orgl-0599Oryza glumaepatula83.543e-143 408
LLPS-Tra-0068Triticum aestivum83.546e-144 410
LLPS-Sei-0047Setaria italica83.548e-143 407
LLPS-Cus-0308Cucumis sativus83.542e-140 401
LLPS-Hov-0643Hordeum vulgare83.263e-140 401
LLPS-Brr-0575Brassica rapa81.895e-143 408
LLPS-Bro-1910Brassica oleracea81.891e-142 407
LLPS-Brn-0114Brassica napus81.895e-143 408
LLPS-Met-1424Medicago truncatula81.891e-140 402
LLPS-Art-0635Arabidopsis thaliana81.483e-143 408
LLPS-Vir-0813Vigna radiata81.127e-141 402
LLPS-Arl-0556Arabidopsis lyrata81.079e-141 402
LLPS-Chr-0685Chlamydomonas reinhardtii80.821e-141 404
LLPS-Lep-0036Leersia perrieri79.35e-140 400
LLPS-Otg-0086Otolemur garnettii77.691e-128 372
LLPS-Cap-0898Cavia porcellus77.691e-128 371
LLPS-Fud-2304Fukomys damarensis77.692e-128 371
LLPS-Bot-0634Bos taurus77.594e-123 357
LLPS-Lac-0271Latimeria chalumnae77.242e-64 204
LLPS-Gog-0605Gorilla gorilla77.166e-122 355
LLPS-Leo-2208Lepisosteus oculatus77.147e-131 377
LLPS-Tar-1861Takifugu rubripes76.954e-125 368
LLPS-Caf-0140Canis familiaris76.865e-127 367
LLPS-Ova-0658Ovis aries76.862e-127 368
LLPS-Myl-0520Myotis lucifugus76.861e-127 369
LLPS-Aim-1446Ailuropoda melanoleuca76.865e-127 367
LLPS-Orn-1352Oreochromis niloticus76.831e-128 371
LLPS-Anc-1012Anolis carolinensis76.731e-130 376
LLPS-Scf-0269Scleropages formosus76.733e-129 373
LLPS-Ict-0683Ictidomys tridecemlineatus76.694e-124 360
LLPS-Cii-0521Ciona intestinalis76.643e-130 375
LLPS-Aon-1324Aotus nancymaae76.454e-126 366
LLPS-Cea-0461Cercocebus atys76.452e-125 364
LLPS-Caj-0749Callithrix jacchus76.454e-126 366
LLPS-Paa-2362Papio anubis76.452e-125 364
LLPS-Orl-2433Oryzias latipes76.427e-128 369
LLPS-Fec-0390Felis catus76.333e-129 373
LLPS-Meg-0111Meleagris gallopavo76.333e-129 373
LLPS-Eqc-0180Equus caballus76.333e-129 373
LLPS-Cas-1872Carlito syrichta76.332e-128 372
LLPS-Gaga-1911Gallus gallus76.333e-129 373
LLPS-Sus-0781Sus scrofa76.336e-129 372
LLPS-Cis-0060Ciona savignyi76.332e-128 371
LLPS-Chc-0415Chondrus crispus76.335e-132 380
LLPS-Orc-0484Oryctolagus cuniculus76.137e-127 367
LLPS-Tag-0027Taeniopygia guttata76.034e-127 367
LLPS-Ran-2316Rattus norvegicus76.033e-126 365
LLPS-Xet-2828Xenopus tropicalis75.943e-69 216
LLPS-Urm-2394Ursus maritimus75.921e-127 369
LLPS-Asm-0744Astyanax mexicanus75.925e-128 370
LLPS-Dio-0383Dipodomys ordii75.924e-129 372
LLPS-Tut-1153Tursiops truncatus75.921e-128 371
LLPS-Mup-0576Mustela putorius furo75.921e-127 369
LLPS-Scm-1936Scophthalmus maximus75.612e-128 371
LLPS-Man-0762Macaca nemestrina75.513e-127 367
LLPS-Mod-1029Monodelphis domestica75.517e-127 367
LLPS-Hos-1849Homo sapiens75.513e-127 367
LLPS-Pap-1605Pan paniscus75.513e-127 367
LLPS-Pat-0111Pan troglodytes75.513e-127 367
LLPS-Rhb-0534Rhinopithecus bieti75.513e-127 367
LLPS-Nol-0777Nomascus leucogenys75.513e-127 367
LLPS-Chs-0426Chlorocebus sabaeus75.513e-127 367
LLPS-Mum-0724Mus musculus75.511e-127 369
LLPS-Maf-0199Macaca fascicularis75.513e-127 367
LLPS-Mal-0272Mandrillus leucophaeus75.513e-127 367
LLPS-Pes-0118Pelodiscus sinensis75.473e-107 315
LLPS-Pof-0157Poecilia formosa75.25e-126 365
LLPS-Xim-1374Xiphophorus maculatus75.25e-126 365
LLPS-Dar-0303Danio rerio75.11e-127 369
LLPS-Icp-0248Ictalurus punctatus75.12e-128 370
LLPS-Abg-0326Absidia glauca75.19e-131 377
LLPS-Ten-1449Tetraodon nigroviridis75.01e-123 358
LLPS-Sah-0864Sarcophilus harrisii74.885e-106 312
LLPS-Loa-0986Loxodonta africana74.798e-124 359
LLPS-Poa-0115Pongo abelii74.693e-126 365
LLPS-Sac-0417Saccharomyces cerevisiae74.691e-129 374
LLPS-Ora-0627Ornithorhynchus anatinus74.596e-87 263
LLPS-Gaa-1213Gasterosteus aculeatus74.591e-125 363
LLPS-Anp-1184Anas platyrhynchos74.188e-90 270
LLPS-Fia-0063Ficedula albicollis73.882e-124 361
LLPS-Scc-0030Schizosaccharomyces cryophilus73.882e-126 365
LLPS-Mea-1234Mesocricetus auratus73.887e-125 362
LLPS-Kop-0526Komagataella pastoris73.062e-129 373
LLPS-Asn-0338Aspergillus nidulans72.841e-114 336
LLPS-Spr-0089Sporisorium reilianum72.362e-121 353
LLPS-Asg-0086Ashbya gossypii72.249e-126 364
LLPS-Tru-0785Triticum urartu71.61e-120 351
LLPS-Usm-0777Ustilago maydis71.548e-120 349
LLPS-Crn-0755Cryptococcus neoformans71.491e-121 353
LLPS-Drm-0881Drosophila melanogaster71.434e-123 357
LLPS-Scp-0453Schizosaccharomyces pombe71.439e-123 356
LLPS-Asni-0753Aspergillus niger71.122e-114 335
LLPS-Asf-0994Aspergillus flavus71.123e-114 335
LLPS-Osl-0024Ostreococcus lucimarinus71.062e-122 355
LLPS-Scj-0528Schizosaccharomyces japonicus71.021e-122 356
LLPS-Cym-0025Cyanidioschyzon merolae70.562e-120 351
LLPS-Gas-0577Galdieria sulphuraria69.922e-118 345
LLPS-Nef-0072Neosartorya fischeri69.831e-112 331
LLPS-Asfu-0241Aspergillus fumigatus69.831e-112 331
LLPS-Yal-0649Yarrowia lipolytica69.743e-110 324
LLPS-Tum-0158Tuber melanosporum69.263e-116 340
LLPS-Nec-0697Neurospora crassa69.268e-114 333
LLPS-Fuo-0638Fusarium oxysporum68.982e-118 345
LLPS-Scs-0132Sclerotinia sclerotiorum68.981e-117 343
LLPS-Fuv-0047Fusarium verticillioides68.982e-118 345
LLPS-Asc-0258Aspergillus clavatus68.978e-112 328
LLPS-Ast-0261Aspergillus terreus68.855e-116 339
LLPS-Miv-0408Microbotryum violaceum68.727e-115 336
LLPS-Beb-0927Beauveria bassiana68.576e-117 342
LLPS-Trr-0760Trichoderma reesei68.571e-118 346
LLPS-Blg-1094Blumeria graminis68.447e-112 328
LLPS-Fus-0429Fusarium solani68.163e-117 342
LLPS-Dos-0400Dothistroma septosporum67.951e-111 328
LLPS-Trv-0090Trichoderma virens67.768e-118 343
LLPS-Coo-1347Colletotrichum orbiculare67.767e-116 339
LLPS-Lem-0256Leptosphaeria maculans67.763e-115 337
LLPS-Zyt-0121Zymoseptoria tritici67.763e-113 332
LLPS-Cog-0127Colletotrichum gloeosporioides67.352e-115 338
LLPS-Phn-0338Phaeosphaeria nodorum67.351e-114 336
LLPS-Cogr-0832Colletotrichum graminicola67.351e-112 330
LLPS-Ved-1191Verticillium dahliae67.352e-114 335
LLPS-Map-0024Magnaporthe poae67.353e-115 337
LLPS-Pug-0185Puccinia graminis67.074e-113 332
LLPS-Pytr-0123Pyrenophora triticirepentis66.948e-114 333
LLPS-Gag-0108Gaeumannomyces graminis66.946e-115 337
LLPS-Pyt-0792Pyrenophora teres66.948e-114 333
LLPS-Put-0362Puccinia triticina66.678e-113 331
LLPS-Mao-0265Magnaporthe oryzae66.531e-113 333
LLPS-Aso-0233Aspergillus oryzae64.25e-108 320
LLPS-Mel-0000Melampsora laricipopulina62.315e-109 322
LLPS-Cae-0001Caenorhabditis elegans60.417e-103 306
LLPS-Mam-1133Macaca mulatta53.364e-69 219